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Mutations in the SARS-CoV-2 RNA dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms. Sci Transl Med. 2022 Apr 28; eabo0718.
Stevens LJ, Pruijssers AJ, Lee HW, Gordon CJ, Tchesnokov EP, Gribble J, George AS, Hughes TM, Lu X, Li J, Perry JK, Porter DP, Cihlar T, Sheahan TP, Baric RS, Götte M, Denison MR. PMID: 35482820.
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Standardized two-step testing of antibody activity in COVID-19 convalescent plasma. iScience. 2022 Jan 21; 25(1):103602.
Gilchuk P, Thomsen I, Yoder S, Brady E, Chappell JD, Stevens LJ, Denison MR, Sutton RE, Chen RE, VanBlargan LA, Suryadevara N, Zost SJ, Schmitz J, Pulley JM, Diamond MS, Rhoads JP, Bernard GR, Self WH, Rice TW, Wheeler AP, Crowe JE, Carnahan RH. PMID: 34901783; PMCID: PMC8653399.
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Stabilized coronavirus spike stem elicits a broadly protective antibody. Cell Rep. 2021 11 02; 37(5):109929.
Hsieh CL, Werner AP, Leist SR, Stevens LJ, Falconer E, Goldsmith JA, Chou CW, Abiona OM, West A, Westendorf K, Muthuraman K, Fritch EJ, Dinnon KH, Schäfer A, Denison MR, Chappell JD, Baric RS, Graham BS, Corbett KS, McLellan JS. PMID: 34710354; PMCID: PMC8519809.
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Durability of mRNA-1273 vaccine-induced antibodies against SARS-CoV-2 variants. Science. 2021 Sep 17; 373(6561):1372-1377.
Pegu A, O'Connell SE, Schmidt SD, O'Dell S, Talana CA, Lai L, Albert J, Anderson E, Bennett H, Corbett KS, Flach B, Jackson L, Leav B, Ledgerwood JE, Luke CJ, Makowski M, Nason MC, Roberts PC, Roederer M, Rebolledo PA, Rostad CA, Rouphael NG, Shi W, Wang L, Widge AT, Yang ES, mRNA-1273 Study Group§, Beigel JH, Graham BS, Mascola JR, Suthar MS, McDermott AB, Doria-Rose NA, Arega J, Beigel JH, Buchanan W, Elsafy M, Hoang B, Lampley R, Kolhekar A, Koo H, Luke C, Makhene M, Nayak S, Pikaart-Tautges R, Roberts PC, Russell J, Sindall E, Albert J, Kunwar P, Makowski M, Anderson EJ, Bechnak A, Bower M, Camacho-Gonzalez AF, Collins M, Drobeniuc A, Edara VV, Edupuganti S, Floyd K, Gibson T, Ackerley CMG, Johnson B, Kamidani S, Kao C, Kelley C, Lai L, Macenczak H, McCullough MP, Peters E, Phadke VK, Rebolledo PA, Rostad CA, Rouphael N, Scherer E, Sherman A, Stephens K, Suthar MS, Teherani M, Traenkner J, Winston J, Yildirim I, Barr L, Benoit J, Carste B, Choe J, Dunstan M, Erolin R, Ffitch J, Fields C, Jackson LA, Kiniry E, Lasicka S, Lee S, Nguyen M, Pimienta S, Suyehira J, Witte M, Bennett H, Altaras NE, Carfi A, Hurley M, Leav B, Pajon R, Sun W, Zaks T, Coler RN, Larsen SE, Neuzil KM, Lindesmith LC, Martinez DR, Munt J, Mallory M, Edwards C, Baric RS, Berkowitz NM, Boritz EA, Carlton K, Corbett KS, Costner P, Creanga A, Doria-Rose NA, Douek DC, Flach B, Gaudinski M, Gordon I, Graham BS, Holman L, Ledgerwood JE, Leung K, Lin BC, Louder MK, Mascola JR, McDermott AB, Morabito KM, Novik L, O'Connell S, O'Dell S, Padilla M, Pegu A, Schmidt SD, Shi W, Swanson PA, Talana CA, Wang L, Widge AT, Yang ES, Zhang Y, Chappell JD, Denison MR, Hughes T, Lu X, Pruijssers AJ, Stevens LJ, Posavad CM, Gale M, Menachery V, Shi PY. PMID: 34385356; PMCID: PMC8691522.
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11 Fields:
Translation:
Humans
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Creative Technology-Based Strategies for Engaging Young People with Serious Mental Health Conditions in Longitudinal Mental Health Services Research. Child Adolesc Social Work J. 2021 Jun 17; 1-12.
Londoño T, Klodnick VV, Emerson KR, Stevens L, Cohen DA. PMID: 34155420; PMCID: PMC8210497.
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The coronavirus proofreading exoribonuclease mediates extensive viral recombination. PLoS Pathog. 2021 01; 17(1):e1009226.
Gribble J, Stevens LJ, Agostini ML, Anderson-Daniels J, Chappell JD, Lu X, Pruijssers AJ, Routh AL, Denison MR. PMID: 33465137; PMCID: PMC7846108.
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27 Fields:
Translation:
Humans
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Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination. N Engl J Med. 2021 01 07; 384(1):80-82.
Widge AT, Rouphael NG, Jackson LA, Anderson EJ, Roberts PC, Makhene M, Chappell JD, Denison MR, Stevens LJ, Pruijssers AJ, McDermott AB, Flach B, Lin BC, Doria-Rose NA, O'Dell S, Schmidt SD, Neuzil KM, Bennett H, Leav B, Makowski M, Albert J, Cross K, Edara VV, Floyd K, Suthar MS, Buchanan W, Luke CJ, Ledgerwood JE, Mascola JR, Graham BS, Beigel JH, mRNA-1273 Study Group. PMID: 33270381; PMCID: PMC7727324.
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149 Fields:
Translation:
HumansCells
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Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults. N Engl J Med. 2020 12 17; 383(25):2427-2438.
Anderson EJ, Rouphael NG, Widge AT, Jackson LA, Roberts PC, Makhene M, Chappell JD, Denison MR, Stevens LJ, Pruijssers AJ, McDermott AB, Flach B, Lin BC, Doria-Rose NA, O'Dell S, Schmidt SD, Corbett KS, Swanson PA, Padilla M, Neuzil KM, Bennett H, Leav B, Makowski M, Albert J, Cross K, Edara VV, Floyd K, Suthar MS, Martinez DR, Baric R, Buchanan W, Luke CJ, Phadke VK, Rostad CA, Ledgerwood JE, Graham BS, Beigel JH, mRNA-1273 Study Group. PMID: 32991794; PMCID: PMC7556339.
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260 Fields:
Translation:
HumansCellsCTClinical Trials
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SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness. Nature. 2020 10; 586(7830):567-571.
Corbett KS, Edwards DK, Leist SR, Abiona OM, Boyoglu-Barnum S, Gillespie RA, Himansu S, Schäfer A, Ziwawo CT, DiPiazza AT, Dinnon KH, Elbashir SM, Shaw CA, Woods A, Fritch EJ, Martinez DR, Bock KW, Minai M, Nagata BM, Hutchinson GB, Wu K, Henry C, Bahl K, Garcia-Dominguez D, Ma L, Renzi I, Kong WP, Schmidt SD, Wang L, Zhang Y, Phung E, Chang LA, Loomis RJ, Altaras NE, Narayanan E, Metkar M, Presnyak V, Liu C, Louder MK, Shi W, Leung K, Yang ES, West A, Gully KL, Stevens LJ, Wang N, Wrapp D, Doria-Rose NA, Stewart-Jones G, Bennett H, Alvarado GS, Nason MC, Ruckwardt TJ, McLellan JS, Denison MR, Chappell JD, Moore IN, Morabito KM, Mascola JR, Baric RS, Carfi A, Graham BS. PMID: 32756549; PMCID: PMC7581537.
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230 Fields:
Translation:
AnimalsCellsPHPublic Health
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An mRNA Vaccine against SARS-CoV-2 - Preliminary Report. N Engl J Med. 2020 11 12; 383(20):1920-1931.
Jackson LA, Anderson EJ, Rouphael NG, Roberts PC, Makhene M, Coler RN, McCullough MP, Chappell JD, Denison MR, Stevens LJ, Pruijssers AJ, McDermott A, Flach B, Doria-Rose NA, Corbett KS, Morabito KM, O'Dell S, Schmidt SD, Swanson PA, Padilla M, Mascola JR, Neuzil KM, Bennett H, Sun W, Peters E, Makowski M, Albert J, Cross K, Buchanan W, Pikaart-Tautges R, Ledgerwood JE, Graham BS, Beigel JH, mRNA-1273 Study Group. PMID: 32663912; PMCID: PMC7377258.
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Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice. Cell Rep. 2020 07 21; 32(3):107940.
Pruijssers AJ, George AS, Schäfer A, Leist SR, Gralinksi LE, Dinnon KH, Yount BL, Agostini ML, Stevens LJ, Chappell JD, Lu X, Hughes TM, Gully K, Martinez DR, Brown AJ, Graham RL, Perry JK, Du Pont V, Pitts J, Ma B, Babusis D, Murakami E, Feng JY, Bilello JP, Porter DP, Cihlar T, Baric RS, Denison MR, Sheahan TP. PMID: 32668216; PMCID: PMC7340027.
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135 Fields:
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SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness. bioRxiv. 2020 Jun 11.
Corbett KS, Edwards D, Leist SR, Abiona OM, Boyoglu-Barnum S, Gillespie RA, Himansu S, Schäfer A, Ziwawo CT, DiPiazza AT, Dinnon KH, Elbashir SM, Shaw CA, Woods A, Fritch EJ, Martinez DR, Bock KW, Minai M, Nagata BM, Hutchinson GB, Bahl K, Garcia-Dominguez D, Ma L, Renzi I, Kong WP, Schmidt SD, Wang L, Zhang Y, Stevens LJ, Phung E, Chang LA, Loomis RJ, Altaras NE, Narayanan E, Metkar M, Presnyak V, Liu C, Louder MK, Shi W, Leung K, Yang ES, West A, Gully KL, Wang N, Wrapp D, Doria-Rose NA, Stewart-Jones G, Bennett H, Nason MC, Ruckwardt TJ, McLellan JS, Denison MR, Chappell JD, Moore IN, Morabito KM, Mascola JR, Baric RS, Carfi A, Graham BS. PMID: 32577634; PMCID: PMC7301911.
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Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice. bioRxiv. 2020 Apr 27.
Pruijssers AJ, George AS, Schäfer A, Leist SR, Gralinksi LE, Dinnon KH, Yount BL, Agostini ML, Stevens LJ, Chappell JD, Lu X, Hughes TM, Gully K, Martinez DR, Brown AJ, Graham RL, Perry JK, Du Pont V, Pitts J, Ma B, Babusis D, Murakami E, Feng JY, Bilello JP, Porter DP, Cihlar T, Baric RS, Denison MR, Sheahan TP. PMID: 32511392; PMCID: PMC7263539.
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An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sci Transl Med. 2020 04 29; 12(541).
Sheahan TP, Sims AC, Zhou S, Graham RL, Pruijssers AJ, Agostini ML, Leist SR, Schäfer A, Dinnon KH, Stevens LJ, Chappell JD, Lu X, Hughes TM, George AS, Hill CS, Montgomery SA, Brown AJ, Bluemling GR, Natchus MG, Saindane M, Kolykhalov AA, Painter G, Harcourt J, Tamin A, Thornburg NJ, Swanstrom R, Denison MR, Baric RS. PMID: 32253226; PMCID: PMC7164393.
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Implementing Adapted Individual Placement and Support (IPS) Supported Employment for Transition-Age Youth in Texas. Community Ment Health J. 2020 04; 56(3):513-523.
Cohen DA, Klodnick VV, Stevens L, Fagan MA, Spencer ES. PMID: 31768929.
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Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD. Cell Rep. 2019 09 24; 28(13):3395-3405.e6.
Wang N, Rosen O, Wang L, Turner HL, Stevens LJ, Corbett KS, Bowman CA, Pallesen J, Shi W, Zhang Y, Leung K, Kirchdoerfer RN, Becker MM, Denison MR, Chappell JD, Ward AB, Graham BS, McLellan JS. PMID: 31553909; PMCID: PMC6935267.
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PubMed Mentions:
27 Fields:
Translation:
HumansCells
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Self-neutralizing oligonucleotides with enhanced cellular uptake. Org Biomol Chem. 2017 Feb 07; 15(6):1363-1380.
Yanachkov I, Zavizion B, Metelev V, Stevens LJ, Tabatadze Y, Yanachkova M, Wright G, Krichevsky AM, Tabatadze DR. PMID: 28074950; PMCID: PMC5696787.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Amounts of Artificial Food Colors in Commonly Consumed Beverages and Potential Behavioral Implications for Consumption in Children: Revisited. Clin Pediatr (Phila). 2015 Oct; 54(12):1228-30.
Stevens LJ, Burgess JR, Stochelski MA, Kuczek T. PMID: 25876924.
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2 Fields:
Translation:
Humans
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Impulsivity in cocaine-dependent individuals with and without attention-deficit/hyperactivity disorder. Eur Addict Res. 2015; 21(3):131-43.
Stevens L, Roeyers H, Dom G, Joos L, Vanderplasschen W. PMID: 25675959.
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Detection of the virulent form of AVR3a from Phytophthora infestans following artificial evolution of potato resistance gene R3a. PLoS One. 2014; 9(10):e110158.
Chapman S, Stevens LJ, Boevink PC, Engelhardt S, Alexander CJ, Harrower B, Champouret N, McGeachy K, Van Weymers PS, Chen X, Birch PR, Hein I. PMID: 25340613; PMCID: PMC4207746.
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12 Fields:
Translation:
AnimalsCells
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Amounts of artificial food dyes and added sugars in foods and sweets commonly consumed by children. Clin Pediatr (Phila). 2015 Apr; 54(4):309-21.
Stevens LJ, Burgess JR, Stochelski MA, Kuczek T. PMID: 24764054.
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7 Fields:
Translation:
Humans
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Amounts of artificial food colors in commonly consumed beverages and potential behavioral implications for consumption in children. Clin Pediatr (Phila). 2014 Feb; 53(2):133-40.
Stevens LJ, Burgess JR, Stochelski MA, Kuczek T. PMID: 24037921.
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9 Fields:
Translation:
Humans
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Mechanisms of behavioral, atopic, and other reactions to artificial food colors in children. Nutr Rev. 2013 May; 71(5):268-81.
Stevens LJ, Kuczek T, Burgess JR, Stochelski MA, Arnold LE, Galland L. PMID: 23590704.
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19 Fields:
Translation:
Humans
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A secreted MMP is required for reepithelialization during wound healing. Mol Biol Cell. 2012 Mar; 23(6):1068-79.
Stevens LJ, Page-McCaw A. PMID: 22262460; PMCID: PMC3302734.
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57 Fields:
Translation:
HumansAnimalsCells
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Solving the puzzle of attention deficit hyperactivity disorder. Nutr Rev. 2011 Jul; 69(7):383-4.
Stevens LJ, Kuczek T, Arnold LE. PMID: 21729091.
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Translation:
HumansAnimals
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Dietary sensitivities and ADHD symptoms: thirty-five years of research. Clin Pediatr (Phila). 2011 Apr; 50(4):279-93.
Stevens LJ, Kuczek T, Burgess JR, Hurt E, Arnold LE. PMID: 21127082.
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PubMed Mentions:
19 Fields:
Translation:
Humans
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Omega-3 fatty acid status in attention-deficit/hyperactivity disorder. Prostaglandins Leukot Essent Fatty Acids. 2006 Oct-Nov; 75(4-5):299-308.
Antalis CJ, Stevens LJ, Campbell M, Pazdro R, Ericson K, Burgess JR. PMID: 16962757.
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PubMed Mentions:
40 Fields:
Translation:
Humans
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EFA supplementation in children with inattention, hyperactivity, and other disruptive behaviors. Lipids. 2003 Oct; 38(10):1007-21.
Stevens L, Zhang W, Peck L, Kuczek T, Grevstad N, Mahon A, Zentall SS, Arnold LE, Burgess JR. PMID: 14669965.
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