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John Adamson

TitleClinical Professor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0878
La Jolla CA 92093
Phone858-642-3348
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    Research Interests
    Dr. Adamson's long-time interests have been in the regulation of red cell production, and particularly the role of erythropoietin in that process.

    He helped organize the original clinical trials of recombinant human erythropoietin in treating the anemia of patients with chronic kidney disease and participated in the application of erythropoietin therapy to the other anemias, including chemotherapy-induced anemia in cancer patients.

    He was on the original advisory National Kidney Foundation's Dialysis Outcomes Quality Initiative (DOQI) group that developed guidelines for "best practices" in the use of erythropoietin in kidney-related anemia. "In 2011, he participated in the international effort to harmonize anemia management in patients with CKD as part of the Kidney Disease: Improving Global Outcomes (KDIGO) effort."

    In parallel, he has been invovled in studies of iron metabolism for many years and the role of iron supply to the erythron. He has been particularly interested in the alterations in iron metabolism that occur with acute and chronic inflammation and in the use of supplemental iron to enhance the marrow's response to erythropoietin therapy.

    Expanded interests include the mechanisms of anemia as part of the aging process and how to effectively manage the anemia.

    Education and Training
    BA - University of California, Berkeley - 1958
    MD - University of California, Los Angeles - 1962
    Internship and Residency - University of Washington - 1962-1964
    Fellowship - Senior Fellow In Hematology, University of Washington - 1964-1967


    Collapse Research 
    Collapse Research Activities and Funding
    SMALL INSTRUMENTATION GRANT
    NIH/NHLBI S15HL053656Aug 1, 1994 - Jul 31, 1995
    Role: Principal Investigator
    PROLIFERATION AND DIFFERENTIATION OF ISOLATED STEM CELLS
    NIH/NHLBI R01HL046524May 1, 1991 - Feb 28, 1995
    Role: Principal Investigator
    PATHOBIOLOGY OF BONE MARROW SUPPRESSION IN AIDS OR ARC
    NIH/NIDDK R01DK041937Jan 15, 1989 - Nov 30, 1991
    Role: Principal Investigator
    Heme synthesis, use and trafficking during erythropoiesis
    NIH/NHLBI R01HL031823Sep 30, 1983 - Dec 31, 2020
    Role: Co-Principal Investigator
    Growth Factors in Normal and Neoplastic Hematopoiesis
    NIH/NCI R01CA031615Apr 1, 1982 - Jan 31, 2008
    Role: Co-Principal Investigator
    MINORITY HIGH SCHOOL STUDENT RESEARCH APPRENTICE PROGRAM
    NIH/NCRR S03RR003112Mar 1, 1981 - Feb 28, 1997
    Role: Principal Investigator
    BIOMEDICAL RESEARCH SUPPORT
    NIH/NCRR S07RR005688Apr 1, 1979 - Sep 29, 1992
    Role: Principal Investigator
    IN VITRO STUDIES OF HEMATOPOIETIC REGULATION
    NIH/NIDDK R01DK019410May 1, 1976 - Oct 31, 1990
    Role: Co-Principal Investigator
    IN VITRO STUDIES OF HEMATOPOIETIC REGULATION
    NIH/NIADDK R01AM019410May 1, 1976 - Apr 30, 1990
    Role: Principal Investigator
    HEMATOLOGY TRAINING
    NIH/NHLBI T32HL007093Jul 1, 1975 - Jun 30, 2020
    Role: Co-Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Auerbach M, Adamson J. Reply to McCulley et al., reports to FDA of fatal anaphylaxis associated with intravenous iron products. Am J Hematol. 2016 Dec; 91(12):E497-E498. PMID: 27538263.
      View in: PubMed
    2. Adamson JW. Blood's 70th anniversary: reflections of a past editor, 1983-1987. Blood. 2016 Feb 04; 127(5):515-7. PMID: 26847063.
      View in: PubMed
    3. Auerbach M, Adamson JW. How we diagnose and treat iron deficiency anemia. Am J Hematol. 2016 Jan; 91(1):31-8. PMID: 26408108.
      View in: PubMed
    4. Tefferi A, Kantarjian H, Rajkumar SV, Baker LH, Abkowitz JL, Adamson JW, Advani RH, Allison J, Antman KH, Bast RC, Bennett JM, Benz EJ, Berliner N, Bertino J, Bhatia R, Bhatia S, Bhojwani D, Blanke CD, Bloomfield CD, Bosserman L, Broxmeyer HE, Byrd JC, Cabanillas F, Canellos GP, Chabner BA, Chanan-Khan A, Cheson B, Clarkson B, Cohn SL, Colon-Otero G, Cortes J, Coutre S, Cristofanilli M, Curran WJ, Daley GQ, DeAngelo DJ, Deeg HJ, Einhorn LH, Erba HP, Esteva FJ, Estey E, Fidler IJ, Foran J, Forman S, Freireich E, Fuchs C, George JN, Gertz MA, Giralt S, Golomb H, Greenberg P, Gutterman J, Handin RI, Hellman S, Hoff PM, Hoffman R, Hong WK, Horowitz M, Hortobagyi GN, Hudis C, Issa JP, Johnson BE, Kantoff PW, Kaushansky K, Khayat D, Khuri FR, Kipps TJ, Kripke M, Kyle RA, Larson RA, Lawrence TS, Levine R, Link MP, Lippman SM, Lonial S, Lyman GH, Markman M, Mendelsohn J, Meropol NJ, Messinger Y, Mulvey TM, O'Brien S, Perez-Soler R, Pollock R, Prchal J, Press O, Radich J, Rai K, Rosenberg SA, Rowe JM, Rugo H, Runowicz CD, Sandmaier BM, Saven A, Schafer AI, Schiffer C, Sekeres MA, Silver RT, Siu LL, Steensma DP, Stewart FM, Stock W, Stone R, Storb R, Strong LC, Tallman MS, Thompson M, Ueno NT, Van Etten RA, Vose JM, Wiernik PH, Winer EP, Younes A, Zelenetz AD, LeMaistre CA. In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs. Mayo Clin Proc. 2015 Aug; 90(8):996-1000. PMID: 26211600.
      View in: PubMed
    5. Auerbach M, Adamson J, Bircher A, Breymann C, Fishbane S, Gafter-Gvili A, Gasche C, Gilreath J, Grazzini G, Henry D, Liumbruno G, Locatelli F, Macdougall I, Munoz M, Rampton D, Rodgers G, Shander A. On the safety of intravenous iron, evidence trumps conjecture. Haematologica. 2015 May; 100(5):e214-5. PMID: 25944640; PMCID: PMC4420237.
    6. Young DC, Layre E, Pan SJ, Tapley A, Adamson J, Seshadri C, Wu Z, Buter J, Minnaard AJ, Coscolla M, Gagneux S, Copin R, Ernst JD, Bishai WR, Snider BB, Moody DB. In vivo biosynthesis of terpene nucleosides provides unique chemical markers of Mycobacterium tuberculosis infection. Chem Biol. 2015 Apr 23; 22(4):516-526. PMID: 25910243; PMCID: PMC4432472.
    7. Adamson JW. Iron, erythropoietic stimulating agents, and anemia in cancer. Crit Rev Oncog. 2013; 18(5):471-83. PMID: 23879591.
      View in: PubMed
    8. Brugnara C, Adamson J, Auerbach M, Kane R, Macdougall I, Mast A. Iron deficiency: what are the future trends in diagnostics and therapeutics? Clin Chem. 2013 May; 59(5):740-5. PMID: 23150055.
      View in: PubMed
    9. von Drygalski A, Adamson JW. Iron metabolism in man. JPEN J Parenter Enteral Nutr. 2013 Sep; 37(5):599-606. PMID: 22968710.
      View in: PubMed
    10. von Drygalski A, Adamson JW. Ironing out fatigue. Blood. 2011 Sep 22; 118(12):3191-2. PMID: 21940826.
      View in: PubMed
    11. Vassallo RR, Adamson JW, Gottschall JL, Snyder EL, Lee W, Houghton J, Elfath MD. In vitro and in vivo evaluation of apheresis platelets stored for 5 days in 65% platelet additive solution/35% plasma. Transfusion. 2010 Nov; 50(11):2376-85. PMID: 20497516.
      View in: PubMed
    12. Carson JL, Adamson JW. Iron deficiency and heart disease: ironclad evidence? Hematology Am Soc Hematol Educ Program. 2010; 2010:348-50. PMID: 21239817.
      View in: PubMed
    13. Adamson JW. Erythropoietic-stimulating agents: the cancer progression controversy and collateral damage to the blood supply. Transfusion. 2009 May; 49(5):824-6. PMID: 19426200.
      View in: PubMed
    14. Adamson JW. Hyporesponsiveness to erythropoiesis stimulating agents in chronic kidney disease: the many faces of inflammation. Adv Chronic Kidney Dis. 2009 Mar; 16(2):76-82. PMID: 19233066.
      View in: PubMed
    15. Adamson JW. Renal disease and anemia in the elderly. Semin Hematol. 2008 Oct; 45(4):235-41. PMID: 18809093.
      View in: PubMed
    16. McCullough J, Kahn J, Adamson J, Anderlini P, Benjamin R, Confer D, Eapen M, Hirsch B, Kuter D, Lazarus E, Pamphilon D, Stroncek D, Sugarman J, Wilson R. Hematopoietic growth factors--use in normal blood and stem cell donors: clinical and ethical issues. Transfusion. 2008 Sep; 48(9):2008-25. PMID: 18564401.
      View in: PubMed
    17. Adamson JW. New blood, old blood, or no blood? N Engl J Med. 2008 Mar 20; 358(12):1295-6. PMID: 18354108.
      View in: PubMed
    18. Adamson JW. The anemia of inflammation/malignancy: mechanisms and management. Hematology Am Soc Hematol Educ Program. 2008; 159-65. PMID: 19074075.
      View in: PubMed
    19. Aubuchon JP, Dumont LJ, Herschel L, Roger J, Beddard RL, Taylor HL, Whitley PH, Sawyer SL, Graminske S, Martinson K, Dora R, Heldke S, Adamson J, Rose LE. Automated collection of double red blood cell units with a variable-volume separation chamber. Transfusion. 2008 Jan; 48(1):147-52. PMID: 17894787.
      View in: PubMed
    20. Dai X, Chen Y, Schuman J, Hua Z, Adamson JW, Wen R, Wang D. Distinct roles of phosphoinositide-3 kinase and phospholipase Cgamma2 in B-cell receptor-mediated signal transduction. Mol Cell Biol. 2006 Jan; 26(1):88-99. PMID: 16354682; PMCID: PMC1317611.
    21. Chen SY, Cressman S, Mao F, Shao H, Low DW, Beilan HS, Cagle EN, Carnevali M, Gueriguian V, Keogh PJ, Porter H, Stratton SM, Wiedeke MC, Savatski L, Adamson JW, Bozzini CE, Kung A, Kent SB, Bradburne JA, Kochendoerfer GG. Synthetic erythropoietic proteins: tuning biological performance by site-specific polymer attachment. Chem Biol. 2005 Mar; 12(3):371-83. PMID: 15797221.
      View in: PubMed
    22. Collins AJ, Li S, Adamson JW, Gilbertson DT. Assessment of pure red cell aplasia in US dialysis patients: the limits of the Medicare data. Am J Kidney Dis. 2004 Mar; 43(3):464-70. PMID: 14981604.
      View in: PubMed
    23. Parviz F, Matullo C, Garrison WD, Savatski L, Adamson JW, Ning G, Kaestner KH, Rossi JM, Zaret KS, Duncan SA. Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis. Nat Genet. 2003 Jul; 34(3):292-6. PMID: 12808453.
      View in: PubMed
    24. Kochendoerfer GG, Chen SY, Mao F, Cressman S, Traviglia S, Shao H, Hunter CL, Low DW, Cagle EN, Carnevali M, Gueriguian V, Keogh PJ, Porter H, Stratton SM, Wiedeke MC, Wilken J, Tang J, Levy JJ, Miranda LP, Crnogorac MM, Kalbag S, Botti P, Schindler-Horvat J, Savatski L, Adamson JW, Kung A, Kent SB, Bradburne JA. Design and chemical synthesis of a homogeneous polymer-modified erythropoiesis protein. Science. 2003 Feb 07; 299(5608):884-7. PMID: 12574628.
      View in: PubMed
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