Nigel Crawford

Title(s)Emeritus Professor, Cell and Developmental Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #0116
La Jolla CA 92093
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    Mechanisms for Nitric Oxide Synthesis and Regulation in Arabidopsis
    NIH/NIGMS R01GM040672Jul 1, 1988 - Nov 30, 2011
    Role: Principal Investigator
    NIH/NIGMS R29GM040672Jul 1, 1988 - Nov 30, 1993
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Nitrate in 2020: Thirty Years from Transport to Signaling Networks. Plant Cell. 2020 07; 32(7):2094-2119. Vidal EA, Alvarez JM, Araus V, Riveras E, Brooks MD, Krouk G, Ruffel S, Lejay L, Crawford NM, Coruzzi GM, Gutiérrez RA. PMID: 32169959.
      View in: PubMed   Mentions: 2     Fields:    
    2. The long noncoding RNA T5120 regulates nitrate response and assimilation in Arabidopsis. New Phytol. 2019 10; 224(1):117-131. Liu F, Xu Y, Chang K, Li S, Liu Z, Qi S, Jia J, Zhang M, Crawford NM, Wang Y. PMID: 31264223.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    3. Molecular Regulation of Nitrate Responses in Plants. Int J Mol Sci. 2018 Jul 13; 19(7). Zhao L, Liu F, Crawford NM, Wang Y. PMID: 30011829.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    4. FIP1 Plays an Important Role in Nitrate Signaling and Regulates CIPK8 and CIPK23 Expression in Arabidopsis. Front Plant Sci. 2018; 9:593. Wang C, Zhang W, Li Z, Li Z, Bi Y, Crawford NM, Wang Y. PMID: 29780398.
      View in: PubMed   Mentions:
    5. The Arabidopsis NLP7 gene regulates nitrate signaling via NRT1.1-dependent pathway in the presence of ammonium. Sci Rep. 2018 01 24; 8(1):1487. Zhao L, Zhang W, Yang Y, Li Z, Li N, Qi S, Crawford NM, Wang Y. PMID: 29367694.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    6. Overexpression of the Maize ZmNLP6 and ZmNLP8 Can Complement the Arabidopsis Nitrate Regulatory Mutant nlp7 by Restoring Nitrate Signaling and Assimilation. Front Plant Sci. 2017; 8:1703. Cao H, Qi S, Sun M, Li Z, Yang Y, Crawford NM, Wang Y. PMID: 29051766.
      View in: PubMed   Mentions:
    7. The Arabidopsis CPSF30-L gene plays an essential role in nitrate signaling and regulates the nitrate transceptor gene NRT1.1. New Phytol. 2017 Dec; 216(4):1205-1222. Li Z, Wang R, Gao Y, Wang C, Zhao L, Xu N, Chen KE, Qi S, Zhang M, Tsay YF, Crawford NM, Wang Y. PMID: 28850721.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    8. Interacting TCP and NLP transcription factors control plant responses to nitrate availability. Proc Natl Acad Sci U S A. 2017 02 28; 114(9):2419-2424. Guan P, Ripoll JJ, Wang R, Vuong L, Bailey-Steinitz LJ, Ye D, Crawford NM. PMID: 28202720.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    9. The Arabidopsis NRG2 Protein Mediates Nitrate Signaling and Interacts with and Regulates Key Nitrate Regulators. Plant Cell. 2016 Feb; 28(2):485-504. Xu N, Wang R, Zhao L, Zhang C, Li Z, Lei Z, Liu F, Guan P, Chu Z, Crawford NM, Wang Y. PMID: 26744214.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    10. Nutrient Signaling by Nitrate and Calcium. Plant Physiol. 2015 Oct; 169(2):911. Crawford N. PMID: 26417052.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    11. AtNIGT1/HRS1 integrates nitrate and phosphate signals at the Arabidopsis root tip. Nat Commun. 2015 Feb 27; 6:6274. Medici A, Marshall-Colon A, Ronzier E, Szponarski W, Wang R, Gojon A, Crawford NM, Ruffel S, Coruzzi GM, Krouk G. PMID: 25723764.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    12. Nitrate foraging by Arabidopsis roots is mediated by the transcription factor TCP20 through the systemic signaling pathway. Proc Natl Acad Sci U S A. 2014 Oct 21; 111(42):15267-72. Guan P, Wang R, Nacry P, Breton G, Kay SA, Pruneda-Paz JL, Davani A, Crawford NM. PMID: 25288754.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCellsPHPublic Health
    13. A framework integrating plant growth with hormones and nutrients. Trends Plant Sci. 2011 Apr; 16(4):178-82. Krouk G, Ruffel S, Gutiérrez RA, Gojon A, Crawford NM, Coruzzi GM, Lacombe B. PMID: 21393048.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    14. Multiple regulatory elements in the Arabidopsis NIA1 promoter act synergistically to form a nitrate enhancer. Plant Physiol. 2010 Sep; 154(1):423-32. Wang R, Guan P, Chen M, Xing X, Zhang Y, Crawford NM. PMID: 20668061.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    15. Nitrate signaling: adaptation to fluctuating environments. Curr Opin Plant Biol. 2010 Jun; 13(3):266-73. Krouk G, Crawford NM, Coruzzi GM, Tsay YF. PMID: 20093067.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    16. The Arabidopsis Prohibitin Gene PHB3 Functions in Nitric Oxide-Mediated Responses and in Hydrogen Peroxide-Induced Nitric Oxide Accumulation. Plant Cell. 2010 Jan; 22(1):249-59. Wang Y, Ries A, Wu K, Yang A, Crawford NM. PMID: 20068191.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    17. A genetic screen for nitrate regulatory mutants captures the nitrate transporter gene NRT1.1. Plant Physiol. 2009 Sep; 151(1):472-8. Wang R, Xing X, Wang Y, Tran A, Crawford NM. PMID: 19633234.
      View in: PubMed   Mentions: 50     Fields:    Translation:Animals
    18. Nitrite acts as a transcriptome signal at micromolar concentrations in Arabidopsis roots. Plant Physiol. 2007 Dec; 145(4):1735-45. Wang R, Xing X, Crawford N. PMID: 17951451.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    19. Interference with the citrulline-based nitric oxide synthase assay by argininosuccinate lyase activity in Arabidopsis extracts. FEBS J. 2007 Aug; 274(16):4238-45. Tischner R, Galli M, Heimer YM, Bielefeld S, Okamoto M, Mack A, Crawford NM. PMID: 17651442.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    20. Insights into the genomic nitrate response using genetics and the Sungear Software System. J Exp Bot. 2007; 58(9):2359-67. Gutiérrez RA, Gifford ML, Poultney C, Wang R, Shasha DE, Coruzzi GM, Crawford NM. PMID: 17470441.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    21. Dissection of the AtNRT2.1:AtNRT2.2 inducible high-affinity nitrate transporter gene cluster. Plant Physiol. 2007 Jan; 143(1):425-33. Li W, Wang Y, Okamoto M, Crawford NM, Siddiqi MY, Glass AD. PMID: 17085507.
      View in: PubMed   Mentions: 63     Fields:    Translation:Animals
    22. High-affinity nitrate transport in roots of Arabidopsis depends on expression of the NAR2-like gene AtNRT3.1. Plant Physiol. 2006 Mar; 140(3):1036-46. Okamoto M, Kumar A, Li W, Wang Y, Siddiqi MY, Crawford NM, Glass AD. PMID: 16415212.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    23. Arabidopsis nitric oxide synthase1 is targeted to mitochondria and protects against oxidative damage and dark-induced senescence. Plant Cell. 2005 Dec; 17(12):3436-50. Guo FQ, Crawford NM. PMID: 16272429.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    24. Nitric oxide represses the Arabidopsis floral transition. Science. 2004 Sep 24; 305(5692):1968-71. He Y, Tang RH, Hao Y, Stevens RD, Cook CW, Ahn SM, Jing L, Yang Z, Chen L, Guo F, Fiorani F, Jackson RB, Crawford NM, Pei ZM. PMID: 15448272.
      View in: PubMed   Mentions: 123     Fields:    Translation:Animals
    25. Genomic analysis of the nitrate response using a nitrate reductase-null mutant of Arabidopsis. Plant Physiol. 2004 Sep; 136(1):2512-22. Wang R, Tischner R, Gutiérrez RA, Hoffman M, Xing X, Chen M, Coruzzi G, Crawford NM. PMID: 15333754.
      View in: PubMed   Mentions: 120     Fields:    Translation:AnimalsCells
    26. Nitrate reductase activity is required for nitrate uptake into fungal but not plant cells. J Biol Chem. 2004 Jul 02; 279(27):28182-6. Unkles SE, Wang R, Wang Y, Glass AD, Crawford NM, Kinghorn JR. PMID: 15123642.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    27. Expression of the Arabidopsis transposable element Tag1 is targeted to developing gametophytes. Genetics. 2003 Dec; 165(4):2093-105. Galli M, Theriault A, Liu D, Crawford NM. PMID: 14704189.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    28. Microarray analysis of the nitrate response in Arabidopsis roots and shoots reveals over 1,000 rapidly responding genes and new linkages to glucose, trehalose-6-phosphate, iron, and sulfate metabolism. Plant Physiol. 2003 Jun; 132(2):556-67. Wang R, Okamoto M, Xing X, Crawford NM. PMID: 12805587.
      View in: PubMed   Mentions: 199     Fields:    Translation:AnimalsCells
    29. The nitrate transporter AtNRT1.1 (CHL1) functions in stomatal opening and contributes to drought susceptibility in Arabidopsis. Plant Cell. 2003 Jan; 15(1):107-17. Guo FQ, Young J, Crawford NM. PMID: 12509525.
      View in: PubMed   Mentions: 61     Fields:    Translation:Animals
    30. The Arabidopsis dual-affinity nitrate transporter gene AtNRT1.1 (CHL1) is regulated by auxin in both shoots and roots. J Exp Bot. 2002 Apr; 53(370):835-44. Guo FQ, Wang R, Crawford NM. PMID: 11912226.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    31. Molecular and developmental biology of inorganic nitrogen nutrition. Arabidopsis Book. 2002; 1:e0011. Crawford NM, Forde BG. PMID: 22303192.
      View in: PubMed   Mentions:
    32. The Arabidopsis TAG1 transposase has an N-terminal zinc finger DNA binding domain that recognizes distinct subterminal motifs. Plant Cell. 2001 Oct; 13(10):2319-31. Mack AM, Crawford NM. PMID: 11595804.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    33. The Arabidopsis dual-affinity nitrate transporter gene AtNRT1.1 (CHL1) is activated and functions in nascent organ development during vegetative and reproductive growth. Plant Cell. 2001 Aug; 13(8):1761-77. Guo FQ, Wang R, Chen M, Crawford NM. PMID: 11487691.
      View in: PubMed   Mentions: 51     Fields:    Translation:Animals
    34. Engineering variegated floral patterns in tobacco plants using the Arabidopsis transposable element Tag1. Plant Cell Physiol. 2001 Apr; 42(4):419-23. Liu D, Galli M, Crawford NM. PMID: 11333313.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    35. Functional dissection of the cis-acting sequences of the Arabidopsis transposable element Tag1 reveals dissimilar subterminal sequence and minimal spacing requirements for transposition. Genetics. 2001 Feb; 157(2):817-30. Liu D, Mack A, Wang R, Galli M, Belk J, Ketpura NI, Crawford NM. PMID: 11156999.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    36. Genomic analysis of a nutrient response in Arabidopsis reveals diverse expression patterns and novel metabolic and potential regulatory genes induced by nitrate. Plant Cell. 2000 Aug; 12(8):1491-509. Wang R, Guegler K, LaBrie ST, Crawford NM. PMID: 10948265.
      View in: PubMed   Mentions: 146     Fields:    Translation:AnimalsCells
    37. Cadmium and iron transport by members of a plant metal transporter family in Arabidopsis with homology to Nramp genes. Proc Natl Acad Sci U S A. 2000 Apr 25; 97(9):4991-6. Thomine S, Wang R, Ward JM, Crawford NM, Schroeder JI. PMID: 10781110.
      View in: PubMed   Mentions: 138     Fields:    Translation:AnimalsCells
    38. The Arabidopsis transposon Tag1 is active in rice, undergoing germinal transposition and restricted, late somatic excision. Mol Gen Genet. 1999 Oct; 262(3):413-20. Liu D, Zhang S, Fauquet C, Crawford NM. PMID: 10589827.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    39. Proteins for transport of water and mineral nutrients across the membranes of plant cells. Plant Cell. 1999 Apr; 11(4):661-76. Chrispeels MJ, Crawford NM, Schroeder JI. PMID: 10213785.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    40. Ser-534 in the hinge 1 region of Arabidopsis nitrate reductase is conditionally required for binding of 14-3-3 proteins and in vitro inhibition. J Biol Chem. 1999 Feb 12; 274(7):4160-5. Kanamaru K, Wang R, Su W, Crawford NM. PMID: 9933611.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    41. The Arabidopsis CHL1 protein plays a major role in high-affinity nitrate uptake. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):15134-9. Wang R, Liu D, Crawford NM. PMID: 9844028.
      View in: PubMed   Mentions: 65     Fields:    Translation:Animals
    42. Characterization of the putative transposase mRNA of Tag1, which is ubiquitously expressed in Arabidopsis and can be induced by Agrobacterium-mediated transformation with dTag1 DNA. Genetics. 1998 Jun; 149(2):693-701. Liu D, Crawford NM. PMID: 9611184.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    43. The Arabidopsis transposable element Tag1 is widely distributed among Arabidopsis ecotypes. Mol Gen Genet. 1998 Feb; 257(4):478-84. Frank MJ, Preuss D, Mack A, Kuhlmann TC, Crawford NM. PMID: 9529529.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    44. Characterization of the germinal and somatic activity of the Arabidopsis transposable element Tag1. Genetics. 1998 Jan; 148(1):445-56. Liu D, Crawford NM. PMID: 9475754.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    45. Analysis of wild-type and mutant plant nitrate reductase expressed in the methylotrophic yeast Pichia pastoris. Plant Physiol. 1997 Nov; 115(3):1135-43. Su W, Mertens JA, Kanamaru K, Campbell WH, Crawford NM. PMID: 9390442.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    46. Tag1 is an autonomous transposable element that shows somatic excision in both Arabidopsis and tobacco. Plant Cell. 1997 Oct; 9(10):1745-56. Frank MJ, Liu D, Tsay YF, Ustach C, Crawford NM. PMID: 9368414.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    47. CHL1 encodes a component of the low-affinity nitrate uptake system in Arabidopsis and shows cell type-specific expression in roots. Plant Cell. 1996 Dec; 8(12):2183-91. Huang NC, Chiang CS, Crawford NM, Tsay YF. PMID: 8989878.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    48. Genetic identification of a gene involved in constitutive, high-affinity nitrate transport in higher plants. Proc Natl Acad Sci U S A. 1996 Aug 20; 93(17):9297-301. Wang R, Crawford NM. PMID: 8799195.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    49. Identification in vitro of a post-translational regulatory site in the hinge 1 region of Arabidopsis nitrate reductase. Plant Cell. 1996 Mar; 8(3):519-27. Su W, Huber SC, Crawford NM. PMID: 8721753.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    50. Multiple genes, tissue specificity, and expression-dependent modulationcontribute to the functional diversity of potassium channels in Arabidopsis thaliana. Plant Physiol. 1995 Nov; 109(3):1093-106. Cao Y, Ward JM, Kelly WB, Ichida AM, Gaber RF, Anderson JA, Uozumi N, Schroeder JI, Crawford NM. PMID: 8552711.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    51. Amino terminus and the first four membrane-spanning segments of the Arabidopsis K+ channel KAT1 confer inward-rectification property of plant-animal chimeric channels. J Biol Chem. 1995 Jul 28; 270(30):17697-701. Cao Y, Crawford NM, Schroeder JI. PMID: 7629068.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    52. Nitrate: nutrient and signal for plant growth. Plant Cell. 1995 Jul; 7(7):859-68. Crawford NM. PMID: 7640524.
      View in: PubMed   Mentions: 153     Fields:    Translation:AnimalsCells
    53. A glycine to aspartic acid change in the MoCo domain of nitrate reductase reduces both activity and phosphorylation levels in Arabidopsis. J Biol Chem. 1994 May 20; 269(20):14497-501. LaBrie ST, Crawford NM. PMID: 8182055.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    54. Ammonium inhibition of Arabidopsis root growth can be reversed by potassium and by auxin resistance mutations aux1, axr1, and axr2. Plant Physiol. 1993 Jul; 102(3):983-9. Cao Y, Glass AD, Crawford NM. PMID: 8278539.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    55. Identification and characterization of a chlorate-resistant mutant of Arabidopsis thaliana with mutations in both nitrate reductase structural genes NIA1 and NIA2. Mol Gen Genet. 1993 May; 239(1-2):289-97. Wilkinson JQ, Crawford NM. PMID: 8510658.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    56. Identification of a mobile endogenous transposon in Arabidopsis thaliana. Science. 1993 Apr 16; 260(5106):342-4. Tsay YF, Frank MJ, Page T, Dean C, Crawford NM. PMID: 8385803.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    57. The herbicide sensitivity gene CHL1 of Arabidopsis encodes a nitrate-inducible nitrate transporter. Cell. 1993 Mar 12; 72(5):705-13. Tsay YF, Schroeder JI, Feldmann KA, Crawford NM. PMID: 8453665.
      View in: PubMed   Mentions: 178     Fields:    Translation:AnimalsCells
    58. The molecular genetics of nitrate assimilation in fungi and plants. Annu Rev Genet. 1993; 27:115-46. Crawford NM, Arst HN. PMID: 8122899.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    59. Expression of an outward-rectifying potassium channel from maize mRNA and complementary RNA in Xenopus oocytes. Plant Cell. 1992 Aug; 4(8):961-9. Cao Y, Anderova M, Crawford NM, Schroeder JI. PMID: 1392603.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    60. Identification of two tungstate-sensitive molybdenum cofactor mutants, chl2 and chl7, of Arabidopsis thaliana. Mol Gen Genet. 1992 May; 233(1-2):169-76. LaBrie ST, Wilkinson JQ, Tsay YF, Feldmann KA, Crawford NM. PMID: 1534867.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    61. The sequence of squash NADH:nitrate reductase and its relationship to the sequences of other flavoprotein oxidoreductases. A family of flavoprotein pyridine nucleotide cytochrome reductases. J Biol Chem. 1991 Dec 15; 266(35):23542-7. Hyde GE, Crawford NM, Campbell WH. PMID: 1748631.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    62. Effect of Chlorate Treatment on Nitrate Reductase and Nitrite Reductase Gene Expression in Arabidopsis thaliana. Plant Physiol. 1991 Nov; 97(3):873-9. Labrie ST, Wilkinson JQ, Crawford NM. PMID: 16668525.
      View in: PubMed   Mentions: 10     Fields:    
    63. Identification of the Arabidopsis CHL3 gene as the nitrate reductase structural gene NIA2. Plant Cell. 1991 May; 3(5):461-71. Wilkinson JQ, Crawford NM. PMID: 1840922.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    64. Sequence and nitrate regulation of the Arabidopsis thaliana mRNA encoding nitrate reductase, a metalloflavoprotein with three functional domains. Proc Natl Acad Sci U S A. 1988 Jul; 85(14):5006-10. Crawford NM, Smith M, Bellissimo D, Davis RW. PMID: 3393528.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    65. Nitrate reductase from squash: cDNA cloning and nitrate regulation. Proc Natl Acad Sci U S A. 1986 Nov; 83(21):8073-6. Crawford NM, Campbell WH, Davis RW. PMID: 16593773.
      View in: PubMed   Mentions: 57     Fields:    
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