Tatiana Mishanina

Title(s)Assistant Professor, Chemistry and Biochemistry
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Mechanism of transcription and related gene expression processes in bacteria and human mitochondria
    NIH R35GM142785Jul 21, 2021 - Jun 30, 2026
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Expression and Purification of Recombinant Human Mitochondrial RNA Polymerase (POLRMT) and the Initiation Factors TFAM and TFB2M. Bio Protoc. 2023 Dec 05; 13(23):e4892. Hsieh AH, Reardon SD, Munozvilla-Cabellon JH, Shen J, Patel SS, Mishanina TV. PMID: 38094251; PMCID: PMC10714150.
      View in: PubMed   Mentions:
    2. A riboswitch-controlled manganese exporter (Alx) tunes intracellular Mn2+ concentration in E. coli at alkaline pH. bioRxiv. 2023 May 08. Sharma R, Mishanina TV. PMID: 37214827; PMCID: PMC10197570.
      View in: PubMed   Mentions:
    3. An ensemble of interconverting conformations of the elemental paused transcription complex creates regulatory options. Proc Natl Acad Sci U S A. 2023 02 21; 120(8):e2215945120. Kang JY, Mishanina TV, Bao Y, Chen J, Llewellyn E, Liu J, Darst SA, Landick R. PMID: 36795753; PMCID: PMC9974457.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    4. Alkaline pH has an unexpected effect on transcriptional pausing during synthesis of the Escherichia coli pH-responsive riboswitch. J Biol Chem. 2022 09; 298(9):102302. Stephen C, Mishanina TV. PMID: 35934054; PMCID: PMC9472077.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    5. Phosphorylation and acetylation of mitochondrial transcription factor A promote transcription processivity without compromising initiation or DNA compaction. J Biol Chem. 2022 04; 298(4):101815. Reardon SD, Mishanina TV. PMID: 35278431; PMCID: PMC9006650.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    6. Conserved Trigger Loop Histidine of RNA Polymerase II Functions as a Positional Catalyst Primarily through Steric Effects. Biochemistry. 2021 11 09; 60(44):3323-3336. Palo MZ, Zhu J, Mishanina TV, Landick R. PMID: 34705427; PMCID: PMC9066048.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    7. Mechanisms of Transcriptional Pausing in Bacteria. J Mol Biol. 2019 09 20; 431(20):4007-4029. Kang JY, Mishanina TV, Landick R, Darst SA. PMID: 31310765; PMCID: PMC6874753.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    8. Chemical quenching and identification of intermediates in flavoenzyme-catalyzed reactions. Methods Enzymol. 2019; 620:89-114. Karunaratne K, Mishanina TV. PMID: 31072502.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    9. The elemental mechanism of transcriptional pausing. Elife. 2019 01 08; 8. Saba J, Chua XY, Mishanina TV, Nayak D, Windgassen TA, Mooney RA, Landick R. PMID: 30618376; PMCID: PMC6336406.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    10. Structural Basis for Transcript Elongation Control by NusG Family Universal Regulators. Cell. 2018 06 14; 173(7):1650-1662.e14. Kang JY, Mooney RA, Nedialkov Y, Saba J, Mishanina TV, Artsimovitch I, Landick R, Darst SA. PMID: 29887376; PMCID: PMC6003885.
      View in: PubMed   Mentions: 88     Fields:    Translation:Cells
    11. RNA Polymerase Accommodates a Pause RNA Hairpin by Global Conformational Rearrangements that Prolong Pausing. Mol Cell. 2018 03 01; 69(5):802-815.e5. Kang JY, Mishanina TV, Bellecourt MJ, Mooney RA, Darst SA, Landick R. PMID: 29499135; PMCID: PMC5903582.
      View in: PubMed   Mentions: 79     Fields:    Translation:Cells
    12. Trigger loop of RNA polymerase is a positional, not acid-base, catalyst for both transcription and proofreading. Proc Natl Acad Sci U S A. 2017 06 27; 114(26):E5103-E5112. Mishanina TV, Palo MZ, Nayak D, Mooney RA, Landick R. PMID: 28607053; PMCID: PMC5495254.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    13. An unprecedented mechanism of nucleotide methylation in organisms containing thyX. Science. 2016 Jan 29; 351(6272):507-10. Mishanina TV, Yu L, Karunaratne K, Mondal D, Corcoran JM, Choi MA, Kohen A. PMID: 26823429; PMCID: PMC4744818.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    14. Transient Kinetic Analysis of Hydrogen Sulfide Oxidation Catalyzed by Human Sulfide Quinone Oxidoreductase. J Biol Chem. 2015 Oct 09; 290(41):25072-80. Mishanina TV, Yadav PK, Ballou DP, Banerjee R. PMID: 26318450; PMCID: PMC4599011.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    15. Synthesis and application of isotopically labeled flavin nucleotides. J Labelled Comp Radiopharm. 2015 Jul; 58(9):370-5. Mishanina TV, Kohen A. PMID: 26149960; PMCID: PMC4523426.
      View in: PubMed   Mentions: 2     Fields:    
    16. Biogenesis of reactive sulfur species for signaling by hydrogen sulfide oxidation pathways. Nat Chem Biol. 2015 Jul; 11(7):457-64. Mishanina TV, Libiad M, Banerjee R. PMID: 26083070; PMCID: PMC4818113.
      View in: PubMed   Mentions: 171     Fields:    Translation:HumansAnimalsCells
    17. Substrate activation in flavin-dependent thymidylate synthase. J Am Chem Soc. 2014 Jul 30; 136(30):10597-600. Mishanina TV, Corcoran JM, Kohen A. PMID: 25025487; PMCID: PMC4121000.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    18. Trapping of an intermediate in the reaction catalyzed by flavin-dependent thymidylate synthase. J Am Chem Soc. 2012 Mar 07; 134(9):4442-8. Mishanina TV, Koehn EM, Conrad JA, Palfey BA, Lesley SA, Kohen A. PMID: 22295882; PMCID: PMC3296878.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    19. Mechanisms and inhibition of uracil methylating enzymes. Bioorg Chem. 2012 Aug; 43:37-43. Mishanina TV, Koehn EM, Kohen A. PMID: 22172597; PMCID: PMC3315608.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    20. Accurate measurement of methyl 13C chemical shifts by solid-state NMR for the determination of protein side chain conformation: the influenza a M2 transmembrane peptide as an example. J Am Chem Soc. 2009 Jun 10; 131(22):7806-16. Hong M, Mishanina TV, Cady SD. PMID: 19441789; PMCID: PMC4082989.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    21. Structure of amantadine-bound M2 transmembrane peptide of influenza A in lipid bilayers from magic-angle-spinning solid-state NMR: the role of Ser31 in amantadine binding. J Mol Biol. 2009 Jan 30; 385(4):1127-41. Cady SD, Mishanina TV, Hong M. PMID: 19061899; PMCID: PMC4132896.
      View in: PubMed   Mentions: 88     Fields:    Translation:Cells
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