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    Eric Ahrens

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentRadiology
    Address9500 Gilman Drive #0695
    CA La Jolla 92093
    Phone858-246-0279
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      CALTECHSenior Research FellowDepartment of Biology
      University of California, Los AngelesPhD Physics
      University of California, Los Angeles BS Physics

      Collapse Research 
      Collapse Research Activities and Funding
      Compositions and methods for enhanced fluorine-19 magnetic resonance imaging cell tracking
      NIH/NIBIB R01EB024015Apr 15, 2017 - Feb 28, 2021
      Role: Principal Investigator
      Intracellular oxygen sensing using 19F MRI
      NIH/NIBIB R01EB017271Sep 1, 2013 - Aug 31, 2017
      Role: Principal Investigator
      Console Electronics Upgrade for 11.7T MRI System
      NIH S10OD010755Jun 15, 2013 - Jun 14, 2014
      Role: Principal Investigator
      Platform for myocardial infarct MRI and delivery of therapeutics
      NIH/NHLBI R41HL116014Aug 20, 2012 - Jul 31, 2013
      Role: Principal Investigator
      IN VIVO VISUALIZATION AND QUANTIFICATION OF EPIGENETIC ACTIVITIES USING MAGNETIC
      NIH/NIDA R56DA030330Sep 17, 2010 - May 31, 2013
      Role: Principal Investigator
      Clinical translation of 19F MRI to visualize cancer immunotherapeutic cells
      NIH/NCI R01CA134633May 10, 2009 - May 31, 2022
      Role: Principal Investigator
      NOVEL MARKERS FOR IMAGING GENE EXPRESSION IN VIVO USING MRI
      NIH/NIBIB R01EB005740Sep 7, 2005 - Jun 30, 2010
      Role: Principal Investigator
      Pluripotent Stem Cells in Development and Disease
      NIH P01HD047675Aug 30, 2005 - May 31, 2012
      Role: Co-Investigator
      19F MRI probes and autoimmune disease
      NIH/NIBIB R01EB003453Feb 1, 2005 - Jan 31, 2010
      Role: Principal Investigator
      Adverse Pregnancy Outcomes: Genetic/Environmental Causes
      NIH P50ES012359Sep 30, 2002 - Jul 31, 2008
      Role: Co-Investigator
      MAGNETIC RESONANCE MICROSCOPY STUDY OF EAE
      NIH/NINDS F32NS010384Aug 1, 1997
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Khurana A, Chapelin F, Xu H, Acevedo JR, Molinolo A, Nguyen Q, Ahrens E. Visualization of macrophage recruitment in head and neck carcinoma model using fluorine-19 magnetic resonance imaging. Magn Reson Med. 2017 Jul 26. PMID: 28748562.
        View in: PubMed
      2. Miyanohara A, Kamizato K, Juhas S, Juhasova J, Navarro M, Marsala S, Lukacova N, Hruska-Plochan M, Curtis E, Gabel B, Ciacci J, Ahrens E, Kaspar BK, Cleveland D, Marsala M. Potent spinal parenchymal AAV9-mediated gene delivery by subpial injection in adult rats and pigs. Mol Ther Methods Clin Dev. 2016; 3:16046. PMID: 27462649; PMCID: PMC4943453.
      3. Kislukhin AA, Xu H, Adams SR, Narsinh KH, Tsien RY, Ahrens E. Paramagnetic fluorinated nanoemulsions for sensitive cellular fluorine-19 magnetic resonance imaging. Nat Mater. 2016 Jun; 15(6):662-8. PMID: 26974409.
        View in: PubMed
      4. Zhong J, Narsinh K, Morel PA, Xu H, Ahrens E. In Vivo Quantification of Inflammation in Experimental Autoimmune Encephalomyelitis Rats Using Fluorine-19 Magnetic Resonance Imaging Reveals Immune Cell Recruitment outside the Nervous System. PLoS One. 2015; 10(10):e0140238. PMID: 26485716; PMCID: PMC4618345.
      5. Ahrens E, Helfer BM, O'Hanlon CF, Schirda C. Clinical cell therapy imaging using a perfluorocarbon tracer and fluorine-19 MRI. Magn Reson Med. 2014 Dec; 72(6):1696-701. PMID: 25241945; PMCID: PMC4253123.
      6. Kadayakkara DK, Damodaran K, Hitchens TK, Bulte JW, Ahrens E. (19)F spin-lattice relaxation of perfluoropolyethers: Dependence on temperature and magnetic field strength (7.0-14.1T). J Magn Reson. 2014 May; 242:18-22. PMID: 24594752; PMCID: PMC4008704.
      7. Hitchens TK, Liu L, Foley LM, Simplaceanu V, Ahrens E, Ho C. Combining perfluorocarbon and superparamagnetic iron-oxide cell labeling for improved and expanded applications of cellular MRI. Magn Reson Med. 2015 Jan; 73(1):367-75. PMID: 24478194; PMCID: PMC4115051.
      8. Ahrens E, Bulte JW. Tracking immune cells in vivo using magnetic resonance imaging. Nat Rev Immunol. 2013 10; 13(10):755-63. PMID: 24013185; PMCID: PMC3886235.
      9. Zwieniecki MA, Melcher PJ, Ahrens E. Analysis of spatial and temporal dynamics of xylem refilling in Acer rubrum L. using magnetic resonance imaging. Front Plant Sci. 2013; 4:265. PMID: 23885258; PMCID: PMC3717611.
      10. Zhong J, Sakaki M, Okada H, Ahrens E. In vivo intracellular oxygen dynamics in murine brain glioma and immunotherapeutic response of cytotoxic T cells observed by fluorine-19 magnetic resonance imaging. PLoS One. 2013; 8(5):e59479. PMID: 23667419; PMCID: PMC3648573.
      11. Ahrens E, Zhong J. In vivo MRI cell tracking using perfluorocarbon probes and fluorine-19 detection. NMR Biomed. 2013 Jul; 26(7):860-71. PMID: 23606473; PMCID: PMC3893103.
      12. Zhong J, Mills PH, Hitchens TK, Ahrens E. Accelerated fluorine-19 MRI cell tracking using compressed sensing. Magn Reson Med. 2013 Jun; 69(6):1683-90. PMID: 22837054; PMCID: PMC3494778.
      13. Balducci A, Helfer BM, Ahrens E, O'Hanlon CF, Wesa AK. Visualizing arthritic inflammation and therapeutic response by fluorine-19 magnetic resonance imaging (19F MRI). J Inflamm (Lond). 2012 Jun 21; 9(1):24. PMID: 22721447; PMCID: PMC3506445.
      14. Kadayakkara DK, Ranganathan S, Young WB, Ahrens E. Assaying macrophage activity in a murine model of inflammatory bowel disease using fluorine-19 MRI. Lab Invest. 2012 Apr; 92(4):636-45. PMID: 22330343; PMCID: PMC3397682.
      15. Bible E, Dell'Acqua F, Solanky B, Balducci A, Crapo PM, Badylak SF, Ahrens E, Modo M. Non-invasive imaging of transplanted human neural stem cells and ECM scaffold remodeling in the stroke-damaged rat brain by (19)F- and diffusion-MRI. Biomaterials. 2012 Apr; 33(10):2858-71. PMID: 22244696; PMCID: PMC3268910.
      16. Iordanova B, Ahrens E. In vivo magnetic resonance imaging of ferritin-based reporter visualizes native neuroblast migration. Neuroimage. 2012 Jan 16; 59(2):1004-12. PMID: 21939774; PMCID: PMC3230706.
      17. Mills PH, Hitchens TK, Foley LM, Link T, Ye Q, Weiss CR, Thompson JD, Gilson WD, Arepally A, Melick JA, Kochanek PM, Ho C, Bulte JW, Ahrens E. Automated detection and characterization of SPIO-labeled cells and capsules using magnetic field perturbations. Magn Reson Med. 2012 Jan; 67(1):278-89. PMID: 21656554; PMCID: PMC3170691.
      18. Morel PA, Srinivas M, Turner MS, Fuschiotti P, Munshi R, Bahar I, Feili-Hariri M, Ahrens E. Gene expression analysis of dendritic cells that prevent diabetes in NOD mice: analysis of chemokines and costimulatory molecules. J Leukoc Biol. 2011 Sep; 90(3):539-50. PMID: 21628331; PMCID: PMC3157898.
      19. Ahrens E, Young WB, Xu H, Pusateri LK. Rapid quantification of inflammation in tissue samples using perfluorocarbon emulsion and fluorine-19 nuclear magnetic resonance. Biotechniques. 2011 Apr; 50(4):229-34. PMID: 21548906; PMCID: PMC5012185.
      20. Hitchens TK, Ye Q, Eytan DF, Janjic JM, Ahrens E, Ho C. 19F MRI detection of acute allograft rejection with in vivo perfluorocarbon labeling of immune cells. Magn Reson Med. 2011 Apr; 65(4):1144-53. PMID: 21305593; PMCID: PMC3135171.
      21. Bonetto F, Srinivas M, Heerschap A, Mailliard R, Ahrens E, Figdor CG, de Vries IJ. A novel (19)F agent for detection and quantification of human dendritic cells using magnetic resonance imaging. Int J Cancer. 2011 Jul 15; 129(2):365-73. PMID: 20839261; PMCID: PMC3085097.
      22. Kadayakkara DK, Janjic JM, Pusateri LK, Young WB, Ahrens E. In vivo observation of intracellular oximetry in perfluorocarbon-labeled glioma cells and chemotherapeutic response in the CNS using fluorine-19 MRI. Magn Reson Med. 2010 Nov; 64(5):1252-9. PMID: 20860007; PMCID: PMC2965778.
      23. Srinivas M, Heerschap A, Ahrens E, Figdor CG, de Vries IJ. (19)F MRI for quantitative in vivo cell tracking. Trends Biotechnol. 2010 Jul; 28(7):363-70. PMID: 20427096; PMCID: PMC2902646.
      24. Helfer BM, Balducci A, Nelson AD, Janjic JM, Gil RR, Kalinski P, de Vries IJ, Ahrens E, Mailliard RB. Functional assessment of human dendritic cells labeled for in vivo (19)F magnetic resonance imaging cell tracking. Cytotherapy. 2010 Apr; 12(2):238-50. PMID: 20053146.
        View in: PubMed
      25. Mills PH, Ahrens E. Enhanced positive-contrast visualization of paramagnetic contrast agents using phase images. Magn Reson Med. 2009 Nov; 62(5):1349-55. PMID: 19780169; PMCID: PMC2783728.
      26. Srinivas M, Turner MS, Janjic JM, Morel PA, Laidlaw DH, Ahrens E. In vivo cytometry of antigen-specific t cells using 19F MRI. Magn Reson Med. 2009 Sep; 62(3):747-53. PMID: 19585593; PMCID: PMC2763624.
      27. Janjic JM, Ahrens E. Fluorine-containing nanoemulsions for MRI cell tracking. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2009 Sep-Oct; 1(5):492-501. PMID: 19920872.
        View in: PubMed
      28. Janjic JM, Srinivas M, Kadayakkara DK, Ahrens E. Self-delivering nanoemulsions for dual fluorine-19 MRI and fluorescence detection. J Am Chem Soc. 2008 Mar 05; 130(9):2832-41. PMID: 18266363.
        View in: PubMed
      29. Srinivas M, Morel PA, Ernst LA, Laidlaw DH, Ahrens E. Fluorine-19 MRI for visualization and quantification of cell migration in a diabetes model. Magn Reson Med. 2007 Oct; 58(4):725-34. PMID: 17899609.
        View in: PubMed
      30. Mills PH, Ahrens E. Theoretical MRI contrast model for exogenous T2 agents. Magn Reson Med. 2007 Feb; 57(2):442-7. PMID: 17260382.
        View in: PubMed
      31. Ahrens E, Srinivas M, Capuano S, Simhan HN, Schatten GP. Magnetic resonance imaging of embryonic and fetal development in model systems. Methods Mol Med. 2006; 124:87-101. PMID: 16506418.
        View in: PubMed
      32. Kaufman JA, Ahrens E, Laidlaw DH, Zhang S, Allman JM. Anatomical analysis of an aye-aye brain (Daubentonia madagascariensis, primates: Prosimii) combining histology, structural magnetic resonance imaging, and diffusion-tensor imaging. Anat Rec A Discov Mol Cell Evol Biol. 2005 Nov; 287(1):1026-37. PMID: 16211637.
        View in: PubMed
      33. Ahrens E, Flores R, Xu H, Morel PA. In vivo imaging platform for tracking immunotherapeutic cells. Nat Biotechnol. 2005 Aug; 23(8):983-7. PMID: 16041364.
        View in: PubMed
      34. Genove G, DeMarco U, Xu H, Goins WF, Ahrens E. A new transgene reporter for in vivo magnetic resonance imaging. Nat Med. 2005 Apr; 11(4):450-4. PMID: 15778721.
        View in: PubMed
      35. Ahrens E. Emerging non-invasive imaging techniques using magnetic resonance imaging. Curr Top Dev Biol. 2005; 70:xi. PMID: 16338334.
        View in: PubMed
      36. Ahrens E, Morel PA. In vivo imaging of autoimmune disease in model systems. Curr Top Dev Biol. 2005; 70:215-38. PMID: 16338343.
        View in: PubMed
      37. Ahrens E, Feili-Hariri M, Xu H, Genove G, Morel PA. Receptor-mediated endocytosis of iron-oxide particles provides efficient labeling of dendritic cells for in vivo MR imaging. Magn Reson Med. 2003 Jun; 49(6):1006-13. PMID: 12768577.
        View in: PubMed
      38. Sadun AA, Carelli V, Bose S, Ross-Cisneros FN, Barboni P, Ahrens E. First application of extremely high-resolution magnetic resonance imaging to study microscopic features of normal and LHON human optic nerve. Ophthalmology. 2002 Jun; 109(6):1085-91. PMID: 12045048.
        View in: PubMed
      39. Holbrook NM, Ahrens E, Burns MJ, Zwieniecki MA. In vivo observation of cavitation and embolism repair using magnetic resonance imaging. Plant Physiol. 2001 May; 126(1):27-31. PMID: 11351066; PMCID: PMC1540104.
      40. Louie AY, Hüber MM, Ahrens E, Rothbächer U, Moats R, Jacobs RE, Fraser SE, Meade TJ. In vivo visualization of gene expression using magnetic resonance imaging. Nat Biotechnol. 2000 Mar; 18(3):321-5. PMID: 10700150.
        View in: PubMed
      41. Ahrens E, Laidlaw DH, Readhead C, Brosnan CF, Fraser SE, Jacobs RE. MR microscopy of transgenic mice that spontaneously acquire experimental allergic encephalomyelitis. Magn Reson Med. 1998 Jul; 40(1):119-32. PMID: 9660562.
        View in: PubMed
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