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John Adamson

Title(s)Clinical Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Research Interests
    Dr. Adamson's long-time interests have been in the regulation of red cell production, and particularly the role of erythropoietin in that process.

    He helped organize the original clinical trials of recombinant human erythropoietin in treating the anemia of patients with chronic kidney disease and participated in the application of erythropoietin therapy to the other anemias, including chemotherapy-induced anemia in cancer patients.

    He was on the original advisory National Kidney Foundation's Dialysis Outcomes Quality Initiative (DOQI) group that developed guidelines for "best practices" in the use of erythropoietin in kidney-related anemia. "In 2011, he participated in the international effort to harmonize anemia management in patients with CKD as part of the Kidney Disease: Improving Global Outcomes (KDIGO) effort."

    In parallel, he has been invovled in studies of iron metabolism for many years and the role of iron supply to the erythron. He has been particularly interested in the alterations in iron metabolism that occur with acute and chronic inflammation and in the use of supplemental iron to enhance the marrow's response to erythropoietin therapy.

    Expanded interests include the mechanisms of anemia as part of the aging process and how to effectively manage the anemia.

    Education and Training
    BA - University of California, Berkeley - 1958
    MD - University of California, Los Angeles - 1962
    Internship and Residency - University of Washington - 1962-1964
    Fellowship - Senior Fellow In Hematology, University of Washington - 1964-1967

    Collapse Research 
    Collapse Research Activities and Funding
    SMALL INSTRUMENTATION GRANT
    NIH/NHLBI S15HL053656Aug 1, 1994 - Jul 31, 1995
    Role: Principal Investigator
    PROLIFERATION AND DIFFERENTIATION OF ISOLATED STEM CELLS
    NIH/NHLBI R01HL046524May 1, 1991 - Feb 28, 1995
    Role: Principal Investigator
    PATHOBIOLOGY OF BONE MARROW SUPPRESSION IN AIDS OR ARC
    NIH/NIDDK R01DK041937Jan 15, 1989 - Nov 30, 1991
    Role: Principal Investigator
    Heme synthesis, use and trafficking during erythropoiesis
    NIH/NHLBI R01HL031823Dec 1, 1986 - Nov 30, 2015
    Role: Co-Principal Investigator
    Growth Factors in Normal and Neoplastic Hematopoiesis
    NIH/NCI R01CA031615Apr 1, 1982 - Sep 30, 2002
    Role: Co-Principal Investigator
    MINORITY HIGH SCHOOL STUDENT RESEARCH APPRENTICE PROGRAM
    NIH/NCRR S03RR003112Mar 1, 1981 - Feb 29, 1992
    Role: Principal Investigator
    BIOMEDICAL RESEARCH SUPPORT
    NIH/NCRR S07RR005688Apr 1, 1979 - Sep 29, 1992
    Role: Principal Investigator
    IN VITRO STUDIES OF HEMATOPOIETIC REGULATION
    NIH/NIDDK R01DK019410May 1, 1976 - Oct 31, 1990
    Role: Co-Principal Investigator
    IN VITRO STUDIES OF HEMATOPOIETIC REGULATION
    NIH/NIADDK R01AM019410May 1, 1976 - Apr 30, 1990
    Role: Principal Investigator
    HEMATOLOGY TRAINING
    NIH/NHLBI T32HL007093Jul 1, 1975 - Jun 30, 2020
    Role: Co-Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Reply to McCulley et al., reports to FDA of fatal anaphylaxis associated with intravenous iron products. Am J Hematol. 2016 Dec; 91(12):E497-E498. Auerbach M, Adamson J. PMID: 27538263.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Blood's 70th anniversary: reflections of a past editor, 1983-1987. Blood. 2016 Feb 04; 127(5):515-7. Adamson JW. PMID: 26847063.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. How we diagnose and treat iron deficiency anemia. Am J Hematol. 2016 Jan; 91(1):31-8. Auerbach M, Adamson JW. PMID: 26408108.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    4. In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs. Mayo Clin Proc. 2015 Aug; 90(8):996-1000. Tefferi A, Kantarjian H, Rajkumar SV, Baker LH, Abkowitz JL, Adamson JW, Advani RH, Allison J, Antman KH, Bast RC, Bennett JM, Benz EJ, Berliner N, Bertino J, Bhatia R, Bhatia S, Bhojwani D, Blanke CD, Bloomfield CD, Bosserman L, Broxmeyer HE, Byrd JC, Cabanillas F, Canellos GP, Chabner BA, Chanan-Khan A, Cheson B, Clarkson B, Cohn SL, Colon-Otero G, Cortes J, Coutre S, Cristofanilli M, Curran WJ, Daley GQ, DeAngelo DJ, Deeg HJ, Einhorn LH, Erba HP, Esteva FJ, Estey E, Fidler IJ, Foran J, Forman S, Freireich E, Fuchs C, George JN, Gertz MA, Giralt S, Golomb H, Greenberg P, Gutterman J, Handin RI, Hellman S, Hoff PM, Hoffman R, Hong WK, Horowitz M, Hortobagyi GN, Hudis C, Issa JP, Johnson BE, Kantoff PW, Kaushansky K, Khayat D, Khuri FR, Kipps TJ, Kripke M, Kyle RA, Larson RA, Lawrence TS, Levine R, Link MP, Lippman SM, Lonial S, Lyman GH, Markman M, Mendelsohn J, Meropol NJ, Messinger Y, Mulvey TM, O'Brien S, Perez-Soler R, Pollock R, Prchal J, Press O, Radich J, Rai K, Rosenberg SA, Rowe JM, Rugo H, Runowicz CD, Sandmaier BM, Saven A, Schafer AI, Schiffer C, Sekeres MA, Silver RT, Siu LL, Steensma DP, Stewart FM, Stock W, Stone R, Storb R, Strong LC, Tallman MS, Thompson M, Ueno NT, Van Etten RA, Vose JM, Wiernik PH, Winer EP, Younes A, Zelenetz AD, LeMaistre CA. PMID: 26211600.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    5. On the safety of intravenous iron, evidence trumps conjecture. Haematologica. 2015 May; 100(5):e214-5. Auerbach M, Adamson J, Bircher A, Breymann C, Fishbane S, Gafter-Gvili A, Gasche C, Gilreath J, Grazzini G, Henry D, Liumbruno G, Locatelli F, Macdougall I, Munoz M, Rampton D, Rodgers G, Shander A. PMID: 25944640.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    6. In vivo biosynthesis of terpene nucleosides provides unique chemical markers of Mycobacterium tuberculosis infection. Chem Biol. 2015 Apr 23; 22(4):516-526. Young DC, Layre E, Pan SJ, Tapley A, Adamson J, Seshadri C, Wu Z, Buter J, Minnaard AJ, Coscolla M, Gagneux S, Copin R, Ernst JD, Bishai WR, Snider BB, Moody DB. PMID: 25910243.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    7. Iron, erythropoietic stimulating agents, and anemia in cancer. Crit Rev Oncog. 2013; 18(5):471-83. Adamson JW. PMID: 23879591.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    8. Iron deficiency: what are the future trends in diagnostics and therapeutics? Clin Chem. 2013 May; 59(5):740-5. Brugnara C, Adamson J, Auerbach M, Kane R, Macdougall I, Mast A. PMID: 23150055.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    9. Iron metabolism in man. JPEN J Parenter Enteral Nutr. 2013 Sep; 37(5):599-606. von Drygalski A, Adamson JW. PMID: 22968710.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    10. Ironing out fatigue. Blood. 2011 Sep 22; 118(12):3191-2. von Drygalski A, Adamson JW. PMID: 21940826.
      View in: PubMed   Mentions: 4     Fields:    
    11. In vitro and in vivo evaluation of apheresis platelets stored for 5 days in 65% platelet additive solution/35% plasma. Transfusion. 2010 Nov; 50(11):2376-85. Vassallo RR, Adamson JW, Gottschall JL, Snyder EL, Lee W, Houghton J, Elfath MD. PMID: 20497516.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCellsCTClinical Trials
    12. Iron deficiency and heart disease: ironclad evidence? Hematology Am Soc Hematol Educ Program. 2010; 2010:348-50. Carson JL, Adamson JW. PMID: 21239817.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    13. Erythropoietic-stimulating agents: the cancer progression controversy and collateral damage to the blood supply. Transfusion. 2009 May; 49(5):824-6. Adamson JW. PMID: 19426200.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    14. Hyporesponsiveness to erythropoiesis stimulating agents in chronic kidney disease: the many faces of inflammation. Adv Chronic Kidney Dis. 2009 Mar; 16(2):76-82. Adamson JW. PMID: 19233066.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    15. Renal disease and anemia in the elderly. Semin Hematol. 2008 Oct; 45(4):235-41. Adamson JW. PMID: 18809093.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    16. Hematopoietic growth factors--use in normal blood and stem cell donors: clinical and ethical issues. Transfusion. 2008 Sep; 48(9):2008-25. McCullough J, Kahn J, Adamson J, Anderlini P, Benjamin R, Confer D, Eapen M, Hirsch B, Kuter D, Lazarus E, Pamphilon D, Stroncek D, Sugarman J, Wilson R. PMID: 18564401.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    17. New blood, old blood, or no blood? N Engl J Med. 2008 Mar 20; 358(12):1295-6. Adamson JW. PMID: 18354108.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    18. The anemia of inflammation/malignancy: mechanisms and management. Hematology Am Soc Hematol Educ Program. 2008; 159-65. Adamson JW. PMID: 19074075.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    19. Automated collection of double red blood cell units with a variable-volume separation chamber. Transfusion. 2008 Jan; 48(1):147-52. Aubuchon JP, Dumont LJ, Herschel L, Roger J, Beddard RL, Taylor HL, Whitley PH, Sawyer SL, Graminske S, Martinson K, Dora R, Heldke S, Adamson J, Rose LE. PMID: 17894787.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    20. Distinct roles of phosphoinositide-3 kinase and phospholipase Cgamma2 in B-cell receptor-mediated signal transduction. Mol Cell Biol. 2006 Jan; 26(1):88-99. Dai X, Chen Y, Schuman J, Hua Z, Adamson JW, Wen R, Wang D. PMID: 16354682.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    21. The rate of marrow recovery and extent of donor engraftment following transplantation of ex vivo-expanded bone marrow cells are independently influenced by the cytokines used for expansion. Stem Cells Dev. 2005 Oct; 14(5):564-75. von Drygalski A, Savatski L, Eastwood D, Klein J, Adamson JW. PMID: 16305341.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    22. Synthetic erythropoietic proteins: tuning biological performance by site-specific polymer attachment. Chem Biol. 2005 Mar; 12(3):371-83. Chen SY, Cressman S, Mao F, Shao H, Low DW, Beilan HS, Cagle EN, Carnevali M, Gueriguian V, Keogh PJ, Porter H, Stratton SM, Wiedeke MC, Savatski L, Adamson JW, Bozzini CE, Kung A, Kent SB, Bradburne JA, Kochendoerfer GG. PMID: 15797221.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    23. Assessment of pure red cell aplasia in US dialysis patients: the limits of the Medicare data. Am J Kidney Dis. 2004 Mar; 43(3):464-70. Collins AJ, Li S, Adamson JW, Gilbertson DT. PMID: 14981604.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    24. Murine bone marrow cells cultured ex vivo in the presence of multiple cytokine combinations lose radioprotective and long-term engraftment potential. Stem Cells Dev. 2004 Feb; 13(1):101-11. Von Drygalski A, Alespeiti G, Ren L, Adamson JW. PMID: 15068698.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    25. Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis. Nat Genet. 2003 Jul; 34(3):292-6. Parviz F, Matullo C, Garrison WD, Savatski L, Adamson JW, Ning G, Kaestner KH, Rossi JM, Zaret KS, Duncan SA. PMID: 12808453.
      View in: PubMed   Mentions: 183     Fields:    Translation:AnimalsCells
    26. Design and chemical synthesis of a homogeneous polymer-modified erythropoiesis protein. Science. 2003 Feb 07; 299(5608):884-7. Kochendoerfer GG, Chen SY, Mao F, Cressman S, Traviglia S, Shao H, Hunter CL, Low DW, Cagle EN, Carnevali M, Gueriguian V, Keogh PJ, Porter H, Stratton SM, Wiedeke MC, Wilken J, Tang J, Levy JJ, Miranda LP, Crnogorac MM, Kalbag S, Botti P, Schindler-Horvat J, Savatski L, Adamson JW, Kung A, Kent SB, Bradburne JA. PMID: 12574628.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    27. Placental/umbilical cord blood (PCB) stem cells for transplantation: early clinical outcomes and the status of ex vivo expansion strategies. Keio J Med. 2000 Dec; 49(4):141-51. von Drygalski A, Adamson JW. PMID: 11192982.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    28. Exposure of endothelial cells to recombinant human erythropoietin induces nitric oxide synthase activity. Kidney Int. 2000 May; 57(5):1895-904. Banerjee D, Rodriguez M, Nag M, Adamson JW. PMID: 10792608.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    29. The frequency and proliferative potential of megakaryocytic colony-forming cells (Meg-CFC) in cord blood, cytokine-mobilized peripheral blood and bone marrow, and their correlation with total CFC numbers: implications for the quantitation of Meg-CFC to predict platelet engraftment following cord blood transplantation. Bone Marrow Transplant. 2000 May; 25(10):1029-34. Drygalski A, Xu G, Constantinescu D, Kashiwakura I, Farley T, Dobrila L, Rubinstein P, Adamson JW. PMID: 10828861.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    30. Identification of a glialblastoma cell differentiation factor-related gene mRNA in human microvascular endothelial cells. Genomics. 2000 May 01; 65(3):243-52. Li C, Rodriguez M, Adamson JW, Banerjee D. PMID: 10857748.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    31. Iron overload in renal failure patients: changes since the introduction of erythropoietin therapy. Kidney Int Suppl. 1999 Mar; 69:S35-43. Eschbach JW, Adamson JW. PMID: 10084284.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    32. Predicting the hematopoietic response to recombinant human erythropoietin (Epoetin alfa) in the treatment of the anemia of cancer. Oncology. 1999; 56(1):46-53. Adamson JW, Ludwig H. PMID: 9885377.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    33. Erythropoietin for end-stage renal disease. N Engl J Med. 1998 Aug 27; 339(9):625-7. Adamson JW, Eschbach JW. PMID: 9718384.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    34. Epoetin alfa: into the new millennium. Semin Oncol. 1998 Jun; 25(3 Suppl 7):76-9. Adamson JW. PMID: 9671336.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    35. Alternatively spliced mRNAs encoding soluble isoforms of the erythropoietin receptor in murine cell lines and bone marrow. Gene. 1994 Sep 30; 147(2):263-8. Barron C, Migliaccio AR, Migliaccio G, Jiang Y, Adamson JW, Ottolenghi S. PMID: 7926812.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    36. GATA-1-independent regulation of the expression of the erythropoietin receptor (EPO-R) gene in a human EPO-dependent cell line, UT-7 EPO. Ann N Y Acad Sci. 1994 Apr 15; 718:359-61. Migliaccio AR, Jiang Y, Migliaccio G, Nicolis S, Crotta S, Ronchi A, Ottolenghi S, Adamson JW. PMID: 8185247.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    37. The relationship of erythropoietin and iron metabolism to red blood cell production in humans. Semin Oncol. 1994 Apr; 21(2 Suppl 3):9-15. Adamson JW. PMID: 8202725.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    38. Physiologic basis for the pharmacologic use of recombinant human erythropoietin in surgery and cancer treatment. Surgery. 1994 Jan; 115(1):7-15. Adamson JW, Spivak JL. PMID: 8284765.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    39. Transcriptional and posttranscriptional regulation of the expression of the erythropoietin receptor gene in human erythropoietin-responsive cell lines. Blood. 1993 Dec 15; 82(12):3760-9. Migliaccio AR, Jiang Y, Migliaccio G, Nicolis S, Crotta S, Ronchi A, Ottolenghi S, Adamson JW. PMID: 8260713.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    40. Recombinant human erythropoietin enhances blood donation for autologous use and reduces exposure to homologous blood during elective surgery. Semin Hematol. 1993 Oct; 30(4 Suppl 6):17-21. Mercuriali F, Adamson JW. PMID: 8153672.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    41. A comparison of the responses to recombinant human erythropoietin in normal and uremic subjects. Kidney Int. 1992 Aug; 42(2):407-16. Eschbach JW, Haley NR, Egrie JC, Adamson JW. PMID: 1405323.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCellsCTClinical Trials
    42. Management of anemia in oncology. Introduction. Semin Oncol. 1992 Jun; 19(3 Suppl 8):1-2. Adamson JW. PMID: 1615333.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    43. Long-term generation of colony-forming cells in liquid culture of CD34+ cord blood cells in the presence of recombinant human stem cell factor. Blood. 1992 May 15; 79(10):2620-7. Migliaccio G, Migliaccio AR, Druzin ML, Giardina PJ, Zsebo KM, Adamson JW. PMID: 1375106.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    44. Expression of the interleukin-3 and granulocyte-macrophage colony-stimulating factor genes in Friend spleen focus-forming virus-induced erythroleukemia. Blood. 1992 May 01; 79(9):2423-31. Shimada Y, Migliaccio G, Ruscetti S, Adamson JW, Migliaccio AR. PMID: 1571554.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    45. Effectiveness of recombinant human erythropoietin therapy in myelodysplastic syndromes. Acta Haematol. 1992; 87 Suppl 1:20-4. Adamson JW, Schuster M, Allen S, Haley NR. PMID: 1574963.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    46. Response to erythropoietin in erythroid subclones of the factor-dependent cell line 32D is determined by translocation of the erythropoietin receptor to the cell surface. Proc Natl Acad Sci U S A. 1991 Dec 15; 88(24):11086-90. Migliaccio AR, Migliaccio G, D'Andrea A, Baiocchi M, Crotta S, Nicolis S, Ottolenghi S, Adamson JW. PMID: 1722318.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    47. Stem cell factor induces proliferation and differentiation of highly enriched murine hematopoietic cells. Proc Natl Acad Sci U S A. 1991 Aug 15; 88(16):7420-4. Migliaccio G, Migliaccio AR, Valinsky J, Langley K, Zsebo K, Visser JW, Adamson JW. PMID: 1714603.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    48. The safety of epoetin-alpha: results of clinical trials in the United States. Contrib Nephrol. 1991; 88:72-80. Eschbach JW, Egrie JC, Downing MR, Browne JK, Adamson JW. PMID: 2040198.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    49. Erythropoietin: its role in the regulation of erythropoiesis and as a therapeutic in humans. Biotechnology. 1991; 19:351-63. Adamson JW. PMID: 1786475.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    50. Hypertension following erythropoietin therapy in anemic hemodialysis patients. Am J Hypertens. 1990 Dec; 3(12 Pt 1):947-55. Buckner FS, Eschbach JW, Haley NR, Davidson RC, Adamson JW. PMID: 2127895.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    51. Muramyl dipeptide induces production of hemopoietic growth factors in vivo by a mechanism independent of tumor necrosis factor. J Immunol. 1990 May 15; 144(10):3789-94. Broudy VC, Kaushansky K, Shoemaker SG, Aggarwal BB, Adamson JW. PMID: 1692060.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    52. Recombinant erythropoietin improves exercise capacity in anemic hemodialysis patients. Am J Kidney Dis. 1990 Apr; 15(4):325-32. Robertson HT, Haley NR, Guthrie M, Cardenas D, Eschbach JW, Adamson JW. PMID: 2321645.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    53. The use of recombinant human erythropoietin [rHuEpo] in man. Prog Clin Biol Res. 1990; 352:505-17. Adamson JW, Eschbach JW. PMID: 2205875.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    54. Treatment of the anemia of chronic renal failure with recombinant human erythropoietin. Annu Rev Med. 1990; 41:349-60. Adamson JW, Eschbach JW. PMID: 2184735.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    55. The anemia of chronic renal failure: pathophysiology and effects of recombinant erythropoietin. Contrib Nephrol. 1990; 78:24-36; discussion 37. Eschbach JW, Haley NR, Adamson JW. PMID: 2225841.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    56. Management of the anaemia of chronic renal failure with recombinant erythropoietin. Q J Med. 1989 Dec; 73(272):1093-101. Adamson JW, Eschbach JW. PMID: 2694210.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    57. Guidelines for recombinant human erythropoietin therapy. Am J Kidney Dis. 1989 Aug; 14(2 Suppl 1):2-8. Eschbach JW, Adamson JW. PMID: 2667349.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    58. Treatment of the anemia of progressive renal failure with recombinant human erythropoietin. N Engl J Med. 1989 Jul 20; 321(3):158-63. Eschbach JW, Kelly MR, Haley NR, Abels RI, Adamson JW. PMID: 2747747.
      View in: PubMed   Mentions: 60     Fields:    Translation:Humans
    59. The promise of recombinant human erythropoietin. Semin Hematol. 1989 Apr; 26(2 Suppl 2):5-8. Adamson JW. PMID: 2658101.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    60. Regulation of differentiation of murine progenitor cells derived from blast cell colonies under serum-deprived conditions. Exp Hematol. 1989 Feb; 17(2):110-5. Migliaccio G, Migliaccio AR, Kaushansky K, Adamson JW. PMID: 2463929.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    61. USA multicenter clinical trial with recombinant human erythropoietin (Amgen). Results in hemodialysis patients. Contrib Nephrol. 1989; 76:160-5; discussion 212-8. Eschbach JW, Downing MR, Egrie JC, Browne JK, Adamson JW. PMID: 2684518.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCTClinical Trials
    62. Effect of red cell hypertransfusion on thrombocytopoietic regeneration following irradiation and bone marrow transplantation in the mouse. Nouv Rev Fr Hematol. 1989; 31(1):27-33. Chatelain C, Burstein SA, Erb SK, Adamson JW, Harker LA. PMID: 2644618.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    63. Tumor necrosis factor-alpha and tumor necrosis factor-beta (lymphotoxin) stimulate the production of granulocyte-macrophage colony-stimulating factor, macrophage colony-stimulating factor, and IL-1 in vivo. J Immunol. 1988 Nov 15; 141(10):3410-5. Kaushansky K, Broudy VC, Harlan JM, Adamson JW. PMID: 2460533.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    64. Erythropoietin: in vitro and in vivo studies of the regulation of erythropoiesis. Schweiz Med Wochenschr. 1988 Oct 22; 118(42):1501-6. Adamson JW. PMID: 2849202.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    65. Identification of the receptor for erythropoietin on human and murine erythroleukemia cells and modulation by phorbol ester and dimethyl sulfoxide. Proc Natl Acad Sci U S A. 1988 Sep; 85(17):6513-7. Broudy VC, Lin N, Egrie J, de Haën C, Weiss T, Papayannopoulou T, Adamson JW. PMID: 2842774.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    66. In vitro differentiation of human granulocyte/macrophage and erythroid progenitors: comparative analysis of the influence of recombinant human erythropoietin, G-CSF, GM-CSF, and IL-3 in serum-supplemented and serum-deprived cultures. Blood. 1988 Jul; 72(1):248-56. Migliaccio G, Migliaccio AR, Adamson JW. PMID: 2455571.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    67. Clonal evolution following chemotherapy-induced stem cell depletion in cats heterozygous for glucose-6-phosphate dehydrogenase. Blood. 1988 Jun; 71(6):1687-92. Abkowitz JL, Ott RM, Holly RD, Adamson JW. PMID: 3370313.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    68. The anemia of end-stage renal disease: hematopoietic progenitor cell response. Kidney Int. 1988 May; 33(5):983-8. Segal GM, Eschbach JW, Egrie JC, Stueve T, Adamson JW. PMID: 3392887.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    69. Recombinant human erythropoietin: implications for nephrology. Am J Kidney Dis. 1988 Mar; 11(3):203-9. Eschbach JW, Adamson JW. PMID: 3278599.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    70. Erythropoietin: in vitro and in vivo studies of the regulation of erythropoiesis. Soc Gen Physiol Ser. 1988; 43:57-65. Adamson JW. PMID: 2855867.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    71. Interleukin 1 stimulates fibroblasts to synthesize granulocyte-macrophage and granulocyte colony-stimulating factors. Mechanism for the hematopoietic response to inflammation. J Clin Invest. 1988 Jan; 81(1):92-7. Kaushansky K, Lin N, Adamson JW. PMID: 2447127.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    72. Retrovirus-induced feline pure red cell aplasia: the kinetics of erythroid marrow failure. J Cell Physiol. 1987 Sep; 132(3):571-7. Abkowitz JL, Holly RD, Adamson JW. PMID: 2821017.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    73. Interleukin 1 stimulates human endothelial cells to produce granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor. J Immunol. 1987 Jul 15; 139(2):464-8. Broudy VC, Kaushansky K, Harlan JM, Adamson JW. PMID: 3298430.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    74. Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. Results of a combined phase I and II clinical trial. N Engl J Med. 1987 Jan 08; 316(2):73-8. Eschbach JW, Egrie JC, Downing MR, Browne JK, Adamson JW. PMID: 3537801.
      View in: PubMed   Mentions: 234     Fields:    Translation:HumansCTClinical Trials
    75. Lymphocytes and antibody in retrovirus-induced feline pure red cell aplasia. J Natl Cancer Inst. 1987 Jan; 78(1):135-9. Abkowitz JL, Ott RL, Holly RD, Adamson JW. PMID: 3025500.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    76. Pure red cell aplasia: response to therapy with anti-thymocyte globulin. Am J Hematol. 1986 Dec; 23(4):363-71. Abkowitz JL, Powell JS, Nakamura JM, Kadin ME, Adamson JW. PMID: 3098093.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    77. Tumor necrosis factor type alpha stimulates human endothelial cells to produce granulocyte/macrophage colony-stimulating factor. Proc Natl Acad Sci U S A. 1986 Oct; 83(19):7467-71. Broudy VC, Kaushansky K, Segal GM, Harlan JM, Adamson JW. PMID: 3489939.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    78. Quantitative studies of erythropoiesis in the clinically normal, phlebotomized, and feline leukemia virus-infected cat. Am J Vet Res. 1986 Oct; 47(10):2274-7. Wardrop KJ, Kramer JW, Abkowitz JL, Clemons G, Adamson JW. PMID: 3022625.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    79. Pure red cell aplasia: lymphocyte inhibition of erythropoiesis. Br J Haematol. 1986 May; 63(1):59-67. Abkowitz JL, Kadin ME, Powell JS, Adamson JW. PMID: 3085703.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    80. Genomic cloning, characterization, and multilineage growth-promoting activity of human granulocyte-macrophage colony-stimulating factor. Proc Natl Acad Sci U S A. 1986 May; 83(10):3101-5. Kaushansky K, O'Hara PJ, Berkner K, Segal GM, Hagen FS, Adamson JW. PMID: 3486413.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    81. Multilineage, non-species specific hematopoietic growth factor(s) elaborated by a feline fibroblast cell line: enhancement by virus infection. J Cell Physiol. 1986 Apr; 127(1):189-96. Abkowitz JL, Holly RD, Segal GM, Adamson JW. PMID: 3007539.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    82. Hematopoietic inhibitors in chronic renal failure: lack of in vitro specificity. Kidney Int. 1986 Mar; 29(3):641-8. Delwiche F, Segal GM, Eschbach JW, Adamson JW. PMID: 3702219.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    83. Hematopoiesis in the rat: quantitation of hematopoietic progenitors and the response to iron deficiency anemia. J Cell Physiol. 1986 Feb; 126(2):298-306. Kimura H, Finch CA, Adamson JW. PMID: 3944211.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    84. Anemia of end-stage renal disease (ESRD). Kidney Int. 1985 Jul; 28(1):1-5. Eschbach JW, Adamson JW. PMID: 3900528.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimals
    85. Feline glucose-6-phosphate dehydrogenase cellular mosaicism. Application to the study of retrovirus-induced pure red cell aplasia. J Clin Invest. 1985 Jan; 75(1):133-40. Abkowitz JL, Ott RL, Nakamura JM, Steinmann L, Fialkow PJ, Adamson JW. PMID: 2981248.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    86. The anemia of chronic renal failure in sheep. Response to erythropoietin-rich plasma in vivo. J Clin Invest. 1984 Aug; 74(2):434-41. Eschbach JW, Mladenovic J, Garcia JF, Wahl PW, Adamson JW. PMID: 6746902.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    87. Clonal evolution in the pathogenesis of pancytopenia. Prog Clin Biol Res. 1984; 148:71-80. Abkowitz JL, Adamson JW. PMID: 6611558.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    88. Pancytopenia as a clonal disorder of a multipotent hematopoietic stem cell. J Clin Invest. 1984 Jan; 73(1):258-61. Abkowitz JL, Fialkow PJ, Niebrugge DJ, Raskind WH, Adamson JW. PMID: 6690481.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    89. The polycythemias: diagnosis and treatment. Hosp Pract (Off Ed). 1983 Dec; 18(12):49-57. Adamson JW. PMID: 6416996.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    90. High levels of the circulating form of parathyroid hormone do not inhibit in vitro erythropoiesis. J Lab Clin Med. 1983 Oct; 102(4):613-20. Delwiche F, Garrity MJ, Powell JS, Robertson RP, Adamson JW. PMID: 6311928.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    91. Chronic myelogenous leukemia: in vitro studies of hematopoietic regulation in a patient undergoing intensive chemotherapy. J Clin Invest. 1981 Jun; 67(6):1593-8. Singer JW, Adamson JW, Arlin ZA, Kempin SJ, Clarkson BD, Fialkow PJ. PMID: 6940866.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    92. Restoration of nonclonal hematopoiesis in chronic myelogenous leukemia (CML) following a chemotherapy-induced loss of the Ph1 chromosome. Blood. 1980 Sep; 56(3):356-60. Singer JW, Arlin ZA, Najfeld V, Adamson JW, Kempin SJ, Clarkson BD, Fialkow PJ. PMID: 6931619.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    93. Treatment of aplastic anemia by bone marrow transplantation in identical twins. Blood. 1980 Jun; 55(6):1033-9. Appelbaum FR, Fefer A, Cheever MA, Sanders JE, Singer JW, Adamson JW, Mickelson EM, Hansen JA, Greenberg PD, Thomas ED. PMID: 6445764.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    94. Erythroid colony stimulating and inhibiting cells in peripheral blood of transfused dogs: separation of function by velocity sedimentation. Blood. 1979 Oct; 54(4):955-8. Torok-Storb B, Deeg HJ, Atkinson K, Weiden PL, Adamson JW, Storb R. PMID: 476309.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    95. Growth in vitro of donor marrow cultured with recipient lymphocytes predicts the fate of marrow grafts in transfused DLA-identical dogs. Blood. 1979 Jan; 53(1):104-8. Torok-Storb BJ, Storb R, Deeg HJ, Graham TC, Wise C, Weiden PL, Adamson JW. PMID: 758205.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    96. Erythropoiesis in vitro: effect of normal versus "transfusion-sensitized" mononuclear cells. Blood. 1978 Oct; 52(4):706-11. Torok-Storb BJ, Storb R, Graham TC, Prentice RL, Weiden PL, Adamson JW. PMID: 687826.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    97. Polycythemia vera. The in vitro response of normal and abnormal stem cell lines to erythropoietin. J Clin Invest. 1978 Apr; 61(4):1044-7. Prchal JF, Adamson JW, Murphy S, Steinmann L, Fialkow PJ. PMID: 659576.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    98. Propranolol effects in long-term hemodialysis patients with renin-dependent hypertension. Ann Intern Med. 1978 Apr; 88(4):457-62. Lindner A, Douglas SW, Adamson JW. PMID: 637424.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    99. Modulation of in vitro erythropoiesis: enhancement of erythroid colony growth by cyclic nucleotides. Cell Tissue Kinet. 1977 May; 10(3):289-98. Brown JE, Adamson JW. PMID: 194698.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    100. Studies of the influence of cyclic nucleotides on in vitro haemoglobin synthesis. Br J Haematol. 1977 Feb; 35(2):193-208. Brown JE, Adamson JW. PMID: 192263.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    101. Differential in vitro sensitivity of marrow erythroid and granulocytic colony forming cells to chloramphenicol. Am J Hematol. 1977; 2(4):355-63. Yunis AA, Adamson JW. PMID: 602925.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    102. Human erythroid colony formation in vitro: evidence for clonal origin. J Cell Physiol. 1976 Nov; 89(3):489-92. Prchal JF, Adamson JW, Steinmann L, Fialkow PJ. PMID: 977665.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    103. Polycythemia vera: stem-cell and probable clonal origin of the disease. N Engl J Med. 1976 Oct 21; 295(17):913-6. Adamson JW, Fialkow PJ, Murphy S, Prchal JF, Steinmann L. PMID: 967201.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansCells
    104. Steroids and hematopoiesis. I. The effect of steroids on in vitro erythroid colony growth: structure/activity relationships. J Cell Physiol. 1976 Jun; 88(2):127-34. Singer JW, Samuels AI, Adamson JW. PMID: 1270518.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    105. Steroids and hematopoiesis. II. The effect of steroids on in vitro erythroid colony growth: evidence for different target cells for different classes of steroids. J Cell Physiol. 1976 Jun; 88(2):135-43. Singer JW, Adamson JW. PMID: 944702.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    106. Familial polycythemia. Semin Hematol. 1975 Oct; 12(4):383-96. Adamson JW. PMID: 1105792.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    107. The anemia of chronic disorders: studies of marrow regulation and iron metabolism. Blood. 1975 Jan; 45(1):55-65. Douglas SW, Adamson JW. PMID: 803111.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    108. Hematopoiesis in the grey collie dog: studies of the regulation of erythropoiesis. J Clin Invest. 1974 Oct; 54(4):965-73. Adamson JW, Dale DC, Elin RJ. PMID: 4430726.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    109. Recessive familial erythrocytosis: aspects of marrow regulation in two families. Blood. 1973 May; 41(5):641-52. Adamson JW, Stamatoyannopoulos G, Kontras S, Lascari A, Detter J. PMID: 4694081.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    110. Improvement in the anemia of chronic renal failure with fluoxymesterone. Ann Intern Med. 1973 Apr; 78(4):527-32. Eschbach JW, Adamson JW. PMID: 4632788.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    111. Erythrocyte function and marrow regulation in hemoglobin Bethesda (beta-145 histidine). J Clin Invest. 1972 Nov; 51(11):2883-8. Adamson JW, Hayashi A, Stamatoyannopoulos G, Burger WF. PMID: 5080413.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    112. The proliferative potential of frozen stored human marrow cells. Transplantation. 1972 Oct; 14(4):490-4. Adamson JW, Storb R. PMID: 4566164.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    113. Anemia of chronic renal failure: studies of marrow regulation in the uremic sheep. Trans Am Soc Artif Intern Organs. 1972; 18(0):295-300. Eschbach JW, Adamson JW, Anderson RG, Dennis MB. PMID: 4681673.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    114. Erythropoietin and the regulation of erythropoiesis in DiGuglielmo's syndrome. Blood. 1970 Nov; 36(5):590-7. Adamson JW, Finch CA. PMID: 5273251.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    115. Disorders of red blood cell production in uremia. Arch Intern Med. 1970 Nov; 126(5):812-5. Eschbach JW, Adamson JW, Cook JD. PMID: 5475703.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    116. Erythrocytosis associated with hemoglobin Rainier: oxygen equilibria and marrow regulation. J Clin Invest. 1969 Aug; 48(8):1376-86. Adamson JW, Parer JT, Stamatoyannopoulos G. PMID: 5796352.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    117. The erythropoietin-hematocrit relationship in normal and polycythemic man: implications of marrow regulation. Blood. 1968 Oct; 32(4):597-609. Adamson JW. PMID: 5683539.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    118. The kidney and erythropoiesis. Am J Med. 1968 May; 44(5):725-33. Adamson JW, Eschbach J, Finch CA. PMID: 4869104.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    119. Mechanisms of erythroid marrow activation. Trans Assoc Am Physicians. 1966; 79:419-25. Adamson JW, Finch CA. PMID: 5929472.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
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