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A non-viral path to efficient and safe prime editing in vivo. Nat Nanotechnol. 2026 Jul; 21(7):914-915.
Han Y, Kim HH. PMID: 42410217.
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PubMed Mentions: Fields:
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Adapting prime editing with split prime editors in Escherichia coli and its application to Staphylococcus aureus genome editing. Appl Microbiol Biotechnol. 2026 Jun 04.
Ma SH, Yu G, Park S, Sung H, Jeong UJ, Kim HH, Cho J, Yoon SS. PMID: 42240651.
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PubMed Mentions: Fields:
Translation:
Cells
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Highly efficient and scarless genome editing via essential-gene-coupled homology-directed repair. Genome Res. 2026 06 01; 36(6):1187-1198.
Yeo JH, Kim HH, Oh SH, Lee J. PMID: 41985988.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Publisher Correction: High-resolution functional mapping of androgen receptor variants. Nat Biomed Eng. 2026 Apr 27.
Oh HC, Chang Y, Park J, Cheong Y, Lee KS, Han H, Kim HH. PMID: 42045674.
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PubMed Mentions: Fields:
-
High-resolution functional mapping of androgen receptor variants. Nat Biomed Eng. 2026 Apr 06.
Oh HC, Chang Y, Park J, Cheong Y, Lee KS, Han H, Kim HH. PMID: 41942549.
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PubMed Mentions: Fields:
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Atypical protein kinase C activation drives intestinal glucose excretion in diabetes mellitus. Nat Commun. 2026 Feb 06; 17(1).
Kang CW, Hong ZY, Oh JH, Farh ME, Wang EK, Lee S, Kang UH, Nam JH, Lee YJ, Shin H, Kim YB, Jeon H, Jeong JW, Kim D, Kim JS, Hong SS, Park JP, Cho HJ, Fang S, Kim HH, Cho A, Lim BK, Sohn I, Ku CR. PMID: 41651859; PMCID: PMC12988217.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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A comprehensive functional atlas of ALK kinase domain variants reveals resistance landscape to ALK inhibitors. Genome Biol. 2026 Feb 03; 27(1).
Oh HC, Han Y, Chang Y, Kim HH. PMID: 41630044; PMCID: PMC12958575.
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PubMed Mentions: Fields:
Translation:
HumansCells
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High-throughput evaluation of in vitro CRISPR activities enables optimized large-scale multiplex enrichment of rare variants. Nat Biomed Eng. 2026 Jul; 10(7):1410-1430.
Yeo JH, Lee S, Kim S, Min JG, Gopalappa R, Oh HC, Kim HK, Nam EJ, Kim HH. PMID: 41168295.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Comprehensive resistance profiling of chronic myeloid leukaemia associated ABL1 variants against five tyrosine kinase inhibitors using prime editing. Nat Biomed Eng. 2026 Jul; 10(7):1392-1409.
Jung Y, Yu G, Oh HC, Lee JH, Jeon E, Bae J, Sim T, Kim HH. PMID: 41125871.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Engineered virus-like particle-assembled Vegfa-targeting Cas9 ribonucleoprotein treatment alleviates neovascularization in wet age-related macular degeneration. Genome Biol. 2025 Oct 09; 26(1):346.
Wu J, Jang H, Kwak H, Son M, Jiang W, Hwang HY, Jo DH, Kim D, Kim HH, Kim JH. PMID: 41068986; PMCID: PMC12509411.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Engineered virus-like particles for in vivo gene editing ameliorate hearing loss in murine DFNA2 model. Mol Ther. 2025 Dec 03; 33(12):6449-6462.
Noh B, Gopalappa R, Lin H, Gee HY, Choi JY, Kim HH, Jung J. PMID: 40898619; PMCID: PMC12703167.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Functional assessment of all ATM SNVs using prime editing and deep learning. Cell. 2025 Sep 04; 188(18):5081-5099.e27.
Lee KS, Min JG, Cheong Y, Oh HC, Jung SY, Park JI, Song M, Seo JH, Cho SR, Kim HH. PMID: 40580951.
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PubMed Mentions:
8 Fields:
Translation:
Humans
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A rational engineering strategy for structural dynamics modulation enables target specificity enhancement of the Cas9 nuclease. Nucleic Acids Res. 2025 Jun 20; 53(12).
Sung K, Jung Y, Kim N, Kim YW, Kim HH, Kim SK, Bae S. PMID: 40539512; PMCID: PMC12204706.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Intravitreal adenine base editing of RS1 improves vision in a preclinical mouse model of retinoschisis. Mol Ther. 2025 Aug 06; 33(8):3955-3967.
Jo DH, Jang H, Cho CS, Lee SJ, Heo JH, Kim JA, Kim SJ, Ryu W, Park CW, Kang BC, Gee HY, Sung YH, Kim HH, Kim JH. PMID: 40253584; PMCID: PMC12461659.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Saturation profiling of drug-resistant genetic variants using prime editing. Nat Biotechnol. 2025 Sep; 43(9):1471-1484.
Kim Y, Oh HC, Lee S, Kim HH. PMID: 39533107.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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SynDesign: web-based prime editing guide RNA design and evaluation tool for saturation genome editing. Nucleic Acids Res. 2024 07 05; 52(W1):W121-W125.
Park J, Yu G, Seo SY, Yang J, Kim HH. PMID: 38682594; PMCID: PMC11223855.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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In vivo adenine base editing rescues adrenoleukodystrophy in a humanized mouse model. Mol Ther. 2024 07 03; 32(7):2190-2206.
Gopalappa R, Lee M, Kim G, Jung ES, Lee H, Hwang HY, Lee JG, Kim SJ, Yoo HJ, Sung YH, Kim D, Baek IJ, Kim HH. PMID: 38796705; PMCID: PMC11286820.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Author Correction: Predicting the efficiency of prime editing guide RNAs in human cells. Nat Biotechnol. 2024 Mar; 42(3):529.
Kim HK, Yu G, Park J, Min S, Lee S, Yoon S, Kim HH. PMID: 38332117.
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PubMed Mentions: Fields:
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Safety of Macitentan for the Treatment of Portopulmonary Hypertension: Real-World Evidence from the Combined OPUS/OrPHeUS Studies. Pulm Ther. 2024 Mar; 10(1):85-107.
Kim NH, Chin KM, McLaughlin VV, DuBrock H, Restrepo-Jaramillo R, Safdar Z, MacDonald G, Martin N, Rosenberg D, Solonets M, Channick R. PMID: 38184507; PMCID: PMC10881949.
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PubMed Mentions:
6
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Deep learning models to predict the editing efficiencies and outcomes of diverse base editors. Nat Biotechnol. 2024 Mar; 42(3):484-497.
Kim N, Choi S, Kim S, Song M, Seo JH, Min S, Park J, Cho SR, Kim HH. PMID: 37188916.
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PubMed Mentions:
38 Fields:
-
Massively parallel evaluation and computational prediction of the activities and specificities of 17 small Cas9s. Nat Methods. 2023 07; 20(7):999-1009.
Seo SY, Min S, Lee S, Seo JH, Park J, Kim HK, Song M, Baek D, Cho SR, Kim HH. PMID: 37188955.
View in:
PubMed Mentions:
8 Fields:
-
Prediction of efficiencies for diverse prime editing systems in multiple cell types. Cell. 2023 05 11; 186(10):2256-2272.e23.
Yu G, Kim HK, Park J, Kwak H, Cheong Y, Kim D, Kim J, Kim J, Kim HH. PMID: 37119812.
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PubMed Mentions:
75 Fields:
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DNA double-strand break-free CRISPR interference delays Huntington's disease progression in mice. Commun Biol. 2023 04 28; 6(1):466.
Seo JH, Shin JH, Lee J, Kim D, Hwang HY, Nam BG, Lee J, Kim HH, Cho SR. PMID: 37117485; PMCID: PMC10147674.
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PubMed Mentions:
12 Translation:
HumansAnimalsCells
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Sniper2L is a high-fidelity Cas9 variant with high activity. Nat Chem Biol. 2023 08; 19(8):972-980.
Kim YH, Kim N, Okafor I, Choi S, Min S, Lee J, Bae SM, Choi K, Choi J, Harihar V, Kim Y, Kim JS, Kleinstiver BP, Lee JK, Ha T, Kim HH. PMID: 36894722; PMCID: PMC10374439.
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PubMed Mentions:
30 Fields:
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Adherens junctions organize size-selective proteolytic hotspots critical for Notch signalling. Nat Cell Biol. 2022 12; 24(12):1739-1753.
Kwak M, Southard KM, Kim WR, Lin A, Kim NH, Gopalappa R, Lee HJ, An M, Choi SH, Jung Y, Noh K, Farlow J, Georgakopoulos A, Robakis NK, Kang MK, Kutys ML, Seo D, Kim HH, Kim YH, Cheon J, Gartner ZJ, Jun YW. PMID: 36456828; PMCID: PMC10665132.
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PubMed Mentions:
11 Fields:
-
In vivo application of base and prime editing to treat inherited retinal diseases. Prog Retin Eye Res. 2023 05; 94:101132.
Jo DH, Bae S, Kim HH, Kim JS, Kim JH. PMID: 36241547.
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PubMed Mentions:
6 Fields:
Translation:
Animals
-
Magnetogenetics with Piezo1 Mechanosensitive Ion Channel for CRISPR Gene Editing. Nano Lett. 2022 09 28; 22(18):7415-7422.
Shin W, Jeong S, Lee JU, Jeong SY, Shin J, Kim HH, Cheon J, Lee JH. PMID: 36069378.
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PubMed Mentions:
9 Fields:
Translation:
Animals
-
High-throughput functional evaluation of human cancer-associated mutations using base editors. Nat Biotechnol. 2022 06; 40(6):874-884.
Kim Y, Lee S, Cho S, Park J, Chae D, Park T, Minna JD, Kim HH. PMID: 35411116; PMCID: PMC10243181.
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PubMed Mentions:
41 Fields:
Translation:
Humans
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In vivo outer hair cell gene editing ameliorates progressive hearing loss in dominant-negative Kcnq4 murine model. Theranostics. 2022; 12(5):2465-2482.
Noh B, Rim JH, Gopalappa R, Lin H, Kim KM, Kang MJ, Gee HY, Choi JY, Kim HH, Jung J. PMID: 35265220; PMCID: PMC8899569.
View in:
PubMed Mentions:
34 Fields:
Translation:
AnimalsCells
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Basic Principles and Clinical Applications of CRISPR-Based Genome Editing. Yonsei Med J. 2022 Feb; 63(2):105-113.
Lim JM, Kim HH. PMID: 35083895; PMCID: PMC8819410.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimals
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Improving CRISPR tools by elucidating DNA repair. Nat Biotechnol. 2021 12; 39(12):1512-1514.
Lim JM, Kim HH. PMID: 34873327.
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PubMed Mentions: Fields:
Translation:
Cells
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Generation of a more efficient prime editor 2 by addition of the Rad51 DNA-binding domain. Nat Commun. 2021 09 23; 12(1):5617.
Song M, Lim JM, Min S, Oh JS, Kim DY, Woo JS, Nishimasu H, Cho SR, Yoon S, Kim HH. PMID: 34556671; PMCID: PMC8460726.
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PubMed Mentions:
49 Fields:
Translation:
HumansCells
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Application of prime editing to the correction of mutations and phenotypes in adult mice with liver and eye diseases. Nat Biomed Eng. 2022 02; 6(2):181-194.
Jang H, Jo DH, Cho CS, Shin JH, Seo JH, Yu G, Gopalappa R, Kim D, Cho SR, Kim JH, Kim HH. PMID: 34446856.
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PubMed Mentions:
117 Fields:
Translation:
Animals
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Recording of elapsed time and temporal information about biological events using Cas9. Cell. 2021 Feb 18; 184(4):1047-1063.e23.
Park J, Lim JM, Jung I, Heo SJ, Park J, Chang Y, Kim HK, Jung D, Yu JH, Min S, Yoon S, Cho SR, Park T, Kim HH. PMID: 33539780.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Patient and disease characteristics of the first 500 patients with pulmonary arterial hypertension treated with selexipag in real-world settings from SPHERE. J Heart Lung Transplant. 2021 04; 40(4):279-288.
Kim NH, Hemnes AR, Chakinala MM, Highland KB, Chin KM, McLaughlin V, Zhao C, Narayan V, Farber HW. PMID: 33526303.
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PubMed Mentions:
7 Fields:
Translation:
Humans
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An autophagy enhancer ameliorates diabetes of human IAPP-transgenic mice through clearance of amyloidogenic oligomer. Nat Commun. 2021 01 08; 12(1):183.
Kim J, Park K, Kim MJ, Lim H, Kim KH, Kim SW, Lee ES, Kim HH, Kim SJ, Hur KY, Kim JH, Ahn JH, Yoon KH, Kim JW, Lee MS. PMID: 33420039; PMCID: PMC7794419.
View in:
PubMed Mentions:
35 Fields:
Translation:
HumansAnimalsCells
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Predicting the efficiency of prime editing guide RNAs in human cells. Nat Biotechnol. 2021 02; 39(2):198-206.
Kim HK, Yu G, Park J, Min S, Lee S, Yoon S, Kim HH. PMID: 32958957.
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PubMed Mentions:
153 Fields:
Translation:
HumansCells
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Chemical Controllable Gene Drive in Drosophila. ACS Synth Biol. 2020 Sep 18; 9(9):2362-2377.
Chae D, Lee J, Lee N, Park K, Moon SJ, Kim HH. PMID: 32786353.
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PubMed Mentions:
13 Fields:
Translation:
Animals
-
Sequence-specific prediction of the efficiencies of adenine and cytosine base editors. Nat Biotechnol. 2020 09; 38(9):1037-1043.
Song M, Kim HK, Lee S, Kim Y, Seo SY, Park J, Choi JW, Jang H, Shin JH, Min S, Quan Z, Kim JH, Kang HC, Yoon S, Kim HH. PMID: 32632303.
View in:
PubMed Mentions:
70 Fields:
Translation:
HumansCells
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Prediction of the sequence-specific cleavage activity of Cas9 variants. Nat Biotechnol. 2020 11; 38(11):1328-1336.
Kim N, Kim HK, Lee S, Seo JH, Choi JW, Park J, Min S, Yoon S, Cho SR, Kim HH. PMID: 32514125.
View in:
PubMed Mentions:
121 Fields:
Translation:
HumansCells
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Genome-scale screening of deubiquitinase subfamily identifies USP3 as a stabilizer of Cdc25A regulating cell cycle in cancer. Cell Death Differ. 2020 11; 27(11):3004-3020.
Das S, Chandrasekaran AP, Suresh B, Haq S, Kang JH, Lee SJ, Kim J, Kim J, Lee S, Kim HH, Kim KS, Ramakrishna S. PMID: 32415280; PMCID: PMC7566649.
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PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
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High-throughput analysis of the activities of xCas9, SpCas9-NG and SpCas9 at matched and mismatched target sequences in human cells. Nat Biomed Eng. 2020 01; 4(1):111-124.
Kim HK, Lee S, Kim Y, Park J, Min S, Choi JW, Huang TP, Yoon S, Liu DR, Kim HH. PMID: 31937939.
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PubMed Mentions:
79 Fields:
Translation:
HumansCells
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SpCas9 activity prediction by DeepSpCas9, a deep learning-based model with high generalization performance. Sci Adv. 2019 11; 5(11):eaax9249.
Kim HK, Kim Y, Lee S, Min S, Bae JY, Choi JW, Park J, Jung D, Yoon S, Kim HH. PMID: 31723604; PMCID: PMC6834390.
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PubMed Mentions:
125 Fields:
Translation:
Humans
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Programmable Nuclease-Based Integration into Novel Extragenic Genomic Safe Harbor Identified from Korean Population-Based CNV Analysis. Mol Ther Oncolytics. 2019 Sep 27; 14:253-265.
Lee ES, Moon S, Abu-Bonsrah KD, Kim YK, Hwang MY, Kim YJ, Kim S, Hwang NS, Kim HH, Kim BJ. PMID: 31463366; PMCID: PMC6708990.
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PubMed Mentions:
1
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En bloc and segmental deletions of human XIST reveal X chromosome inactivation-involving RNA elements. Nucleic Acids Res. 2019 05 07; 47(8):3875-3887.
Lee HJ, Gopalappa R, Sunwoo H, Choi SW, Ramakrishna S, Lee JT, Kim HH, Nam JW. PMID: 30783652; PMCID: PMC6486550.
View in:
PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Paired D10A Cas9 nickases are sometimes more efficient than individual nucleases for gene disruption. Nucleic Acids Res. 2018 07 06; 46(12):e71.
Gopalappa R, Suresh B, Ramakrishna S, Kim HH. PMID: 29584876; PMCID: PMC6158698.
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PubMed Mentions:
45 Fields:
Translation:
HumansAnimalsCells
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Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination. Neuron. 2018 07 11; 99(1):83-97.e7.
Park SM, Lim JS, Ramakrishina S, Kim SH, Kim WK, Lee J, Kang HC, Reiter JF, Kim DS, Kim HH, Lee JH. PMID: 29937275.
View in:
PubMed Mentions:
68 Fields:
Translation:
HumansAnimalsCells
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In vivo gene correction with targeted sequence substitution through microhomology-mediated end joining. Biochem Biophys Res Commun. 2018 07 07; 502(1):116-122.
Shin JH, Jung S, Ramakrishna S, Kim HH, Lee J. PMID: 29787760.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Targeting mutant KRAS with CRISPR-Cas9 controls tumor growth. Genome Res. 2018 Mar 01; 28(3):374-382.
Kim W, Lee S, Kim HS, Song M, Cha YH, Kim YH, Shin J, Lee ES, Joo Y, Song JJ, Choi EJ, Choi JW, Lee J, Kang M, Yook JI, Lee MG, Kim YS, Paik S, Kim HH. PMID: 29326299; PMCID: PMC5848616.
View in:
PubMed Mentions:
56 Fields:
Translation:
HumansAnimalsCells
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Deep learning improves prediction of CRISPR-Cpf1 guide RNA activity. Nat Biotechnol. 2018 Mar; 36(3):239-241.
Kim HK, Min S, Song M, Jung S, Choi JW, Kim Y, Lee S, Yoon S, Kim HH. PMID: 29431740.
View in:
PubMed Mentions:
192 Fields:
Translation:
Cells
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RanBPM: a potential therapeutic target for modulating diverse physiological disorders. Drug Discov Today. 2017 12; 22(12):1816-1824.
Das S, Suresh B, Kim HH, Ramakrishna S. PMID: 28847759.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimals
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Somatic Mutations in TSC1 and TSC2 Cause Focal Cortical Dysplasia. Am J Hum Genet. 2017 Mar 02; 100(3):454-472.
Lim JS, Gopalappa R, Kim SH, Ramakrishna S, Lee M, Kim WI, Kim J, Park SM, Lee J, Oh JH, Kim HD, Park CH, Lee JS, Kim S, Kim DS, Han JM, Kang HC, Kim HH, Lee JH. PMID: 28215400; PMCID: PMC5339289.
View in:
PubMed Mentions:
104 Fields:
Translation:
HumansAnimalsCells
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Targeted Genome Engineering to Control VEGF Expression in Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells: Potential Implications for the Treatment of Myocardial Infarction. Stem Cells Transl Med. 2017 03; 6(3):1040-1051.
Cho HM, Kim PH, Chang HK, Shen YM, Bonsra K, Kang BJ, Yum SY, Kim JH, Lee SY, Choi MC, Kim HH, Jang G, Cho JY. PMID: 28186692; PMCID: PMC5442764.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Astroglial Activation by an Enriched Environment after Transplantation of Mesenchymal Stem Cells Enhances Angiogenesis after Hypoxic-Ischemic Brain Injury. Int J Mol Sci. 2016 Sep 14; 17(9).
Cho SR, Suh H, Yu JH, Kim HH, Seo JH, Seo CH. PMID: 27649153; PMCID: PMC5037823.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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Group 4 Pulmonary Hypertension: Chronic Thromboembolic Pulmonary Hypertension: Epidemiology, Pathophysiology, and Treatment. Cardiol Clin. 2016 Aug; 34(3):435-41.
Kim NH. PMID: 27443139.
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PubMed Mentions:
29 Fields:
Translation:
Humans
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Concise Review: Fate Determination of Stem Cells by Deubiquitinating Enzymes. Stem Cells. 2017 01; 35(1):9-16.
Chandrasekaran AP, Suresh B, Kim HH, Kim KS, Ramakrishna S. PMID: 27341175.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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In Situ Pluripotency Factor Expression Promotes Functional Recovery From Cerebral Ischemia. Mol Ther. 2016 09; 24(9):1538-49.
Seo JH, Lee MY, Yu JH, Kim MS, Song M, Seo CH, Kim HH, Cho SR. PMID: 27455881; PMCID: PMC5113101.
View in:
PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Chronic thromboembolic pulmonary hypertension: the evolving treatment landscape. Eur Respir Rev. 2015 Jun; 24(136):173-7.
Kim NH, Mayer E. PMID: 26028629; PMCID: PMC9487821.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Chronic thromboembolic pulmonary hypertension. J Am Coll Cardiol. 2013 Dec 24; 62(25 Suppl):D92-9.
Kim NH, Delcroix M, Jenkins DP, Channick R, Dartevelle P, Jansa P, Lang I, Madani MM, Ogino H, Pengo V, Mayer E. PMID: 24355646.
View in:
PubMed Mentions:
179 Fields:
Translation:
HumansAnimals
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Risk factors for chronic thromboembolic pulmonary hypertension. Eur Respir Rev. 2012 Mar 01; 21(123):27-31.
Kim NH, Lang IM. PMID: 22379171; PMCID: PMC9487479.
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PubMed Mentions:
50 Fields:
Translation:
Humans
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Riociguat: an upcoming therapy in chronic thromboembolic pulmonary hypertension? Eur Respir Rev. 2010 Mar; 19(115):68-71.
Kim NH. PMID: 20956169; PMCID: PMC9491640.
View in:
PubMed Mentions:
8 Fields:
Translation:
Humans
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Assessment of operability in chronic thromboembolic pulmonary hypertension. Proc Am Thorac Soc. 2006 Sep; 3(7):584-8.
Kim NH. PMID: 16963538.
View in:
PubMed Mentions:
19 Fields:
Translation:
Humans
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Diagnosis and evaluation of the patient with pulmonary hypertension. Cardiol Clin. 2004 Aug; 22(3):367-73, v-vi.
Kim NH. PMID: 15302357.
View in:
PubMed Mentions:
1 Fields:
Translation:
Humans