Edward Koellhoffer

Title(s)	Resident Physician, Radiology
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Biography

Education and Training

University of Texas Health Sciences Center at Houston, Houston, TX		06/2019	Preliminary Internship (Internal Medicine)
McGovern Medical School at UTHealth, Houston, TX	MD	05/2019	Doctor of Medicine
The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX	PhD	05/2019	Neuroscience
Boston College, Chestnut Hill, MA	BS	05/2009	Biochemistry

Research

Research Activities and Funding

The Aging Microglia: the Role of Exh2 in Pro-Inflammatory Phenotype Polarization
NIH F30NS095511Sep 1, 2016 - Jan 31, 2020
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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3D bioprinting cowpea mosaic virus as an immunotherapy depot for ovarian cancer prevention in a preclinical mouse model. Mater Adv. 2024 Feb 19; 5(4):1480-1486. Zhao Z, Xiang Y, Koellhoffer EC, Shukla S, Fiering S, Chen S, Steinmetz NF. PMID: 38380337; PMCID: PMC10876074.

View in: PubMed Mentions:
Inactivated Cowpea Mosaic Virus for In Situ Vaccination: Differential Efficacy of Formalin vs UV-Inactivated Formulations. Mol Pharm. 2023 01 02; 20(1):500-507. Jung E, Mao C, Bhatia M, Koellhoffer EC, Fiering SN, Steinmetz NF. PMID: 36399598; PMCID: PMC9812890.

View in: PubMed Mentions: 3 Fields:
Mol Molecular Biology Pha Pharmacology
Translation:Animals Cells PHPublic Health
Cowpea Mosaic Virus and Natural Killer Cell Agonism for In Situ Cancer Vaccination. Nano Lett. 2022 07 13; 22(13):5348-5356. Koellhoffer EC, Steinmetz NF. PMID: 35713326; PMCID: PMC9665426.

View in: PubMed Mentions: 6 Fields:
Nan Nanotechnology
Translation:Humans Animals Cells PHPublic Health
Inactivated Cowpea Mosaic Virus in Combination with OX40 Agonist Primes Potent Antitumor Immunity in a Bilateral Melanoma Mouse Model. Mol Pharm. 2022 02 07; 19(2):592-601. Koellhoffer EC, Mao C, Beiss V, Wang L, Fiering SN, Boone CE, Steinmetz NF. PMID: 34978197; PMCID: PMC9207558.

View in: PubMed Mentions: 5 Fields:
Mol Molecular Biology Pha Pharmacology
Translation:Humans Animals Cells
Integrating plant molecular farming and materials research for next-generation vaccines. Nat Rev Mater. 2022; 7(5):372-388. Chung YH, Church D, Koellhoffer EC, Osota E, Shukla S, Rybicki EP, Pokorski JK, Steinmetz NF. PMID: 34900343; PMCID: PMC8647509.

View in: PubMed Mentions: 32
Transforming growth factor-β promotes basement membrane fibrosis, alters perivascular cerebrospinal fluid distribution, and worsens neurological recovery in the aged brain after stroke. Geroscience. 2019 10; 41(5):543-559. Howe MD, Furr JW, Munshi Y, Roy-O'Reilly MA, Maniskas ME, Koellhoffer EC, d'Aigle J, Sansing LH, McCullough LD, Urayama A. PMID: 31721012; PMCID: PMC6885082.

View in: PubMed Mentions: 17 Fields:
Ger Geriatrics
Translation:Humans Animals
Inhibition of calcium/calmodulin-dependent protein kinase kinase (CaMKK) exacerbates impairment of endothelial cell and blood-brain barrier after stroke. Eur J Neurosci. 2019 01; 49(1):27-39. Sun P, Bu F, Min JW, Munshi Y, Howe MD, Liu L, Koellhoffer EC, Qi L, McCullough LD, Li J. PMID: 30422362; PMCID: PMC6590081.

View in: PubMed Mentions: 18 Fields:
Neu Neurology
Translation:Humans Animals Cells
Myeloid-specific TAK1 deletion results in reduced brain monocyte infiltration and improved outcomes after stroke. J Neuroinflammation. 2018 May 17; 15(1):148. Chauhan A, Hudobenko J, Al Mamun A, Koellhoffer EC, Patrizz A, Ritzel RM, Ganesh BP, McCullough LD. PMID: 29776451; PMCID: PMC5960093.

View in: PubMed Mentions: 5 Fields:
Neu Neurology
Translation:Animals Cells
Ras-Related C3 Botulinum Toxin Substrate 1 Promotes Axonal Regeneration after Stroke in Mice. Transl Stroke Res. 2018 10; 9(5):506-514. Liu L, Yuan H, Yi Y, Koellhoffer EC, Munshi Y, Bu F, Zhang Y, Zhang Z, McCullough LD, Li J. PMID: 29476448; PMCID: PMC6598679.

View in: PubMed Mentions: 16 Fields:
Bra Brain Vas Vascular Diseases
Translation:Animals Cells
The G-quadruplex DNA stabilizing drug pyridostatin promotes DNA damage and downregulates transcription of Brca1 in neurons. Aging (Albany NY). 2017 09 12; 9(9):1957-1970. Moruno-Manchon JF, Koellhoffer EC, Gopakumar J, Hambarde S, Kim N, McCullough LD, Tsvetkov AS. PMID: 28904242; PMCID: PMC5636668.

View in: PubMed Mentions: 40 Fields:
Ger Geriatrics
Translation:Animals Cells
Multiparity improves outcomes after cerebral ischemia in female mice despite features of increased metabovascular risk. Proc Natl Acad Sci U S A. 2017 07 11; 114(28):E5673-E5682. Ritzel RM, Patel AR, Spychala M, Verma R, Crapser J, Koellhoffer EC, Schrecengost A, Jellison ER, Zhu L, Venna VR, McCullough LD. PMID: 28645895; PMCID: PMC5514696.

View in: PubMed Mentions: 21 Fields:
Sci Science
Translation:Animals Cells
Old Maids: Aging and Its Impact on Microglia Function. Int J Mol Sci. 2017 Apr 05; 18(4). Koellhoffer EC, McCullough LD, Ritzel RM. PMID: 28379162; PMCID: PMC5412353.

View in: PubMed Mentions: 101 Fields:
Bio Biochemistry Che Chemistry Mol Molecular Biology
Translation:Humans Animals Cells
Ischemic stroke induces gut permeability and enhances bacterial translocation leading to sepsis in aged mice. Aging (Albany NY). 2016 05; 8(5):1049-63. Crapser J, Ritzel R, Verma R, Venna VR, Liu F, Chauhan A, Koellhoffer E, Patel A, Ricker A, Maas K, Graf J, McCullough LD. PMID: 27115295; PMCID: PMC4931853.

View in: PubMed Mentions: 74 Fields:
Ger Geriatrics
Translation:Animals
Swi/Snf chromatin remodeling/tumor suppressor complex establishes nucleosome occupancy at target promoters. Proc Natl Acad Sci U S A. 2013 Jun 18; 110(25):10165-70. Tolstorukov MY, Sansam CG, Lu P, Koellhoffer EC, Helming KC, Alver BH, Tillman EJ, Evans JA, Wilson BG, Park PJ, Roberts CW. PMID: 23723349; PMCID: PMC3690861.

View in: PubMed Mentions: 107 Fields:
Sci Science
Translation:Animals Cells
The effects of estrogen in ischemic stroke. Transl Stroke Res. 2013 Aug; 4(4):390-401. Koellhoffer EC, McCullough LD. PMID: 24323337; PMCID: PMC4275797.

View in: PubMed Mentions: 85 Fields:
Bra Brain Vas Vascular Diseases
Translation:Humans Animals Cells
Epigenetic inactivation of the tumor suppressor BIN1 drives proliferation of SNF5-deficient tumors. Cell Cycle. 2012 May 15; 11(10):1956-65. McKenna ES, Tamayo P, Cho YJ, Tillman EJ, Mora-Blanco EL, Sansam CG, Koellhoffer EC, Pomeroy SL, Roberts CW. PMID: 22544318; PMCID: PMC3359122.

View in: PubMed Mentions: 13 Fields:
Cel Cell Biology
Translation:Humans Animals Cells
Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation. Cancer Cell. 2010 Oct 19; 18(4):316-28. Wilson BG, Wang X, Shen X, McKenna ES, Lemieux ME, Cho YJ, Koellhoffer EC, Pomeroy SL, Orkin SH, Roberts CW. PMID: 20951942; PMCID: PMC2957473.

View in: PubMed Mentions: 331 Fields:
Neo Neoplasms
Translation:Humans Animals Cells