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James Lohr

Title(s)Senate Emeritus, Psychiatry
SchoolHealth Sciences
Phone858-552-8585
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    Biography

    Dr. Lohr received his BA from the University of Chicago and MD from the Pritzker School of Medicine at the University of Chicago. From there, he went to the University of Pittsburgh where he completed his residency in General Psychiatry at the Western Psychiatric Institute and Clinics, and then completed a Neuropsychiatry Fellowship at the National Institute of Mental Health in Washington DC. He joined the Department of Psychiatry faculty at UCSD in 1987, and for 12 years was the Chief of Psychiatry at the VA San Diego Healthcare System. For the last three years he has been Vice Chair for Clinical Affairs in the Department of Psychiatry at UCSD, and Clinical Service Chief for the Department as well. He oversees the clinical operations for all mental health services at UCSD. He is also the Director of the Psychopharmacology Research Initiatives Center of Excellence (PRICE) in the Department of Psychiatry, which coordinates studies of psychotropic medications.

    Research Interests

    Dr. Lohr’s primary research interest has been neuropsychiatric movement disorders and the major psychotic illnesses of schizophrenia and bipolar disorder. He has been involved in studies of motor function, brain imaging, oxidative metabolism, and lateralized hemispheric functioning in these disorders, as well as studies of psychopharmacology and of healthcare systems and delivery.

    Clinical Focus

    Dr. Lohr’s primary clinical focus is on serious mental disorders, predominantly the major psychotic disorders of schizophrenia, schizoaffective disorder, and bipolar disorder.

    Collapse Research 
    Collapse Research Activities and Funding
    Accelerated Aging among Veterans with PTSD
    VA I01CX001351Apr 1, 2017 - Mar 31, 2021
    Role: Principal Investigator
    MOTOR/COGNITIVE ASYMMETRY IN OLDER PSYCHOTIC PATIENTS
    NIH/NIMH R01MH057140Sep 1, 1998 - May 31, 2003
    Role: Principal Investigator
    TARDIVE DYSKINESIA: FREE RADICAL MECHANISMS &VITAMIN E
    NIH/NIMH R29MH045142Aug 1, 1989 - Jul 31, 1994
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lohr JB, Chang H, Sexton M, Palmer BW. Allostatic load and the cannabinoid system: implications for the treatment of physiological abnormalities in post-traumatic stress disorder (PTSD). CNS Spectr. 2019 Jul 15; 1-7. PMID: 31303187.
      View in: PubMed
    2. Caligiuri MP, Teulings HL, Dean CE, Lohr JB. The nature of bradykinesia in schizophrenia treated with antipsychotics. Psychiatry Res. 2019 Jan 15; 273:537-543. PMID: 30710809.
      View in: PubMed
    3. Rasmusson AM, Marx CE, Jain S, Farfel GM, Tsai J, Sun X, Geracioti TD, Hamner MB, Lohr J, Rosse R, Summerall L, Naylor JC, Cusin C, Lang AJ, Raman R, Stein MB. A randomized controlled trial of ganaxolone in posttraumatic stress disorder. Psychopharmacology (Berl). 2017 Aug; 234(15):2245-2257. PMID: 28667510.
      View in: PubMed
    4. Pittman JOE, Floto E, Lindamer L, Baker DG, Lohr JB, Afari N. VA eScreening program: Technology to improve care for post-9/11 veterans. Psychol Serv. 2017 02; 14(1):23-33. PMID: 28134554.
      View in: PubMed
    5. Lohr JB, Eidt CA, Abdulrazzaq Alfaraj A, Soliman MA. The clinical challenges of akathisia. CNS Spectr. 2015 Dec; 20 Suppl 1:1-14; quiz 15-6. PMID: 26683525.
      View in: PubMed
    6. Twamley EW, Thomas KR, Gregory AM, Jak AJ, Bondi MW, Delis DC, Lohr JB. CogSMART Compensatory Cognitive Training for Traumatic Brain Injury: Effects Over 1 Year. J Head Trauma Rehabil. 2015 Nov-Dec; 30(6):391-401. PMID: 25033034.
      View in: PubMed
    7. McAllister TW, Zafonte R, Jain S, Flashman LA, George MS, Grant GA, He F, Lohr JB, Andaluz N, Summerall L, Paulus MP, Raman R, Stein MB. Randomized Placebo-Controlled Trial of Methylphenidate or Galantamine for Persistent Emotional and Cognitive Symptoms Associated with PTSD and/or Traumatic Brain Injury. Neuropsychopharmacology. 2016 Apr; 41(5):1191-8. PMID: 26361060.
      View in: PubMed
    8. Lohr JB, Palmer BW, Eidt CA, Aailaboyina S, Mausbach BT, Wolkowitz OM, Thorp SR, Jeste DV. Is Post-Traumatic Stress Disorder Associated with Premature Senescence? A Review of the Literature. Am J Geriatr Psychiatry. 2015 Jul; 23(7):709-25. PMID: 25959921.
      View in: PubMed
    9. Caligiuri MP, Teulings HL, Dean CE, Lohr JB. A quantitative measure of handwriting dysfluency for assessing tardive dyskinesia. J Clin Psychopharmacol. 2015 Apr; 35(2):168-74. PMID: 25679121.
      View in: PubMed
    10. Afari N, Pittman J, Floto E, Owen L, Buttner M, Hossain N, Baker DG, Lindamer L, Lohr JB. Differential impact of combat on postdeployment symptoms in female and male veterans of iraq and afghanistan. Mil Med. 2015 Mar; 180(3):296-303. PMID: 25735020.
      View in: PubMed
    11. Mostoufi S, Godfrey KM, Ahumada SM, Hossain N, Song T, Wright LJ, Lohr JB, Afari N. Pain sensitivity in posttraumatic stress disorder and other anxiety disorders: a preliminary case control study. Ann Gen Psychiatry. 2014; 13(1):31. PMID: 25422670.
      View in: PubMed
    12. Tylee DS, Chandler SD, Nievergelt CM, Liu X, Pazol J, Woelk CH, Lohr JB, Kremen WS, Baker DG, Glatt SJ, Tsuang MT. Blood-based gene-expression biomarkers of post-traumatic stress disorder among deployed marines: A pilot study. Psychoneuroendocrinology. 2015 Jan; 51:472-94. PMID: 25311155.
      View in: PubMed
    13. Agorastos A, Hauger RL, Barkauskas DA, Moeller-Bertram T, Clopton PL, Haji U, Lohr JB, Geracioti TD, Patel PM, Chrousos GP, Baker DG. Circadian rhythmicity, variability and correlation of interleukin-6 levels in plasma and cerebrospinal fluid of healthy men. Psychoneuroendocrinology. 2014 Jun; 44:71-82. PMID: 24767621.
      View in: PubMed
    14. Gowda M, Nainani N, Lohr J, Arora P. Quiz page March 2014: A patient with malignant hypertension, thrombotic microangiopathy, and nephrotic-range proteinuria. Am J Kidney Dis. 2014 Mar; 63(3):A23-5. PMID: 24560161.
      View in: PubMed
    15. Franz CE, Lyons MJ, Spoon KM, Hauger RL, Jacobson KC, Lohr JB, McKenzie R, Panizzon MS, Thompson WK, Tsuang MT, Vasilopoulos T, Vuoksimaa E, Xian H, Kremen WS. Post-traumatic stress symptoms and adult attachment: a 24-year longitudinal study. Am J Geriatr Psychiatry. 2014 Dec; 22(12):1603-12. PMID: 24636844.
      View in: PubMed
    16. Sorg SF, Delano-Wood L, Luc N, Schiehser DM, Hanson KL, Nation DA, Lanni E, Jak AJ, Lu K, Meloy MJ, Frank LR, Lohr JB, Bondi MW. White matter integrity in veterans with mild traumatic brain injury: associations with executive function and loss of consciousness. J Head Trauma Rehabil. 2014 Jan-Feb; 29(1):21-32. PMID: 23640539.
      View in: PubMed
    17. Twamley EW, Jak AJ, Delis DC, Bondi MW, Lohr JB. Cognitive Symptom Management and Rehabilitation Therapy (CogSMART) for veterans with traumatic brain injury: pilot randomized controlled trial. J Rehabil Res Dev. 2014; 51(1):59-70. PMID: 24805894.
      View in: PubMed
    18. Lyons MJ, Genderson M, Grant MD, Logue M, Zink T, McKenzie R, Franz CE, Panizzon M, Lohr JB, Jerskey B, Kremen WS. Gene-environment interaction of ApoE genotype and combat exposure on PTSD. Am J Med Genet B Neuropsychiatr Genet. 2013 Oct; 162B(7):762-9. PMID: 24132908.
      View in: PubMed
    19. Lohr JB, Liu L, Caligiuri MP, Kash TP, May TA, Murphy JD, Ancoli-Israel S. Modafinil improves antipsychotic-induced parkinsonism but not excessive daytime sleepiness, psychiatric symptoms or cognition in schizophrenia and schizoaffective disorder: a randomized, double-blind, placebo-controlled study. Schizophr Res. 2013 Oct; 150(1):289-96. PMID: 23938173.
      View in: PubMed
    20. Acheson D, Feifel D, de Wilde S, McKinney R, Lohr J, Risbrough V. The effect of intranasal oxytocin treatment on conditioned fear extinction and recall in a healthy human sample. Psychopharmacology (Berl). 2013 Sep; 229(1):199-208. PMID: 23644911.
      View in: PubMed
    21. Glatt SJ, Tylee DS, Chandler SD, Pazol J, Nievergelt CM, Woelk CH, Baker DG, Lohr JB, Kremen WS, Litz BT, Tsuang MT. Blood-based gene-expression predictors of PTSD risk and resilience among deployed marines: a pilot study. Am J Med Genet B Neuropsychiatr Genet. 2013 Jun; 162B(4):313-26. PMID: 23650250.
      View in: PubMed
    22. Schuitevoerder S, Rosen JW, Twamley EW, Ayers CR, Sones H, Lohr JB, Goetter EM, Fonzo GA, Holloway KJ, Thorp SR. A meta-analysis of cognitive functioning in older adults with PTSD. J Anxiety Disord. 2013 Aug; 27(6):550-8. PMID: 23422492.
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    23. Agorastos A, Nash WP, Nunnink S, Yurgil KA, Goldsmith A, Litz BT, Johnson H, Lohr JB, Baker DG. The Peritraumatic Behavior Questionnaire: development and initial validation of a new measure for combat-related peritraumatic reactions. BMC Psychiatry. 2013 Jan 05; 13:9. PMID: 23289606.
      View in: PubMed
    24. Bousman CA, Glatt SJ, Chandler SD, Lohr J, Kremen WS, Tsuang MT, Everall IP. Negative Symptoms of Psychosis Correlate with Gene Expression of the Wnt/ß-Catenin Signaling Pathway in Peripheral Blood. Psychiatry J. 2013; 2013:852930. PMID: 24236287.
      View in: PubMed
    25. Twamley EW, Baker DG, Norman SB, Pittman JO, Lohr JB, Resnick SG. Veterans Health Administration vocational services for Operation Iraqi Freedom/Operation Enduring Freedom Veterans with mental health conditions. J Rehabil Res Dev. 2013; 50(5):663-70. PMID: 24013914.
      View in: PubMed
    26. Smith RC, Jin H, Li C, Bark N, Shekhar A, Dwivedi S, Mortiere C, Lohr J, Hu Q, Davis JM. Effects of pioglitazone on metabolic abnormalities, psychopathology, and cognitive function in schizophrenic patients treated with antipsychotic medication: a randomized double-blind study. Schizophr Res. 2013 Jan; 143(1):18-24. PMID: 23200554.
      View in: PubMed
    27. Matthews SC, Spadoni AD, Lohr JB, Strigo IA, Simmons AN. Diffusion tensor imaging evidence of white matter disruption associated with loss versus alteration of consciousness in warfighters exposed to combat in Operations Enduring and Iraqi Freedom. Psychiatry Res. 2012 Nov 30; 204(2-3):149-54. PMID: 23149025.
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    28. Heppner PS, Lohr JB, Kash TP, Jin H, Wang H, Baker DG. Metabolic syndrome: relative risk associated with post-traumatic stress disorder (PTSD) severity and antipsychotic medication use. Psychosomatics. 2012 Nov-Dec; 53(6):550-8. PMID: 23157993.
      View in: PubMed
    29. Lohr JB, May T, Caligiuri MP. Quantitative assessment of motor abnormalities in untreated patients with major depressive disorder. J Affect Disord. 2013 Mar 20; 146(1):84-90. PMID: 22985485.
      View in: PubMed
    30. Simmons AN, Flagan TM, Wittmann M, Strigo IA, Matthews SC, Donovan H, Lohr JB, Paulus MP. The effects of temporal unpredictability in anticipation of negative events in combat veterans with PTSD. J Affect Disord. 2013 Apr 25; 146(3):426-32. PMID: 22910447.
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    31. Acheson DT, Stein MB, Paulus MP, Ravindran L, Simmons AN, Lohr JB, Risbrough VB. Effects of anxiolytic treatment on potentiated startle during aversive image anticipation. Hum Psychopharmacol. 2012 Jul; 27(4):419-27. PMID: 22782542.
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    32. Backhaus A, Agha Z, Maglione ML, Repp A, Ross B, Zuest D, Rice-Thorp NM, Lohr J, Thorp SR. Videoconferencing psychotherapy: a systematic review. Psychol Serv. 2012 May; 9(2):111-131. PMID: 22662727.
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    33. Hauger RL, Olivares-Reyes JA, Dautzenberg FM, Lohr JB, Braun S, Oakley RH. Molecular and cell signaling targets for PTSD pathophysiology and pharmacotherapy. Neuropharmacology. 2012 Feb; 62(2):705-14. PMID: 22122881.
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    34. Brown GG, Lee JS, Strigo IA, Caligiuri MP, Meloy MJ, Lohr J. Voxel-based morphometry of patients with schizophrenia or bipolar I disorder: a matched control study. Psychiatry Res. 2011 Nov 30; 194(2):149-56. PMID: 21924872.
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    35. Wang H, Jin H, Nunnink SE, Guo W, Sun J, Shi J, Zhao B, Bi Y, Yan T, Yu H, Wang G, Gao Z, Zhao H, Ou Y, Song Z, Chen F, Lohr JB, Baker DG. Identification of post traumatic stress disorder and risk factors in military first responders 6 months after Wen Chuan earthquake in China. J Affect Disord. 2011 Apr; 130(1-2):213-9. PMID: 20950864.
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    36. Bousman CA, Chana G, Glatt SJ, Chandler SD, May T, Lohr J, Kremen WS, Tsuang MT, Everall IP. Positive symptoms of psychosis correlate with expression of ubiquitin proteasome genes in peripheral blood. Am J Med Genet B Neuropsychiatr Genet. 2010 Oct 05; 153B(7):1336-41. PMID: 20552680.
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    37. Caligiuri MP, Teulings HL, Dean CE, Niculescu AB, Lohr JB. Handwriting movement kinematics for quantifying extrapyramidal side effects in patients treated with atypical antipsychotics. Psychiatry Res. 2010 May 15; 177(1-2):77-83. PMID: 20381875.
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    38. Bousman CA, Chana G, Glatt SJ, Chandler SD, Lucero GR, Tatro E, May T, Lohr JB, Kremen WS, Tsuang MT, Everall IP. Preliminary evidence of ubiquitin proteasome system dysregulation in schizophrenia and bipolar disorder: convergent pathway analysis findings from two independent samples. Am J Med Genet B Neuropsychiatr Genet. 2010 Mar 05; 153B(2):494-502. PMID: 19582768.
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    39. Hawthorne WB, Green EE, Folsom D, Lohr JB. A randomized study comparing the treatment environment in alternative and hospital-based acute psychiatric care. Psychiatr Serv. 2009 Sep; 60(9):1239-44. PMID: 19723739.
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    40. Caligiuri MP, Teulings HL, Dean CE, Niculescu AB, Lohr J. Handwriting movement analyses for monitoring drug-induced motor side effects in schizophrenia patients treated with risperidone. Hum Mov Sci. 2009 Oct; 28(5):633-42. PMID: 19692133.
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    41. Brown GG, Lohr J, Notestine R, Turner T, Gamst A, Eyler LT. Performance of schizophrenia and bipolar patients on verbal and figural working memory tasks. J Abnorm Psychol. 2007 Nov; 116(4):741-53. PMID: 18020720.
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    42. Ozdemir V, Williams-Jones B, Graham JE, Preskorn SH, Gripeos D, Glatt SJ, Friis RH, Reist C, Szabo S, Lohr JB, Someya T. Asymmetry in scientific method and limits to cross-disciplinary dialogue: toward a shared language and science policy in pharmacogenomics and human disease genetics. J Investig Med. 2007 Apr; 55(3):130-41. PMID: 17481382.
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    43. Niculescu AB, Lulow LL, Ogden CA, Le-Niculescu H, Salomon DR, Schork NJ, Caligiuri MP, Lohr JB. PhenoChipping of psychotic disorders: a novel approach for deconstructing and quantitating psychiatric phenotypes. Am J Med Genet B Neuropsychiatr Genet. 2006 Sep 05; 141B(6):653-62. PMID: 16838358.
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    44. Ozdemir V, Williams-Jones B, Glatt SJ, Tsuang MT, Lohr JB, Reist C. Shifting emphasis from pharmacogenomics to theragnostics. Nat Biotechnol. 2006 Aug; 24(8):942-6. PMID: 16900136.
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    45. Lohr JB, Hellige JB, Cherry BJ, Lulow L, Kwok W, Caligiuri MP. Impaired hemispheric communication in schizophrenia: a study using the consonant-vowel-consonant task. Schizophr Res. 2006 Oct; 87(1-3):279-88. PMID: 16822652.
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    46. Caligiuri MP, Teulings HL, Filoteo JV, Song D, Lohr JB. Quantitative measurement of handwriting in the assessment of drug-induced parkinsonism. Hum Mov Sci. 2006 Oct; 25(4-5):510-22. PMID: 16647772.
      View in: PubMed
    47. Caligiuri MP, Brown GG, Meloy MJ, Eberson S, Niculescu AB, Lohr JB. Striatopallidal regulation of affect in bipolar disorder. J Affect Disord. 2006 Apr; 91(2-3):235-42. PMID: 16503055.
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    48. Ozdemir V, Aklillu E, Mee S, Bertilsson L, Albers LJ, Graham JE, Caligiuri M, Lohr JB, Reist C. Pharmacogenetics for off-patent antipsychotics: reframing the risk for tardive dyskinesia and access to essential medicines. Expert Opin Pharmacother. 2006 Feb; 7(2):119-33. PMID: 16433578.
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    49. Lohr JB, Caligiuri MP. Abnormalities in motor physiology in bipolar disorder. J Neuropsychiatry Clin Neurosci. 2006; 18(3):342-9. PMID: 16963583.
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    50. Hawthorne WB, Green EE, Gilmer T, Garcia P, Hough RL, Lee M, Hammond L, Lohr JB. A randomized trial of short-term acute residential treatment for veterans. Psychiatr Serv. 2005 Nov; 56(11):1379-86. PMID: 16282256.
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    51. Caligiuri MP, Hellige JB, Cherry BJ, Kwok W, Lulow LL, Lohr JB. Lateralized cognitive dysfunction and psychotic symptoms in schizophrenia. Schizophr Res. 2005 Dec 15; 80(2-3):151-61. PMID: 16125374.
      View in: PubMed
    52. Caligiuri MP, Brown GG, Meloy MJ, Eyler LT, Kindermann SS, Eberson S, Frank LR, Lohr JB. A functional magnetic resonance imaging study of cortical asymmetry in bipolar disorder. Bipolar Disord. 2004 Jun; 6(3):183-96. PMID: 15117397.
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    53. Brown GG, Caligiuri M, Meloy MJ, Eberson SC, Kindermann SS, Frank LR, Eyler Zorrilla LT, Lohr JB. Functional brain asymmetries during visuomotor tracking. J Clin Exp Neuropsychol. 2004 May; 26(3):356-68. PMID: 15512926.
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    54. Lohr JB, Braff DL. The value of referring to recently introduced antipsychotics as "second generation". Am J Psychiatry. 2003 Aug; 160(8):1371-2. PMID: 12900294.
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    55. Caligiuri MP, Brown GG, Meloy MJ, Eberson SC, Kindermann SS, Frank LR, Zorrilla LE, Lohr JB. An fMRI study of affective state and medication on cortical and subcortical brain regions during motor performance in bipolar disorder. Psychiatry Res. 2003 Jul 30; 123(3):171-82. PMID: 12928105.
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    56. Lohr JB, Kuczenski R, Niculescu AB. Oxidative mechanisms and tardive dyskinesia. CNS Drugs. 2003; 17(1):47-62. PMID: 12467492.
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    57. Lohr JB, Caligiuri MP, Edson R, Lavori P, Adler LA, Rotrosen J, Hitzemann R. Treatment predictors of extrapyramidal side effects in patients with tardive dyskinesia: results from Veterans Affairs Cooperative Study 394. J Clin Psychopharmacol. 2002 Apr; 22(2):196-200. PMID: 11910266.
      View in: PubMed