Alex Guseman

Home
About
Help/FAQs
Search Options
- UC Davis
- UCI
- UCLA
- UCSD
- UCSF
- All UC Health
- USC
- All
- Find People
- Find Everything

Title(s)	Assistant Professor, Chemistry and Biochemistry
School	Vc-academic Affairs
Address	9500 Gilman Drive # La Jolla CA 92093
vCard	Download vCard

Bibliographic

selected publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

Altmetrics Details

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Glycopolymers stabilize protein folding and protein-protein interactions via enthalpic interactions. bioRxiv. 2025 Aug 13. Richter SM, Brook N, Guseman AJ. PMID: 40832317; PMCID: PMC12363903.

View in: PubMed Mentions:
Precision dendritic-supramolecular glycan assemblies for probing multivalent lectin interactions. Chem Sci. 2025 Jul 30; 16(30):13636-13645. Bhide TM, Musil GJ, Shipley W, Hall E, Guseman AJ, Tao AR, Stauber JM. PMID: 40636579; PMCID: PMC12236194.

View in: PubMed Mentions:
Cataract-prone variants of γD-crystallin populate a conformation with a partially unfolded N-terminal domain under native conditions. Proc Natl Acad Sci U S A. 2025 Feb 11; 122(6):e2410860122. Volz S, Malone JR, Guseman AJ, Gronenborn AM, Marqusee S. PMID: 39899721; PMCID: PMC11831119.

View in: PubMed Mentions: 1 Fields:
Sci Science
Translation:Humans Cells
Cumulative asparagine to aspartate deamidation fails to perturb γD-crystallin structure and stability. Protein Sci. 2024 Aug; 33(8):e5120. Guseman AJ, González JJ, Yang D, Gronenborn AM. PMID: 39022918; PMCID: PMC11255865.

View in: PubMed Mentions: 1 Fields:
Bio Biochemistry
Translation:Humans Cells
Probing effects of site-specific aspartic acid isomerization on structure and stability of GB1 through chemical protein synthesis. Protein Sci. 2024 Mar; 33(3):e4883. Heath SL, Guseman AJ, Gronenborn AM, Horne WS. PMID: 38143426; PMCID: PMC10868458.

View in: PubMed Mentions: 1 Fields:
Bio Biochemistry
Translation:Cells
The role of cryptic ancestral symmetry in histone folding mechanisms across Eukarya and Archaea. PLoS Comput Biol. 2024 Jan; 20(1):e1011721. Zhao H, Wu H, Guseman A, Abeykoon D, Camara CM, Dalal Y, Fushman D, Papoian GA. PMID: 38181064; PMCID: PMC10796010.

View in: PubMed Mentions: 2 Fields:
Com Computational Biology
Translation:Humans Animals Cells
Targeting spike glycans to inhibit SARS-CoV2 viral entry. Proc Natl Acad Sci U S A. 2023 09 19; 120(38):e2301518120. Guseman AJ, Rennick LJ, Nambulli S, Roy CN, Martinez DR, Yang DT, Bhinderwala F, Vergara S, Schaefer A, Baric RS, Ambrose Z, Duprex WP, Gronenborn AM. PMID: 37695910; PMCID: PMC10515186.

View in: PubMed Mentions: 4 Fields:
Sci Science
Translation:Humans Cells
Targeting Spike Glycans to Inhibit SARS-CoV2 Viral Entry. bioRxiv. 2022 Dec 22. Guseman AJ, Rennick LJ, Nambulli S, Roy CN, Martinez DR, Yang DT, Bhinderwhala F, Vergara S, Baric RS, Ambrose Z, Duprex WP, Gronenborn AM. PMID: 36597530; PMCID: PMC9810211.

View in: PubMed Mentions: 1
Visualizing Proteins in Mammalian Cells by 19 F NMR Spectroscopy. Angew Chem Int Ed Engl. 2022 06 07; 61(23):e202201097. Zhu W, Guseman AJ, Bhinderwala F, Lu M, Su XC, Gronenborn AM. PMID: 35278268; PMCID: PMC9156538.

View in: PubMed Mentions: 16 Fields:
Che Chemistry
Translation:Animals Cells
The intracellular environment affects protein-protein interactions. Proc Natl Acad Sci U S A. 2021 03 16; 118(11). Speer SL, Zheng W, Jiang X, Chu IT, Guseman AJ, Liu M, Pielak GJ, Li C. PMID: 33836588; PMCID: PMC7980425.

View in: PubMed Mentions: 33 Fields:
Sci Science
Translation:Animals Cells
Assessing the Structures and Interactions of γD-Crystallin Deamidation Variants. Structure. 2021 03 04; 29(3):284-291.e3. Guseman AJ, Whitley MJ, González JJ, Rathi N, Ambarian M, Gronenborn AM. PMID: 33264606; PMCID: PMC7935750.

View in: PubMed Mentions: 9 Fields:
Bio Biochemistry Bio Biotechnology Mol Molecular Biology
Translation:Humans Cells
Thermodynamic consequences of Tyr to Trp mutations in the cation-π-mediated binding of trimethyllysine by the HP1 chromodomain. Chem Sci. 2020 Mar 04; 11(13):3495-3500. Krone MW, Albanese KI, Leighton GO, He CQ, Lee GY, Garcia-Borràs M, Guseman AJ, Williams DC, Houk KN, Brustad EM, Waters ML. PMID: 34109021; PMCID: PMC8152637.

View in: PubMed Mentions: 9
Restricted myeloperoxidase epitopes drive the adaptive immune response in MPO-ANCA vasculitis. J Autoimmun. 2020 01; 106:102306. Free ME, Stember KG, Hess JJ, McInnis EA, Lardinois O, Hogan SL, Hu Y, Mendoza C, Le AK, Guseman AJ, Pilkinton MA, Bortone DS, Cowens K, Sidney J, Karosiene E, Peters B, James E, Kwok WW, Vincent BG, Mallal SA, Jennette JC, Ciavatta DJ, Falk RJ. PMID: 31383567; PMCID: PMC6930338.

View in: PubMed Mentions: 17 Fields:
All Allergy and Immunology
Translation:Humans Animals Cells
Controlling and quantifying protein concentration in Escherichia coli. Protein Sci. 2019 07; 28(7):1307-1311. Speer SL, Guseman AJ, Patteson JB, Ehrmann BM, Pielak GJ. PMID: 31054180; PMCID: PMC6566559.

View in: PubMed Mentions: 3 Fields:
Bio Biochemistry
Translation:Cells
Isomerization as the secret Achilles' heel of long-lived proteins. J Biol Chem. 2019 05 10; 294(19):7556-7557. Guseman AJ, Gronenborn AM. PMID: 31076522; PMCID: PMC6514620.

View in: PubMed Mentions: 3 Fields:
Bio Biochemistry
Translation:Humans Cells
Protecting activity of desiccated enzymes. Protein Sci. 2019 05; 28(5):941-951. Piszkiewicz S, Gunn KH, Warmuth O, Propst A, Mehta A, Nguyen KH, Kuhlman E, Guseman AJ, Stadmiller SS, Boothby TC, Neher SB, Pielak GJ. PMID: 30868674; PMCID: PMC6459994.

View in: PubMed Mentions: 35 Fields:
Bio Biochemistry
Translation:Animals Cells
Protein shape modulates crowding effects. Proc Natl Acad Sci U S A. 2018 10 23; 115(43):10965-10970. Guseman AJ, Perez Goncalves GM, Speer SL, Young GB, Pielak GJ. PMID: 30301792; PMCID: PMC6205421.

View in: PubMed Mentions: 27 Fields:
Sci Science
Translation:Cells
Surface Charge Modulates Protein-Protein Interactions in Physiologically Relevant Environments. Biochemistry. 2018 03 20; 57(11):1681-1684. Guseman AJ, Speer SL, Perez Goncalves GM, Pielak GJ. PMID: 29473738; PMCID: PMC5977980.

View in: PubMed Mentions: 23 Fields:
Bio Biochemistry
Translation:Cells
Osmotic Shock Induced Protein Destabilization in Living Cells and Its Reversal by Glycine Betaine. J Mol Biol. 2017 04 21; 429(8):1155-1161. Stadmiller SS, Gorensek-Benitez AH, Guseman AJ, Pielak GJ. PMID: 28263768; PMCID: PMC5985519.

View in: PubMed Mentions: 42 Fields:
Mol Molecular Biology
Translation:Cells
Cosolute and Crowding Effects on a Side-By-Side Protein Dimer. Biochemistry. 2017 02 21; 56(7):971-976. Guseman AJ, Pielak GJ. PMID: 28102665; PMCID: PMC5985514.

View in: PubMed Mentions: 16 Fields:
Bio Biochemistry
Translation:Cells
Multi-Drug Resistance Transporters and a Mechanism-Based Strategy for Assessing Risks of Pesticide Combinations to Honey Bees. PLoS One. 2016; 11(2):e0148242. Guseman AJ, Miller K, Kunkle G, Dively GP, Pettis JS, Evans JD, vanEngelsdorp D, Hawthorne DJ. PMID: 26840460; PMCID: PMC4740413.

View in: PubMed Mentions: 8 Fields:
Med Medicine (General)Sci Science
Translation:Animals PHPublic Health
Intracellular pH modulates quinary structure. Protein Sci. 2015 Nov; 24(11):1748-55. Cohen RD, Guseman AJ, Pielak GJ. PMID: 26257390; PMCID: PMC4622208.

View in: PubMed Mentions: 19 Fields:
Bio Biochemistry
Translation:Cells