Carola Ledderose

Title(s)ACAD PRG MGT OFCR 3, Surgery
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Impaired ATP hydrolysis in blood plasma contributes to age-related neutrophil dysfunction. Immun Ageing. 2024 Jul 03; 21(1):45. Ledderose C, Valsami EA, Elevado M, Liu Q, Giva B, Curatolo J, Delfin J, Abutabikh R, Junger WG. PMID: 38961477; PMCID: PMC11221114.
      View in: PubMed   Mentions:
    2. Editorial overview: "Purinergic immune cell regulation reveals novel pharmacological targets". Curr Opin Pharmacol. 2024 Apr; 75:102435. Junger W, Ledderose C. PMID: 38277943.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. ATP release from influenza-infected lungs enhances neutrophil activation and promotes disease progression. J Infect Dis. 2023 Oct 06. Ledderose C, Valsami EA, Elevado M, Junger WG. PMID: 37804120.
      View in: PubMed   Mentions: 1     Fields:    
    4. P2X1 and P2X7 Receptor Overexpression Is a Negative Predictor of Survival in Muscle-Invasive Bladder Cancer. Cancers (Basel). 2023 Apr 16; 15(8). Ledderose S, Rodler S, Eismann L, Ledderose G, Rudelius M, Junger WG, Ledderose C. PMID: 37190249; PMCID: PMC10136747.
      View in: PubMed   Mentions: 3  
    5. ATP breakdown in plasma of children limits the antimicrobial effectiveness of their neutrophils. Purinergic Signal. 2023 Dec; 19(4):651-662. Ledderose C, Valsami EA, Newhams M, Elevado MJ, Novak T, Randolph AG, Junger WG. PMID: 36596963; PMCID: PMC10754799.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    6. Characterization of the tumor-infiltrating lymphocyte landscape in sinonasal mucosal melanoma. Pathol Res Pract. 2022 Dec 26; 241:154289. Ledderose S, Schulz H, Paul T, Ledderose C, Ledderose GJ. PMID: 36584498.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Optimized flow cytometry assays to monitor neutrophil activation in human and mouse whole blood samples. J Immunol Methods. 2023 01; 512:113403. Ledderose C, Hashiguchi N, Valsami EA, Rusu C, Junger WG. PMID: 36502881.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    8. Tumor-infiltrating lymphocytes predict survival in ≥ pT2 urothelial bladder cancer. Pathol Res Pract. 2022 Sep; 237:154037. Ledderose S, Rodler S, Eismann L, Ledderose G, Ledderose C. PMID: 35908386.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    9. Extracellular mitochondria drive CD8 T cell dysfunction in trauma by upregulating CD39. Thorax. 2023 02; 78(2):151-159. Tiwari-Heckler S, Lee GR, Harbison J, Ledderose C, Csizmadia E, Melton D, Zhang Q, Junger W, Chen G, Hauser CJ, Otterbein LE, Longhi MS, Robson SC. PMID: 35613855; PMCID: PMC9691787.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    10. Optimized HPLC method to elucidate the complex purinergic signaling dynamics that regulate ATP, ADP, AMP, and adenosine levels in human blood. Purinergic Signal. 2022 06; 18(2):223-239. Ledderose C, Valsami EA, Junger WG. PMID: 35132577; PMCID: PMC9123122.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    11. Evaluation of an image enhancement system for the assessment of nasal and paranasal sinus diseases. Am J Otolaryngol. 2022 Mar-Apr; 43(2):103323. Englhard AS, Ledderose C, Volgger V, Ledderose GJ. PMID: 34933164.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    12. Prognostic Value of Tumor-Infiltrating Lymphocytes in Sinonasal Mucosal Melanoma. Laryngoscope. 2022 07; 132(7):1334-1339. Ledderose S, Ledderose C, Penkava J, Ledderose GJ. PMID: 34415055.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    13. Endoscopic endonasal repair of complete bilateral choanal atresia in neonates. Eur J Pediatr. 2021 Jul; 180(7):2245-2251. Ledderose GJ, Havel M, Ledderose C, Betz CS. PMID: 33709157.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    14. Structural and functional characterization of engineered bifunctional fusion proteins of CD39 and CD73 ectonucleotidases. Am J Physiol Cell Physiol. 2021 01 01; 320(1):C15-C29. Zhong EH, Ledderose C, De Andrade Mello P, Enjyoji K, Lunderberg JM, Junger W, Robson SC. PMID: 33052071; PMCID: PMC7846972.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    15. Negative feedback control of neuronal activity by microglia. Nature. 2020 10; 586(7829):417-423. Badimon A, Strasburger HJ, Ayata P, Chen X, Nair A, Ikegami A, Hwang P, Chan AT, Graves SM, Uweru JO, Ledderose C, Kutlu MG, Wheeler MA, Kahan A, Ishikawa M, Wang YC, Loh YE, Jiang JX, Surmeier DJ, Robson SC, Junger WG, Sebra R, Calipari ES, Kenny PJ, Eyo UB, Colonna M, Quintana FJ, Wake H, Gradinaru V, Schaefer A. PMID: 32999463; PMCID: PMC7577179.
      View in: PubMed   Mentions: 289     Fields:    Translation:HumansAnimalsCells
    16. The purinergic receptor P2Y11 choreographs the polarization, mitochondrial metabolism, and migration of T lymphocytes. Sci Signal. 2020 09 29; 13(651). Ledderose C, Bromberger S, Slubowski CJ, Sueyoshi K, Aytan D, Shen Y, Junger WG. PMID: 32994212; PMCID: PMC8826773.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    17. Mitochondria Synergize With P2 Receptors to Regulate Human T Cell Function. Front Immunol. 2020; 11:549889. Ledderose C, Junger WG. PMID: 33133068; PMCID: PMC7550529.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    18. Adenosine 5'-Monophosphate Protects from Hypoxia by Lowering Mitochondrial Metabolism and Oxygen Demand. Shock. 2020 08; 54(2):237-244. Kondo Y, Sueyoshi K, Zhang J, Bao Y, Li X, Fakhari M, Slubowski CJ, Bahrami S, Ledderose C, Junger WG. PMID: 31460871; PMCID: PMC7044067.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    19. Frontline Science: P2Y11 receptors support T cell activation by directing mitochondrial trafficking to the immune synapse. J Leukoc Biol. 2021 03; 109(3):497-508. Ledderose C, Bromberger S, Slubowski CJ, Sueyoshi K, Junger WG. PMID: 32531829; PMCID: PMC8772287.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    20. Airway brush cells generate cysteinyl leukotrienes through the ATP sensor P2Y2. Sci Immunol. 2020 01 17; 5(43). Ualiyeva S, Hallen N, Kanaoka Y, Ledderose C, Matsumoto I, Junger WG, Barrett NA, Bankova LG. PMID: 31953256; PMCID: PMC7176051.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    21. Frontline Science: Escherichia coli use LPS as decoy to impair neutrophil chemotaxis and defeat antimicrobial host defense. J Leukoc Biol. 2019 12; 106(6):1211-1219. Kondo Y, Ledderose C, Slubowski CJ, Fakhari M, Sumi Y, Sueyoshi K, Bezler AK, Aytan D, Arbab M, Junger WG. PMID: 31392789; PMCID: PMC6883117.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    22. Plasma Adenylate Levels are Elevated in Cardiopulmonary Arrest Patients and May Predict Mortality. Shock. 2019 06; 51(6):698-705. Sumi Y, Ledderose C, Li L, Inoue Y, Okamoto K, Kondo Y, Sueyoshi K, Junger WG, Tanaka H. PMID: 30052576; PMCID: PMC6347542.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    23. Autocrine stimulation of P2Y1 receptors is part of the purinergic signaling mechanism that regulates T cell activation. Purinergic Signal. 2019 06; 15(2):127-137. Woehrle T, Ledderose C, Rink J, Slubowski C, Junger WG. PMID: 30919205; PMCID: PMC6635541.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    24. Lipopolysaccharide suppresses T cells by generating extracellular ATP that impairs their mitochondrial function via P2Y11 receptors. J Biol Chem. 2019 04 19; 294(16):6283-6293. Sueyoshi K, Ledderose C, Shen Y, Lee AH, Shapiro NI, Junger WG. PMID: 30787105; PMCID: PMC6484120.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    25. Adenosine Triphosphate Release is Required for Toll-Like Receptor-Induced Monocyte/Macrophage Activation, Inflammasome Signaling, Interleukin-1β Production, and the Host Immune Response to Infection. Crit Care Med. 2018 12; 46(12):e1183-e1189. Lee AH, Ledderose C, Li X, Slubowski CJ, Sueyoshi K, Staudenmaier L, Bao Y, Zhang J, Junger WG. PMID: 30247270; PMCID: PMC6239954.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    26. Purinergic P2X4 receptors and mitochondrial ATP production regulate T cell migration. J Clin Invest. 2018 08 01; 128(8):3583-3594. Ledderose C, Liu K, Kondo Y, Slubowski CJ, Dertnig T, Denicoló S, Arbab M, Hubner J, Konrad K, Fakhari M, Lederer JA, Robson SC, Visner GA, Junger WG. PMID: 29894310; PMCID: PMC6063471.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    27. Cerebrospinal fluid leaks during endoscopic sinus surgery in thirty-two patients. Clin Otolaryngol. 2017 10; 42(5):1105-1108. Ledderose GJ, Stelter K, Betz CS, Englhard AS, Ledderose C, Leunig A. PMID: 28317322.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    28. Systemic Adenosine Triphosphate Impairs Neutrophil Chemotaxis and Host Defense in Sepsis. Crit Care Med. 2017 Jan; 45(1):e97-e104. Li X, Kondo Y, Bao Y, Staudenmaier L, Lee A, Zhang J, Ledderose C, Junger WG. PMID: 27548819; PMCID: PMC5546305.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    29. Adenosine arrests breast cancer cell motility by A3 receptor stimulation. Purinergic Signal. 2016 12; 12(4):673-685. Ledderose C, Hefti MM, Chen Y, Bao Y, Seier T, Li L, Woehrle T, Zhang J, Junger WG. PMID: 27577957; PMCID: PMC5124008.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    30. Plant Posters. In Vitro Cell Dev Biol Anim. 2016 Jun; 52 Suppl 1:52-73. Ledderose C. PMID: 27198144.
      View in: PubMed   Mentions:    Fields:    
    31. Purinergic Signaling and the Immune Response in Sepsis: A Review. Clin Ther. 2016 05; 38(5):1054-65. Ledderose C, Bao Y, Kondo Y, Fakhari M, Slubowski C, Zhang J, Junger WG. PMID: 27156007; PMCID: PMC4875817.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    32. Cutting off the power: inhibition of leukemia cell growth by pausing basal ATP release and P2X receptor signaling? Purinergic Signal. 2016 09; 12(3):439-51. Ledderose C, Woehrle T, Ledderose S, Strasser K, Seist R, Bao Y, Zhang J, Junger WG. PMID: 27020575; PMCID: PMC5023625.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    33. CD39 Expression Identifies Terminally Exhausted CD8+ T Cells. PLoS Pathog. 2015 Oct; 11(10):e1005177. Gupta PK, Godec J, Wolski D, Adland E, Yates K, Pauken KE, Cosgrove C, Ledderose C, Junger WG, Robson SC, Wherry EJ, Alter G, Goulder PJ, Klenerman P, Sharpe AH, Lauer GM, Haining WN. PMID: 26485519; PMCID: PMC4618999.
      View in: PubMed   Mentions: 200     Fields:    Translation:HumansAnimalsCells
    34. mTOR and differential activation of mitochondria orchestrate neutrophil chemotaxis. J Cell Biol. 2015 Sep 28; 210(7):1153-64. Bao Y, Ledderose C, Graf AF, Brix B, Birsak T, Lee A, Zhang J, Junger WG. PMID: 26416965; PMCID: PMC4586745.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    35. Inhibition of Neutrophils by Hypertonic Saline Involves Pannexin-1, CD39, CD73, and Other Ectonucleotidases. Shock. 2015 Sep; 44(3):221-7. Chen Y, Bao Y, Zhang J, Woehrle T, Sumi Y, Ledderose S, Li X, Ledderose C, Junger WG. PMID: 26009814; PMCID: PMC4537693.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    36. Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense. J Infect Dis. 2016 Feb 01; 213(3):456-64. Ledderose C, Bao Y, Ledderose S, Woehrle T, Heinisch M, Yip L, Zhang J, Robson SC, Shapiro NI, Junger WG. PMID: 26150546; PMCID: PMC4704665.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    37. Novel method for real-time monitoring of ATP release reveals multiple phases of autocrine purinergic signalling during immune cell activation. Acta Physiol (Oxf). 2015 Feb; 213(2):334-45. Ledderose C, Bao Y, Zhang J, Junger WG. PMID: 25482154; PMCID: PMC4293224.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    38. Mitochondria regulate neutrophil activation by generating ATP for autocrine purinergic signaling. J Biol Chem. 2014 Sep 26; 289(39):26794-26803. Bao Y, Ledderose C, Seier T, Graf AF, Brix B, Chong E, Junger WG. PMID: 25104353; PMCID: PMC4175322.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCellsCTClinical Trials
    39. Mitochondria are gate-keepers of T cell function by producing the ATP that drives purinergic signaling. J Biol Chem. 2014 Sep 12; 289(37):25936-45. Ledderose C, Bao Y, Lidicky M, Zipperle J, Li L, Strasser K, Shapiro NI, Junger WG. PMID: 25070895; PMCID: PMC4162192.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    40. Local expression of myocardial galectin-3 does not correlate with its serum levels in patients undergoing heart transplantation. Ann Transplant. 2013 Nov 22; 18:643-50. Beiras-Fernandez A, Weis F, Rothkopf J, Kaczmarek I, Ledderose C, Dick A, Keller T, Beiras A, Kreth S. PMID: 24264380.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    41. MicroRNA-150 inhibits expression of adiponectin receptor 2 and is a potential therapeutic target in patients with chronic heart failure. J Heart Lung Transplant. 2014 Mar; 33(3):252-60. Kreth S, Ledderose C, Schütz S, Beiras A, Heyn J, Weis F, Beiras-Fernandez A. PMID: 24239242.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    42. Pannexin 1 channels link chemoattractant receptor signaling to local excitation and global inhibition responses at the front and back of polarized neutrophils. J Biol Chem. 2013 Aug 02; 288(31):22650-7. Bao Y, Chen Y, Ledderose C, Li L, Junger WG. PMID: 23798685; PMCID: PMC3829350.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    43. Experimental miRNA target validation. Methods Mol Biol. 2013; 936:83-90. Heyn J, Hinske LC, Ledderose C, Limbeck E, Kreth S. PMID: 23007501.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    44. Corticosteroid resistance in sepsis is influenced by microRNA-124--induced downregulation of glucocorticoid receptor-α. Crit Care Med. 2012 Oct; 40(10):2745-53. Ledderose C, Möhnle P, Limbeck E, Schütz S, Weis F, Rink J, Briegel J, Kreth S. PMID: 22846781.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    45. Adenosine A2A receptor upregulation in human PMNs is controlled by miRNA-214, miRNA-15, and miRNA-16. Shock. 2012 Feb; 37(2):156-63. Heyn J, Ledderose C, Hinske LC, Limbeck E, Möhnle P, Lindner HA, Kreth S. PMID: 22249219.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    46. Selection of reliable reference genes for quantitative real-time PCR in human T cells and neutrophils. BMC Res Notes. 2011 Oct 20; 4:427. Ledderose C, Heyn J, Limbeck E, Kreth S. PMID: 22011438; PMCID: PMC3229292.
      View in: PubMed   Mentions: 63     Fields:    
    47. O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation. PLoS One. 2011 Feb 18; 6(2):e17156. Kreth S, Thon N, Eigenbrod S, Lutz J, Ledderose C, Egensperger R, Tonn JC, Kretzschmar HA, Hinske LC, Kreth FW. PMID: 21365007; PMCID: PMC3041820.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    48. Ghrelin, a novel peptide hormone in the regulation of energy balance and cardiovascular function. Recent Pat Endocr Metab Immune Drug Discov. 2011 Jan; 5(1):1-6. Ledderose C, Kreth S, Beiras-Fernandez A. PMID: 22074572.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    49. Altered myocardial expression of ghrelin and its receptor (GHSR-1a) in patients with severe heart failure. Peptides. 2010 Dec; 31(12):2222-8. Beiras-Fernandez A, Kreth S, Weis F, Ledderose C, Pöttinger T, Dieguez C, Beiras A, Reichart B. PMID: 20804798.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    50. Immunomodulatory properties of pentoxifylline are mediated via adenosine-dependent pathways. Shock. 2010 Jul; 34(1):10-6. Kreth S, Ledderose C, Luchting B, Weis F, Thiel M. PMID: 19997047.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    51. Reduced ligand affinity leads to an impaired function of the adenosine A2A receptor of human granulocytes in sepsis. J Cell Mol Med. 2009 May; 13(5):985-94. Kreth S, Kaufmann I, Ledderose C, Luchting B, Thiel M. PMID: 19538256; PMCID: PMC3823413.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    52. Differential expression of 5'-UTR splice variants of the adenosine A2A receptor gene in human granulocytes: identification, characterization, and functional impact on activation. FASEB J. 2008 Sep; 22(9):3276-86. Kreth S, Ledderose C, Kaufmann I, Groeger G, Thiel M. PMID: 18541693.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
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