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Saeeda Kirmani

Title(s)Clinical Professor, Medicine
SchoolHealth Sciences
Phone858-552-8585
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    Research Interests
    Dr. Kirmani is a clinical investigator conducting a wide range of phase I-III cancer trials primarily at the San Diego Veterans Hospital. She is the VA-responsible investigator for all cancer cooperative group studies including CALGB, RTOG and VA-CORNET. In addition, she is a clinical investigator for a number of industry-sponsored, as well as investigator-initiated studies.

    Education and Training
    Fellow of Science - Premedical, Punjab University, Pakistan - 1968
    MBBS - Punjab University, Pakistan - 1974
    Intern/Resident - University of Maryland, Baltimore - 1975-1978
    Fellow, Hematology-Oncology - Letterman Army Medical Center, San Francisco - 1979-7982
    Training in Hematopathology - Armed Forces Institute of Pathology, Washington DC- 1980

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Volk A, Conboy E, Wical B, Patterson M, Kirmani S. Whole-Exome Sequencing in the Clinic: Lessons from Six Consecutive Cases from the Clinician's Perspective. Mol Syndromol. 2015 Feb; 6(1):23-31. PMID: 25852444.
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    2. Dvorak LA, Vassallo R, Kirmani S, Johnson G, Hartman TE, Tazelaar HD, Leslie KO, Colby TV, Cockcroft DW, Churg AM, Yi ES. Pulmonary fibrosis in dyskeratosis congenita: report of 2 cases. Hum Pathol. 2015 Jan; 46(1):147-52. PMID: 25455995.
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    3. Farr JN, Khosla S, Achenbach SJ, Atkinson EJ, Kirmani S, McCready LK, Melton LJ, Amin S. Diminished bone strength is observed in adult women and men who sustained a mild trauma distal forearm fracture during childhood. J Bone Miner Res. 2014 Oct; 29(10):2193-202. PMID: 24753047.
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    4. Brodsky MC, Turan KE, Khanna CL, Patton A, Kirmani S. Congenital mydriasis and prune belly syndrome in a child with an ACTA2 mutation. J AAPOS. 2014 Aug; 18(4):393-5. PMID: 24998021.
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    5. Dhamija R, Kirmani S, Wang X, Ferber MJ, Wieben ED, Lazaridis KN, Babovic-Vuksanovic D. Novel de novo heterozygous FGFR1 mutation in two siblings with Hartsfield syndrome: a case of gonadal mosaicism. Am J Med Genet A. 2014 Sep; 164A(9):2356-9. PMID: 24888332.
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    6. Dhamija R, Kirmani S. A 7-year-old girl with hypertrophic cardiomyopathy and progressive scoliosis. Semin Pediatr Neurol. 2014 Jun; 21(2):67-71. PMID: 25149925.
      View in: PubMed
    7. Farr JN, Amin S, Melton LJ, Kirmani S, McCready LK, Atkinson EJ, Müller R, Khosla S. Bone strength and structural deficits in children and adolescents with a distal forearm fracture resulting from mild trauma. J Bone Miner Res. 2014 Mar; 29(3):590-9. PMID: 23959563.
      View in: PubMed
    8. Dhamija R, Graham JM, Smaoui N, Thorland E, Kirmani S. Novel de novo SPOCK1 mutation in a proband with developmental delay, microcephaly and agenesis of corpus callosum. Eur J Med Genet. 2014 Mar; 57(4):181-4. PMID: 24583203.
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    9. Myrick LK, Nakamoto-Kinoshita M, Lindor NM, Kirmani S, Cheng X, Warren ST. Fragile X syndrome due to a missense mutation. Eur J Hum Genet. 2014 Oct; 22(10):1185-9. PMID: 24448548.
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    10. Fujita K, Roforth MM, Demaray S, McGregor U, Kirmani S, McCready LK, Peterson JM, Drake MT, Monroe DG, Khosla S. Effects of estrogen on bone mRNA levels of sclerostin and other genes relevant to bone metabolism in postmenopausal women. J Clin Endocrinol Metab. 2014 Jan; 99(1):E81-8. PMID: 24170101.
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    11. Roforth MM, Fujita K, McGregor UI, Kirmani S, McCready LK, Peterson JM, Drake MT, Monroe DG, Khosla S. Effects of age on bone mRNA levels of sclerostin and other genes relevant to bone metabolism in humans. Bone. 2014 Feb; 59:1-6. PMID: 24184314.
      View in: PubMed
    12. Kochhar A, Kirmani S, Cetta F, Younge B, Hyland JC, Michels V. Similarity of geleophysic dysplasia and Weill-Marchesani syndrome. Am J Med Genet A. 2013 Dec; 161A(12):3130-2. PMID: 24214363.
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    13. Dhamija R, Wirrell E, Falcao G, Kirmani S, Wong-Kisiel LC. Novel de novo SCN2A mutation in a child with migrating focal seizures of infancy. Pediatr Neurol. 2013 Dec; 49(6):486-8. PMID: 23988467.
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    14. Amin S, Melton LJ, Achenbach SJ, Atkinson EJ, Dekutoski MB, Kirmani S, Fischer PR, Khosla S. A distal forearm fracture in childhood is associated with an increased risk for future fragility fractures in adult men, but not women. J Bone Miner Res. 2013 Aug; 28(8):1751-9. PMID: 23456800.
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    15. Dhamija R, Waltman L, Hoppman N, Kirmani S. Septo-optic dysplasia in a patient with an unbalanced 5;12 translocation. Pediatr Neurol. 2013 Jul; 49(1):e2-3. PMID: 23827435.
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    16. Hodge JC, Kirmani S. Response to Cobben et al. "Array CGH on unstimulated blood does not detect all cases of Pallister-Killian syndrome: buccal smear analysis should remain the diagnostic procedure of first choice". Am J Med Genet A. 2013 Jun; 161A(6):1520-1. PMID: 23613434.
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    17. Hodge JC, Mitchell E, Pillalamarri V, Toler TL, Bartel F, Kearney HM, Zou YS, Tan WH, Hanscom C, Kirmani S, Hanson RR, Skinner SA, Rogers RC, Everman DB, Boyd E, Tapp C, Mullegama SV, Keelean-Fuller D, Powell CM, Elsea SH, Morton CC, Gusella JF, DuPont B, Chaubey A, Lin AE, Talkowski ME. Disruption of MBD5 contributes to a spectrum of psychopathology and neurodevelopmental abnormalities. Mol Psychiatry. 2014 Mar; 19(3):368-79. PMID: 23587880.
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    18. Dauxois JY, Guilloux A, Kirmani SN. Estimation in a competing risks proportional hazards model under length-biased sampling with censoring. Lifetime Data Anal. 2014 Apr; 20(2):276-302. PMID: 23456312.
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    19. Lionel AC, Vaags AK, Sato D, Gazzellone MJ, Mitchell EB, Chen HY, Costain G, Walker S, Egger G, Thiruvahindrapuram B, Merico D, Prasad A, Anagnostou E, Fombonne E, Zwaigenbaum L, Roberts W, Szatmari P, Fernandez BA, Georgieva L, Brzustowicz LM, Roetzer K, Kaschnitz W, Vincent JB, Windpassinger C, Marshall CR, Trifiletti RR, Kirmani S, Kirov G, Petek E, Hodge JC, Bassett AS, Scherer SW. Rare exonic deletions implicate the synaptic organizer Gephyrin (GPHN) in risk for autism, schizophrenia and seizures. Hum Mol Genet. 2013 May 15; 22(10):2055-66. PMID: 23393157.
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    20. Bang GM, Kirmani S, Patton A, Pulido JS, Brodsky MC. "Ocular moyamoya" syndrome in a patient with features of microcephalic osteodysplastic primordial dwarfism type II. J AAPOS. 2013 Feb; 17(1):100-2. PMID: 23337351.
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    21. Javed A, Leonard JM, Cramer C, Kumar S, Kirmani S, Brands CK. Pseudohypoaldosteronism presenting with thrombocytosis and bilateral pneumothoraces in an infant. J Pediatr Endocrinol Metab. 2013; 26(3-4):393-5. PMID: 23327809.
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    22. Lindor NM, Smyrk TC, Buehler S, Gunawardena SR, Thomas BC, Limburg P, Kirmani S, Thibodeau SN. Multiple jejunal cancers resulting from combination of germline APC and MLH1 mutations. Fam Cancer. 2012 Dec; 11(4):667-9. PMID: 22886683.
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    23. Abraham RS, Recher M, Giliani S, Walter JE, Lee YN, Frugoni F, Maddox DE, Kirmani S, Notarangelo LD. Adult-onset manifestation of idiopathic T-cell lymphopenia due to a heterozygous RAG1 mutation. J Allergy Clin Immunol. 2013 May; 131(5):1421-3. PMID: 23122631.
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    24. Morimoto M, Yu Z, Stenzel P, Clewing JM, Najafian B, Mayfield C, Hendson G, Weinkauf JG, Gormley AK, Parham DM, Ponniah U, André JL, Asakura Y, Basiratnia M, Bogdanovic R, Bokenkamp A, Bonneau D, Buck A, Charrow J, Cochat P, Cordeiro I, Deschenes G, Fenkçi MS, Frange P, Fründ S, Fryssira H, Guillen-Navarro E, Keller K, Kirmani S, Kobelka C, Lamfers P, Levtchenko E, Lewis DB, Massella L, McLeod DR, Milford DV, Nobili F, Saraiva JM, Semerci CN, Shoemaker L, Stajic N, Stein A, Taha D, Wand D, Zonana J, Lücke T, Boerkoel CF. Reduced elastogenesis: a clue to the arteriosclerosis and emphysematous changes in Schimke immuno-osseous dysplasia? Orphanet J Rare Dis. 2012 Sep 22; 7:70. PMID: 22998683.
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    25. Raca G, Baas BS, Kirmani S, Laffin JJ, Jackson CA, Strand EA, Jakielski KJ, Shriberg LD. Childhood Apraxia of Speech (CAS) in two patients with 16p11.2 microdeletion syndrome. Eur J Hum Genet. 2013 Apr; 21(4):455-9. PMID: 22909774.
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    26. Carlson AM, Thomas KB, Kirmani S, Lindor NM. Chronic tibial nonunion in a Rothmund-Thomson syndrome patient. Am J Med Genet A. 2012 Sep; 158A(9):2250-3. PMID: 22821900.
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    27. Murphy-Ryan M, Kirmani S, Thompson DM, Binkovitz LA, Thomas KB, Babovic-Vuksanovic D. A novel sclerosing skeletal dysplasia with mixed sclerosing bone dysplasia, characteristic syndromic features, and clinical and radiographic evidence of male-male transmission. Am J Med Genet A. 2012 Sep; 158A(9):2292-6. PMID: 22821701.
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    28. Morimoto M, Kérourédan O, Gendronneau M, Shuen C, Baradaran-Heravi A, Asakura Y, Basiratnia M, Bogdanovic R, Bonneau D, Buck A, Charrow J, Cochat P, Dehaai KA, Fenkçi MS, Frange P, Fründ S, Fryssira H, Keller K, Kirmani S, Kobelka C, Kohler K, Lewis DB, Massella L, McLeod DR, Milford DV, Nobili F, Olney AH, Semerci CN, Stajic N, Stein A, Taque S, Zonana J, Lücke T, Hendson G, Bonnaure-Mallet M, Boerkoel CF. Dental abnormalities in Schimke immuno-osseous dysplasia. J Dent Res. 2012 Jul; 91(7 Suppl):29S-37S. PMID: 22699664.
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    29. Rashid M, Kirmani S, Rashid M. Giant intradural extramedullary spinal hydatid cyst--a rare presentation. Clin Imaging. 2012 Nov-Dec; 36(6):881-3. PMID: 23154030.
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    30. Hodge JC, Hulshizer RL, Seger P, St Antoine A, Bair J, Kirmani S. Array CGH on unstimulated blood does not detect all cases of Pallister-Killian syndrome: a skin biopsy should remain the diagnostic gold standard. Am J Med Genet A. 2012 Mar; 158A(3):669-73. PMID: 22315202.
      View in: PubMed
    31. Kirmani S. Molecular genetic testing in endocrinology - a practical guide. Endocr Pract. 2012 Jan-Feb; 18(1):85-9. PMID: 22336444.
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    32. Kirmani S, Atkinson EJ, Melton LJ, Riggs BL, Amin S, Khosla S. Relationship of testosterone and osteocalcin levels during growth. J Bone Miner Res. 2011 Sep; 26(9):2212-6. PMID: 21590731.
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    33. Kirmani S, Rashid M, Ali I, Badar F. External jugular vein aneurysm: a rare cause of neck swelling. J Ultrasound Med. 2011 Aug; 30(8):1157-8. PMID: 21795494.
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    34. Badar F, Azfar SF, Ahmad I, Kirmani S, Rashid M. Balo's concentric sclerosis involving bilateral thalami. Neurol India. 2011 Jul-Aug; 59(4):597-600. PMID: 21891941.
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    35. Kirmani S, Amin S, McCready LK, Atkinson EJ, Melton LJ, Müller R, Khosla S. Sclerostin levels during growth in children. Osteoporos Int. 2012 Mar; 23(3):1123-30. PMID: 21617991.
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    36. Badar F, Azfar SF, Ahmad I, Yasmeen S, Kirmani S. Diagnostic difficulties in differentiating sarcoidosis from tuberculosis. Oman Med J. 2011 May; 26(3):210-1. PMID: 22043421.
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    37. Badar F, Kirmani S, Rashid M, Azfar SF, Yasmeen S, Ullah E. Spontaneous spinal epidural hematoma during pregnancy: a rare obstetric emergency. Emerg Radiol. 2011 Oct; 18(5):433-6. PMID: 21484460.
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    38. Ali Pervaiz M, Patterson MC, Struys EA, Salomons GS, Jakobs C, Oglesbee D, Kirmani S. Co-morbidity of Sanfilippo syndrome type C and D-2-hydroxyglutaric aciduria. J Neurol. 2011 Aug; 258(8):1564-5. PMID: 21384162.
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    39. Azfar SF, Badar F, Akhtar N, Kirmani S. Diabetic women with Fever and right flank pain. Oman Med J. 2011 Mar; 26(2):141-2. PMID: 22043403.
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    40. Azfar SF, Kirmani S, Badar F, Ahmad I. Isolated intramedullary spinal cysticercosis in a 10-year-old female showing dramatic response with albendazole. J Pediatr Neurosci. 2011 Jan; 6(1):52-4. PMID: 21977090.
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    41. Gertsch E, Kirmani S, Ackerman MJ, Babovic-Vuksanovic D. Transient QT interval prolongation in an infant with Simpson-Golabi-Behmel syndrome. Am J Med Genet A. 2010 Sep; 152A(9):2379-82. PMID: 20683991.
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    42. Kirmani SN, Banks PB, McArthur C. Integrating the costs of plant toxins and predation risk in foraging decisions of a mammalian herbivore. Oecologia. 2010 Oct; 164(2):349-56. PMID: 20652597.
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    43. de las Alas MM, Christen RD, Gately DP, Weiner DE, Benbatoul K, Kirmani S, D'Agostino HR, Plaxe SC, Darrah D, McClay EF, Aebi S, Howell SB, Los G. Increase in tumor GADD153 mRNA level following treatment correlates with response to paclitaxel. Cancer Chemother Pharmacol. 2000; 45(5):381-8. PMID: 10803921.
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    44. Los G, Benbatoul K, Gately DP, Barton R, Christen R, Robbins KT, Vicario D, Kirmani S, Orloff LA, Weisman R, Howell SB. Quantitation of the change in GADD153 messenger RNA level as a molecular marker of tumor response in head and neck cancer. Clin Cancer Res. 1999 Jul; 5(7):1610-8. PMID: 10430059.
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    45. Weisman RA, Christen R, Los G, Jones V, Kerber C, Seagren S, Glassmeyer S, Orloff LA, Wong W, Kirmani S, Howell S. Phase I trial of retinoic acid and cis-platinum for advanced squamous cell cancer of the head and neck based on experimental evidence of drug synergism. Otolaryngol Head Neck Surg. 1998 May; 118(5):597-602. PMID: 9591856.
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    46. McClay EF, Braly PD, Kirmani S, Plaxe SC, Kim S, McClay ME, Wilgus L, Howell SB. A phase II trial of intraperitoneal high-dose carboplatin and etoposide with granulocyte macrophage-colony stimulating factor support in patients with ovarian carcinoma. Am J Clin Oncol. 1995 Feb; 18(1):23-6. PMID: 7847254.
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    47. Plaxe S, Freddo J, Kim S, Kirmani S, McClay E, Christen R, Braly P, Howell S. Phase I trial of cisplatin in combination with glutathione. Gynecol Oncol. 1994 Oct; 55(1):82-6. PMID: 7959273.
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    48. Kirmani S, Braly PS, McClay EF, Saltzstein SL, Plaxe SC, Kim S, Cates C, Howell SB. A comparison of intravenous versus intraperitoneal chemotherapy for the initial treatment of ovarian cancer. Gynecol Oncol. 1994 Sep; 54(3):338-44. PMID: 8088611.
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    49. McClay EF, Braly PD, Kirmani S, Plaxe SC, McClay ME, Wilgus L, Kim S, Howell SB. A phase I trial of intraperitoneal carboplatin and etoposide with granulocyte macrophage colony stimulating factor support in patients with intraabdominal malignancies. Cancer. 1994 Jul 15; 74(2):664-9. PMID: 8033046.
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    50. McClay EF, Goel R, Andrews P, Gorelick S, Kirmani S, Kim S, Braly P, Plaxe S, Hoff S, Alcaraz J. A phase I and pharmacokinetic study of intraperitoneal carboplatin and etoposide. Br J Cancer. 1993 Oct; 68(4):783-8. PMID: 8398708.
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    51. Plaxe SC, Braly PS, Freddo JL, McClay E, Christen RD, Kirmani S, Kim S, Heath D, Howell SB. Phase I and pharmacokinetic study of intraperitoneal ormaplatin. Gynecol Oncol. 1993 Oct; 51(1):72-7. PMID: 8244179.
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    52. Bonetti A, Howell SB, McClay E, Kirmani S, Goel R, Plaxe S, Braly P, Kim S. High-dose biweekly intraperitoneal cisplatin: an effective way to increase cisplatin dose intensity. Gynecol Oncol. 1993 Jun; 49(3):318-24. PMID: 8314533.
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    53. Plaxe SC, Braly PS, Freddo JL, McClay E, Kirmani S, Howell SB. Profiles of women age 30-39 and age less than 30 with epithelial ovarian cancer. Obstet Gynecol. 1993 May; 81(5 ( Pt 1)):651-4. PMID: 8469449.
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    54. Kim S, Howell SB, McClay E, Kirmani S, Goel R, Plaxe S, Braly P, Bonetti A. Dose intensification of cisplatin chemotherapy through biweekly administration. Ann Oncol. 1993 Mar; 4(3):221-7. PMID: 8471554.
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    55. Goel R, McClay EF, Kirmani S, Kim S, Braly PF, Plaxe SC, Alcaraz J, Andrews PA, Reichman B, Markman M. Pharmacokinetic study of intraperitoneal streptozotocin. Clin Invest Med. 1992 Oct; 15(5):420-6. PMID: 1458714.
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    56. Isonishi S, Kirmani S, Kim S, Plaxe SC, Braly PS, McClay EF, Howell SB. Phase I and pharmacokinetic trial of intraperitoneal etoposide in combination with the multidrug-resistance-modulating agent dipyridamole. J Natl Cancer Inst. 1991 May 01; 83(9):621-6. PMID: 2023280.
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    57. Kirmani S, Lucas WE, Kim S, Goel R, McVey L, Morris J, Howell SB. A phase II trial of intraperitoneal cisplatin and etoposide as salvage treatment for minimal residual ovarian carcinoma. J Clin Oncol. 1991 Apr; 9(4):649-57. PMID: 2066761.
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    58. McDonald BR, Kirmani S, Vasquez M, Mehta RL. Acute renal failure associated with the use of intraperitoneal carboplatin: a report of two cases and review of the literature. Am J Med. 1991 Mar; 90(3):386-91. PMID: 2003521.
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    59. Howell SB, Kirmani S, McClay EF, Kim S, Braly P, Plaxe S. Intraperitoneal cisplatin-based chemotherapy for ovarian carcinoma. Semin Oncol. 1991 Feb; 18(1 Suppl 3):5-10. PMID: 2003227.
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    60. Kirmani S, McVey L, Loo D, Howell SB. A phase I clinical trial of intraperitoneal thiotepa for refractory ovarian cancer. Gynecol Oncol. 1990 Mar; 36(3):331-4. PMID: 2108079.
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    61. Kirmani S, Zimm S, Cleary SM, Mowry J, Howell SB. Extremely prolonged continuous intraperitoneal infusion of cytosine arabinoside. Cancer Chemother Pharmacol. 1990; 25(6):454-8. PMID: 2311175.
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    62. Howell SB, Kirmani S, Lucas WE, Zimm S, Goel R, Kim S, Horton MC, McVey L, Morris J, Weiss RJ. A phase II trial of intraperitoneal cisplatin and etoposide for primary treatment of ovarian epithelial cancer. J Clin Oncol. 1990 Jan; 8(1):137-45. PMID: 2295904.
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    63. Goel R, Andrews PA, Pfeifle CE, Abramson IS, Kirmani S, Howell SB. Comparison of the pharmacokinetics of ultrafilterable cisplatin species detectable by derivatization with diethyldithiocarbamate or atomic absorption spectroscopy. Eur J Cancer. 1990 Jan; 26(1):21-7. PMID: 2156545.
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    64. Goel R, Cleary SM, Horton C, Kirmani S, Abramson I, Kelly C, Howell SB. Effect of sodium thiosulfate on the pharmacokinetics and toxicity of cisplatin. J Natl Cancer Inst. 1989 Oct 18; 81(20):1552-60. PMID: 2552131.
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    65. Goel R, Cleary SM, Horton C, Balis FM, Zimm S, Kirmani S, Howell SB. Selective intraperitoneal biochemical modulation of methotrexate by dipyridamole. J Clin Oncol. 1989 Feb; 7(2):262-9. PMID: 2915241.
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    66. Howell SB, Kirmani S, Goel R. Novel approaches to intraperitoneal drug delivery. Acta Med Austriaca. 1989; 16(3-4):61-4. PMID: 2514552.
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