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From Betel Nuts to Cobenfy: How an Ancient Recreational Drug Gave Rise to a New Class of Schizophrenia Medications - ERRATUM. CNS Spectr. 2025 Sep 17; 30(1):e74.
Creeden JF, Machiraju SN, Amin JB, Stahl SM. PMID: 40960160.
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PubMed Mentions: Fields:
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From betel nuts to Cobenfy: how an ancient recreational drug gave rise to a new class of schizophrenia medications. CNS Spectr. 2025 07 17; 30(1):e55.
Creeden JF, Machiraju SN, Amin JB, Stahl SM. PMID: 40671308.
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HumansAnimals
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Sex-specific sequels of early life stress on serine/threonine kinase activity in visceral adipose tissue from obese mice. bioRxiv. 2024 Apr 04.
Leachman J, Creeden J, Turner M, Ahmed N, Dalmasso C, Loria AS. PMID: 38617246; PMCID: PMC11014506.
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Smart exosomes enhance PDAC targeted therapy. J Control Release. 2024 Apr; 368:413-429.
Creeden JF, Sevier J, Zhang JT, Lapitsky Y, Brunicardi FC, Jin G, Nemunaitis J, Liu JY, Kalinoski A, Rao D, Liu SH. PMID: 38431093; PMCID: PMC12312550.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
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FOXS1 is increased in liver fibrosis and regulates TGFβ responsiveness and proliferation pathways in human hepatic stellate cells. J Biol Chem. 2024 03; 300(3):105691.
Bates EA, Kipp ZA, Lee WH, Martinez GJ, Weaver L, Becker KN, Pauss SN, Creeden JF, Anspach GB, Helsley RN, Xu M, Bruno MEC, Starr ME, Hinds TD. PMID: 38280429; PMCID: PMC10878791.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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The application, safety, and future of ex vivo immune cell therapies and prognosis in different malignancies. Bioimpacts. 2023; 13(6):439-455.
Einloth KR, Gayfield S, McMaster T, Didier A, Dworkin L, Creeden JF. PMID: 38022382; PMCID: PMC10676524.
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PubMed Mentions:
1
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Trends in Racial and Gender Diversity Among Complex General Surgical Oncology Fellowship Trainees. Ann Surg Oncol. 2023 Oct; 30(11):6824-6834.
Didier AJ, Creeden JF, Pannell SM, Sutton JM. PMID: 37351734.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Loss of hepatic PPARα in mice causes hypertension and cardiovascular disease. Am J Physiol Regul Integr Comp Physiol. 2023 07 01; 325(1):R81-R95.
Badmus OO, Kipp ZA, Bates EA, da Silva AA, Taylor LC, Martinez GJ, Lee WH, Creeden JF, Hinds TD, Stec DE. PMID: 37212551; PMCID: PMC10292975.
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PubMed Mentions:
14 Fields:
Translation:
Animals
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Developmental pyrethroid exposure causes a neurodevelopmental disorder phenotype in mice. PNAS Nexus. 2023 Apr; 2(4):pgad085.
Curtis MA, Dhamsania RK, Branco RC, Guo JD, Creeden J, Neifer KL, Black CA, Winokur EJ, Andari E, Dias BG, Liu RC, Gourley SL, Miller GW, Burkett JP. PMID: 37113978; PMCID: PMC10129348.
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PubMed Mentions:
12
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Antioxidant and Anti-Tumor Effects of Dietary Vitamins A, C, and E. Antioxidants (Basel). 2023 Mar 03; 12(3).
Didier AJ, Stiene J, Fang L, Watkins D, Dworkin LD, Creeden JF. PMID: 36978880; PMCID: PMC10045152.
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PubMed Mentions:
57
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Emerging Immunotherapeutic and Diagnostic Modalities in Carcinoid Tumors. Molecules. 2023 Feb 22; 28(5).
Vellani SD, Nigro A, Varatharajan S, Dworkin LD, Creeden JF. PMID: 36903295; PMCID: PMC10004351.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Suppressing Hepatic UGT1A1 Increases Plasma Bilirubin, Lowers Plasma Urobilin, Reorganizes Kinase Signaling Pathways and Lipid Species and Improves Fatty Liver Disease. Biomolecules. 2023 01 29; 13(2).
Bates EA, Kipp ZA, Martinez GJ, Badmus OO, Soundarapandian MM, Foster D, Xu M, Creeden JF, Greer JR, Morris AJ, Stec DE, Hinds TD. PMID: 36830621; PMCID: PMC9953728.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Folate Receptor as a Biomarker and Therapeutic Target in Solid Tumors. Curr Probl Cancer. 2023 02; 47(1):100917.
Young O, Ngo N, Lin L, Stanbery L, Creeden JF, Hamouda D, Nemunaitis J. PMID: 36508886.
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PubMed Mentions:
21 Fields:
Translation:
Humans
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Subcellular partitioning of protein kinase activity revealed by functional kinome profiling. Sci Rep. 2022 10 15; 12(1):17300.
Wegman-Points L, Alganem K, Imami AS, Mathis V, Creeden JF, McCullumsmith R, Yuan LL. PMID: 36243751; PMCID: PMC9569338.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Hepatic kinome atlas: An in-depth identification of kinase pathways in liver fibrosis of humans and rodents. Hepatology. 2022 11; 76(5):1376-1388.
Creeden JF, Kipp ZA, Xu M, Flight RM, Moseley HNB, Martinez GJ, Lee WH, Alganem K, Imami AS, McMullen MR, Roychowdhury S, Nawabi AM, Hipp JA, Softic S, Weinman SA, McCullumsmith R, Nagy LE, Hinds TD. PMID: 35313030; PMCID: PMC9489820.
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PubMed Mentions:
31 Fields:
Translation:
HumansAnimals
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The active kinome: The modern view of how active protein kinase networks fit in biological research. Curr Opin Pharmacol. 2022 02; 62:117-129.
Alganem K, Hamoud AR, Creeden JF, Henkel ND, Imami AS, Joyce AW, Ryan V WG, Rethman JB, Shukla R, O'Donovan SM, Meller J, McCullumsmith R. PMID: 34968947; PMCID: PMC9438800.
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PubMed Mentions:
14 Fields:
Translation:
Humans
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Homologous recombination proficiency in ovarian and breast cancer patients. BMC Cancer. 2021 Oct 28; 21(1):1154.
Creeden JF, Nanavaty NS, Einloth KR, Gillman CE, Stanbery L, Hamouda DM, Dworkin L, Nemunaitis J. PMID: 34711195; PMCID: PMC8555001.
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PubMed Mentions:
50 Fields:
Translation:
HumansCells
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SSRIs: Applications in inflammatory lung disease and implications for COVID-19. Neuropsychopharmacol Rep. 2021 09; 41(3):325-335.
Meikle CKS, Creeden JF, McCullumsmith C, Worth RG. PMID: 34254465; PMCID: PMC8411309.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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BRCA1/2 signaling and homologous recombination deficiency in breast and ovarian cancer. Future Oncol. 2021 Jul; 17(21):2817-2830.
Royfman R, Whiteley E, Noe O, Morand S, Creeden J, Stanbery L, Hamouda D, Nemunaitis J. PMID: 34058833.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Fluoxetine as an anti-inflammatory therapy in SARS-CoV-2 infection. Biomed Pharmacother. 2021 Jun; 138:111437.
Creeden JF, Imami AS, Eby HM, Gillman C, Becker KN, Reigle J, Andari E, Pan ZK, O'Donovan SM, McCullumsmith RE, McCullumsmith CB. PMID: 33691249; PMCID: PMC7904450.
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PubMed Mentions:
32 Fields:
Translation:
HumansCells
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Identification of candidate repurposable drugs to combat COVID-19 using a signature-based approach. Sci Rep. 2021 02 24; 11(1):4495.
O'Donovan SM, Imami A, Eby H, Henkel ND, Creeden JF, Asah S, Zhang X, Wu X, Alnafisah R, Taylor RT, Reigle J, Thorman A, Shamsaei B, Meller J, McCullumsmith RE. PMID: 33627767; PMCID: PMC7904823.
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PubMed Mentions:
21 Fields:
Translation:
HumansCellsPHPublic Health
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Bilirubin Nanoparticles Reduce Diet-Induced Hepatic Steatosis, Improve Fat Utilization, and Increase Plasma β-Hydroxybutyrate. Front Pharmacol. 2020; 11:594574.
Hinds TD, Creeden JF, Gordon DM, Stec DF, Donald MC, Stec DE. PMID: 33390979; PMCID: PMC7775678.
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PubMed Mentions:
58
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Bilirubin as a metabolic hormone: the physiological relevance of low levels. Am J Physiol Endocrinol Metab. 2021 02 01; 320(2):E191-E207.
Creeden JF, Gordon DM, Stec DE, Hinds TD. PMID: 33284088; PMCID: PMC8260361.
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PubMed Mentions:
109 Fields:
Translation:
HumansAnimals
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Emerging Kinase Therapeutic Targets in Pancreatic Ductal Adenocarcinoma and Pancreatic Cancer Desmoplasia. Int J Mol Sci. 2020 Nov 21; 21(22).
Creeden JF, Alganem K, Imami AS, Henkel ND, Brunicardi FC, Liu SH, Shukla R, Tomar T, Naji F, McCullumsmith RE. PMID: 33233470; PMCID: PMC7700673.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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Kinome Array Profiling of Patient-Derived Pancreatic Ductal Adenocarcinoma Identifies Differentially Active Protein Tyrosine Kinases. Int J Mol Sci. 2020 Nov 17; 21(22).
Creeden JF, Alganem K, Imami AS, Brunicardi FC, Liu SH, Shukla R, Tomar T, Naji F, McCullumsmith RE. PMID: 33213062; PMCID: PMC7698519.
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PubMed Mentions:
26 Fields:
Translation:
Humans
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Resident Memory T Cells and Their Effect on Cancer. Vaccines (Basel). 2020 Oct 01; 8(4).
Craig DJ, Creeden JF, Einloth KR, Gillman CE, Stanbery L, Hamouda D, Edelman G, Dworkin L, Nemunaitis JJ. PMID: 33019493; PMCID: PMC7711795.
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PubMed Mentions:
18
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Rats Genetically Selected for High Aerobic Exercise Capacity Have Elevated Plasma Bilirubin by Upregulation of Hepatic Biliverdin Reductase-A (BVRA) and Suppression of UGT1A1. Antioxidants (Basel). 2020 Sep 19; 9(9).
Hinds TD, Creeden JF, Gordon DM, Spegele AC, Britton SL, Koch LG, Stec DE. PMID: 32961782; PMCID: PMC7554716.
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PubMed Mentions:
22
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Repurposing metformin, simvastatin and digoxin as a combination for targeted therapy for pancreatic ductal adenocarcinoma. Cancer Lett. 2020 10 28; 491:97-107.
Liu SH, Yu J, Creeden JF, Sutton JM, Markowiak S, Sanchez R, Nemunaitis J, Kalinoski A, Zhang JT, Damoiseaux R, Erhardt P, Brunicardi FC. PMID: 32829010; PMCID: PMC8766172.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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Oxytocin's anti-inflammatory and proimmune functions in COVID-19: a transcriptomic signature-based approach. Physiol Genomics. 2020 09 01; 52(9):401-407.
Imami AS, O'Donovan SM, Creeden JF, Wu X, Eby H, McCullumsmith CB, Uvnäs-Moberg K, McCullumsmith RE, Andari E. PMID: 32809918; PMCID: PMC7877479.
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PubMed Mentions:
25 Fields:
Translation:
HumansCellsPHPublic Health
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Relationship of hypothyroidism and immune response to pegylated IL-10/nivolumab. Immunotherapy. 2020 10; 12(14):1041-1046.
Albrethsen M, Creeden J, Morand S, DeBiase J, Berry B, Stanbery L, Edelman G, Nemunaitis J. PMID: 32808556.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Signature-based approaches for informed drug repurposing: targeting CNS disorders. Neuropsychopharmacology. 2021 01; 46(1):116-130.
Shukla R, Henkel ND, Alganem K, Hamoud AR, Reigle J, Alnafisah RS, Eby HM, Imami AS, Creeden JF, Miruzzi SA, Meller J, Mccullumsmith RE. PMID: 32604402; PMCID: PMC7688959.
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PubMed Mentions:
32 Fields:
Translation:
Humans
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Identification of new drug treatments to combat COVID19: A signature-based approach using iLINCS. Res Sq. 2020 Apr 30.
O'Donovan SM, Eby H, Henkel ND, Creeden J, Imami A, Asah S, Zhang X, Wu X, Alnafisah R, Taylor RT, Reigle J, Thorman A, Shamsaei B, Meller J, McCullumsmith RE. PMID: 32702077; PMCID: PMC7336712.
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Biliverdin Reductase A (BVRA) Knockout in Adipocytes Induces Hypertrophy and Reduces Mitochondria in White Fat of Obese Mice. Biomolecules. 2020 03 02; 10(3).
Stec DE, Gordon DM, Nestor-Kalinoski AL, Donald MC, Mitchell ZL, Creeden JF, Hinds TD. PMID: 32131495; PMCID: PMC7175174.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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Molecular mechanisms underlying rheumatoid arthritis and cancer development and treatment. Future Oncol. 2020 Mar; 16(9):483-495.
Morand S, Staats H, Creeden JF, Iqbal A, Kahaleh B, Stanbery L, Dworkin L, Nemunaitis J. PMID: 32100561.
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PubMed Mentions:
18 Fields:
Translation:
Humans
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Bifidobacterium spp: the promising Trojan Horse in the era of precision oncology. Future Oncol. 2019 Nov; 15(33):3861-3876.
Ngo N, Choucair K, Creeden JF, Qaqish H, Bhavsar K, Murphy C, Lian K, Albrethsen MT, Stanbery L, Phinney RC, Brunicardi FC, Dworkin L, Nemunaitis J. PMID: 31668087.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Sign-tracking behavior is difficult to extinguish and resistant to multiple cognitive enhancers. Neurobiol Learn Mem. 2019 09; 163:107045.
Fitzpatrick CJ, Geary T, Creeden JF, Morrow JD. PMID: 31319166; PMCID: PMC6773616.
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PubMed Mentions:
15 Fields:
Translation:
Animals
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BIRC5 is a target for molecular imaging and detection of human pancreatic cancer. Cancer Lett. 2019 08 10; 457:10-19.
Liu SH, Hong Y, Markowiak S, Sanchez R, Creeden J, Nemunaitis J, Kalinoski A, Willey J, Erhardt P, Lee J, van Dam M, Brunicardi FC. PMID: 31059751.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Lesions of the ventral hippocampus attenuate the acquisition but not expression of sign-tracking behavior in rats. Hippocampus. 2016 11; 26(11):1424-1434.
Fitzpatrick CJ, Creeden JF, Perrine SA, Morrow JD. PMID: 27438780.
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PubMed Mentions:
12 Fields:
Translation:
Animals