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Arnold Mandell

TitleEmeritus Professor
InstitutionUniversity of California San Diego
DepartmentPsychiatry
Address9500 Gilman Drive #0603
La Jolla CA 92093
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    Biography

    His research (1957 to the present) has involved animal neurophysiology, indole chemistry, human pituitary-adrenal regulation, non-linear brain enzyme kinetics, neurochemistry, neuropharmacology, protein structure and function, algorithmic neuropeptide design and currently dynamical systems measure-theoretic approaches to magneto-encephalographic analyses. He has published over 450 scientific reports and reviews. He has written and/or edited four books in brain science and has written two trade books published by Random House, Nightmare Season and and Simon and Schuster, Coming of Middle Age He has received the NIMH Career Teacher Award, the A.E. Bennett Research Prize of the Society for Biological Psychiatry, a MacArthur Prize Fellowship in Theoretical Neuroscience (1984-1989), a Senior Humboldt Prize Fellowship in Dynamical Systems, Bremen University, FRG (1994), and the Foundation’s Fund Research Prize of the American Psychiatric Association, 1989-90. He has been a principle investigator and consultant for the Fetzer Franklin Trust and the Fetzer Foundation since 1996. He has been a Johananoff International Prize Fellow in Psychopharmacology (Mario Negril Institute, Milan, Italy). He has been a psychiatric consultant for the San Diego Chargers, 1971-75. Dr. Mandell has been the recipient of Federal, State and/or Foundation support continuously since 1962.


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    Algorithmic Peptides Target Multidrug Resistance Protein
    NIH/NCI R43CA091384Sep 30, 2002 - Sep 29, 2004
    Role: Principal Investigator
    COMPUTATIONAL NEUROPEPTIDE DESIGN AND RECEPTOR MATCHING
    NIH/NIMH R44MH058026Jul 1, 1998 - Jun 30, 2002
    Role: Principal Investigator
    COMPUTATIONAL NEUROPEPTIDE DESIGN AND RECEPTOR MATCHING
    NIH/NIMH R43MH058026Mar 1, 1998 - Jun 30, 1999
    Role: Principal Investigator
    DYNAMICAL SYSTEMS IN THE NEUROSCIENCES OF PSYCHIATRY
    NIH/NIMH T32MH016109Jul 1, 1979 - Jun 30, 1991
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Robinson SE, Mandell AJ. Mutual Information in a MEG complexity measure suggests regional hyper-connectivity in schizophrenic probands. Neuropsychopharmacology. 2015 Jan; 40(1):251-2. PMID: 25482179; PMCID: PMC4262904.
    2. Robinson SE, Mandell AJ, Coppola R. Spatiotemporal imaging of complexity. Front Comput Neurosci. 2012; 6:101. PMID: 23355820; PMCID: PMC3553423.
    3. Sorokulova IB, Krumnow AA, Pathirana S, Mandell AJ, Vodyanoy V. Novel methods for storage stability and release of Bacillus spores. Biotechnol Prog. 2008 Sep-Oct; 24(5):1147-53. PMID: 19194925.
      View in: PubMed
    4. Selz KA, Samoylova TI, Samoylov AM, Vodyanoy VJ, Mandell AJ. Designing allosteric peptide ligands targeting a globular protein. Biopolymers. 2007 Jan; 85(1):38-59. PMID: 17009317.
      View in: PubMed
    5. Kinkead B, Selz KA, Owens MJ, Mandell AJ. Algorithmically designed peptides ameliorate behavioral defects in animal model of ADHD by an allosteric mechanism. J Neurosci Methods. 2006 Feb 15; 151(1):68-81. PMID: 16423408.
      View in: PubMed
    6. Selz KA, Mandell AJ, Shlesinger MF, Arcuragi V, Owens MJ. Designing human m1 muscarinic receptor-targeted hydrophobic eigenmode matched peptides as functional modulators. Biophys J. 2004 Mar; 86(3):1308-31. PMID: 14990463; PMCID: PMC1303971.
    7. Mandell AJ, Selz KA, Owens MJ, Kinkead B, Shlesinger MF, Gutman DA, Arguragi V. Cellular and behavioral effects of D2 dopamine receptor hydrophobic eigenmode-targeted peptide ligands. Neuropsychopharmacology. 2003 Jul; 28 Suppl 1:S98-107. PMID: 12827150.
      View in: PubMed
    8. Mandell AJ, Selz KA. Entropy conservation as h(T(&mgr;) ) approximately lambda(&mgr;) (+)d(&mgr;) in neurobiological dynamical systems. Chaos. 1997 Mar; 7(1):67-81. PMID: 12779638.
      View in: PubMed
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