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    Arnold Mandell

    TitleEmeritus Professor
    SchoolUniversity of California, San Diego
    DepartmentPsychiatry
    Address9500 Gilman Drive #0603
    CA La Jolla 92093
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      Biography

      His research (1957 to the present) has involved animal neurophysiology, indole chemistry, human pituitary-adrenal regulation, non-linear brain enzyme kinetics, neurochemistry, neuropharmacology, protein structure and function, algorithmic neuropeptide design and currently dynamical systems measure-theoretic approaches to magneto-encephalographic analyses. He has published over 450 scientific reports and reviews. He has written and/or edited four books in brain science and has written two trade books published by Random House, Nightmare Season and and Simon and Schuster, Coming of Middle Age He has received the NIMH Career Teacher Award, the A.E. Bennett Research Prize of the Society for Biological Psychiatry, a MacArthur Prize Fellowship in Theoretical Neuroscience (1984-1989), a Senior Humboldt Prize Fellowship in Dynamical Systems, Bremen University, FRG (1994), and the Foundation’s Fund Research Prize of the American Psychiatric Association, 1989-90. He has been a principle investigator and consultant for the Fetzer Franklin Trust and the Fetzer Foundation since 1996. He has been a Johananoff International Prize Fellow in Psychopharmacology (Mario Negril Institute, Milan, Italy). He has been a psychiatric consultant for the San Diego Chargers, 1971-75. Dr. Mandell has been the recipient of Federal, State and/or Foundation support continuously since 1962.


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      Algorithmic Peptides Target Multidrug Resistance Protein
      NIH/NCI R43CA091384Sep 30, 2002 - Sep 29, 2004
      Role: Principal Investigator
      COMPUTATIONAL NEUROPEPTIDE DESIGN AND RECEPTOR MATCHING
      NIH/NIMH R44MH058026Jul 1, 1998 - Jun 30, 2002
      Role: Principal Investigator
      COMPUTATIONAL NEUROPEPTIDE DESIGN AND RECEPTOR MATCHING
      NIH/NIMH R43MH058026Mar 1, 1998 - Jun 30, 1999
      Role: Principal Investigator
      DYNAMICAL SYSTEMS IN THE NEUROSCIENCES OF PSYCHIATRY
      NIH/NIMH T32MH016109Jul 1, 1979 - Jun 30, 1991
      Role: Co-Principal Investigator

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Zhang X, Wang YT, Wang Y, Jung TP, Huang M, Cheng CK, Mandell A. Ultra-slow frequency bands reflecting potential coherence between neocortical brain regions. Neuroscience. 2015 Mar 19; 289:71-84. PMID: 25592429.
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      2. Robinson SE, Mandell A. Mutual Information in a MEG complexity measure suggests regional hyper-connectivity in schizophrenic probands. Neuropsychopharmacology. 2015 Jan; 40(1):251-2. PMID: 25482179; PMCID: PMC4262904.
      3. Huang X, Huang L, Jung TP, Cheng CK, Mandell A. Intrinsic mode functions locate implicit turbulent attractors in time in frontal lobe MEG recordings. Neuroscience. 2014 May 16; 267:91-101. PMID: 24613718.
        View in: PubMed
      4. Robinson SE, Mandell A, Coppola R. Spatiotemporal imaging of complexity. Front Comput Neurosci. 2012; 6:101. PMID: 23355820; PMCID: PMC3553423.
      5. Sorokulova IB, Krumnow AA, Pathirana S, Mandell A, Vodyanoy V. Novel methods for storage stability and release of Bacillus spores. Biotechnol Prog. 2008 Sep-Oct; 24(5):1147-53. PMID: 19194925.
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      6. Selz KA, Samoylova TI, Samoylov AM, Vodyanoy VJ, Mandell A. Designing allosteric peptide ligands targeting a globular protein. Biopolymers. 2007 Jan; 85(1):38-59. PMID: 17009317.
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      7. Kinkead B, Selz KA, Owens MJ, Mandell A. Algorithmically designed peptides ameliorate behavioral defects in animal model of ADHD by an allosteric mechanism. J Neurosci Methods. 2006 Feb 15; 151(1):68-81. PMID: 16423408.
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      8. Selz KA, Mandell A, Shlesinger MF, Arcuragi V, Owens MJ. Designing human m1 muscarinic receptor-targeted hydrophobic eigenmode matched peptides as functional modulators. Biophys J. 2004 Mar; 86(3):1308-31. PMID: 14990463; PMCID: PMC1303971.
      9. Mandell A, Selz KA, Owens MJ, Kinkead B, Shlesinger MF, Gutman DA, Arguragi V. Cellular and behavioral effects of D2 dopamine receptor hydrophobic eigenmode-targeted peptide ligands. Neuropsychopharmacology. 2003 Jul; 28 Suppl 1:S98-107. PMID: 12827150.
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      10. Selz KA, Mandell A, Shlesinger MF. Hydrophobic free energy eigenfunctions of pore, channel, and transporter proteins contain beta-burst patterns. Biophys J. 1998 Nov; 75(5):2332-42. PMID: 9788928; PMCID: PMC1299907.
      11. Mandell A, Owens MJ, Selz KA, Morgan WN, Shlesinger MF, Nemeroff CB. Mode matches in hydrophobic free energy eigenfunctions predict peptide-protein interactions. Biopolymers. 1998 Aug; 46(2):89-101. PMID: 9664843.
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      12. Anderson CM, Mandell A, Selz KA, Terry LM, Wong CH, Robinson SR, Robertson SS, Smotherman WP. The development of nuchal atonia associated with active (REM) sleep in fetal sheep: presence of recurrent fractal organization. Brain Res. 1998 Mar 23; 787(2):351-7. PMID: 9518691.
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      13. Mandell A, Selz KA, Shlesinger MF. Mode matches and their locations in the hydrophobic free energy sequences of peptide ligands and their receptor eigenfunctions. Proc Natl Acad Sci U S A. 1997 Dec 09; 94(25):13576-81. PMID: 9391068; PMCID: PMC28348.
      14. Mandell A, Selz KA. Entropy conservation as h(T(&mgr;) ) approximately lambda(&mgr;) (+)d(&mgr;) in neurobiological dynamical systems. Chaos. 1997 Mar; 7(1):67-81. PMID: 12779638.
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      15. Smotherman WP, Selz KA, Mandell A. Dynamical entropy is conserved during cocaine-induced changes in fetal rat motor patterns. Psychoneuroendocrinology. 1996 Feb; 21(2):173-87. PMID: 8774061.
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      16. Mandell A, Selz KA. Nonlinear dynamical patterns as personality theory for neurobiology and psychiatry. Psychiatry. 1995 Nov; 58(4):371-90. PMID: 8746494.
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      17. Mandell A, Selz KA. Dynamical systems in psychiatry: now what? Biol Psychiatry. 1992 Aug 15; 32(4):299-301. PMID: 1358230.
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      18. Paulus MP, Geyer MA, Gold LH, Mandell A. Application of entropy measures derived from the ergodic theory of dynamical systems to rat locomotor behavior. Proc Natl Acad Sci U S A. 1990 Jan; 87(2):723-7. PMID: 1967830; PMCID: PMC53338.
      19. Kelleher JF, Mandell A. Dystonia musculorum deformans: a 'critical phenomenon' model involving nigral dopaminergic and caudate pathways. Med Hypotheses. 1990 Jan; 31(1):55-8. PMID: 2179685.
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      20. Zeytin FN, Rusk SF, Raymond V, Mandell A. Fibroblast growth factor stabilizes ribonucleic acid and regulates differentiated functions in a multipeptide-secreting neuroendocrine cell line. Endocrinology. 1988 Mar; 122(3):1121-8. PMID: 2449340.
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      21. Zeytin FN, Rusk SF, Baird A, Raymond V, Leff SE, Haaparanta T, Mandell A. Induction of c-fos, calcitonin gene expression, and acidic fibroblast growth factor production in a multipeptide-secreting neuroendocrine cell line. Endocrinology. 1988 Mar; 122(3):1114-20. PMID: 2893727.
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      22. Mandell A, Russo PV, Blomgren BW. Geometric universality in brain allosteric protein dynamics: complex hydrophobic transformation predicts mutual recognition by polypeptides and proteins. Ann N Y Acad Sci. 1987; 504:88-117. PMID: 2820290.
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      23. Hole K, Russo PV, Mandell A. The influence of neuropeptides on amine synthesis: Cholecystokinin-8 and neurotensin reduce striatal tyrosine hydroxylase activity. Neurochem Int. 1986; 9(4):493-8. PMID: 20493152.
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      24. Russo PV, Mandell A. Sonication, calcium, and peptides have systematic effects on the nonlinear dynamics of tyrosine hydroxylase activity. Neurochem Int. 1986; 9(1):171-6. PMID: 20493114.
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      25. Mandell A. Interhemispheric fusion. J Psychoactive Drugs. 1985 Oct-Dec; 17(4):257-66. PMID: 3003313.
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      26. Goldberger AL, Bhargava V, West BJ, Mandell A. On a mechanism of cardiac electrical stability. The fractal hypothesis. Biophys J. 1985 Sep; 48(3):525-8. PMID: 4041542; PMCID: PMC1329366.
      27. Lee EH, Mandell A. Relationships between drug-induced changes in tetrahydrobiopterin and biogenic amine concentrations in rat brain. J Pharmacol Exp Ther. 1985 Jul; 234(1):141-6. PMID: 3874280.
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      28. Lee EH, Mandell A. Effects of amphetamine on hemispheric asymmetry and regional distribution of tetrahydrobiopterin in rat brain. Neurochem Int. 1985; 7(5):777-81. PMID: 20492987.
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      29. Russo PV, Mandell A. Metrics from nonlinear dynamics adapted for characterizing the behavior of nonequilibrium enzymatic rate functions. Anal Biochem. 1984 May 15; 139(1):91-9. PMID: 6146273.
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      30. Russo PV, Mandell A. A kinetic scattering approach to the non-linear instabilities of rat brain tyrosine hydroxylase preparations at several levels of tetrahydrobiopterin cofactor demonstrates evolutionary behavior characteristic of global dynamical systems. Brain Res. 1984 May 14; 299(2):313-22. PMID: 6145494.
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      31. Knapp S, Mandell A. TRH influences the pterin cofactor- and time-dependent instabilities of rat raphe tryptophan hydroxylase activity assessed under far-from-equilibrium conditions. Neurochem Int. 1984; 6(6):801-12. PMID: 20488111.
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      32. Mandell A. From intermittency to transitivity in neuropsychobiological flows. Am J Physiol. 1983 Oct; 245(4):R484-94. PMID: 6624945.
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      33. Knapp S, Mandell A. Lithium and chlorimipramine differentially alter the stability properties of tryptophan hydroxylase as seen in allosteric and scattering kinetics. Psychiatry Res. 1983 Apr; 8(4):311-23. PMID: 6576397.
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      34. Knapp S, Mandell A. Scattering kinetics in a complex tryptophan hydroxylase preparation from rat brainstem raphe nuclei: statistical evidence that the lithium-induced sigmoid velocity function reflects two states of available catalytic potential. J Neural Transm. 1983; 58(3-4):169-82. PMID: 6663300.
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      35. Mandell A, Knapp S. Regulation of tryptophan hydroxylase: variational kinetics suggest a neuropharmacology of phase. Adv Biochem Psychopharmacol. 1982; 34:1-15. PMID: 6127915.
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      36. Knapp S, Mandell A, Russo PV, Vitto A, Stewart KD. Strain differences in kinetic and thermal stability of two mouse brain tryptophan hydroxylase activities. Brain Res. 1981 Dec 28; 230(1-2):317-36. PMID: 6172184.
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      37. Mandell A, Russo PV. Short-term regulation of hydroxylase cofactor activity in rat brain. J Neurochem. 1981 Dec; 37(6):1573-8. PMID: 6120998.
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      38. Mandell A, Stewart KD, Russo PV. The Sunday syndrome: from kinetics to altered consciousness. Fed Proc. 1981 Oct; 40(12):2693-8. PMID: 7286249.
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      39. Vitto A, Mandell A. Stability properties of activated tryptophan hydroxylase from rat midbrain. J Neurochem. 1981 Sep; 37(3):601-7. PMID: 7276942.
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      40. Mandell A, Russo PV. Striatal tyrosine hydroxylase activity: multiple conformational kinetic oscillators and product concentration frequencies. J Neurosci. 1981 Apr; 1(4):380-9. PMID: 6114998.
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      41. Knapp S, Mandell A. Mouse midbrain tryptophan hydroxylase: strain differences in variational properties. J Physiol (Paris). 1981; 77(2-3):281-2. PMID: 7288644.
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      42. Mandell A, Stewart KD, Knapp S, Russo PV. Protein fluctuations and time-space asymmetries in brain [proceedings]. Psychopharmacol Bull. 1980 Oct; 16(4):47-50. PMID: 6256798.
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      43. Mandell A, Bullard WP, Yellin JB, Russo PV. The influence of D-amphetamine on rat brain striatal reduced biopterin concentration. J Pharmacol Exp Ther. 1980 Jun; 213(3):569-74. PMID: 7193728.
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      44. Knapp S, Mandell A. Lithium and chlorimipramine differentially alter bilateral asymmetry in mesostriatal serotonin metabolites and kinetic conformations of midbrain tryptophan hydroxylase with respect to tetrahydrobiopterin cofactor. Neuropharmacology. 1980 Jan; 19(1):1-7. PMID: 7360323.
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      45. Mandell A. On a mechanism for the mood and personality changes of adult and later life. A psychobiological hypothesis. J Nerv Ment Dis. 1979 Aug; 167(8):457-66. PMID: 469508.
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      46. Mandell A, Knapp S. Asymmetry and mood, emergent properties of serotonin regulation. Arch Gen Psychiatry. 1979 Jul 20; 36(8 Spec No):909-16. PMID: 454111.
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      47. Knapp S, Mandell A. Conformational influences on brain tryptophan hydroxylase by submicromolar calcium: opposite effects of equimolar lithium. J Neural Transm. 1979; 45(1):1-15. PMID: 469519.
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      48. Geyer MA, Petersen LR, Rose GJ, Horwitt DD, Light RK, Adams LM, Zook JA, Hawkins RL, Mandell A. The effects of lysergic acid diethylamide and mescaline-derived hallucinogens on sensory-integrative function: tactile startle. J Pharmacol Exp Ther. 1978 Dec; 207(3):837-47. PMID: 731434.
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      49. Geyer MA, Dawsey WJ, Mandell A. Fading: a new cytofluorimetric measure quantifying serotonin in the presence of catecholamines at the cellular level in brain. J Pharmacol Exp Ther. 1978 Nov; 207(2):650-67. PMID: 309507.
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      50. Bullard WP, Guthrie PB, Russo PV, Mandell A. Regional and subcellular distribution and some factors in the regulation of reduced pterins in rat brain. J Pharmacol Exp Ther. 1978 Jul; 206(1):4-20. PMID: 660556.
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      51. Weinberger SB, Knapp S, Mandell A. Failure of tryptophan load-induced increases in brain serotonin to alter food intake in the rat. Life Sci. 1978 May 08; 22(18):1595-602. PMID: 672415.
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      52. Mandell A, Knapp S. Regulation of serotonin biosynthesis in brain: role of the high affinity uptake of tryptophan into serotonergic neurons. Fed Proc. 1977 Jul; 36(8):2142-8. PMID: 872948.
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      53. Mandell A, Knapp S. Acute versus chronic effects of psychotropic drugs: adaptative responses in brain amine systems and their clinical implications. Evidence for multiphasic presynaptic adaptation: studies with cocaine and lithium [proceedings]. Psychopharmacol Bull. 1977 Jan; 13(1):40-2. PMID: 834818.
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      54. Knapp S, Mandell A. Coincidence of blockade of synaptosomal 5-hydroxytryptamine uptake and decrease in tryptophan hydroxylase activity: effects of fenfluramine. J Pharmacol Exp Ther. 1976 Jul; 198(1):123-32. PMID: 933002.
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      55. Mandell A, Knapp S. A neurobiological model for the symmetrical prophylactic action of lithium in bipolar affective disorder. Pharmakopsychiatr Neuropsychopharmakol. 1976 May; 9(3):116-26. PMID: 988597.
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      56. Geyer MA, Puerto A, Dawsey WJ, Knapp S, Bullard WP, Mandell A. Histologic and enzymatic studies of the mesolimbic and mesostriatal serotonergic pathways. Brain Res. 1976 Apr 23; 106(2):241-56. PMID: 6112.
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      57. Geyer MA, Puerto A, Menkes DB, Segal DS, Mandell A. Behavioral studies following lesions of the mesolimbic and mesostriatal serotonergic pathways. Brain Res. 1976 Apr 23; 106(2):257-69. PMID: 1276871.
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      58. Knapp S, Mandell A. Cocaine and lithium: neurobiological antagonism in the serotonin biosynthetic system in rat brain. Life Sci. 1976 Apr 01; 18(7):679-83. PMID: 1263750.
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      59. Hsu LL, Geyer MA, Mandell A. Extrapineal amine N-acetylation in rat brain. Regional and subcellular distribution and enzyme kinetics. Biochem Pharmacol. 1976 Apr 01; 25(7):815-9. PMID: 938582.
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      60. Mandell A, Knapp S. Cocaine, amphetamine, and lithium interactions: neurobiological correlates. Ann N Y Acad Sci. 1976; 281:441-55. PMID: 798530.
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      61. Mandell A, Knapp S. A model for the neurobiological mechanisms of action involved in lithium prophylaxis of bipolar affective disorder. Natl Inst Drug Abuse Res Monogr Ser. 1975 Nov; (3):97-107. PMID: 1241915.
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      62. Geyer MA, Warbritton JD, Menkes DB, Zook JA, Mandell A. Opposite effects of intraventricular serotonin and bufotenin on rat startle responses. Pharmacol Biochem Behav. 1975 Jul-Aug; 3(4):687-91. PMID: 1187731.
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      63. Mandell A, Knapp S. Lithium-induced changes in serotonergic mechanisms--its potential relevance to the treatment of some addictive disorders. Psychopharmacol Bull. 1975 Jul; 11(3):33-4. PMID: 1171501.
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      64. Knapp S, Mandell A. Effects of lithium chloride on parameters biosynthetic capacity for 5-hydroxytryptamin in rat brain. J Pharmacol Exp Ther. 1975 Jun; 193(3):812-23. PMID: 1151731.
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      65. Knapp S, Mandell A, Bullard WP. Calcium activation of brain tryptophan hydroxylase. Life Sci. 1975 May 15; 16(10):1583-93. PMID: 566.
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      66. Segal DS, Callaghan M, Mandell A. Alterations in behaviour and catecholamine biosynthesis induced by lithium. Nature. 1975 Mar 06; 254(5495):58-9. PMID: 234597.
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      67. Geyer MA, Dawsey WJ, Mandell A. Differential effects of caffeine, D-amphetamine and methylphenidate on individual raphe cell fluorescence: a microspectrofluorimetric demonstration. Brain Res. 1975 Feb 21; 85(1):135-9. PMID: 1109692.
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      68. Mandell A, Knapp S. Current research in the indoleamine hypothesis of affective disorders. Psychopharmacol Commun. 1975; 1(6):587-97. PMID: 1241455.
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      69. Rogawski MA, Knapp S, MAndell AJ. Effects of ethanol on tryptophan hydroxylase activity from striate synaptosomes. Biochem Pharmacol. 1974 Jul 15; 23(14):1955-62. PMID: 4418689.
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      70. Mandell A, Knapp S. Proceedings: Regulation of function of tryptophan hydroxylase. Psychopharmacol Bull. 1974 Jul; 10(3):30-1. PMID: 4419433.
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      71. Knapp S, Mandell A, Geyer MA. Effects of amphetamines on regional tryptophan hydroxylase activity and synaptosomal conversion of tryptophan to 5-hydroxytryptamine in rat brain. J Pharmacol Exp Ther. 1974 Jun; 189(3):676-89. PMID: 4843167.
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      72. Segal DS, Mandell A. Long-term administration of d-amphetamine: progressive augmentation of motor activity and stereotypy. Pharmacol Biochem Behav. 1974 Mar-Apr; 2(2):249-55. PMID: 4857295.
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      73. Mandell A, Knapp S. Regulation of function of tryptophan hydroxylase. Adv Biochem Psychopharmacol. 1974; 12(0):177-88. PMID: 4278783.
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      74. Mandell A, Knapp S, Hsu LL. Some factors in the regulation of central serotonergic synapses. Life Sci. 1974 Jan 01; 14(1):1-17. PMID: 4589654.
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      75. Korevaar WC, Geyer MA, Knapp S, Hsu LL, Mandell A. Regional distribution of 5-methyltetrahydrofolic acid in brain. Nat New Biol. 1973 Oct 24; 245(147):244-5. PMID: 4518367.
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      76. Knapp S, Mandell A. Short- and long-term lithium administration: effects on the brain's serotonergic biosynthetic systems. Science. 1973 May 11; 180(4086):645-7. PMID: 4700609.
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      77. Segal DS, Knapp S, Kuczenski RT, Mandell A. The effects of environmental isolation on behavior and regional rat brain tyrosine hydroxylase and tryptophan hydroxylase activities. Behav Biol. 1973 Jan; 8(1):47-53. PMID: 4144216.
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      78. Mandell A, Knapp S, Kuczenski RT, Segal DS. Methamphetamine-induced alteration in the physical state of rat caudate tyrosine hydroxylase. Biochem Pharmacol. 1972 Oct 15; 21(20):2737-50. PMID: 4405233.
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      79. Knapp S, Mandell A. Narcotic drugs: effects on the serotonin biosynthetic systems of the brain. Science. 1972 Sep 29; 177(4055):1209-11. PMID: 5057629.
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      80. Knapp S, Mandell A. Parachlorophenylalanine--its three phase sequence of interactions with the two forms of brain tryptophan hydroxylase. Life Sci I. 1972 Aug 15; 11(16):761-71. PMID: 4266248.
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      81. Sullivan JL, Segal DS, Kuczenski RT, Mandell A. Propranolol-induced rapid activation of rat striatal tyrosine hydroxylase concomitant with behavioral depression. Biol Psychiatry. 1972 Jun; 4(3):193-203. PMID: 4402871.
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      82. Geyer MA, Segal DS, Mandell A. Effect of intraventricular infusion of dopamine and norepinephrine on motor activity. Physiol Behav. 1972 Apr; 8(4):653-8. PMID: 5038135.
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      83. Segal DS, Kuczenski RT, Mandell A. Strain differences in behavior and brain tyrosine hydroxylase activity. Behav Biol. 1972 Feb; 7(7):75-81. PMID: 4402928.
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      84. Emlen W, Segal DS, Mandell A. Thyroid state: effects on pre- and postsynaptic central noradrenergic mechanisms. Science. 1972 Jan 07; 175(4017):79-82. PMID: 4400216.
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      85. Segal DS, Sullivan JL, Kuczenski RT, Mandell A. Effects of long-term reserpine treatment on brain tyrosine hydroxylase and behavioral activity. Science. 1971 Aug 27; 173(3999):847-9. PMID: 5572177.
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      86. Mandell A, Knapp S. The effects of chronic administration of some cholinergic and adrenergic drugs on the activity of choline acetyltransferase in the optic lobes of the chick brain. Neuropharmacology. 1971 Jul; 10(4):513-6. PMID: 5094311.
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      87. Mandell A, Morgan M. Amphetamine induced increase in tyrosine hydroxylase activity. Nature. 1970 Jul 04; 227(5253):75-6. PMID: 5463606.
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