Tatiana Mishanina

Title(s)	Assistant Professor, Chemistry and Biochemistry
School	Vc-academic Affairs
Address	9500 Gilman Drive # La Jolla CA 92093
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Research

Research Activities and Funding

Mechanism of transcription and related gene expression processes in bacteria and human mitochondria
NIH R35GM142785Jul 21, 2021 - Jun 30, 2026
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Opportunities for Riboswitch Inhibition by Targeting Co-Transcriptional RNA Folding Events. Int J Mol Sci. 2024 Sep 29; 25(19). Stephen C, Palmer D, Mishanina TV. PMID: 39408823; PMCID: PMC11476745.

View in: PubMed Mentions: Fields:
Bio Biochemistry Che Chemistry Mol Molecular Biology
Translation:Cells
A riboswitch-controlled TerC family transporter Alx tunes intracellular manganese concentration in Escherichia coli at alkaline pH. J Bacteriol. 2024 07 25; 206(7):e0016824. Sharma R, Mishanina TV. PMID: 38869303; PMCID: PMC11270866.

View in: PubMed Mentions: 2 Fields:
Bac Bacteriology
Translation:Cells
Expression and Purification of Recombinant Human Mitochondrial RNA Polymerase (POLRMT) and the Initiation Factors TFAM and TFB2M. Bio Protoc. 2023 Dec 05; 13(23):e4892. Hsieh AH, Reardon SD, Munozvilla-Cabellon JH, Shen J, Patel SS, Mishanina TV. PMID: 38094251; PMCID: PMC10714150.

View in: PubMed Mentions:
A riboswitch-controlled manganese exporter (Alx) tunes intracellular Mn2+ concentration in E. coli at alkaline pH. bioRxiv. 2023 May 08. Sharma R, Mishanina TV. PMID: 37214827; PMCID: PMC10197570.

View in: PubMed Mentions:
An ensemble of interconverting conformations of the elemental paused transcription complex creates regulatory options. Proc Natl Acad Sci U S A. 2023 02 21; 120(8):e2215945120. Kang JY, Mishanina TV, Bao Y, Chen J, Llewellyn E, Liu J, Darst SA, Landick R. PMID: 36795753; PMCID: PMC9974457.

View in: PubMed Mentions: 7 Fields:
Sci Science
Translation:Cells
Alkaline pH has an unexpected effect on transcriptional pausing during synthesis of the Escherichia coli pH-responsive riboswitch. J Biol Chem. 2022 09; 298(9):102302. Stephen C, Mishanina TV. PMID: 35934054; PMCID: PMC9472077.

View in: PubMed Mentions: 1 Fields:
Bio Biochemistry
Translation:Cells
Phosphorylation and acetylation of mitochondrial transcription factor A promote transcription processivity without compromising initiation or DNA compaction. J Biol Chem. 2022 04; 298(4):101815. Reardon SD, Mishanina TV. PMID: 35278431; PMCID: PMC9006650.

View in: PubMed Mentions: 6 Fields:
Bio Biochemistry
Translation:Cells
Conserved Trigger Loop Histidine of RNA Polymerase II Functions as a Positional Catalyst Primarily through Steric Effects. Biochemistry. 2021 11 09; 60(44):3323-3336. Palo MZ, Zhu J, Mishanina TV, Landick R. PMID: 34705427; PMCID: PMC9066048.

View in: PubMed Mentions: 5 Fields:
Bio Biochemistry
Translation:Animals Cells
Mechanisms of Transcriptional Pausing in Bacteria. J Mol Biol. 2019 09 20; 431(20):4007-4029. Kang JY, Mishanina TV, Landick R, Darst SA. PMID: 31310765; PMCID: PMC6874753.

View in: PubMed Mentions: 35 Fields:
Mol Molecular Biology
Translation:Cells
Chemical quenching and identification of intermediates in flavoenzyme-catalyzed reactions. Methods Enzymol. 2019; 620:89-114. Karunaratne K, Mishanina TV. PMID: 31072502.

View in: PubMed Mentions: Fields:
Bio Biochemistry
Translation:Cells
The elemental mechanism of transcriptional pausing. Elife. 2019 01 08; 8. Saba J, Chua XY, Mishanina TV, Nayak D, Windgassen TA, Mooney RA, Landick R. PMID: 30618376; PMCID: PMC6336406.

View in: PubMed Mentions: 31 Fields:
Bio Biology
Translation:Cells
Structural Basis for Transcript Elongation Control by NusG Family Universal Regulators. Cell. 2018 06 14; 173(7):1650-1662.e14. Kang JY, Mooney RA, Nedialkov Y, Saba J, Mishanina TV, Artsimovitch I, Landick R, Darst SA. PMID: 29887376; PMCID: PMC6003885.

View in: PubMed Mentions: 91 Fields:
Cel Cell Biology
Translation:Cells
RNA Polymerase Accommodates a Pause RNA Hairpin by Global Conformational Rearrangements that Prolong Pausing. Mol Cell. 2018 03 01; 69(5):802-815.e5. Kang JY, Mishanina TV, Bellecourt MJ, Mooney RA, Darst SA, Landick R. PMID: 29499135; PMCID: PMC5903582.

View in: PubMed Mentions: 85 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Cells
Trigger loop of RNA polymerase is a positional, not acid-base, catalyst for both transcription and proofreading. Proc Natl Acad Sci U S A. 2017 06 27; 114(26):E5103-E5112. Mishanina TV, Palo MZ, Nayak D, Mooney RA, Landick R. PMID: 28607053; PMCID: PMC5495254.

View in: PubMed Mentions: 32 Fields:
Sci Science
Translation:Cells
An unprecedented mechanism of nucleotide methylation in organisms containing thyX. Science. 2016 Jan 29; 351(6272):507-10. Mishanina TV, Yu L, Karunaratne K, Mondal D, Corcoran JM, Choi MA, Kohen A. PMID: 26823429; PMCID: PMC4744818.

View in: PubMed Mentions: 22 Fields:
Sci Science
Translation:Humans Cells
Transient Kinetic Analysis of Hydrogen Sulfide Oxidation Catalyzed by Human Sulfide Quinone Oxidoreductase. J Biol Chem. 2015 Oct 09; 290(41):25072-80. Mishanina TV, Yadav PK, Ballou DP, Banerjee R. PMID: 26318450; PMCID: PMC4599011.

View in: PubMed Mentions: 33 Fields:
Bio Biochemistry
Translation:Humans Cells
Synthesis and application of isotopically labeled flavin nucleotides. J Labelled Comp Radiopharm. 2015 Jul; 58(9):370-5. Mishanina TV, Kohen A. PMID: 26149960; PMCID: PMC4523426.

View in: PubMed Mentions: 2 Fields:
Nuc Nuclear Medicine Pha Pharmacology Rad Radiotherapy
Biogenesis of reactive sulfur species for signaling by hydrogen sulfide oxidation pathways. Nat Chem Biol. 2015 Jul; 11(7):457-64. Mishanina TV, Libiad M, Banerjee R. PMID: 26083070; PMCID: PMC4818113.

View in: PubMed Mentions: 181 Fields:
Bio Biology Che Chemistry
Translation:Humans Animals Cells
Substrate activation in flavin-dependent thymidylate synthase. J Am Chem Soc. 2014 Jul 30; 136(30):10597-600. Mishanina TV, Corcoran JM, Kohen A. PMID: 25025487; PMCID: PMC4121000.

View in: PubMed Mentions: 8 Fields:
Che Chemistry
Translation:Cells
Trapping of an intermediate in the reaction catalyzed by flavin-dependent thymidylate synthase. J Am Chem Soc. 2012 Mar 07; 134(9):4442-8. Mishanina TV, Koehn EM, Conrad JA, Palfey BA, Lesley SA, Kohen A. PMID: 22295882; PMCID: PMC3296878.

View in: PubMed Mentions: 17 Fields:
Che Chemistry
Translation:Humans Cells
Mechanisms and inhibition of uracil methylating enzymes. Bioorg Chem. 2012 Aug; 43:37-43. Mishanina TV, Koehn EM, Kohen A. PMID: 22172597; PMCID: PMC3315608.

View in: PubMed Mentions: 10 Fields:
Bio Biochemistry Che Chemistry
Translation:Cells
Accurate measurement of methyl 13C chemical shifts by solid-state NMR for the determination of protein side chain conformation: the influenza a M2 transmembrane peptide as an example. J Am Chem Soc. 2009 Jun 10; 131(22):7806-16. Hong M, Mishanina TV, Cady SD. PMID: 19441789; PMCID: PMC4082989.

View in: PubMed Mentions: 17 Fields:
Che Chemistry
Translation:Cells
Structure of amantadine-bound M2 transmembrane peptide of influenza A in lipid bilayers from magic-angle-spinning solid-state NMR: the role of Ser31 in amantadine binding. J Mol Biol. 2009 Jan 30; 385(4):1127-41. Cady SD, Mishanina TV, Hong M. PMID: 19061899; PMCID: PMC4132896.

View in: PubMed Mentions: 85 Fields:
Mol Molecular Biology
Translation:Cells