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FLT3 inhibitors added to induction therapy induce deeper remissions. Blood. 2020 01 02; 135(1):75-78.
Levis M, Shi W, Chang K, Laing C, Pollner R, Gocke C, Adams E, Berisha F, Lameh J, Lesegretain A. PMID: 31722002.
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12 Fields:
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HumansCTClinical Trials
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Quantitative Spatial Profiling of PD-1/PD-L1 Interaction and HLA-DR/IDO-1 Predicts Improved Outcomes of Anti-PD-1 Therapies in Metastatic Melanoma. Clin Cancer Res. 2018 11 01; 24(21):5250-5260.
Johnson DB, Bordeaux J, Kim JY, Vaupel C, Rimm DL, Ho TH, Joseph RW, Daud AI, Conry RM, Gaughan EM, Hernandez-Aya LF, Dimou A, Funchain P, Smithy J, Witte JS, McKee SB, Ko J, Wrangle JM, Dabbas B, Tangri S, Lameh J, Hall J, Markowitz J, Balko JM, Dakappagari N. PMID: 30021908; PMCID: PMC6214750.
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81 Fields:
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HumansCells
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Discovery of potential antipsychotic agents possessing pro-cognitive properties. Naunyn Schmiedebergs Arch Pharmacol. 2012 Mar; 385(3):313-23.
Lameh J, McFarland K, Ohlsson J, Ek F, Piu F, Burstein ES, Tabatabaei A, Olsson R, Bradley SR, Bonhaus DW. PMID: 22083558.
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1 Fields:
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HumansAnimalsCells
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Neuropeptide FF receptors have opposing modulatory effects on nociception. J Pharmacol Exp Ther. 2010 Jul; 334(1):244-54.
Lameh J, Bertozzi F, Kelly N, Jacobi PM, Nguyen D, Bajpai A, Gaubert G, Olsson R, Gardell LR. PMID: 20354177.
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14 Fields:
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AnimalsCells
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Differential regulation of muscarinic M1 receptors by orthosteric and allosteric ligands. BMC Pharmacol. 2009 Dec 02; 9:14.
Davis CN, Bradley SR, Schiffer HH, Friberg M, Koch K, Tolf BR, Bonhaus DW, Lameh J. PMID: 19951444; PMCID: PMC2794843.
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11 Fields:
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HumansAnimalsCells
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Discovery of selective nonpeptidergic neuropeptide FF2 receptor agonists. J Med Chem. 2009 Nov 12; 52(21):6511-4.
Gaubert G, Bertozzi F, Kelly NM, Pawlas J, Scully AL, Nash NR, Gardell LR, Lameh J, Olsson R. PMID: 19803524.
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7 Fields:
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HumansAnimalsCells
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AC-260584, an orally bioavailable M(1) muscarinic receptor allosteric agonist, improves cognitive performance in an animal model. Neuropharmacology. 2010 Feb; 58(2):365-73.
Bradley SR, Lameh J, Ohrmund L, Son T, Bajpai A, Nguyen D, Friberg M, Burstein ES, Spalding TA, Ott TR, Schiffer HH, Tabatabaei A, McFarland K, Davis RE, Bonhaus DW. PMID: 19835892.
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27 Fields:
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AnimalsCells
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Identification and characterization of novel small-molecule protease-activated receptor 2 agonists. J Pharmacol Exp Ther. 2008 Dec; 327(3):799-808.
Gardell LR, Ma JN, Seitzberg JG, Knapp AE, Schiffer HH, Tabatabaei A, Davis CN, Owens M, Clemons B, Wong KK, Lund B, Nash NR, Gao Y, Lameh J, Schmelzer K, Olsson R, Burstein ES. PMID: 18768780.
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19 Fields:
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AnimalsCells
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Identification of novel selective V2 receptor non-peptide agonists. Biochem Pharmacol. 2008 Oct 30; 76(9):1134-41.
Del Tredici AL, Vanover KE, Knapp AE, Bertozzi SM, Nash NR, Burstein ES, Lameh J, Currier EA, Davis RE, Brann MR, Mohell N, Olsson R, Piu F. PMID: 18761325.
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1 Fields:
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HumansAnimalsCells
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Pharmacology of N-desmethylclozapine. Pharmacol Ther. 2007 Aug; 115(2):223-31.
Lameh J, Burstein ES, Taylor E, Weiner DM, Vanover KE, Bonhaus DW. PMID: 17583355.
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29 Fields:
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HumansAnimals
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Transcutaneous blood gas CO2 monitoring of induced ventilatory depression in mice. Anesth Analg. 2006 Sep; 103(3):620-5.
Sahbaie P, Modanlou S, Madanlou S, Gharagozlou P, Clark JD, Lameh J, Delorey TM. PMID: 16931671.
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2 Fields:
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Animals
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Pharmacological and behavioral profile of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1) (ACP-103), a novel 5-hydroxytryptamine(2A) receptor inverse agonist. J Pharmacol Exp Ther. 2006 May; 317(2):910-8.
Vanover KE, Weiner DM, Makhay M, Veinbergs I, Gardell LR, Lameh J, Del Tredici AL, Piu F, Schiffer HH, Ott TR, Burstein ES, Uldam AK, Thygesen MB, Schlienger N, Andersson CM, Son TY, Harvey SC, Powell SB, Geyer MA, Tolf BR, Brann MR, Davis RE. PMID: 16469866.
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61 Fields:
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HumansAnimalsCells
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Pharmacological profiles of opioid ligands at kappa opioid receptors. BMC Pharmacol. 2006 Jan 25; 6:3.
Gharagozlou P, Hashemi E, DeLorey TM, Clark JD, Lameh J. PMID: 16433932; PMCID: PMC1403760.
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29 Fields:
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The role of M1 muscarinic receptor agonism of N-desmethylclozapine in the unique clinical effects of clozapine. Psychopharmacology (Berl). 2004 Dec; 177(1-2):207-16.
Weiner DM, Meltzer HY, Veinbergs I, Donohue EM, Spalding TA, Smith TT, Mohell N, Harvey SC, Lameh J, Nash N, Vanover KE, Olsson R, Jayathilake K, Lee M, Levey AI, Hacksell U, Burstein ES, Davis RE, Brann MR. PMID: 15258717.
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68 Fields:
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Pharmacology of polymorphic variants of the human 5-HT1A receptor. Biochem Pharmacol. 2004 Feb 01; 67(3):479-90.
Del Tredici AL, Schiffer HH, Burstein ES, Lameh J, Mohell N, Hacksell U, Brann MR, Weiner DM. PMID: 15037200.
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5 Fields:
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HumansAnimalsCells
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Activity of opioid ligands in cells expressing cloned mu opioid receptors. BMC Pharmacol. 2003 Jan 04; 3:1.
Gharagozlou P, Demirci H, David Clark J, Lameh J. PMID: 12513698; PMCID: PMC140036.
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27 Fields:
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HumansCells
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Activation profiles of opioid ligands in HEK cells expressing delta opioid receptors. BMC Neurosci. 2002 Nov 18; 3:19.
Gharagozlou P, Demirci H, Clark JD, Lameh J. PMID: 12437765; PMCID: PMC137588.
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13 Fields:
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Influence of benzodiazepine binding site ligands on fear-conditioned contextual memory. Eur J Pharmacol. 2001 Aug 24; 426(1-2):45-54.
DeLorey TM, Lin RC, McBrady B, He X, Cook JM, Lameh J, Loew GH. PMID: 11525770.
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6 Fields:
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AnimalsCells
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Characterization of novel benzodiazepine ligands in Spodotera frugiperda (Sf-9) insect cells. Neurosci Lett. 2001 Jun 22; 306(1-2):25-8.
Lameh J, Keohane A, Clark DJ, Loew GH. PMID: 11403949.
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2 Fields:
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AnimalsCells
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Characterization of benzodiazepine receptors in the cerebellum. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Aug; 24(6):979-91.
Lameh J, Wang P, Meredith D, Shafer SL, Loew GH. PMID: 11041538.
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2 Fields:
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AnimalsCells
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Unraveling the identity of benzodiazepine binding sites in rat hipppocampus and olfactory bulb. Eur J Pharmacol. 2000 Jul 21; 400(2-3):167-76.
Lameh J, Wang P, Elgart D, Meredith D, Shafer SL, Loew GH. PMID: 10988330.
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1 Fields:
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AnimalsCells
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Differential regulation of muscarinic M1 and M3 receptors by a putative phosphorylation domain. Eur J Pharmacol. 1999 Jul 14; 377(1):137-46.
Shockley MS, Tolbert LM, Tobin AB, Nahorski SR, Sadée W, Lameh J. PMID: 10448936.
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4 Fields:
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HumansAnimalsCells
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A constitutively internalizing and recycling mutant of the mu-opioid receptor. J Neurochem. 1997 Jun; 68(6):2395-404.
Segredo V, Burford NT, Lameh J, Sadée W. PMID: 9166733.
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17 Fields:
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HumansAnimalsCells
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Residues specifically involved in down-regulation but not internalization of the m1 muscarinic acetylcholine receptor. J Neurochem. 1997 Feb; 68(2):601-9.
Shockley MS, Burford NT, Sadée W, Lameh J. PMID: 9003046.
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4 Fields:
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HumansAnimalsCells
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Agonist-induced internalization of human ml muscarinic receptor mutants: immunofluorescence confocal microscopy. Proc West Pharmacol Soc. 1996; 39:51-4.
Arden J, Lameh J. PMID: 8895968.
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1 Fields:
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HumansCells
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Interaction among mu-opioid receptors and alpha 2-adrenoceptors on SH-SY5Y human neuroblastoma cells. Eur J Pharmacol. 1992 Sep 01; 227(1):19-24.
Lameh J, Eiger S, Sadée W. PMID: 1358661.
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4 Fields:
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HumansCells
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125I-beta-endorphin binding to neuroblastoma X glioma NG108-15 cells: distribution of delta opioid receptors. Life Sci. 1992; 51(22):PL219-24.
Cone RI, Rosenfeld S, Lameh J, Sadée W. PMID: 1331640.
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Rapid agonist-induced loss of 125I-beta-endorphin opioid receptor sites in NG108-15, but not SK-N-SH neuroblastoma cells. Life Sci. 1991; 49(19):PL147-52.
Cone RI, Lameh J, Sadée W. PMID: 1658508.
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1 Fields:
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HumansAnimalsCells
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Regulation of cyclic AMP by the mu-opioid receptor in human neuroblastoma SH-SY5Y cells. J Neurochem. 1990 Oct; 55(4):1390-6.
Yu VC, Eiger S, Duan DS, Lameh J, Sadée W. PMID: 1697894.
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19 Fields:
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HumansCells