Simpson Joseph

Title(s)	Professor, Chemistry and Biochemistry
School	Vc-academic Affairs
Address	9500 Gilman Drive # La Jolla CA 92093
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Research

research activities and funding

Mechanism of Protein Synthesis and Translational Control
NIH R35GM141864Jun 1, 2021 - May 31, 2026
Role: Principal Investigator

Interaction of Influenza A virus NS1 protein with PABP1 and eIF4G
NIH R03AI123873Dec 1, 2016 - Nov 30, 2019
Role: Principal Investigator

Translational Control by the Fragile X Mental Retardation Protein
NIH R01GM114261Jan 1, 2016 - Nov 30, 2020
Role: Principal Investigator

Molecular Mechanism of Translation
NIH R01GM065265Apr 1, 2002 - May 31, 2013
Role: Principal Investigator

Bibliographic

selected publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

Altmetrics Details

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

PABP1 Drives the Selective Translation of Influenza A Virus mRNA. J Mol Biol. 2022 03 15; 434(5):167460. de Rozières CM, Pequeno A, Shahabi S, Lucas TM, Godula K, Ghosh G, Joseph S. PMID: 35074482; PMCID: PMC8897273.

View in: PubMed Mentions: 8 Fields:
Mol Molecular Biology
Translation:Humans Cells
The Fragile X Proteins Differentially Regulate Translation of Reporter mRNAs with G-quadruplex Structures. J Mol Biol. 2022 01 30; 434(2):167396. Edwards M, Joseph S. PMID: 34896112; PMCID: PMC8892671.

View in: PubMed Mentions: 4 Fields:
Mol Molecular Biology
Translation:Humans Cells
A simple procedure for bacterial expression and purification of the fragile X protein family. Sci Rep. 2020 09 28; 10(1):15858. Edwards M, Xu M, Joseph S. PMID: 32985615; PMCID: PMC7522082.

View in: PubMed Mentions: 2 Fields:
Sci Science
Translation:Humans Cells
RNA-Binding Specificity of the Human Fragile X Mental Retardation Protein. J Mol Biol. 2020 06 12; 432(13):3851-3868. Athar YM, Joseph S. PMID: 32343993; PMCID: PMC7306444.

View in: PubMed Mentions: 18 Fields:
Mol Molecular Biology
Translation:Humans Cells
Optimization of ClpXP activity and protein synthesis in an E. coli extract-based cell-free expression system. Sci Rep. 2018 02 22; 8(1):3488. Shi X, Wu T, M Cole C, K Devaraj N, Joseph S. PMID: 29472573; PMCID: PMC5823941.

View in: PubMed Mentions: 8 Fields:
Sci Science
Translation:Cells
Ribosome Induces a Closed to Open Conformational Change in Release Factor 1. J Mol Biol. 2016 Mar 27; 428(6):1333-1344. Trappl K, Joseph S. PMID: 26827724.

View in: PubMed Mentions: 13 Fields:
Mol Molecular Biology
Translation:Cells
Fragile X mental retardation protein: A paradigm for translational control by RNA-binding proteins. Biochimie. 2015 Jul; 114:147-54. Chen E, Joseph S. PMID: 25701550; PMCID: PMC4458461.

View in: PubMed Mentions: 37 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Modification interference analysis of the ribosome. Methods Mol Biol. 2015; 1240:113-23. Joseph S. PMID: 25352140.

View in: PubMed Mentions: Fields:
Mol Molecular Biology
Translation:Cells