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    Jeffrey Bada

    TitleEmeritus Professor
    SchoolUniversity of California, San Diego
    DepartmentScripps Institution of Oceanography Department
    Address9500 Gilman Drive #0212
    CA La Jolla 92093
    Phone858-534-4258
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Parker ET, Cleaves HJ, Bada J, Fernández FM. Quantitation of a-hydroxy acids in complex prebiotic mixtures via liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2016 Sep 30; 30(18):2043-51. PMID: 27467333.
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      2. Raggi L, Bada J, Lazcano A. On the lack of evolutionary continuity between prebiotic peptides and extant enzymes. Phys Chem Chem Phys. 2016 Jul 27; 18(30):20028-32. PMID: 27121024.
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      3. Bada J, Chalmers JH, Cleaves HJ. Is formamide a geochemically plausible prebiotic solvent? Phys Chem Chem Phys. 2016 Jul 27; 18(30):20085-90. PMID: 27253848.
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      4. Bada J, Cleaves HJ. Ab initio simulations and the Miller prebiotic synthesis experiment. Proc Natl Acad Sci U S A. 2015 Jan 27; 112(4):E342. PMID: 25572968.
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      5. Parker ET, Zhou M, Burton AS, Glavin DP, Dworkin JP, Krishnamurthy R, Fernández FM, Bada J. A plausible simultaneous synthesis of amino acids and simple peptides on the primordial Earth. Angew Chem Int Ed Engl. 2014 Jul 28; 53(31):8132-6. PMID: 24966137.
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      6. Parker ET, Cleaves JH, Burton AS, Glavin DP, Dworkin JP, Zhou M, Bada J, Fernández FM. Conducting miller-urey experiments. J Vis Exp. 2014; (83). PMID: 24473135.
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      7. Onstott TC, Magnabosco C, Aubrey AD, Burton AS, Dworkin JP, Elsila JE, Grunsfeld S, Cao BH, Hein JE, Glavin DP, Kieft TL, Silver BJ, Phelps TJ, van Heerden E, Opperman DJ, Bada J. Does aspartic acid racemization constrain the depth limit of the subsurface biosphere? Geobiology. 2014 Jan; 12(1):1-19. PMID: 24289240.
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      8. Bada J. New insights into prebiotic chemistry from Stanley Miller's spark discharge experiments. Chem Soc Rev. 2013 Mar 7; 42(5):2186-96. PMID: 23340907.
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      9. Bennett RV, Cleaves HJ, Davis JM, Sokolov DA, Orlando TM, Bada J, Fernández FM. Desorption electrospray ionization imaging mass spectrometry as a tool for investigating model prebiotic reactions on mineral surfaces. Anal Chem. 2013 Feb 5; 85(3):1276-9. PMID: 23286321.
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      10. Elsila JE, Glavin DP, Dworkin JP, Martins Z, Bada J. Inconclusive evidence for nonterrestrial isoleucine enantiomeric excesses in primitive meteorites. Proc Natl Acad Sci U S A. 2012 Nov 27; 109(48):E3288; author reply E3289. PMID: 23064644.
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      11. Bada J. Curiosity and contamination. Science. 2012 Sep 28; 337(6102):1604. PMID: 23019627.
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      12. Kua J, Bada J. Primordial ocean chemistry and its compatibility with the RNA world. Orig Life Evol Biosph. 2011 Dec; 41(6):553-8. PMID: 22139511.
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      13. Parker ET, Cleaves HJ, Callahan MP, Dworkin JP, Glavin DP, Lazcano A, Bada J. Enhanced synthesis of alkyl amino acids in Miller's 1958 H2S experiment. Orig Life Evol Biosph. 2011 Dec; 41(6):569-74. PMID: 22139514.
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      14. Schoeninger MJ, Bada J, Masters PM, Bettinger RL, White TD. Unexamined bodies of evidence. Science. 2011 May 20; 332(6032):916. PMID: 21596975.
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      15. Rivas M, Becerra A, Peretó J, Bada J, Lazcano A. Metalloproteins and the pyrite-based origin of life: a critical assessment. Orig Life Evol Biosph. 2011 Aug; 41(4):347-56. PMID: 21431891.
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      16. Parker ET, Cleaves HJ, Dworkin JP, Glavin DP, Callahan M, Aubrey A, Lazcano A, Bada J. Primordial synthesis of amines and amino acids in a 1958 Miller H2S-rich spark discharge experiment. Proc Natl Acad Sci U S A. 2011 Apr 5; 108(14):5526-31. PMID: 21422282.
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      17. Grew ES, Bada J, Hazen RM. Borate minerals and origin of the RNA world. Orig Life Evol Biosph. 2011 Aug; 41(4):307-16. PMID: 21221809.
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      18. Parker ET, Cleaves HJ, Callahan MP, Dworkin JP, Glavin DP, Lazcano A, Bada J. Prebiotic synthesis of methionine and other sulfur-containing organic compounds on the primitive Earth: a contemporary reassessment based on an unpublished 1958 Stanley Miller experiment. Orig Life Evol Biosph. 2011 Jun; 41(3):201-12. PMID: 21063908.
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      19. Bada J. Enantiomeric excesses in the Murchison meteorite and the origin of homochirality in terrestrial biology. Proc Natl Acad Sci U S A. 2009 Aug 11; 106(32):E85; author reply E86. PMID: 19666556.
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      20. Peretó J, Bada J, Lazcano A. Charles Darwin and the origin of life. Orig Life Evol Biosph. 2009 Oct; 39(5):395-406. PMID: 19633921.
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      21. Schwarz C, Debruyne R, Kuch M, McNally E, Schwarcz H, Aubrey AD, Bada J, Poinar H. New insights from old bones: DNA preservation and degradation in permafrost preserved mammoth remains. Nucleic Acids Res. 2009 Jun; 37(10):3215-29. PMID: 19321502.
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      22. Cleaves HJ, Aubrey AD, Bada J. An evaluation of the critical parameters for abiotic peptide synthesis in submarine hydrothermal systems. Orig Life Evol Biosph. 2009 Apr; 39(2):109-26. PMID: 19037745.
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      23. Aubrey AD, Cleaves HJ, Bada J. The role of submarine hydrothermal systems in the synthesis of amino acids. Orig Life Evol Biosph. 2009 Apr; 39(2):91-108. PMID: 19034685.
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      24. Johnson AP, Cleaves HJ, Dworkin JP, Glavin DP, Lazcano A, Bada J. The Miller volcanic spark discharge experiment. Science. 2008 Oct 17; 322(5900):404. PMID: 18927386.
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      25. Lazcano A, Bada J. Stanley L. Miller (1930--2007): reflections and remembrances. Orig Life Evol Biosph. 2008 Oct; 38(5):373-81. PMID: 18726708.
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      26. Aubrey AD, Chalmers JH, Bada J, Grunthaner FJ, Amashukeli X, Willis P, Skelley AM, Mathies RA, Quinn RC, Zent AP, Ehrenfreund P, Amundson R, Glavin DP, Botta O, Barron L, Blaney DL, Clark BC, Coleman M, Hofmann BA, Josset JL, Rettberg P, Ride S, Robert F, Sephton MA, Yen A. The Urey instrument: an advanced in situ organic and oxidant detector for Mars exploration. Astrobiology. 2008 Jun; 8(3):583-95. PMID: 18680409.
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      27. Cleaves HJ, Chalmers JH, Lazcano A, Miller SL, Bada J. A reassessment of prebiotic organic synthesis in neutral planetary atmospheres. Orig Life Evol Biosph. 2008 Apr; 38(2):105-15. PMID: 18204914.
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      28. Bump JK, Fox-Dobbs K, Bada J, Koch PL, Peterson RO, Vucetich JA. Stable isotopes, ecological integration and environmental change: wolves record atmospheric carbon isotope trend better than tree rings. Proc Biol Sci. 2007 Oct 7; 274(1624):2471-80. PMID: 17686730.
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      29. Bada J, Fegley B, Miller SL, Lazcano A, Cleaves HJ, Hazen RM, Chalmers J. Debating evidence for the origin of life on Earth. Science. 2007 Feb 16; 315(5814):937-9; author reply 937-9. PMID: 17303735.
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      30. Skelley AM, Cleaves HJ, Jayarajah CN, Bada J, Mathies RA. Application of the Mars Organic Analyzer to nucleobase and amine biomarker detection. Astrobiology. 2006 Dec; 6(6):824-37. PMID: 17155883.
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      31. Bada J. Don't dismiss astrobiology. Response. Science. 2005 Apr 22; 308(5721):495-7. PMID: 15849862.
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      32. Skelley AM, Scherer JR, Aubrey AD, Grover WH, Ivester RH, Ehrenfreund P, Grunthaner FJ, Bada J, Mathies RA. Development and evaluation of a microdevice for amino acid biomarker detection and analysis on Mars. Proc Natl Acad Sci U S A. 2005 Jan 25; 102(4):1041-6. PMID: 15657130.
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      33. Glavin DP, Cleaves HJ, Schubert M, Aubrey A, Bada J. New method for estimating bacterial cell abundances in natural samples by use of sublimation. Appl Environ Microbiol. 2004 Oct; 70(10):5923-8. PMID: 15466534.
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      34. Kminek G, Bada J, Pogliano K, Ward JF. Radiation-dependent limit for the viability of bacterial spores in halite fluid inclusions and on Mars. Radiat Res. 2003 Jun; 159(6):722-9. PMID: 12751954.
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      35. Lazcano A, Bada J. The 1953 Stanley L. Miller experiment: fifty years of prebiotic organic chemistry. Orig Life Evol Biosph. 2003 Jun; 33(3):235-42. PMID: 14515862.
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      36. Bada J, Lazcano A. Perceptions of science. Prebiotic soup--revisiting the Miller experiment. Science. 2003 May 2; 300(5620):745-6. PMID: 12730584.
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      37. Glavin DP, Schubert M, Bada J. Direct isolation of purines and pyrimidines from nucleic acids using sublimation. Anal Chem. 2002 Dec 15; 74(24):6408-12. PMID: 12510767.
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      38. Bada J, Lazcano A. Origin of life. Some like it hot, but not the first biomolecules. Science. 2002 Jun 14; 296(5575):1982-3. PMID: 12065824.
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      39. Bada J, Lazcano A. Miller revealed new ways to study the origins of life. Nature. 2002 Apr 4; 416(6880):475. PMID: 11932715.
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      40. Botta O, Glavin DP, Kminek G, Bada J. Relative amino acid concentrations as a signature for parent body processes of carbonaceous chondrites. Orig Life Evol Biosph. 2002 Apr; 32(2):143-63. PMID: 12185673.
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      41. Ehrenfreund P, Glavin DP, Botta O, Cooper G, Bada J. Extraterrestrial amino acids in Orgueil and Ivuna: tracing the parent body of CI type carbonaceous chondrites. Proc Natl Acad Sci U S A. 2001 Feb 27; 98(5):2138-41. PMID: 11226205.
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      42. Bada J. State-of-the-art instruments for detecting extraterrestrial life. Proc Natl Acad Sci U S A. 2001 Jan 30; 98(3):797-800. PMID: 11158548.
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      43. Glavin DP, Bada J. Survival of amino acids in micrometeorites during atmospheric entry. Astrobiology. 2001; 1(3):259-69. PMID: 12448989.
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      44. Levy M, Miller SL, Brinton K, Bada J. Prebiotic synthesis of adenine and amino acids under Europa-like conditions. Icarus. 2000 Jun; 145(2):609-13. PMID: 11543508.
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      45. Hutt LD, Glavin DP, Bada J, Mathies RA. Microfabricated capillary electrophoresis amino acid chirality analyzer for extraterrestrial exploration. Anal Chem. 1999 Sep 15; 71(18):4000-6. PMID: 10500487.
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      46. Glavin DP, Bada J, Brinton KL, McDonald GD. Amino acids in the Martian meteorite Nakhla. Proc Natl Acad Sci U S A. 1999 Aug 3; 96(16):8835-8. PMID: 10430856.
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      47. Becker L, Popp B, Rust T, Bada J. The origin of organic matter in the Martian meteorite ALH84001. Earth Planet Sci Lett. 1999 Mar 30; 167(1-2):71-9. PMID: 11542930.
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      48. Arrhenius G, Bada J, Joyce GF, Lazcano A, Miller S, Orgel LE. Origin and ancestor: separate environments. Science. 1999 Feb 5; 283(5403):792. PMID: 10049121.
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      49. Bada J, Wang XS, Hamilton H. Preservation of key biomolecules in the fossil record: current knowledge and future challenges. Philos Trans R Soc Lond B Biol Sci. 1999 Jan 29; 354(1379):77-86; discussion 86-7. PMID: 10091249.
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      50. Becker L, Popp B, Rust T, Bada J. The origin of organic matter in the Martian meteorite ALH84001. Adv Space Res. 1999; 24(4):477-88. PMID: 11543335.
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      51. Brinton KL, Engrand C, Glavin DP, Bada J, Maurette M. A search for extraterrestrial amino acids in carbonaceous Antarctic micrometeorites. Orig Life Evol Biosph. 1998 Oct; 28(4-6):413-24. PMID: 9742723.
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      52. Glavin DP, Bada J. Isolation of amino acids from natural samples using sublimation. Anal Chem. 1998 Aug 1; 70(15):3119-22. PMID: 11013716.
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      53. Bada J, Glavin DP, McDonald GD, Becker L. A search for endogenous amino acids in martian meteorite ALH84001. Science. 1998 Jan 16; 279(5349):362-5. PMID: 9430583.
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      54. Bada J. Meteoritics. Extraterrestrial handedness? Science. 1997 Feb 14; 275(5302):942-3. PMID: 9053998.
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      55. Becker L, Glavin DP, Bada J. Polycyclic aromatic hydrocarbons (PAHs) in Antarctic Martian meteorites, carbonaceous chondrites, and polar ice. Geochim Cosmochim Acta. 1997; 61(2):475-81. PMID: 11541466.
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      56. Poinar HN, Höss M, Bada J, Pääbo S. Amino acid racemization and the preservation of ancient DNA. Science. 1996 May 10; 272(5263):864-6. PMID: 8629020.
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      57. Durán E, Cabezos J, Ros M, Terre M, Zarzuela F, Bada J. [Tuberculosis in recent immigrants in Barcelona]. Med Clin (Barc). 1996 Apr 13; 106(14):525-8. PMID: 8656740.
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      58. Becker L, Poreda RJ, Bada J. Extraterrestrial helium trapped in fullerenes in the Sudbury impact structure. Science. 1996 Apr 12; 272(5259):249-52. PMID: 8602508.
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      59. Bada J, McDonald GD. Detecting amino acids on Mars. Anal Chem. 1996; 68:668A-673A. PMID: 11541467.
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      60. Brinton KL, Bada J. A reexamination of amino acids in lunar soils: implications for the survival of exogenous organic material during impact delivery. Geochim Cosmochim Acta. 1996 Jan; 60(2):349-54. PMID: 11541128.
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      61. Keefe AD, Miller SL, McDonald G, Bada J. Investigation of the prebiotic synthesis of amino acids and RNA bases from CO2 using FeS/H2S as a reducing agent. Proc Natl Acad Sci U S A. 1995 Dec 5; 92(25):11904-6. PMID: 8524872.
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      62. Bada J, Miller SL, Zhao M. The stability of amino acids at submarine hydrothermal vent temperatures. Orig Life Evol Biosph. 1995 Jun; 25(1-3):111-8. PMID: 11536665.
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      63. Bada J. Origins of homochirality. Nature. 1995 Apr 13; 374(6523):594-5. PMID: 7536302.
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      64. McDonald GD, Bada J. A search for endogenous amino acids in the Martian meteorite EETA79001. Geochim Cosmochim Acta. 1995 Mar; 59(6):1179-84. PMID: 11540048.
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      65. Cabezos J, Durán E, Treviño B, Bada J. [Malaria imported by immigrants in Catalonia]. Med Clin (Barc). 1995 Jan 21; 104(2):45-8. PMID: 7869778.
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      66. Bada J, McDonald GD. Amino acid racemization on Mars: implications for the preservation of biomolecules from an extinct martian biota. Icarus. 1995; 114:139-43. PMID: 11539479.
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      67. Zhao M, Bada J. Determination of alpha-dialkylamino acids and their enantiomers in geological samples by high-performance liquid chromatography after derivatization with a chiral adduct of o-phthaldialdehyde. J Chromatogr A. 1995; 690:55-63. PMID: 11541458.
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      68. Becker L, Bada J, Winans RE, Bunch TE. Fullerenes in Allende meteorite. Nature. 1994 Dec 8; 372(6506):507. PMID: 7990921.
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      69. Becker L, Bada J, Winans RE, Hunt JE, Bunch TE, French BM. Fullerenes in the 1.85-billion-year-old Sudbury impact structure. Science. 1994 Jul 29; 265(5172):642-5. PMID: 11536660.
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      70. Bada J, Bigham C, Miller SL. Impact melting of frozen oceans on the early Earth: implications for the origin of life. Proc Natl Acad Sci U S A. 1994 Feb; 91:1248-50. PMID: 11539550.
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      71. Bada J, Wang XS, Poinar HN, Paabo S, Poinar GO. Amino acid racemization in amber-entombed insects: implications for DNA preservation. Geochim Cosmochim Acta. 1994; 58(14):3131-5. PMID: 11539553.
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      72. Sagan C, Khare BN, Thompson WR, McDonald GD, Wing MR, Bada J, Vo-Dinh T, Arakawa ET. Polycyclic aromatic hydrocarbons in the atmospheres of Titan and Jupiter. Astrophys J. 1993 Sep 1; 414(1):399-405. PMID: 11539501.
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      73. Miller SL, Bada J. Comment on "Summary and implications of reported amino acid concentrations in the Murchison meteorite" by E.L. Shock and M.D. Schulte Geochim Cosmochim Acta. 1993 Jul; 57(14):3473-4. PMID: 11538301.
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      74. Becker L, McDonald GD, Bada J. Carbon onions in meteorites [letter]. Nature. 1993 Feb 18; 361(6413):595. PMID: 11536529.
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      75. Becker L, Evans TP, Bada J. Synthesis of C60H2 by rhodium-catalyzed hydrogenation of C60. J Org Chem. 1993; 58(27):7630-1. PMID: 11543597.
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      76. Zenobi R, Philippoz JM, Zare RN, Wing MR, Bada J, Marti K. Organic compounds in the Forest Vale, H4 ordinary chondrite. Geochim Cosmochim Acta. 1992 Jul; 56(7):2899-905. PMID: 11537804.
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      77. Miller SL, Bada J. Extraterrestrial synthesis. Nature. 1991 Apr 4; 350(6317):387-8. PMID: 11536481.
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      78. Bada J. Racemization dating. Science. 1990 May 4; 248(4955):539-40. PMID: 17791452.
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      79. Zhao M, Bada J. Extraterrestrial amino acids in Cretaceous/Tertiary boundary sediments at Stevns Klint, Denmark. Nature. 1989 Jun 8; 339(6224):463-5. PMID: 2725679.
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      80. Miller SL, Bada J. Submarine hot springs and the origin of life. Nature. 1988 Aug 18; 334(6183):609-11. PMID: 11536607.
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      81. Bada J. Paleoanthropological applications of amino acid racemization dating of fossil bones and teeth. Anthropol Anz. 1987 Mar; 45(1):1-8. PMID: 3107460.
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      82. Bada J, Miller SL. Racemization and the origin of optically active organic compounds in living organisms. Biosystems. 1987; 20(1):21-6. PMID: 3580530.
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      83. Bada J, Miller SL. Racemization and the origin of optically active organic compounds in living organisms. Biosystems. 1987; 20:21-6. PMID: 11542094.
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      84. Bada J, Gillespie R, Gowlett JA, Hedges RE. Accelerator mass spectrometry radiocarbon ages of amino acid extracts from Californian palaeoindian skeletons. Nature. 1984 Nov 29-Dec 5; 312(5993):442-4. PMID: 6438531.
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      85. Boehm MF, Bada J. Racemization of aspartic acid and phenylalanine in the sweetener aspartame at 100 degrees C. Proc Natl Acad Sci U S A. 1984 Aug; 81(16):5263-6. PMID: 6591191.
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      86. Peltzer ET, Bada J, Schlesinger G, Miller SL. The chemical conditions on the parent body of the Murchison meteorite: some conclusions based on amino, hydroxy and dicarboxylic acids. Adv Space Res. 1984; 4(12):69-74. PMID: 11537797.
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      87. Bada J. In vivo racemization in mammalian proteins. Methods Enzymol. 1984; 106:98-115. PMID: 6493067.
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      88. Steinberg S, Bada J. Diketopiperazine formation during investigations of amino Acid racemization in dipeptides. Science. 1981 Jul 31; 213(4507):544-5. PMID: 17794841.
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      89. Masters PM, Bada J, Zigler JS. Aspartic acid racemization in heavy molecular weight crystallins and water insoluble protein from normal human lenses and cataracts. Proc Natl Acad Sci U S A. 1978 Mar; 75(3):1204-8. PMID: 274711.
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      90. Masters PM, Bada J, Zigler JS. Aspartic acid racemisation in the human lens during ageing and in cataract formation. Nature. 1977 Jul 7; 268(5615):71-3. PMID: 887151.
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      91. Helfman PM, Bada J, Shou MY. Considerations on the role of aspartic acid racemization in the aging process. Gerontology. 1977; 23(6):419-25. PMID: 892449.
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      92. Helfman PM, Bada J. Aspartic acid racemisation in dentine as a measure of ageing. Nature. 1976 Jul 22; 262(5566):279-81. PMID: 958370.
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      93. Bada J, Helfman PM. Amino acid racemization dating of fossil bones. World Archaeol. 1975 Oct; 7(2):160-73. PMID: 16470964.
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      94. Helfman PM, Bada J. Aspartic acid racemization in tooth enamel from living humans. Proc Natl Acad Sci U S A. 1975 Aug; 72(8):2891-4. PMID: 1059082.
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      95. Bada J, Schroeder RA, Carter GF. New evidence for the antiquity of man in North America deduced from aspartic acid racemization. Science. 1974 May 17; 184(4138):791-3. PMID: 4595240.
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      96. Bada J, Schroeder RA, Protsch R, Berger R. Concordance of collagen-based radiocarbon and aspartic-acid racemization ages. Proc Natl Acad Sci U S A. 1974 Mar; 71(3):914-7. PMID: 4522802.
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      97. Schroeder RA, Bada J. Glacial-postglacial temperature difference deduced from aspartic Acid racemization in fossil bones. Science. 1973 Nov 2; 182(4111):479-82. PMID: 17832466.
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      98. Bada J, Protsch R. Racemization reaction of aspartic Acid and its use in dating fossil bones. Proc Natl Acad Sci U S A. 1973 May; 70(5):1331-4. PMID: 16592082.
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      99. Bada J, Luyendyk BP, Maynard JB. Marine sediments: dating by the racemization of amino acids. Science. 1970 Nov 13; 170(3959):730-2. PMID: 5479627.
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      100. Bada J, Miller SL. The kinetics and mechanism of the reversible nonenzymatic deamination of aspartic acid. J Am Chem Soc. 1970 May 6; 92(9):2774-82. PMID: 5439970.
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      101. Bada J, Miller SL. Equilibrium constant for the reversible deamination of aspartic acid. Biochemistry. 1968 Oct; 7(10):3403-8. PMID: 5681454.
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      102. Bada J, Miller SL. Ammonium ion concentration in the primitive ocean. Science. 1968 Jan 26; 159(3813):423-5. PMID: 5634660.
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