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    Linda Holland

    TitleEmeritus Professor
    SchoolUniversity of California, San Diego
    DepartmentMarine Biology
    Address9500 Gilman Drive #0202
    CA La Jolla 92093
    Phone858-534-5607
    vCardDownload vCard

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Yue JX, Kozmikova I, Ono H, Nossa CW, Kozmik Z, Putnam NH, Yu JK, Holland L. Conserved Noncoding Elements in the Most Distant Genera of Cephalochordates: The Goldilocks Principle. Genome Biol Evol. 2016 Aug 25; 8(8):2387-405. PMID: 27412606; PMCID: PMC5010895.
      2. Yue JX, Holland ND, Holland L, Deheyn DD. The evolution of genes encoding for green fluorescent proteins: insights from cephalochordates (amphioxus). Sci Rep. 2016 Jun 17; 6:28350. PMID: 27311567; PMCID: PMC4911609.
      3. Holland L. Tunicates. Curr Biol. 2016 Feb 22; 26(4):R146-52. PMID: 26906481.
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      4. Holland L. The origin and evolution of chordate nervous systems. Philos Trans R Soc Lond B Biol Sci. 2015 Dec 19; 370(1684). PMID: 26554041; PMCID: PMC4650125 [Available on 12/19/16].
      5. Holland ND, Holland L, Holland PW. Scenarios for the making of vertebrates. Nature. 2015 Apr 23; 520(7548):450-5. PMID: 25903626.
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      6. Holland L. Evolution of basal deuterostome nervous systems. J Exp Biol. 2015 Feb 15; 218(Pt 4):637-45. PMID: 25696827.
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      7. Holland ND, Holland L, Heimberg A. Hybrids between the Florida amphioxus (Branchiostoma floridae) and the Bahamas lancelet (Asymmetron lucayanum): developmental morphology and chromosome counts. Biol Bull. 2015 Feb; 228(1):13-24. PMID: 25745097.
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      8. Koop D, Chen J, Theodosiou M, Carvalho JE, Alvarez S, de Lera AR, Holland L, Schubert M. Roles of retinoic acid and Tbx1/10 in pharyngeal segmentation: amphioxus and the ancestral chordate condition. Evodevo. 2014; 5(1):36. PMID: 25664163; PMCID: PMC4320481.
      9. Yue JX, Yu JK, Putnam NH, Holland L. The transcriptome of an amphioxus, Asymmetron lucayanum, from the Bahamas: a window into chordate evolution. Genome Biol Evol. 2014 Sep 19; 6(10):2681-96. PMID: 25240057; PMCID: PMC4224339.
      10. Striedter GF, Belgard TG, Chen CC, Davis FP, Finlay BL, Güntürkün O, Hale ME, Harris JA, Hecht EE, Hof PR, Hofmann HA, Holland L, Iwaniuk AN, Jarvis ED, Karten HJ, Katz PS, Kristan WB, Macagno ER, Mitra PP, Moroz LL, Preuss TM, Ragsdale CW, Sherwood CC, Stevens CF, Stüttgen MC, Tsumoto T, Wilczynski W. NSF workshop report: discovering general principles of nervous system organization by comparing brain maps across species. J Comp Neurol. 2014 May 01; 522(7):1445-53. PMID: 24596113.
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      11. Holland L. Genomics, evolution and development of amphioxus and tunicates: The Goldilocks principle. J Exp Zool B Mol Dev Evol. 2015 Jun; 324(4):342-52. PMID: 24665055.
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      12. Striedter GF, Belgard TG, Chen CC, Davis FP, Finlay BL, Güntürkün O, Hale ME, Harris JA, Hecht EE, Hof PR, Hofmann HA, Holland L, Iwaniuk AN, Jarvis ED, Karten HJ, Katz PS, Kristan WB, Macagno ER, Mitra PP, Moroz LL, Preuss TM, Ragsdale CW, Sherwood CC, Stevens CF, Stüttgen MC, Tsumoto T, Wilczynski W. NSF workshop report: discovering general principles of nervous system organization by comparing brain maps across species. Brain Behav Evol. 2014; 83(1):1-8. PMID: 24603302; PMCID: PMC4028317.
      13. Holland L, Carvalho JE, Escriva H, Laudet V, Schubert M, Shimeld SM, Yu JK. Evolution of bilaterian central nervous systems: a single origin? Evodevo. 2013 Oct 07; 4(1):27. PMID: 24098981; PMCID: PMC3856589.
      14. Holland L. Evolution of new characters after whole genome duplications: insights from amphioxus. Semin Cell Dev Biol. 2013 Feb; 24(2):101-9. PMID: 23291260.
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      15. Short S, Kozmik Z, Holland L. The function and developmental expression of alternatively spliced isoforms of amphioxus and Xenopus laevis Pax2/5/8 genes: revealing divergence at the invertebrate to vertebrate transition. J Exp Zool B Mol Dev Evol. 2012 Nov; 318(7):555-71. PMID: 22791613.
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      16. Onai T, Takai A, Setiamarga DH, Holland L. Essential role of Dkk3 for head formation by inhibiting Wnt/ß-catenin and Nodal/Vg1 signaling pathways in the basal chordate amphioxus. Evol Dev. 2012 Jul; 14(4):338-50. PMID: 22765205.
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      17. Holland L. Amphioxus genomics. Brief Funct Genomics. 2012 Mar; 11(2):87-8. PMID: 22441552.
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      18. Holland L, Onai T. Early development of cephalochordates (amphioxus). Wiley Interdiscip Rev Dev Biol. 2012 Mar-Apr; 1(2):167-83. PMID: 23801434.
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      19. Koop D, Holland L, Setiamarga D, Schubert M, Holland ND. Tail regression induced by elevated retinoic acid signaling in amphioxus larvae occurs by tissue remodeling, not cell death. Evol Dev. 2011 Sep-Oct; 13(5):427-35. PMID: 23016904.
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      20. Wu HR, Chen YT, Su YH, Luo YJ, Holland L, Yu JK. Asymmetric localization of germline markers Vasa and Nanos during early development in the amphioxus Branchiostoma floridae. Dev Biol. 2011 May 01; 353(1):147-59. PMID: 21354126.
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      21. Holland L, Onai T. Analyses of gene function in amphioxus embryos by microinjection of mRNAs and morpholino oligonucleotides. Methods Mol Biol. 2011; 770:423-38. PMID: 21805274.
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      22. Holland ND, Holland L. Laboratory spawning and development of the Bahama lancelet, Asymmetron lucayanum (cephalochordata): fertilization through feeding larvae. Biol Bull. 2010 Oct; 219(2):132-41. PMID: 20972258.
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      23. Onai T, Yu JK, Blitz IL, Cho KW, Holland L. Opposing Nodal/Vg1 and BMP signals mediate axial patterning in embryos of the basal chordate amphioxus. Dev Biol. 2010 Aug 01; 344(1):377-89. PMID: 20488174; PMCID: PMC4781670.
      24. Holland L, Short S. Alternative splicing in development and function of chordate endocrine systems: a focus on Pax genes. Integr Comp Biol. 2010 Jul; 50(1):22-34. PMID: 21558185.
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      25. Holland L, Sower SA. "Insights of early chordate genomics: endocrinology and development in amphioxus, tunicates and lampreys": introduction to the symposium. Integr Comp Biol. 2010 Jul; 50(1):17-21. PMID: 21558184.
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      26. Holland L. Bio. Evol Dev. 2010 Mar-Apr; 12(2):109-12. PMID: 20433452.
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      27. Koop D, Holland ND, Sémon M, Alvarez S, de Lera AR, Laudet V, Holland L, Schubert M. Retinoic acid signaling targets Hox genes during the amphioxus gastrula stage: insights into early anterior-posterior patterning of the chordate body plan. Dev Biol. 2010 Feb 01; 338(1):98-106. PMID: 19914237.
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      28. Mathews A, Holland L, Yankulov K. The interaction between EAP30 and ELL is modulated by MCM2. FEBS Lett. 2009 Nov 03; 583(21):3431-6. PMID: 19819239.
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      29. Holland L. Chordate roots of the vertebrate nervous system: expanding the molecular toolkit. Nat Rev Neurosci. 2009 Oct; 10(10):736-46. PMID: 19738625.
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      30. Yu JK, Holland L. Extraction of DNA from adult amphioxus tissue. Cold Spring Harb Protoc. 2009 Sep; 2009(9):pdb.prot5287. PMID: 20147272.
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      31. Yu JK, Holland L. Extraction of RNA from small amounts of amphioxus embryos for cDNA synthesis by RT-PCR. Cold Spring Harb Protoc. 2009 Sep; 2009(9):pdb.prot5289. PMID: 20147274.
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      32. Yu JK, Holland L. Amphioxus whole-mount in situ hybridization. Cold Spring Harb Protoc. 2009 Sep; 2009(9):pdb.prot5286. PMID: 20147271.
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      33. Yu JK, Holland L. Extraction of RNA from amphioxus embryos or adult amphioxus tissue. Cold Spring Harb Protoc. 2009 Sep; 2009(9):pdb.prot5288. PMID: 20147273.
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      34. Yu JK, Holland L. Cephalochordates (amphioxus or lancelets): a model for understanding the evolution of chordate characters. Cold Spring Harb Protoc. 2009 Sep; 2009(9):pdb.emo130. PMID: 20147258.
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      35. Yu JK, Holland L. Amphioxus (Branchiostoma floridae) spawning and embryo collection. Cold Spring Harb Protoc. 2009 Sep; 2009(9):pdb.prot5285. PMID: 20147270.
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      36. Onai T, Lin HC, Schubert M, Koop D, Osborne PW, Alvarez S, Alvarez R, Holland ND, Holland L. Retinoic acid and Wnt/beta-catenin have complementary roles in anterior/posterior patterning embryos of the basal chordate amphioxus. Dev Biol. 2009 Aug 15; 332(2):223-33. PMID: 19497318.
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      37. Kaltenbach SL, Holland L, Holland ND, Koop D. Developmental expression of the three iroquois genes of amphioxus (BfIrxA, BfIrxB, and BfIrxC) with special attention to the gastrula organizer and anteroposterior boundaries in the central nervous system. Gene Expr Patterns. 2009 Jun; 9(5):329-34. PMID: 19233318.
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      38. Beaster-Jones L, Kaltenbach SL, Koop D, Yuan S, Chastain R, Holland L. Expression of somite segmentation genes in amphioxus: a clock without a wavefront? Dev Genes Evol. 2008 Dec; 218(11-12):599-611. PMID: 18949486.
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      39. Holland L, Short S. Gene duplication, co-option and recruitment during the origin of the vertebrate brain from the invertebrate chordate brain. Brain Behav Evol. 2008; 72(2):91-105. PMID: 18836256.
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      40. Yu JK, Wang MC, Shin-I T, Kohara Y, Holland L, Satoh N, Satou Y. A cDNA resource for the cephalochordate amphioxus Branchiostoma floridae. Dev Genes Evol. 2008 Dec; 218(11-12):723-7. PMID: 18773220.
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      41. Koop D, Holland L. The basal chordate amphioxus as a simple model for elucidating developmental mechanisms in vertebrates. Birth Defects Res C Embryo Today. 2008 Sep; 84(3):175-87. PMID: 18773463.
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      42. Holland L, Holland ND, Gilland E. Amphioxus and the evolution of head segmentation. Integr Comp Biol. 2008 Nov; 48(5):630-46. PMID: 21669822.
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      43. Putnam NH, Butts T, Ferrier DE, Furlong RF, Hellsten U, Kawashima T, Robinson-Rechavi M, Shoguchi E, Terry A, Yu JK, Benito-Gutiérrez EL, Dubchak I, Garcia-Fernàndez J, Gibson-Brown JJ, Grigoriev IV, Horton AC, de Jong PJ, Jurka J, Kapitonov VV, Kohara Y, Kuroki Y, Lindquist E, Lucas S, Osoegawa K, Pennacchio LA, Salamov AA, Satou Y, Sauka-Spengler T, Schmutz J, Shin-I T, Toyoda A, Bronner-Fraser M, Fujiyama A, Holland L, Holland PW, Satoh N, Rokhsar DS. The amphioxus genome and the evolution of the chordate karyotype. Nature. 2008 Jun 19; 453(7198):1064-71. PMID: 18563158.
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      44. Holland L, Albalat R, Azumi K, Benito-Gutiérrez E, Blow MJ, Bronner-Fraser M, Brunet F, Butts T, Candiani S, Dishaw LJ, Ferrier DE, Garcia-Fernàndez J, Gibson-Brown JJ, Gissi C, Godzik A, Hallböök F, Hirose D, Hosomichi K, Ikuta T, Inoko H, Kasahara M, Kasamatsu J, Kawashima T, Kimura A, Kobayashi M, Kozmik Z, Kubokawa K, Laudet V, Litman GW, McHardy AC, Meulemans D, Nonaka M, Olinski RP, Pancer Z, Pennacchio LA, Pestarino M, Rast JP, Rigoutsos I, Robinson-Rechavi M, Roch G, Saiga H, Sasakura Y, Satake M, Satou Y, Schubert M, Sherwood N, Shiina T, Takatori N, Tello J, Vopalensky P, Wada S, Xu A, Ye Y, Yoshida K, Yoshizaki F, Yu JK, Zhang Q, Zmasek CM, de Jong PJ, Osoegawa K, Putnam NH, Rokhsar DS, Satoh N, Holland PW. The amphioxus genome illuminates vertebrate origins and cephalochordate biology. Genome Res. 2008 Jul; 18(7):1100-11. PMID: 18562680; PMCID: PMC2493399.
      45. Short S, Holland L. The evolution of alternative splicing in the Pax family: the view from the Basal chordate amphioxus. J Mol Evol. 2008 Jun; 66(6):605-20. PMID: 18473110.
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      46. Holland L, Holland ND. A revised fate map for amphioxus and the evolution of axial patterning in chordates. Integr Comp Biol. 2007 Sep; 47(3):360-72. PMID: 21672845.
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      47. Beaster-Jones L, Schubert M, Holland L. Cis-regulation of the amphioxus engrailed gene: insights into evolution of a muscle-specific enhancer. Mech Dev. 2007 Aug; 124(7-8):532-42. PMID: 17624741.
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      48. Holland L. Developmental biology: a chordate with a difference. Nature. 2007 May 10; 447(7141):153-5. PMID: 17495912.
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      49. Kozmik Z, Holland ND, Kreslova J, Oliveri D, Schubert M, Jonasova K, Holland L, Pestarino M, Benes V, Candiani S. Pax-Six-Eya-Dach network during amphioxus development: conservation in vitro but context specificity in vivo. Dev Biol. 2007 Jun 01; 306(1):143-59. PMID: 17477914.
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      50. Rasmussen SL, Holland L, Schubert M, Beaster-Jones L, Holland ND. Amphioxus AmphiDelta: evolution of Delta protein structure, segmentation, and neurogenesis. Genesis. 2007 Mar; 45(3):113-22. PMID: 17299746.
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      51. Yu JK, Satou Y, Holland ND, Shin-I T, Kohara Y, Satoh N, Bronner-Fraser M, Holland L. Axial patterning in cephalochordates and the evolution of the organizer. Nature. 2007 Feb 08; 445(7128):613-7. PMID: 17237766.
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      52. Lin HC, Holland L, Holland ND. Expression of the AmphiTcf gene in amphioxus: insights into the evolution of the TCF/LEF gene family during vertebrate evolution. Dev Dyn. 2006 Dec; 235(12):3396-403. PMID: 17013891.
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      53. Escriva H, Bertrand S, Germain P, Robinson-Rechavi M, Umbhauer M, Cartry J, Duffraisse M, Holland L, Gronemeyer H, Laudet V. Neofunctionalization in vertebrates: the example of retinoic acid receptors. PLoS Genet. 2006 Jul; 2(7):e102. PMID: 16839186; PMCID: PMC1500811.
      54. Castro LF, Rasmussen SL, Holland PW, Holland ND, Holland L. A Gbx homeobox gene in amphioxus: insights into ancestry of the ANTP class and evolution of the midbrain/hindbrain boundary. Dev Biol. 2006 Jul 01; 295(1):40-51. PMID: 16687133.
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      55. Langeland JA, Holland L, Chastain RA, Holland ND. An amphioxus LIM-homeobox gene, AmphiLim1/5, expressed early in the invaginating organizer region and later in differentiating cells of the kidney and central nervous system. Int J Biol Sci. 2006; 2(3):110-6. PMID: 16763670; PMCID: PMC1458433.
      56. Schubert M, Holland ND, Laudet V, Holland L. A retinoic acid-Hox hierarchy controls both anterior/posterior patterning and neuronal specification in the developing central nervous system of the cephalochordate amphioxus. Dev Biol. 2006 Aug 01; 296(1):190-202. PMID: 16750825.
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      57. Holland L. A SINE in the genome of the cephalochordate amphioxus is an Alu element. Int J Biol Sci. 2006; 2(2):61-5. PMID: 16733535; PMCID: PMC1458429.
      58. Marlétaz F, Holland L, Laudet V, Schubert M. Retinoic acid signaling and the evolution of chordates. Int J Biol Sci. 2006; 2(2):38-47. PMID: 16733532; PMCID: PMC1458431.
      59. Beaster-Jones L, Horton AC, Gibson-Brown JJ, Holland ND, Holland L. The amphioxus T-box gene, AmphiTbx15/18/22, illuminates the origins of chordate segmentation. Evol Dev. 2006 Mar-Apr; 8(2):119-29. PMID: 16509891.
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      60. Holland ND, Holland L. Stage- and tissue-specific patterns of cell division in embryonic and larval tissues of amphioxus during normal development. Evol Dev. 2006 Mar-Apr; 8(2):142-9. PMID: 16509893.
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      61. Holland L, Panfilio KA, Chastain R, Schubert M, Holland ND. Nuclear beta-catenin promotes non-neural ectoderm and posterior cell fates in amphioxus embryos. Dev Dyn. 2005 Aug; 233(4):1430-43. PMID: 15973712.
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      62. Holland L. Non-neural ectoderm is really neural: evolution of developmental patterning mechanisms in the non-neural ectoderm of chordates and the problem of sensory cell homologies. J Exp Zool B Mol Dev Evol. 2005 Jul 15; 304(4):304-23. PMID: 15834938.
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      63. Bardet PL, Schubert M, Horard B, Holland L, Laudet V, Holland ND, Vanacker JM. Expression of estrogen-receptor related receptors in amphioxus and zebrafish: implications for the evolution of posterior brain segmentation at the invertebrate-to-vertebrate transition. Evol Dev. 2005 May-Jun; 7(3):223-33. PMID: 15876195.
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      64. Schubert M, Yu JK, Holland ND, Escriva H, Laudet V, Holland L. Retinoic acid signaling acts via Hox1 to establish the posterior limit of the pharynx in the chordate amphioxus. Development. 2005 Jan; 132(1):61-73. PMID: 15576409.
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      65. Yu JK, Holland ND, Holland L. Tissue-specific expression of FoxD reporter constructs in amphioxus embryos. Dev Biol. 2004 Oct 15; 274(2):452-61. PMID: 15385171.
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      66. Holland L, Laudet V, Schubert M. The chordate amphioxus: an emerging model organism for developmental biology. Cell Mol Life Sci. 2004 Sep; 61(18):2290-308. PMID: 15378201.
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      67. Schubert M, Holland ND, Escriva H, Holland L, Laudet V. Retinoic acid influences anteroposterior positioning of epidermal sensory neurons and their gene expression in a developing chordate (amphioxus). Proc Natl Acad Sci U S A. 2004 Jul 13; 101(28):10320-5. PMID: 15226493; PMCID: PMC478570.
      68. Holland L, Yu JK. Cephalochordate (amphioxus) embryos: procurement, culture, and basic methods. Methods Cell Biol. 2004; 74:195-215. PMID: 15575608.
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      69. Gibson-Brown JJ, Osoegawa K, McPherson JD, Waterston RH, De Jong PJ, Rokhsar DS, Holland L. A proposal to sequence the amphioxus genome submitted to the Joint Genome Institute of the US Department of Energy. J Exp Zool B Mol Dev Evol. 2003 Dec 15; 300(1):5-22. PMID: 14984031.
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      70. Mazet F, Yu JK, Liberles DA, Holland L, Shimeld SM. Phylogenetic relationships of the Fox (Forkhead) gene family in the Bilateria. Gene. 2003 Oct 16; 316:79-89. PMID: 14563554.
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      71. Holland L, Gibson-Brown JJ. The Ciona intestinalis genome: when the constraints are off. Bioessays. 2003 Jun; 25(6):529-32. PMID: 12766941.
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      72. Schubert M, Meulemans D, Bronner-Fraser M, Holland L, Holland ND. Differential mesodermal expression of two amphioxus MyoD family members (AmphiMRF1 and AmphiMRF2). Gene Expr Patterns. 2003 May; 3(2):199-202. PMID: 12711549.
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      73. Holland ND, Venkatesh TV, Holland L, Jacobs DK, Bodmer R. AmphiNk2-tin, an amphioxus homeobox gene expressed in myocardial progenitors: insights into evolution of the vertebrate heart. Dev Biol. 2003 Mar 01; 255(1):128-37. PMID: 12618138.
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      74. Yu JK, Holland ND, Holland L. AmphiFoxQ2, a novel winged helix/forkhead gene, exclusively marks the anterior end of the amphioxus embryo. Dev Genes Evol. 2003 Mar; 213(2):102-5. PMID: 12632180.
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      75. Holland L, Gauthier L, Bell-Rogers P, Yankulov K. Distinct parts of minichromosome maintenance protein 2 associate with histone H3/H4 and RNA polymerase II holoenzyme. Eur J Biochem. 2002 Nov; 269(21):5192-202. PMID: 12392551.
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      76. Yu JK, Holland L, Holland ND. An amphioxus nodal gene (AmphiNodal) with early symmetrical expression in the organizer and mesoderm and later asymmetrical expression associated with left-right axis formation. Evol Dev. 2002 Nov-Dec; 4(6):418-25. PMID: 12492142.
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      77. Yu JK, Holland ND, Holland L. An amphioxus winged helix/forkhead gene, AmphiFoxD: insights into vertebrate neural crest evolution. Dev Dyn. 2002 Nov; 225(3):289-97. PMID: 12412011.
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      78. Escriva H, Holland ND, Gronemeyer H, Laudet V, Holland L. The retinoic acid signaling pathway regulates anterior/posterior patterning in the nerve cord and pharynx of amphioxus, a chordate lacking neural crest. Development. 2002 Jun; 129(12):2905-16. PMID: 12050138.
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      79. Holland L. Heads or tails? Amphioxus and the evolution of anterior-posterior patterning in deuterostomes. Dev Biol. 2002 Jan 15; 241(2):209-28. PMID: 11784106.
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      80. Krelová J, Holland L, Schubert M, Burgtorf C, Benes V, Kozmik Z. Functional equivalency of amphioxus and vertebrate Pax258 transcription factors suggests that the activation of mid-hindbrain specific genes in vertebrates occurs via the recruitment of Pax regulatory elements. Gene. 2002 Jan 09; 282(1-2):143-50. PMID: 11814686.
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      81. Yu JK, Holland L, Jamrich M, Blitz IL, Hollan ND. AmphiFoxE4, an amphioxus winged helix/forkhead gene encoding a protein closely related to vertebrate thyroid transcription factor-2: expression during pharyngeal development. Evol Dev. 2002 Jan-Feb; 4(1):9-15. PMID: 11868660.
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      82. Schubert M, Holland L, Stokes MD, Holland ND. Three amphioxus Wnt genes (AmphiWnt3, AmphiWnt5, and AmphiWnt6) associated with the tail bud: the evolution of somitogenesis in chordates. Dev Biol. 2001 Dec 01; 240(1):262-73. PMID: 11784062.
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      83. Holland L, Holland ND. Evolution of neural crest and placodes: amphioxus as a model for the ancestral vertebrate? J Anat. 2001 Jul-Aug; 199(Pt 1-2):85-98. PMID: 11523831; PMCID: PMC1594956.
      84. Holland L, Rached LA, Tamme R, Holland ND, Kortschak D, Inoko H, Shiina T, Burgtorf C, Lardelli M. Characterization and developmental expression of the amphioxus homolog of Notch (AmphiNotch): evolutionary conservation of multiple expression domains in amphioxus and vertebrates. Dev Biol. 2001 Apr 15; 232(2):493-507. PMID: 11401408.
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      85. Kozmik Z, Holland L, Schubert M, Lacalli TC, Kreslova J, Vlcek C, Holland ND. Characterization of Amphioxus AmphiVent, an evolutionarily conserved marker for chordate ventral mesoderm. Genesis. 2001 Apr; 29(4):172-9. PMID: 11309850.
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      86. Schubert M, Holland L, Holland ND, Jacobs DK. A phylogenetic tree of the Wnt genes based on all available full-length sequences, including five from the cephalochordate amphioxus. Mol Biol Evol. 2000 Dec; 17(12):1896-903. PMID: 11110906.
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      87. Holland L, Schubert M, Holland ND, Neuman T. Evolutionary conservation of the presumptive neural plate markers AmphiSox1/2/3 and AmphiNeurogenin in the invertebrate chordate amphioxus. Dev Biol. 2000 Oct 01; 226(1):18-33. PMID: 10993671.
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      88. Langlois MC, Vanacker JM, Holland ND, Escriva H, Queva C, Laudet V, Holland L. Amphicoup-TF, a nuclear orphan receptor of the lancelet Branchiostoma floridae, is implicated in retinoic acid signalling pathways. Dev Genes Evol. 2000 Oct; 210(10):471-82. PMID: 11180796.
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      89. Holland L, Holland NN, Schubert M. Developmental expression of AmphiWnt1, an amphioxus gene in the Wnt1/wingless subfamily. Dev Genes Evol. 2000 Oct; 210(10):522-4. PMID: 11180802.
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      90. Holland L. Body-plan evolution in the Bilateria: early antero-posterior patterning and the deuterostome-protostome dichotomy. Curr Opin Genet Dev. 2000 Aug; 10(4):434-42. PMID: 10889057.
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      91. Schubert M, Holland L, Holland ND. Characterization of an amphioxus wnt gene, AmphiWnt11, with possible roles in myogenesis and tail outgrowth. Genesis. 2000 May; 27(1):1-5. PMID: 10862149.
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      92. Schubert M, Holland L, Panopoulou GD, Lehrach H, Holland ND. Characterization of amphioxus AmphiWnt8: insights into the evolution of patterning of the embryonic dorsoventral axis. Evol Dev. 2000 Mar-Apr; 2(2):85-92. PMID: 11258394.
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      93. Schubert M, Holland L, Holland ND. Characterization of two amphioxus Wnt genes (AmphiWnt4 and AmphiWnt7b) with early expression in the developing central nervous system. Dev Dyn. 2000 Feb; 217(2):205-15. PMID: 10706144.
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      94. Holland L, Schubert M, Kozmik Z, Holland ND. AmphiPax3/7, an amphioxus paired box gene: insights into chordate myogenesis, neurogenesis, and the possible evolutionary precursor of definitive vertebrate neural crest. Evol Dev. 1999 Nov-Dec; 1(3):153-65. PMID: 11324100.
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      95. Holland L, Holland ND. Chordate origins of the vertebrate central nervous system. Curr Opin Neurobiol. 1999 Oct; 9(5):596-602. PMID: 10508734.
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      96. Venkatesh TV, Holland ND, Holland L, Su MT, Bodmer R. Sequence and developmental expression of amphioxus AmphiNk2-1: insights into the evolutionary origin of the vertebrate thyroid gland and forebrain. Dev Genes Evol. 1999 Apr; 209(4):254-9. PMID: 10079369.
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      97. Kozmik Z, Holland ND, Kalousova A, Paces J, Schubert M, Holland L. Characterization of an amphioxus paired box gene, AmphiPax2/5/8: developmental expression patterns in optic support cells, nephridium, thyroid-like structures and pharyngeal gill slits, but not in the midbrain-hindbrain boundary region. Development. 1999 Mar; 126(6):1295-304. PMID: 10021347.
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      98. Kusakabe R, Satoh N, Holland L, Kusakabe T. Genomic organization and evolution of actin genes in the amphioxus Branchiostoma belcheri and Branchiostoma floridae. Gene. 1999 Feb 04; 227(1):1-10. PMID: 9931404.
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      99. Panopoulou GD, Clark MD, Holland L, Lehrach H, Holland ND. AmphiBMP2/4, an amphioxus bone morphogenetic protein closely related to Drosophila decapentaplegic and vertebrate BMP2 and BMP4: insights into evolution of dorsoventral axis specification. Dev Dyn. 1998 Sep; 213(1):130-9. PMID: 9733108.
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      100. Glardon S, Holland L, Gehring WJ, Holland ND. Isolation and developmental expression of the amphioxus Pax-6 gene (AmphiPax-6): insights into eye and photoreceptor evolution. Development. 1998 Jul; 125(14):2701-10. PMID: 9636084.
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      101. Holland L, Venkatesh TV, Gorlin A, Bodmer R, Holland ND. Characterization and developmental expression of AmphiNk2-2, an NK2 class homeobox gene from Amphioxus. (Phylum Chordata; Subphylum Cephalochordata). Dev Genes Evol. 1998 Apr; 208(2):100-5. PMID: 9569351.
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      102. Kusakabe R, Kusakabe T, Satoh N, Holland ND, Holland L. Differential gene expression and intracellular mRNA localization of amphioxus actin isoforms throughout development: Implications for conserved mechanisms of chordate development. Dev Genes Evol. 1997 Oct; 207(4):203-215. PMID: 27747419.
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      103. Holland ND, Zhang SC, Clark M, Panopoulou G, Lehrach H, Holland L. Sequence and developmental expression of AmphiTob, an amphioxus homolog of vertebrate Tob in the PC3/BTG1/Tob family of tumor suppressor genes. Dev Dyn. 1997 Sep; 210(1):11-8. PMID: 9286591.
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      104. Holland L, Kene M, Williams NA, Holland ND. Sequence and embryonic expression of the amphioxus engrailed gene (AmphiEn): the metameric pattern of transcription resembles that of its segment-polarity homolog in Drosophila. Development. 1997 May; 124(9):1723-32. PMID: 9165120.
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      105. Zhang SC, Holland ND, Holland L. Topographic changes in nascent and early mesoderm in amphioxus embryos studied by DiI labeling and by in situ hybridization for a Brachyury gene. Dev Genes Evol. 1997 May; 206(8):532-535. PMID: 27747379.
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      106. Holland L, McFall-Ngai M, Somero GN. Evolution of lactate dehydrogenase-A homologs of barracuda fishes (genus Sphyraena) from different thermal environments: differences in kinetic properties and thermal stability are due to amino acid substitutions outside the active site. Biochemistry. 1997 Mar 18; 36(11):3207-15. PMID: 9115998.
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      107. Holland ND, Panganiban G, Henyey EL, Holland L. Sequence and developmental expression of AmphiDll, an amphioxus Distal-less gene transcribed in the ectoderm, epidermis and nervous system: insights into evolution of craniate forebrain and neural crest. Development. 1996 Sep; 122(9):2911-20. PMID: 8787764.
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      108. Holland L, Holland ND. Expression of AmphiHox-1 and AmphiPax-1 in amphioxus embryos treated with retinoic acid: insights into evolution and patterning of the chordate nerve cord and pharynx. Development. 1996 Jun; 122(6):1829-38. PMID: 8674422.
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      109. Holland PW, Koschorz B, Holland L, Herrmann BG. Conservation of Brachyury (T) genes in amphioxus and vertebrates: developmental and evolutionary implications. Development. 1995 Dec; 121(12):4283-91. PMID: 8575328.
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      110. Holland L, Pace DA, Blink ML, Kene M, Holland ND. Sequence and expression of amphioxus alkali myosin light chain (AmphiMLC-alk) throughout development: implications for vertebrate myogenesis. Dev Biol. 1995 Oct; 171(2):665-76. PMID: 7556945.
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      111. Holland ND, Holland L, Kozmik Z. An amphioxus Pax gene, AmphiPax-1, expressed in embryonic endoderm, but not in mesoderm: implications for the evolution of class I paired box genes. Mol Mar Biol Biotechnol. 1995 Sep; 4(3):206-14. PMID: 7670596.
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      112. Holland PW, Holland L, Williams NA, Holland ND. An amphioxus homeobox gene: sequence conservation, spatial expression during development and insights into vertebrate evolution. Development. 1992 Nov; 116(3):653-61. PMID: 1363226.
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      113. Fujimura Y, Holland L, Ruggeri ZM, Zimmerman TS. The von willebrand factor domain-mediating botrocetin-induced binding to glycoprotein IB lies between Val449 and Lys728. Blood. 1987 Oct; 70(4):985-8. PMID: 3498523.
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      114. Fujimura Y, Titani K, Holland L, Roberts JR, Kostel P, Ruggeri ZM, Zimmerman TS. A heparin-binding domain of human von Willebrand factor. Characterization and localization to a tryptic fragment extending from amino acid residue Val-449 to Lys-728. J Biol Chem. 1987 Feb 05; 262(4):1734-9. PMID: 3100536.
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      115. Pareti FI, Fujimura Y, Dent JA, Holland L, Zimmerman TS, Ruggeri ZM. Isolation and characterization of a collagen binding domain in human von Willebrand factor. J Biol Chem. 1986 Nov 15; 261(32):15310-5. PMID: 3490481.
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      116. Cross NL, Slezynger TC, Holland L. Isolation and partial characterization of Urechis caupo egg envelopes. J Cell Sci. 1985 Mar; 74:193-205. PMID: 4040920.
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      117. Gould M, Holland L. Fertilization acid release in Urechis eggs. II. The stoichiometry of Na+ uptake and H+ release. Dev Biol. 1984 Aug; 104(2):329-35. PMID: 6086428.
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      118. Holland L, Gould-Somero M, Paul M. Fertilization acid release in Urechis eggs. I. The nature of the acid and the dependence of acid release and egg activation on external pH. Dev Biol. 1984 Jun; 103(2):337-42. PMID: 6327433.
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      119. Holland L, Cross NL. The pH within the jelly coat of sea urchin eggs. Dev Biol. 1983 Sep; 99(1):258-60. PMID: 6684606.
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      120. Holland L, Gould-Somero M. Fertilization acid of sea urchin eggs: evidence that it is H+, not CO2. Dev Biol. 1982 Aug; 92(2):549-52. PMID: 6811353.
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      121. Jaffe LA, Gould-Somero M, Holland L. Studies of the mechanism of the electrical polyspermy block using voltage clamp during cross-species fertilization. J Cell Biol. 1982 Mar; 92(3):616-21. PMID: 7085751; PMCID: PMC2112040.
      122. Gould-Somero M, Jaffe LA, Holland L. Electrically mediated fast polyspermy block in eggs of the marine worm, Urechis caupo. J Cell Biol. 1979 Aug; 82(2):426-40. PMID: 39082; PMCID: PMC2110452.
      123. Jaffe LA, Gould-Somero M, Holland L. Ionic mechanism of the fertilization potential of the marine worm, Urechis caupo (Echiura). J Gen Physiol. 1979 Apr; 73(4):469-92. PMID: 571895; PMCID: PMC2215169.
      124. Gould-Somero M, Holland L, Paul M. Cytochalasin B inhibits sperm penetration into eggs of Urechis caupo (Echiura). Dev Biol. 1977 Jul 01; 58(1):11-22. PMID: 559601.
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      125. Gould-Somero M, Holland L. Oocyte differentiation in Urechis caupo (Echiura): a fine structural study. J Morphol. 1975 Dec; 147(4):475-505. PMID: 1202226.
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      126. Gould-Somero M, Holland L. Fine structural investigation of the insemination response in Urechis caupo. Dev Biol. 1975 Oct; 46(2):358-69. PMID: 1242380.
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      127. Gould-Somero M, Hardy R, Holland L. The Y chromosome and sperm length in D. melanogaster. Exp Cell Res. 1974 Aug; 87(2):397-8. PMID: 4213495.
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      128. Gould-Somero M, Holland L. The timing of RNA synthesis for spermiogenesis in organ cultures ofDrosophila melanogaster testes. Wilhelm Roux Arch Entwickl Mech Org. 1974 Jun; 174(2):133-148. PMID: 28305043.
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