Benjamin Zaepfel

Title(s)	Postdoctoral Scholar, Cellular and Molecular Medicine
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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A robust evaluation of TDP-43, poly GP, cellular pathology and behavior in an AAV-C9ORF72 (G4C2)66 mouse model. Acta Neuropathol Commun. 2024 Dec 26; 12(1):203. Thompson EG, Spead O, Akerman SC, Curcio C, Zaepfel BL, Kent ER, Philips T, Vijayakumar BG, Zacco A, Zhou W, Nagappan G, Rothstein JD. PMID: 39722074; PMCID: PMC11670477.

View in: PubMed Mentions: Fields:
Neu Neurology
Translation:Humans Animals Cells
A robust evaluation of TDP-43, poly GP, cellular pathology and behavior in a AAV- C9ORF72 (G 4 C 2) 66 mouse model. Res Sq. 2024 Dec 10. Thompson EG, Spead O, Akerman SC, Curcio C, Zaepfel BL, Kent ER, Philips T, Vijayakumar BG, Zacco A, Zhou W, Nagappan G, Rothstein JD. PMID: 39711523; PMCID: PMC11661372.

View in: PubMed Mentions:
A robust evaluation of TDP-43, poly GP, cellular pathology and behavior in a AAV-C9ORF72 (G4C2)66 mouse model. bioRxiv. 2024 Aug 27. Thompson EG, Spead O, Akerman SC, Curcio C, Zaepfel BL, Kent ER, Philips T, Vijayakumar BG, Zacco A, Zhou W, Nagappan G, Rothstein JD. PMID: 39253499; PMCID: PMC11383318.

View in: PubMed Mentions:
Counter-regulation of RNA stability by UPF1 and TDP43. bioRxiv. 2024 Feb 15. Gomez N, Hsieh C, Li X, Dykstra M, Waksmacki J, Altheim C, Bechar Y, Klim J, Zaepfel B, Rothstein J, Tank EE, Barmada SJ. PMID: 38352350; PMCID: PMC10862862.

View in: PubMed Mentions:
Nuclear Pore Dysfunction in Neurodegeneration. Neurotherapeutics. 2022 07; 19(4):1050-1060. Spead O, Zaepfel BL, Rothstein JD. PMID: 36070178; PMCID: PMC9587172.

View in: PubMed Mentions: 16 Fields:
Neu Neurology
Translation:Humans Cells
Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export. Cell Rep. 2022 07 19; 40(3):111106. Duan L, Zaepfel BL, Aksenova V, Dasso M, Rothstein JD, Kalab P, Hayes LR. PMID: 35858577; PMCID: PMC9345261.

View in: PubMed Mentions: 23 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Cells
Polyadenylated RNA and RNA-Binding Proteins Exhibit Unique Response to Hyperosmotic Stress. Front Cell Dev Biol. 2021; 9:809859. Zaepfel BL, Rothstein JD. PMID: 34970554; PMCID: PMC8712688.

View in: PubMed Mentions:
Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS. Sci Transl Med. 2021 07 28; 13(604). Coyne AN, Baskerville V, Zaepfel BL, Dickson DW, Rigo F, Bennett F, Lusk CP, Rothstein JD. PMID: 34321318; PMCID: PMC9022198.

View in: PubMed Mentions: 56 Fields:
Med Medicine (General)Sci Science
Translation:Humans Cells
RNA Is a Double-Edged Sword in ALS Pathogenesis. Front Cell Neurosci. 2021; 15:708181. Zaepfel BL, Rothstein JD. PMID: 34349625; PMCID: PMC8326408.

View in: PubMed Mentions: 10
UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction. Cell Rep. 2021 03 30; 34(13):108925. Zaepfel BL, Zhang Z, Maulding K, Coyne AN, Cheng W, Hayes LR, Lloyd TE, Sun S, Rothstein JD. PMID: 33789100; PMCID: PMC8063722.

View in: PubMed Mentions: 10 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals Cells
G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD. Neuron. 2020 09 23; 107(6):1124-1140.e11. Coyne AN, Zaepfel BL, Hayes L, Fitchman B, Salzberg Y, Luo EC, Bowen K, Trost H, Aigner S, Rigo F, Yeo GW, Harel A, Svendsen CN, Sareen D, Rothstein JD. PMID: 32673563; PMCID: PMC8077944.

View in: PubMed Mentions: 73 Fields:
Neu Neurology
Translation:Humans Cells
Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS. Cell Rep. 2017 Oct 03; 21(1):110-125. Coyne AN, Lorenzini I, Chou CC, Torvund M, Rogers RS, Starr A, Zaepfel BL, Levy J, Johannesmeyer J, Schwartz JC, Nishimune H, Zinsmaier K, Rossoll W, Sattler R, Zarnescu DC. PMID: 28978466; PMCID: PMC5679478.

View in: PubMed Mentions: 56 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals Cells
Failure to Deliver and Translate-New Insights into RNA Dysregulation in ALS. Front Cell Neurosci. 2017; 11:243. Coyne AN, Zaepfel BL, Zarnescu DC. PMID: 28860970; PMCID: PMC5562674.

View in: PubMed Mentions: 24
Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation. Hum Mol Genet. 2015 Dec 15; 24(24):6886-98. Coyne AN, Yamada SB, Siddegowda BB, Estes PS, Zaepfel BL, Johannesmeyer JS, Lockwood DB, Pham LT, Hart MP, Cassel JA, Freibaum B, Boehringer AV, Taylor JP, Reitz AB, Gitler AD, Zarnescu DC. PMID: 26385636; PMCID: PMC5007633.

View in: PubMed Mentions: 44 Fields:
Gen Genetics Mol Molecular Biology
Translation:Humans Animals Cells