Arnold Mandell

Title(s)Emeritus Professor, Psychiatry
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Biography

    His research (1957 to the present) has involved animal neurophysiology, indole chemistry, human pituitary-adrenal regulation, non-linear brain enzyme kinetics, neurochemistry, neuropharmacology, protein structure and function, algorithmic neuropeptide design and currently dynamical systems measure-theoretic approaches to magneto-encephalographic analyses. He has published over 450 scientific reports and reviews. He has written and/or edited four books in brain science and has written two trade books published by Random House, Nightmare Season and and Simon and Schuster, Coming of Middle Age He has received the NIMH Career Teacher Award, the A.E. Bennett Research Prize of the Society for Biological Psychiatry, a MacArthur Prize Fellowship in Theoretical Neuroscience (1984-1989), a Senior Humboldt Prize Fellowship in Dynamical Systems, Bremen University, FRG (1994), and the Foundation’s Fund Research Prize of the American Psychiatric Association, 1989-90. He has been a principle investigator and consultant for the Fetzer Franklin Trust and the Fetzer Foundation since 1996. He has been a Johananoff International Prize Fellow in Psychopharmacology (Mario Negril Institute, Milan, Italy). He has been a psychiatric consultant for the San Diego Chargers, 1971-75. Dr. Mandell has been the recipient of Federal, State and/or Foundation support continuously since 1962.

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    Algorithmic Peptides Target Multidrug Resistance Protein
    NIH R43CA091384Sep 30, 2002 - Sep 29, 2004
    Role: Principal Investigator
    COMPUTATIONAL NEUROPEPTIDE DESIGN AND RECEPTOR MATCHING
    NIH R44MH058026Jul 1, 1998 - Jun 30, 2002
    Role: Principal Investigator
    COMPUTATIONAL NEUROPEPTIDE DESIGN AND RECEPTOR MATCHING
    NIH R43MH058026Mar 1, 1998 - Jun 30, 1999
    Role: Principal Investigator
    DYNAMICAL SYSTEMS IN THE NEUROSCIENCES OF PSYCHIATRY
    NIH T32MH016109Jul 1, 1979 - Jun 30, 1991
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Ultra-slow frequency bands reflecting potential coherence between neocortical brain regions. Neuroscience. 2015 Mar 19; 289:71-84. Zhang X, Wang YT, Wang Y, Jung TP, Huang M, Cheng CK, Mandell AJ. PMID: 25592429.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    2. Mutual Information in a MEG complexity measure suggests regional hyper-connectivity in schizophrenic probands. Neuropsychopharmacology. 2015 Jan; 40(1):251-2. Robinson SE, Mandell AJ. PMID: 25482179; PMCID: PMC4262904.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    3. Intrinsic mode functions locate implicit turbulent attractors in time in frontal lobe MEG recordings. Neuroscience. 2014 May 16; 267:91-101. Huang X, Huang L, Jung TP, Cheng CK, Mandell AJ. PMID: 24613718.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Spatiotemporal imaging of complexity. Front Comput Neurosci. 2012; 6:101. Robinson SE, Mandell AJ, Coppola R. PMID: 23355820; PMCID: PMC3553423.
      View in: PubMed   Mentions: 9  
    5. Novel methods for storage stability and release of Bacillus spores. Biotechnol Prog. 2008 Sep-Oct; 24(5):1147-53. Sorokulova IB, Krumnow AA, Pathirana S, Mandell AJ, Vodyanoy V. PMID: 19194925.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    6. Designing allosteric peptide ligands targeting a globular protein. Biopolymers. 2007 Jan; 85(1):38-59. Selz KA, Samoylova TI, Samoylov AM, Vodyanoy VJ, Mandell AJ. PMID: 17009317.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    7. Algorithmically designed peptides ameliorate behavioral defects in animal model of ADHD by an allosteric mechanism. J Neurosci Methods. 2006 Feb 15; 151(1):68-81. Kinkead B, Selz KA, Owens MJ, Mandell AJ. PMID: 16423408.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    8. Designing human m1 muscarinic receptor-targeted hydrophobic eigenmode matched peptides as functional modulators. Biophys J. 2004 Mar; 86(3):1308-31. Selz KA, Mandell AJ, Shlesinger MF, Arcuragi V, Owens MJ. PMID: 14990463; PMCID: PMC1303971.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    9. Cellular and behavioral effects of D2 dopamine receptor hydrophobic eigenmode-targeted peptide ligands. Neuropsychopharmacology. 2003 Jul; 28 Suppl 1:S98-107. Mandell AJ, Selz KA, Owens MJ, Kinkead B, Shlesinger MF, Gutman DA, Arguragi V. PMID: 12827150.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    10. Hydrophobic free energy eigenfunctions of pore, channel, and transporter proteins contain beta-burst patterns. Biophys J. 1998 Nov; 75(5):2332-42. Selz KA, Mandell AJ, Shlesinger MF. PMID: 9788928; PMCID: PMC1299907.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    11. Mode matches in hydrophobic free energy eigenfunctions predict peptide-protein interactions. Biopolymers. 1998 Aug; 46(2):89-101. Mandell AJ, Owens MJ, Selz KA, Morgan WN, Shlesinger MF, Nemeroff CB. PMID: 9664843.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    12. The development of nuchal atonia associated with active (REM) sleep in fetal sheep: presence of recurrent fractal organization. Brain Res. 1998 Mar 23; 787(2):351-7. Anderson CM, Mandell AJ, Selz KA, Terry LM, Wong CH, Robinson SR, Robertson SS, Smotherman WP. PMID: 9518691.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    13. Mode matches and their locations in the hydrophobic free energy sequences of peptide ligands and their receptor eigenfunctions. Proc Natl Acad Sci U S A. 1997 Dec 09; 94(25):13576-81. Mandell AJ, Selz KA, Shlesinger MF. PMID: 9391068; PMCID: PMC28348.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    14. Entropy conservation as h(T(&mgr;) ) approximately lambda(&mgr;) (+)d(&mgr;) in neurobiological dynamical systems. Chaos. 1997 Mar; 7(1):67-81. Mandell AJ, Selz KA. PMID: 12779638.
      View in: PubMed   Mentions: 7     Fields:    
    15. Dynamical entropy is conserved during cocaine-induced changes in fetal rat motor patterns. Psychoneuroendocrinology. 1996 Feb; 21(2):173-87. Smotherman WP, Selz KA, Mandell AJ. PMID: 8774061.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    16. Nonlinear dynamical patterns as personality theory for neurobiology and psychiatry. Psychiatry. 1995 Nov; 58(4):371-90. Mandell AJ, Selz KA. PMID: 8746494.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    17. Dynamical systems in psychiatry: now what? Biol Psychiatry. 1992 Aug 15; 32(4):299-301. Mandell AJ, Selz KA. PMID: 1358230.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    18. Dystonia musculorum deformans: a 'critical phenomenon' model involving nigral dopaminergic and caudate pathways. Med Hypotheses. 1990 Jan; 31(1):55-8. Kelleher JF, Mandell AJ. PMID: 2179685.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    19. Application of entropy measures derived from the ergodic theory of dynamical systems to rat locomotor behavior. Proc Natl Acad Sci U S A. 1990 Jan; 87(2):723-7. Paulus MP, Geyer MA, Gold LH, Mandell AJ. PMID: 1967830; PMCID: PMC53338.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    20. Induction of c-fos, calcitonin gene expression, and acidic fibroblast growth factor production in a multipeptide-secreting neuroendocrine cell line. Endocrinology. 1988 Mar; 122(3):1114-20. Zeytin FN, Rusk SF, Baird A, Raymond V, Leff SE, Haaparanta T, Mandell AJ. PMID: 2893727.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    21. Fibroblast growth factor stabilizes ribonucleic acid and regulates differentiated functions in a multipeptide-secreting neuroendocrine cell line. Endocrinology. 1988 Mar; 122(3):1121-8. Zeytin FN, Rusk SF, Raymond V, Mandell AJ. PMID: 2449340.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    22. Geometric universality in brain allosteric protein dynamics: complex hydrophobic transformation predicts mutual recognition by polypeptides and proteins. Ann N Y Acad Sci. 1987; 504:88-117. Mandell AJ, Russo PV, Blomgren BW. PMID: 2820290.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    23. The influence of neuropeptides on amine synthesis: Cholecystokinin-8 and neurotensin reduce striatal tyrosine hydroxylase activity. Neurochem Int. 1986; 9(4):493-8. Hole K, Russo PV, Mandell AJ. PMID: 20493152.
      View in: PubMed   Mentions: 1     Fields:    
    24. Sonication, calcium, and peptides have systematic effects on the nonlinear dynamics of tyrosine hydroxylase activity. Neurochem Int. 1986; 9(1):171-6. Russo PV, Mandell AJ. PMID: 20493114.
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    25. Interhemispheric fusion. J Psychoactive Drugs. 1985 Oct-Dec; 17(4):257-66. Mandell AJ. PMID: 3003313.
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    26. On a mechanism of cardiac electrical stability. The fractal hypothesis. Biophys J. 1985 Sep; 48(3):525-8. Goldberger AL, Bhargava V, West BJ, Mandell AJ. PMID: 4041542; PMCID: PMC1329366.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    27. Relationships between drug-induced changes in tetrahydrobiopterin and biogenic amine concentrations in rat brain. J Pharmacol Exp Ther. 1985 Jul; 234(1):141-6. Lee EH, Mandell AJ. PMID: 3874280.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    28. Effects of amphetamine on hemispheric asymmetry and regional distribution of tetrahydrobiopterin in rat brain. Neurochem Int. 1985; 7(5):777-81. Lee EH, Mandell AJ. PMID: 20492987.
      View in: PubMed   Mentions:    Fields:    
    29. Metrics from nonlinear dynamics adapted for characterizing the behavior of nonequilibrium enzymatic rate functions. Anal Biochem. 1984 May 15; 139(1):91-9. Russo PV, Mandell AJ. PMID: 6146273.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    30. A kinetic scattering approach to the non-linear instabilities of rat brain tyrosine hydroxylase preparations at several levels of tetrahydrobiopterin cofactor demonstrates evolutionary behavior characteristic of global dynamical systems. Brain Res. 1984 May 14; 299(2):313-22. Russo PV, Mandell AJ. PMID: 6145494.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    31. TRH influences the pterin cofactor- and time-dependent instabilities of rat raphe tryptophan hydroxylase activity assessed under far-from-equilibrium conditions. Neurochem Int. 1984; 6(6):801-12. Knapp S, Mandell AJ. PMID: 20488111.
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    32. From intermittency to transitivity in neuropsychobiological flows. Am J Physiol. 1983 Oct; 245(4):R484-94. Mandell AJ. PMID: 6624945.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    33. Lithium and chlorimipramine differentially alter the stability properties of tryptophan hydroxylase as seen in allosteric and scattering kinetics. Psychiatry Res. 1983 Apr; 8(4):311-23. Knapp S, Mandell AJ. PMID: 6576397.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    34. Scattering kinetics in a complex tryptophan hydroxylase preparation from rat brainstem raphe nuclei: statistical evidence that the lithium-induced sigmoid velocity function reflects two states of available catalytic potential. J Neural Transm. 1983; 58(3-4):169-82. Knapp S, Mandell AJ. PMID: 6663300.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    35. Regulation of tryptophan hydroxylase: variational kinetics suggest a neuropharmacology of phase. Adv Biochem Psychopharmacol. 1982; 34:1-15. Mandell AJ, Knapp S. PMID: 6127915.
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    36. Strain differences in kinetic and thermal stability of two mouse brain tryptophan hydroxylase activities. Brain Res. 1981 Dec 28; 230(1-2):317-36. Knapp S, Mandell AJ, Russo PV, Vitto A, Stewart KD. PMID: 6172184.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    37. Short-term regulation of hydroxylase cofactor activity in rat brain. J Neurochem. 1981 Dec; 37(6):1573-8. Mandell AJ, Russo PV. PMID: 6120998.
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    38. The Sunday syndrome: from kinetics to altered consciousness. Fed Proc. 1981 Oct; 40(12):2693-8. Mandell AJ, Stewart KD, Russo PV. PMID: 7286249.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    39. Stability properties of activated tryptophan hydroxylase from rat midbrain. J Neurochem. 1981 Sep; 37(3):601-7. Vitto A, Mandell AJ. PMID: 7276942.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    40. Striatal tyrosine hydroxylase activity: multiple conformational kinetic oscillators and product concentration frequencies. J Neurosci. 1981 Apr; 1(4):380-9. Mandell AJ, Russo PV. PMID: 6114998; PMCID: PMC6564138.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    41. Mouse midbrain tryptophan hydroxylase: strain differences in variational properties. J Physiol (Paris). 1981; 77(2-3):281-2. Knapp S, Mandell AJ. PMID: 7288644.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    42. Protein fluctuations and time-space asymmetries in brain [proceedings]. Psychopharmacol Bull. 1980 Oct; 16(4):47-50. Mandell AJ, Stewart KD, Knapp S, Russo PV. PMID: 6256798.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    43. The influence of D-amphetamine on rat brain striatal reduced biopterin concentration. J Pharmacol Exp Ther. 1980 Jun; 213(3):569-74. Mandell AJ, Bullard WP, Yellin JB, Russo PV. PMID: 7193728.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    44. Lithium and chlorimipramine differentially alter bilateral asymmetry in mesostriatal serotonin metabolites and kinetic conformations of midbrain tryptophan hydroxylase with respect to tetrahydrobiopterin cofactor. Neuropharmacology. 1980 Jan; 19(1):1-7. Knapp S, Mandell AJ. PMID: 7360323.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    45. On a mechanism for the mood and personality changes of adult and later life. A psychobiological hypothesis. J Nerv Ment Dis. 1979 Aug; 167(8):457-66. Mandell AJ. PMID: 469508.
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    46. Asymmetry and mood, emergent properties of serotonin regulation. Arch Gen Psychiatry. 1979 Jul 20; 36(8 Spec No):909-16. Mandell AJ, Knapp S. PMID: 454111.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    47. Conformational influences on brain tryptophan hydroxylase by submicromolar calcium: opposite effects of equimolar lithium. J Neural Transm. 1979; 45(1):1-15. Knapp S, Mandell AJ. PMID: 469519.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    48. The effects of lysergic acid diethylamide and mescaline-derived hallucinogens on sensory-integrative function: tactile startle. J Pharmacol Exp Ther. 1978 Dec; 207(3):837-47. Geyer MA, Petersen LR, Rose GJ, Horwitt DD, Light RK, Adams LM, Zook JA, Hawkins RL, Mandell AJ. PMID: 731434.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    49. Fading: a new cytofluorimetric measure quantifying serotonin in the presence of catecholamines at the cellular level in brain. J Pharmacol Exp Ther. 1978 Nov; 207(2):650-67. Geyer MA, Dawsey WJ, Mandell AJ. PMID: 309507.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    50. Regional and subcellular distribution and some factors in the regulation of reduced pterins in rat brain. J Pharmacol Exp Ther. 1978 Jul; 206(1):4-20. Bullard WP, Guthrie PB, Russo PV, Mandell AJ. PMID: 660556.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    51. Failure of tryptophan load-induced increases in brain serotonin to alter food intake in the rat. Life Sci. 1978 May 08; 22(18):1595-602. Weinberger SB, Knapp S, Mandell AJ. PMID: 672415.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    52. Regulation of serotonin biosynthesis in brain: role of the high affinity uptake of tryptophan into serotonergic neurons. Fed Proc. 1977 Jul; 36(8):2142-8. Mandell AJ, Knapp S. PMID: 872948.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    53. Acute versus chronic effects of psychotropic drugs: adaptative responses in brain amine systems and their clinical implications. Evidence for multiphasic presynaptic adaptation: studies with cocaine and lithium [proceedings]. Psychopharmacol Bull. 1977 Jan; 13(1):40-2. Mandell AJ, Knapp S. PMID: 834818.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    54. Coincidence of blockade of synaptosomal 5-hydroxytryptamine uptake and decrease in tryptophan hydroxylase activity: effects of fenfluramine. J Pharmacol Exp Ther. 1976 Jul; 198(1):123-32. Knapp S, Mandell AJ. PMID: 933002.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    55. The effects of chronic mescaline administration on operant behavior in the pigeon. Behav Biol. 1976 Jul; 17(3):403-9. Hadorn D, Mandell AJ, Segal DS. PMID: 971192.
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    56. A neurobiological model for the symmetrical prophylactic action of lithium in bipolar affective disorder. Pharmakopsychiatr Neuropsychopharmakol. 1976 May; 9(3):116-26. Mandell AJ, Knapp S. PMID: 988597.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    57. Behavioral studies following lesions of the mesolimbic and mesostriatal serotonergic pathways. Brain Res. 1976 Apr 23; 106(2):257-69. Geyer MA, Puerto A, Menkes DB, Segal DS, Mandell AJ. PMID: 1276871.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    58. Histologic and enzymatic studies of the mesolimbic and mesostriatal serotonergic pathways. Brain Res. 1976 Apr 23; 106(2):241-56. Geyer MA, Puerto A, Dawsey WJ, Knapp S, Bullard WP, Mandell AJ. PMID: 6112.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    59. Extrapineal amine N-acetylation in rat brain. Regional and subcellular distribution and enzyme kinetics. Biochem Pharmacol. 1976 Apr 01; 25(7):815-9. Hsu LL, Geyer MA, Mandell AJ. PMID: 938582.
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    60. Cocaine and lithium: neurobiological antagonism in the serotonin biosynthetic system in rat brain. Life Sci. 1976 Apr 01; 18(7):679-83. Knapp S, Mandell AJ. PMID: 1263750.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    61. Cocaine, amphetamine, and lithium interactions: neurobiological correlates. Ann N Y Acad Sci. 1976; 281:441-55. Mandell AJ, Knapp S. PMID: 798530.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    62. A model for the neurobiological mechanisms of action involved in lithium prophylaxis of bipolar affective disorder. Natl Inst Drug Abuse Res Monogr Ser. 1975 Nov; (3):97-107. Mandell AJ, Knapp S. PMID: 1241915.
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    63. Opposite effects of intraventricular serotonin and bufotenin on rat startle responses. Pharmacol Biochem Behav. 1975 Jul-Aug; 3(4):687-91. Geyer MA, Warbritton JD, Menkes DB, Zook JA, Mandell AJ. PMID: 1187731.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    64. Lithium-induced changes in serotonergic mechanisms--its potential relevance to the treatment of some addictive disorders. Psychopharmacol Bull. 1975 Jul; 11(3):33-4. Mandell AJ, Knapp S. PMID: 1171501.
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    65. Effects of lithium chloride on parameters biosynthetic capacity for 5-hydroxytryptamin in rat brain. J Pharmacol Exp Ther. 1975 Jun; 193(3):812-23. Knapp S, Mandell AJ. PMID: 1151731.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    66. Alterations in behaviour and catecholamine biosynthesis induced by lithium. Nature. 1975 Mar 06; 254(5495):58-9. Segal DS, Callaghan M, Mandell AJ. PMID: 234597.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    67. Differential effects of caffeine, D-amphetamine and methylphenidate on individual raphe cell fluorescence: a microspectrofluorimetric demonstration. Brain Res. 1975 Feb 21; 85(1):135-9. Geyer MA, Dawsey WJ, Mandell AJ. PMID: 1109692.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    68. Current research in the indoleamine hypothesis of affective disorders. Psychopharmacol Commun. 1975; 1(6):587-97. Mandell AJ, Knapp S. PMID: 1241455.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    69. Theoretical implications of drug-induced adaptive regulation for a biogenic amine hypothesis of affective disorder. Biol Psychiatry. 1974 Oct; 9(2):147-59. Segal DS, Kuczenski R, Mandell AJ. PMID: 4154114.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    70. Effects of ethanol on tryptophan hydroxylase activity from striate synaptosomes. Biochem Pharmacol. 1974 Jul 15; 23(14):1955-62. Rogawski MA, Knapp S, MAndell AJ. PMID: 4418689.
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    71. Proceedings: Regulation of function of tryptophan hydroxylase. Psychopharmacol Bull. 1974 Jul; 10(3):30-1. Mandell AJ, Knapp S. PMID: 4419433.
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    72. Effects of amphetamines on regional tryptophan hydroxylase activity and synaptosomal conversion of tryptophan to 5-hydroxytryptamine in rat brain. J Pharmacol Exp Ther. 1974 Jun; 189(3):676-89. Knapp S, Mandell AJ, Geyer MA. PMID: 4843167.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    73. Long-term administration of d-amphetamine: progressive augmentation of motor activity and stereotypy. Pharmacol Biochem Behav. 1974 Mar-Apr; 2(2):249-55. Segal DS, Mandell AJ. PMID: 4857295.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansAnimals
    74. Regulation of function of tryptophan hydroxylase. Adv Biochem Psychopharmacol. 1974; 12(0):177-88. Mandell AJ, Knapp S. PMID: 4278783.
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    75. Some factors in the regulation of central serotonergic synapses. Life Sci. 1974 Jan 01; 14(1):1-17. Mandell AJ, Knapp S, Hsu LL. PMID: 4589654.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    76. Regional distribution of 5-methyltetrahydrofolic acid in brain. Nat New Biol. 1973 Oct 24; 245(147):244-5. Korevaar WC, Geyer MA, Knapp S, Hsu LL, Mandell AJ. PMID: 4518367.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    77. Short- and long-term lithium administration: effects on the brain's serotonergic biosynthetic systems. Science. 1973 May 11; 180(4086):645-7. Knapp S, Mandell AJ. PMID: 4700609.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    78. The effects of environmental isolation on behavior and regional rat brain tyrosine hydroxylase and tryptophan hydroxylase activities. Behav Biol. 1973 Jan; 8(1):47-53. Segal DS, Knapp S, Kuczenski RT, Mandell AJ. PMID: 4144216.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    79. Methamphetamine-induced alteration in the physical state of rat caudate tyrosine hydroxylase. Biochem Pharmacol. 1972 Oct 15; 21(20):2737-50. Mandell AJ, Knapp S, Kuczenski RT, Segal DS. PMID: 4405233.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    80. Narcotic drugs: effects on the serotonin biosynthetic systems of the brain. Science. 1972 Sep 29; 177(4055):1209-11. Knapp S, Mandell AJ. PMID: 5057629.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    81. Parachlorophenylalanine--its three phase sequence of interactions with the two forms of brain tryptophan hydroxylase. Life Sci I. 1972 Aug 15; 11(16):761-71. Knapp S, Mandell AJ. PMID: 4266248.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    82. Propranolol-induced rapid activation of rat striatal tyrosine hydroxylase concomitant with behavioral depression. Biol Psychiatry. 1972 Jun; 4(3):193-203. Sullivan JL, Segal DS, Kuczenski RT, Mandell AJ. PMID: 4402871.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    83. Effect of intraventricular infusion of dopamine and norepinephrine on motor activity. Physiol Behav. 1972 Apr; 8(4):653-8. Geyer MA, Segal DS, Mandell AJ. PMID: 5038135.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    84. Strain differences in behavior and brain tyrosine hydroxylase activity. Behav Biol. 1972 Feb; 7(7):75-81. Segal DS, Kuczenski RT, Mandell AJ. PMID: 4402928.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    85. Thyroid state: effects on pre- and postsynaptic central noradrenergic mechanisms. Science. 1972 Jan 07; 175(4017):79-82. Emlen W, Segal DS, Mandell AJ. PMID: 4400216.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
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