Nigel Crawford

TitleEmeritus Professor
InstitutionUniversity of California San Diego
DepartmentCell and Developmental Biology
Address9500 Gilman Drive #0116
La Jolla CA 92093
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    Mechanisms for Nitric Oxide Synthesis and Regulation in Arabidopsis
    NIH/NIGMS R01GM040672Jul 1, 1988 - Nov 30, 2011
    Role: Principal Investigator
    NIH/NIGMS R29GM040672Jul 1, 1988 - Nov 30, 1993
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zhao L, Liu F, Crawford NM, Wang Y. Molecular Regulation of Nitrate Responses in Plants. Int J Mol Sci. 2018 Jul 13; 19(7). PMID: 30011829.
      View in: PubMed
    2. Wang C, Zhang W, Li Z, Li Z, Bi Y, Crawford NM, Wang Y. FIP1 Plays an Important Role in Nitrate Signaling and Regulates CIPK8 and CIPK23 Expression in Arabidopsis. Front Plant Sci. 2018; 9:593. PMID: 29780398.
      View in: PubMed
    3. Zhao L, Zhang W, Yang Y, Li Z, Li N, Qi S, Crawford NM, Wang Y. The Arabidopsis NLP7 gene regulates nitrate signaling via NRT1.1-dependent pathway in the presence of ammonium. Sci Rep. 2018 Jan 24; 8(1):1487. PMID: 29367694.
      View in: PubMed
    4. Cao H, Qi S, Sun M, Li Z, Yang Y, Crawford NM, Wang Y. Overexpression of the Maize ZmNLP6 and ZmNLP8 Can Complement the Arabidopsis Nitrate Regulatory Mutant nlp7 by Restoring Nitrate Signaling and Assimilation. Front Plant Sci. 2017; 8:1703. PMID: 29051766.
      View in: PubMed
    5. Li Z, Wang R, Gao Y, Wang C, Zhao L, Xu N, Chen KE, Qi S, Zhang M, Tsay YF, Crawford NM, Wang Y. The Arabidopsis CPSF30-L gene plays an essential role in nitrate signaling and regulates the nitrate transceptor gene NRT1.1. New Phytol. 2017 Dec; 216(4):1205-1222. PMID: 28850721.
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    6. Guan P, Ripoll JJ, Wang R, Vuong L, Bailey-Steinitz LJ, Ye D, Crawford NM. Interacting TCP and NLP transcription factors control plant responses to nitrate availability. Proc Natl Acad Sci U S A. 2017 02 28; 114(9):2419-2424. PMID: 28202720.
      View in: PubMed
    7. Xu N, Wang R, Zhao L, Zhang C, Li Z, Lei Z, Liu F, Guan P, Chu Z, Crawford NM, Wang Y. The Arabidopsis NRG2 Protein Mediates Nitrate Signaling and Interacts with and Regulates Key Nitrate Regulators. Plant Cell. 2016 Feb; 28(2):485-504. PMID: 26744214; PMCID: PMC4790867.
    8. Crawford N. Nutrient Signaling by Nitrate and Calcium. Plant Physiol. 2015 Oct; 169(2):911. PMID: 26417052; PMCID: PMC4587481 [Available on 10/01/16].
    9. Medici A, Marshall-Colon A, Ronzier E, Szponarski W, Wang R, Gojon A, Crawford NM, Ruffel S, Coruzzi GM, Krouk G. AtNIGT1/HRS1 integrates nitrate and phosphate signals at the Arabidopsis root tip. Nat Commun. 2015 Feb 27; 6:6274. PMID: 25723764; PMCID: PMC4373655.
    10. Guan P, Wang R, Nacry P, Breton G, Kay SA, Pruneda-Paz JL, Davani A, Crawford NM. Nitrate foraging by Arabidopsis roots is mediated by the transcription factor TCP20 through the systemic signaling pathway. Proc Natl Acad Sci U S A. 2014 Oct 21; 111(42):15267-72. PMID: 25288754; PMCID: PMC4210337.
    11. Krouk G, Ruffel S, Gutiérrez RA, Gojon A, Crawford NM, Coruzzi GM, Lacombe B. A framework integrating plant growth with hormones and nutrients. Trends Plant Sci. 2011 Apr; 16(4):178-82. PMID: 21393048.
      View in: PubMed
    12. Wang R, Guan P, Chen M, Xing X, Zhang Y, Crawford NM. Multiple regulatory elements in the Arabidopsis NIA1 promoter act synergistically to form a nitrate enhancer. Plant Physiol. 2010 Sep; 154(1):423-32. PMID: 20668061; PMCID: PMC2938143.
    13. Krouk G, Crawford NM, Coruzzi GM, Tsay YF. Nitrate signaling: adaptation to fluctuating environments. Curr Opin Plant Biol. 2010 Jun; 13(3):266-73. PMID: 20093067.
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    14. Wang Y, Ries A, Wu K, Yang A, Crawford NM. The Arabidopsis Prohibitin Gene PHB3 Functions in Nitric Oxide-Mediated Responses and in Hydrogen Peroxide-Induced Nitric Oxide Accumulation. Plant Cell. 2010 Jan; 22(1):249-59. PMID: 20068191; PMCID: PMC2828708.
    15. Wang R, Xing X, Wang Y, Tran A, Crawford NM. A genetic screen for nitrate regulatory mutants captures the nitrate transporter gene NRT1.1. Plant Physiol. 2009 Sep; 151(1):472-8. PMID: 19633234; PMCID: PMC2735993.
    16. Wang R, Xing X, Crawford N. Nitrite acts as a transcriptome signal at micromolar concentrations in Arabidopsis roots. Plant Physiol. 2007 Dec; 145(4):1735-45. PMID: 17951451; PMCID: PMC2151675.
    17. Tischner R, Galli M, Heimer YM, Bielefeld S, Okamoto M, Mack A, Crawford NM. Interference with the citrulline-based nitric oxide synthase assay by argininosuccinate lyase activity in Arabidopsis extracts. FEBS J. 2007 Aug; 274(16):4238-45. PMID: 17651442.
      View in: PubMed
    18. Gutiérrez RA, Gifford ML, Poultney C, Wang R, Shasha DE, Coruzzi GM, Crawford NM. Insights into the genomic nitrate response using genetics and the Sungear Software System. J Exp Bot. 2007; 58(9):2359-67. PMID: 17470441.
      View in: PubMed
    19. Li W, Wang Y, Okamoto M, Crawford NM, Siddiqi MY, Glass AD. Dissection of the AtNRT2.1:AtNRT2.2 inducible high-affinity nitrate transporter gene cluster. Plant Physiol. 2007 Jan; 143(1):425-33. PMID: 17085507; PMCID: PMC1761961.
    20. Okamoto M, Kumar A, Li W, Wang Y, Siddiqi MY, Crawford NM, Glass AD. High-affinity nitrate transport in roots of Arabidopsis depends on expression of the NAR2-like gene AtNRT3.1. Plant Physiol. 2006 Mar; 140(3):1036-46. PMID: 16415212; PMCID: PMC1400568.
    21. Guo FQ, Crawford NM. Arabidopsis nitric oxide synthase1 is targeted to mitochondria and protects against oxidative damage and dark-induced senescence. Plant Cell. 2005 Dec; 17(12):3436-50. PMID: 16272429; PMCID: PMC1315380.
    22. He Y, Tang RH, Hao Y, Stevens RD, Cook CW, Ahn SM, Jing L, Yang Z, Chen L, Guo F, Fiorani F, Jackson RB, Crawford NM, Pei ZM. Nitric oxide represses the Arabidopsis floral transition. Science. 2004 Sep 24; 305(5692):1968-71. PMID: 15448272.
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    23. Wang R, Tischner R, Gutiérrez RA, Hoffman M, Xing X, Chen M, Coruzzi G, Crawford NM. Genomic analysis of the nitrate response using a nitrate reductase-null mutant of Arabidopsis. Plant Physiol. 2004 Sep; 136(1):2512-22. PMID: 15333754; PMCID: PMC523318.
    24. Unkles SE, Wang R, Wang Y, Glass AD, Crawford NM, Kinghorn JR. Nitrate reductase activity is required for nitrate uptake into fungal but not plant cells. J Biol Chem. 2004 Jul 02; 279(27):28182-6. PMID: 15123642.
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    25. Galli M, Theriault A, Liu D, Crawford NM. Expression of the Arabidopsis transposable element Tag1 is targeted to developing gametophytes. Genetics. 2003 Dec; 165(4):2093-105. PMID: 14704189; PMCID: PMC1462897.
    26. Wang R, Okamoto M, Xing X, Crawford NM. Microarray analysis of the nitrate response in Arabidopsis roots and shoots reveals over 1,000 rapidly responding genes and new linkages to glucose, trehalose-6-phosphate, iron, and sulfate metabolism. Plant Physiol. 2003 Jun; 132(2):556-67. PMID: 12805587; PMCID: PMC166997.
    27. Guo FQ, Young J, Crawford NM. The nitrate transporter AtNRT1.1 (CHL1) functions in stomatal opening and contributes to drought susceptibility in Arabidopsis. Plant Cell. 2003 Jan; 15(1):107-17. PMID: 12509525; PMCID: PMC143464.
    28. Guo FQ, Wang R, Crawford NM. The Arabidopsis dual-affinity nitrate transporter gene AtNRT1.1 (CHL1) is regulated by auxin in both shoots and roots. J Exp Bot. 2002 Apr; 53(370):835-44. PMID: 11912226.
      View in: PubMed
    29. Crawford NM, Forde BG. Molecular and developmental biology of inorganic nitrogen nutrition. Arabidopsis Book. 2002; 1:e0011. PMID: 22303192; PMCID: PMC3243300.
    30. Mack AM, Crawford NM. The Arabidopsis TAG1 transposase has an N-terminal zinc finger DNA binding domain that recognizes distinct subterminal motifs. Plant Cell. 2001 Oct; 13(10):2319-31. PMID: 11595804; PMCID: PMC139161.
    31. Guo FQ, Wang R, Chen M, Crawford NM. The Arabidopsis dual-affinity nitrate transporter gene AtNRT1.1 (CHL1) is activated and functions in nascent organ development during vegetative and reproductive growth. Plant Cell. 2001 Aug; 13(8):1761-77. PMID: 11487691; PMCID: PMC139138.
    32. Liu D, Galli M, Crawford NM. Engineering variegated floral patterns in tobacco plants using the Arabidopsis transposable element Tag1. Plant Cell Physiol. 2001 Apr; 42(4):419-23. PMID: 11333313.
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    33. Liu D, Mack A, Wang R, Galli M, Belk J, Ketpura NI, Crawford NM. Functional dissection of the cis-acting sequences of the Arabidopsis transposable element Tag1 reveals dissimilar subterminal sequence and minimal spacing requirements for transposition. Genetics. 2001 Feb; 157(2):817-30. PMID: 11156999; PMCID: PMC1461541.
    34. Wang R, Guegler K, LaBrie ST, Crawford NM. Genomic analysis of a nutrient response in Arabidopsis reveals diverse expression patterns and novel metabolic and potential regulatory genes induced by nitrate. Plant Cell. 2000 Aug; 12(8):1491-509. PMID: 10948265; PMCID: PMC149118.
    35. Thomine S, Wang R, Ward JM, Crawford NM, Schroeder JI. Cadmium and iron transport by members of a plant metal transporter family in Arabidopsis with homology to Nramp genes. Proc Natl Acad Sci U S A. 2000 Apr 25; 97(9):4991-6. PMID: 10781110; PMCID: PMC18345.
    36. Liu D, Zhang S, Fauquet C, Crawford NM. The Arabidopsis transposon Tag1 is active in rice, undergoing germinal transposition and restricted, late somatic excision. Mol Gen Genet. 1999 Oct; 262(3):413-20. PMID: 10589827.
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    37. Chrispeels MJ, Crawford NM, Schroeder JI. Proteins for transport of water and mineral nutrients across the membranes of plant cells. Plant Cell. 1999 Apr; 11(4):661-76. PMID: 10213785; PMCID: PMC144211.
    38. Kanamaru K, Wang R, Su W, Crawford NM. Ser-534 in the hinge 1 region of Arabidopsis nitrate reductase is conditionally required for binding of 14-3-3 proteins and in vitro inhibition. J Biol Chem. 1999 Feb 12; 274(7):4160-5. PMID: 9933611.
      View in: PubMed
    39. Wang R, Liu D, Crawford NM. The Arabidopsis CHL1 protein plays a major role in high-affinity nitrate uptake. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):15134-9. PMID: 9844028; PMCID: PMC24588.
    40. Liu D, Crawford NM. Characterization of the putative transposase mRNA of Tag1, which is ubiquitously expressed in Arabidopsis and can be induced by Agrobacterium-mediated transformation with dTag1 DNA. Genetics. 1998 Jun; 149(2):693-701. PMID: 9611184; PMCID: PMC1460181.
    41. Frank MJ, Preuss D, Mack A, Kuhlmann TC, Crawford NM. The Arabidopsis transposable element Tag1 is widely distributed among Arabidopsis ecotypes. Mol Gen Genet. 1998 Feb; 257(4):478-84. PMID: 9529529.
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    42. Liu D, Crawford NM. Characterization of the germinal and somatic activity of the Arabidopsis transposable element Tag1. Genetics. 1998 Jan; 148(1):445-56. PMID: 9475754; PMCID: PMC1459774.
    43. Su W, Mertens JA, Kanamaru K, Campbell WH, Crawford NM. Analysis of wild-type and mutant plant nitrate reductase expressed in the methylotrophic yeast Pichia pastoris. Plant Physiol. 1997 Nov; 115(3):1135-43. PMID: 9390442; PMCID: PMC158578.
    44. Frank MJ, Liu D, Tsay YF, Ustach C, Crawford NM. Tag1 is an autonomous transposable element that shows somatic excision in both Arabidopsis and tobacco. Plant Cell. 1997 Oct; 9(10):1745-56. PMID: 9368414; PMCID: PMC157018.
    45. Huang NC, Chiang CS, Crawford NM, Tsay YF. CHL1 encodes a component of the low-affinity nitrate uptake system in Arabidopsis and shows cell type-specific expression in roots. Plant Cell. 1996 Dec; 8(12):2183-91. PMID: 8989878; PMCID: PMC161344.
    46. Wang R, Crawford NM. Genetic identification of a gene involved in constitutive, high-affinity nitrate transport in higher plants. Proc Natl Acad Sci U S A. 1996 Aug 20; 93(17):9297-301. PMID: 8799195; PMCID: PMC38636.
    47. Su W, Huber SC, Crawford NM. Identification in vitro of a post-translational regulatory site in the hinge 1 region of Arabidopsis nitrate reductase. Plant Cell. 1996 Mar; 8(3):519-27. PMID: 8721753; PMCID: PMC161117.
    48. Cao Y, Ward JM, Kelly WB, Ichida AM, Gaber RF, Anderson JA, Uozumi N, Schroeder JI, Crawford NM. Multiple genes, tissue specificity, and expression-dependent modulationcontribute to the functional diversity of potassium channels in Arabidopsis thaliana. Plant Physiol. 1995 Nov; 109(3):1093-106. PMID: 8552711; PMCID: PMC161413.
    49. Cao Y, Crawford NM, Schroeder JI. Amino terminus and the first four membrane-spanning segments of the Arabidopsis K+ channel KAT1 confer inward-rectification property of plant-animal chimeric channels. J Biol Chem. 1995 Jul 28; 270(30):17697-701. PMID: 7629068.
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    50. Crawford NM. Nitrate: nutrient and signal for plant growth. Plant Cell. 1995 Jul; 7(7):859-68. PMID: 7640524; PMCID: PMC160877.
    51. LaBrie ST, Crawford NM. A glycine to aspartic acid change in the MoCo domain of nitrate reductase reduces both activity and phosphorylation levels in Arabidopsis. J Biol Chem. 1994 May 20; 269(20):14497-501. PMID: 8182055.
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    52. Cao Y, Glass AD, Crawford NM. Ammonium inhibition of Arabidopsis root growth can be reversed by potassium and by auxin resistance mutations aux1, axr1, and axr2. Plant Physiol. 1993 Jul; 102(3):983-9. PMID: 8278539; PMCID: PMC158872.
    53. Wilkinson JQ, Crawford NM. Identification and characterization of a chlorate-resistant mutant of Arabidopsis thaliana with mutations in both nitrate reductase structural genes NIA1 and NIA2. Mol Gen Genet. 1993 May; 239(1-2):289-97. PMID: 8510658.
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    54. Tsay YF, Frank MJ, Page T, Dean C, Crawford NM. Identification of a mobile endogenous transposon in Arabidopsis thaliana. Science. 1993 Apr 16; 260(5106):342-4. PMID: 8385803.
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    55. Tsay YF, Schroeder JI, Feldmann KA, Crawford NM. The herbicide sensitivity gene CHL1 of Arabidopsis encodes a nitrate-inducible nitrate transporter. Cell. 1993 Mar 12; 72(5):705-13. PMID: 8453665.
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    56. Crawford NM, Arst HN. The molecular genetics of nitrate assimilation in fungi and plants. Annu Rev Genet. 1993; 27:115-46. PMID: 8122899.
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    57. Cao Y, Anderova M, Crawford NM, Schroeder JI. Expression of an outward-rectifying potassium channel from maize mRNA and complementary RNA in Xenopus oocytes. Plant Cell. 1992 Aug; 4(8):961-9. PMID: 1392603; PMCID: PMC160188.
    58. LaBrie ST, Wilkinson JQ, Tsay YF, Feldmann KA, Crawford NM. Identification of two tungstate-sensitive molybdenum cofactor mutants, chl2 and chl7, of Arabidopsis thaliana. Mol Gen Genet. 1992 May; 233(1-2):169-76. PMID: 1534867.
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    59. Hyde GE, Crawford NM, Campbell WH. The sequence of squash NADH:nitrate reductase and its relationship to the sequences of other flavoprotein oxidoreductases. A family of flavoprotein pyridine nucleotide cytochrome reductases. J Biol Chem. 1991 Dec 15; 266(35):23542-7. PMID: 1748631.
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    60. Labrie ST, Wilkinson JQ, Crawford NM. Effect of Chlorate Treatment on Nitrate Reductase and Nitrite Reductase Gene Expression in Arabidopsis thaliana. Plant Physiol. 1991 Nov; 97(3):873-9. PMID: 16668525.
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    61. Wilkinson JQ, Crawford NM. Identification of the Arabidopsis CHL3 gene as the nitrate reductase structural gene NIA2. Plant Cell. 1991 May; 3(5):461-71. PMID: 1840922; PMCID: PMC160014.
    62. Crawford NM, Smith M, Bellissimo D, Davis RW. Sequence and nitrate regulation of the Arabidopsis thaliana mRNA encoding nitrate reductase, a metalloflavoprotein with three functional domains. Proc Natl Acad Sci U S A. 1988 Jul; 85(14):5006-10. PMID: 3393528; PMCID: PMC281676.
    63. Crawford NM, Campbell WH, Davis RW. Nitrate reductase from squash: cDNA cloning and nitrate regulation. Proc Natl Acad Sci U S A. 1986 Nov; 83(21):8073-6. PMID: 16593773.
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