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    John Adamson

    TitleClinical Professor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #9111-E
    CA La Jolla 92093
    Phone858-822-6276

       Overview 
       Overview
      Research Interests
      Dr. Adamson's long-time interests have been in the regulation of red cell production, and particularly the role of erythropoietin in that process.

      He helped organize the original clinical trials of recombinant human erythropoietin in treating the anemia of patients with chronic kidney disease and participated in the application of erythropoietin therapy to the other anemias, including chemotherapy-induced anemia in cancer patients.

      He was on the original advisory National Kidney Foundation's Dialysis Outcomes Quality Initiative (DOQI) group that developed guidelines for "best practices" in the use of erythropoietin in kidney-related anemia. "In 2011, he participated in the international effort to harmonize anemia management in patients with CKD as part of the Kidney Disease: Improving Global Outcomes (KDIGO) effort."

      In parallel, he has been invovled in studies of iron metabolism for many years and the role of iron supply to the erythron. He has been particularly interested in the alterations in iron metabolism that occur with acute and chronic inflammation and in the use of supplemental iron to enhance the marrow's response to erythropoietin therapy.

      Expanded interests include the mechanisms of anemia as part of the aging process and how to effectively manage the anemia.

      Education and Training
      BA - University of California, Berkeley - 1958
      MD - University of California, Los Angeles - 1962
      Internship and Residency - University of Washington - 1962-1964
      Fellowship - Senior Fellow In Hematology, University of Washington - 1964-1967


       ORNG Applications 
       Websites

       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Tefferi A, Kantarjian H, Rajkumar SV, Baker LH, Abkowitz JL, Adamson JW, Advani RH, Allison J, Antman KH, Bast RC, Bennett JM, Benz EJ, Berliner N, Bertino J, Bhatia R, Bhatia S, Bhojwani D, Blanke CD, Bloomfield CD, Bosserman L, Broxmeyer HE, Byrd JC, Cabanillas F, Canellos GP, Chabner BA, Chanan-Khan A, Cheson B, Clarkson B, Cohn SL, Colon-Otero G, Cortes J, Coutre S, Cristofanilli M, Curran WJ, Daley GQ, DeAngelo DJ, Deeg HJ, Einhorn LH, Erba HP, Esteva FJ, Estey E, Fidler IJ, Foran J, Forman S, Freireich E, Fuchs C, George JN, Gertz MA, Giralt S, Golomb H, Greenberg P, Gutterman J, Handin RI, Hellman S, Hoff PM, Hoffman R, Hong WK, Horowitz M, Hortobagyi GN, Hudis C, Issa JP, Johnson BE, Kantoff PW, Kaushansky K, Khayat D, Khuri FR, Kipps TJ, Kripke M, Kyle RA, Larson RA, Lawrence TS, Levine R, Link MP, Lippman SM, Lonial S, Lyman GH, Markman M, Mendelsohn J, Meropol NJ, Messinger Y, Mulvey TM, O'Brien S, Perez-Soler R, Pollock R, Prchal J, Press O, Radich J, Rai K, Rosenberg SA, Rowe JM, Rugo H, Runowicz CD, Sandmaier BM, Saven A, Schafer AI, Schiffer C, Sekeres MA, Silver RT, Siu LL, Steensma DP, Stewart FM, Stock W, Stone R, Storb R, Strong LC, Tallman MS, Thompson M, Ueno NT, Van Etten RA, Vose JM, Wiernik PH, Winer EP, Younes A, Zelenetz AD, LeMaistre CA. In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs. Mayo Clin Proc. 2015 Aug; 90(8):996-1000.
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      2. Young DC, Layre E, Pan SJ, Tapley A, Adamson J, Seshadri C, Wu Z, Buter J, Minnaard AJ, Coscolla M, Gagneux S, Copin R, Ernst JD, Bishai WR, Snider BB, Moody DB. In Vivo Biosynthesis of Terpene Nucleosides Provides Unique Chemical Markers of Mycobacterium tuberculosis Infection. Chem Biol. 2015 Apr 23; 22(4):516-26.
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      3. Adamson JW. Iron, erythropoietic stimulating agents, and anemia in cancer. Crit Rev Oncog. 2013; 18(5):471-83.
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      4. von Drygalski A, Adamson JW. Iron metabolism in man. JPEN J Parenter Enteral Nutr. 2013 Sep; 37(5):599-606.
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      5. von Drygalski A, Adamson JW. Ironing out fatigue. Blood. 2011 Sep 22; 118(12):3191-2.
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      6. Vassallo RR, Adamson JW, Gottschall JL, Snyder EL, Lee W, Houghton J, Elfath MD. In vitro and in vivo evaluation of apheresis platelets stored for 5 days in 65% platelet additive solution/35% plasma. Transfusion. 2010 Nov; 50(11):2376-85.
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      7. Carson JL, Adamson JW. Iron deficiency and heart disease: ironclad evidence? Hematology Am Soc Hematol Educ Program. 2010; 2010:348-50.
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      8. Adamson JW. Erythropoietic-stimulating agents: the cancer progression controversy and collateral damage to the blood supply. Transfusion. 2009 May; 49(5):824-6.
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      9. Adamson JW. Hyporesponsiveness to erythropoiesis stimulating agents in chronic kidney disease: the many faces of inflammation. Adv Chronic Kidney Dis. 2009 Mar; 16(2):76-82.
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      10. Adamson JW. Renal disease and anemia in the elderly. Semin Hematol. 2008 Oct; 45(4):235-41.
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      11. McCullough J, Kahn J, Adamson J, Anderlini P, Benjamin R, Confer D, Eapen M, Hirsch B, Kuter D, Lazarus E, Pamphilon D, Stroncek D, Sugarman J, Wilson R. Hematopoietic growth factors--use in normal blood and stem cell donors: clinical and ethical issues. Transfusion. 2008 Sep; 48(9):2008-25.
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      12. Adamson JW. New blood, old blood, or no blood? N Engl J Med. 2008 Mar 20; 358(12):1295-6.
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      13. Adamson JW. The anemia of inflammation/malignancy: mechanisms and management. Hematology Am Soc Hematol Educ Program. 2008; 159-65.
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      14. Aubuchon JP, Dumont LJ, Herschel L, Roger J, Beddard RL, Taylor HL, Whitley PH, Sawyer SL, Graminske S, Martinson K, Dora R, Heldke S, Adamson J, Rose LE. Automated collection of double red blood cell units with a variable-volume separation chamber. Transfusion. 2008 Jan; 48(1):147-52.
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      15. Dai X, Chen Y, Schuman J, Hua Z, Adamson JW, Wen R, Wang D. Distinct roles of phosphoinositide-3 kinase and phospholipase Cgamma2 in B-cell receptor-mediated signal transduction. Mol Cell Biol. 2006 Jan; 26(1):88-99.
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      16. von Drygalski A, Savatski L, Eastwood D, Klein J, Adamson JW. The rate of marrow recovery and extent of donor engraftment following transplantation of ex vivo-expanded bone marrow cells are independently influenced by the cytokines used for expansion. Stem Cells Dev. 2005 Oct; 14(5):564-75.
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      17. Hess JR, Kagen LR, van der Meer PF, Simon T, Cardigan R, Greenwalt TJ, AuBuchon JP, Brand A, Lockwood W, Zanella A, Adamson J, Snyder E, Taylor HL, Moroff G, Hogman C. Interlaboratory comparison of red-cell ATP, 2,3-diphosphoglycerate and haemolysis measurements. Vox Sang. 2005 Jul; 89(1):44-8.
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      18. Chen SY, Cressman S, Mao F, Shao H, Low DW, Beilan HS, Cagle EN, Carnevali M, Gueriguian V, Keogh PJ, Porter H, Stratton SM, Wiedeke MC, Savatski L, Adamson JW, Bozzini CE, Kung A, Kent SB, Bradburne JA, Kochendoerfer GG. Synthetic erythropoietic proteins: tuning biological performance by site-specific polymer attachment. Chem Biol. 2005 Mar; 12(3):371-83.
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      19. Collins AJ, Li S, Adamson JW, Gilbertson DT. Assessment of pure red cell aplasia in US dialysis patients: the limits of the Medicare data. Am J Kidney Dis. 2004 Mar; 43(3):464-70.
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      20. Von Drygalski A, Alespeiti G, Ren L, Adamson JW. Murine bone marrow cells cultured ex vivo in the presence of multiple cytokine combinations lose radioprotective and long-term engraftment potential. Stem Cells Dev. 2004 Feb; 13(1):101-11.
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      21. Parviz F, Matullo C, Garrison WD, Savatski L, Adamson JW, Ning G, Kaestner KH, Rossi JM, Zaret KS, Duncan SA. Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis. Nat Genet. 2003 Jul; 34(3):292-6.
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      22. Kochendoerfer GG, Chen SY, Mao F, Cressman S, Traviglia S, Shao H, Hunter CL, Low DW, Cagle EN, Carnevali M, Gueriguian V, Keogh PJ, Porter H, Stratton SM, Wiedeke MC, Wilken J, Tang J, Levy JJ, Miranda LP, Crnogorac MM, Kalbag S, Botti P, Schindler-Horvat J, Savatski L, Adamson JW, Kung A, Kent SB, Bradburne JA. Design and chemical synthesis of a homogeneous polymer-modified erythropoiesis protein. Science. 2003 Feb 7; 299(5608):884-7.
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      23. von Drygalski A, Adamson JW. Placental/umbilical cord blood (PCB) stem cells for transplantation: early clinical outcomes and the status of ex vivo expansion strategies. Keio J Med. 2000 Dec; 49(4):141-51.
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      24. Drygalski A, Xu G, Constantinescu D, Kashiwakura I, Farley T, Dobrila L, Rubinstein P, Adamson JW. The frequency and proliferative potential of megakaryocytic colony-forming cells (Meg-CFC) in cord blood, cytokine-mobilized peripheral blood and bone marrow, and their correlation with total CFC numbers: implications for the quantitation of Meg-CFC to predict platelet engraftment following cord blood transplantation. Bone Marrow Transplant. 2000 May; 25(10):1029-34.
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      25. Li C, Rodriguez M, Adamson JW, Banerjee D. Identification of a glialblastoma cell differentiation factor-related gene mRNA in human microvascular endothelial cells. Genomics. 2000 May 1; 65(3):243-52.
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      26. Banerjee D, Rodriguez M, Nag M, Adamson JW. Exposure of endothelial cells to recombinant human erythropoietin induces nitric oxide synthase activity. Kidney Int. 2000 May; 57(5):1895-904.
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      27. Eschbach JW, Adamson JW. Iron overload in renal failure patients: changes since the introduction of erythropoietin therapy. Kidney Int Suppl. 1999 Mar; 69:S35-43.
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      28. Adamson JW, Ludwig H. Predicting the hematopoietic response to recombinant human erythropoietin (Epoetin alfa) in the treatment of the anemia of cancer. Oncology. 1999; 56(1):46-53.
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      29. Adamson JW, Eschbach JW. Erythropoietin for end-stage renal disease. N Engl J Med. 1998 Aug 27; 339(9):625-7.
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      30. Adamson JW. Epoetin alfa: into the new millennium. Semin Oncol. 1998 Jun; 25(3 Suppl 7):76-9.
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      31. Adamson J. Perisurgical use of epoetin alfa in orthopedic surgery patients. Semin Hematol. 1996 Apr; 33(2 Suppl 2):55-8; discussion 59.
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      32. Adamson J. Erythropoietin, iron metabolism, and red blood cell production. Semin Hematol. 1996 Apr; 33(2 Suppl 2):5-7; discussion 8-9.
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      33. Adamson J. Epoetin alfa as an adjunct to autologous blood donation in patients with a low hematocrit scheduled for elective orthopedic surgery. Semin Hematol. 1996 Apr; 33(2 Suppl 2):15-6; discussion 17.
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      34. Barron C, Migliaccio AR, Migliaccio G, Jiang Y, Adamson JW, Ottolenghi S. Alternatively spliced mRNAs encoding soluble isoforms of the erythropoietin receptor in murine cell lines and bone marrow. Gene. 1994 Sep 30; 147(2):263-8.
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      35. Migliaccio AR, Jiang Y, Migliaccio G, Nicolis S, Crotta S, Ronchi A, Ottolenghi S, Adamson JW. GATA-1-independent regulation of the expression of the erythropoietin receptor (EPO-R) gene in a human EPO-dependent cell line, UT-7 EPO. Ann N Y Acad Sci. 1994 Apr 15; 718:359-61.
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      36. Adamson JW. The relationship of erythropoietin and iron metabolism to red blood cell production in humans. Semin Oncol. 1994 Apr; 21(2 Suppl 3):9-15.
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      37. Adamson JW, Spivak JL. Physiologic basis for the pharmacologic use of recombinant human erythropoietin in surgery and cancer treatment. Surgery. 1994 Jan; 115(1):7-15.
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      38. Migliaccio AR, Jiang Y, Migliaccio G, Nicolis S, Crotta S, Ronchi A, Ottolenghi S, Adamson JW. Transcriptional and posttranscriptional regulation of the expression of the erythropoietin receptor gene in human erythropoietin-responsive cell lines. Blood. 1993 Dec 15; 82(12):3760-9.
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      39. Mercuriali F, Adamson JW. Recombinant human erythropoietin enhances blood donation for autologous use and reduces exposure to homologous blood during elective surgery. Semin Hematol. 1993 Oct; 30(4 Suppl 6):17-21.
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      40. Nicolis S, Ottolenghi S, Papayannopoulou T, Baiocchi M, Migliaccio G, Adamson J, Migliaccio AR. Dependence for the proliferative response to erythropoietin on an established erythroid differentiation program in a human hematopoietic cell line, UT-7. Exp Hematol. 1993 May; 21(5):665-70.
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      41. Eschbach JW, Haley NR, Egrie JC, Adamson JW. A comparison of the responses to recombinant human erythropoietin in normal and uremic subjects. Kidney Int. 1992 Aug; 42(2):407-16.
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      42. Adamson JW. Management of anemia in oncology. Introduction. Semin Oncol. 1992 Jun; 19(3 Suppl 8):1-2.
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      43. Migliaccio G, Migliaccio AR, Druzin ML, Giardina PJ, Zsebo KM, Adamson JW. Long-term generation of colony-forming cells in liquid culture of CD34+ cord blood cells in the presence of recombinant human stem cell factor. Blood. 1992 May 15; 79(10):2620-7.
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      44. Shimada Y, Migliaccio G, Ruscetti S, Adamson JW, Migliaccio AR. Expression of the interleukin-3 and granulocyte-macrophage colony-stimulating factor genes in Friend spleen focus-forming virus-induced erythroleukemia. Blood. 1992 May 1; 79(9):2423-31.
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      45. Adamson JW, Schuster M, Allen S, Haley NR. Effectiveness of recombinant human erythropoietin therapy in myelodysplastic syndromes. Acta Haematol. 1992; 87 Suppl 1:20-4.
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      46. Migliaccio AR, Migliaccio G, D'Andrea A, Baiocchi M, Crotta S, Nicolis S, Ottolenghi S, Adamson JW. Response to erythropoietin in erythroid subclones of the factor-dependent cell line 32D is determined by translocation of the erythropoietin receptor to the cell surface. Proc Natl Acad Sci U S A. 1991 Dec 15; 88(24):11086-90.
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      47. Migliaccio G, Migliaccio AR, Valinsky J, Langley K, Zsebo K, Visser JW, Adamson JW. Stem cell factor induces proliferation and differentiation of highly enriched murine hematopoietic cells. Proc Natl Acad Sci U S A. 1991 Aug 15; 88(16):7420-4.
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      48. Adamson JW. Erythropoietin: its role in the regulation of erythropoiesis and as a therapeutic in humans. Biotechnology. 1991; 19:351-63.
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      49. Eschbach JW, Egrie JC, Downing MR, Browne JK, Adamson JW. The safety of epoetin-alpha: results of clinical trials in the United States. Contrib Nephrol. 1991; 88:72-80.
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      50. Buckner FS, Eschbach JW, Haley NR, Davidson RC, Adamson JW. Hypertension following erythropoietin therapy in anemic hemodialysis patients. Am J Hypertens. 1990 Dec; 3(12 Pt 1):947-55.
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      51. Broudy VC, Kaushansky K, Shoemaker SG, Aggarwal BB, Adamson JW. Muramyl dipeptide induces production of hemopoietic growth factors in vivo by a mechanism independent of tumor necrosis factor. J Immunol. 1990 May 15; 144(10):3789-94.
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      52. Robertson HT, Haley NR, Guthrie M, Cardenas D, Eschbach JW, Adamson JW. Recombinant erythropoietin improves exercise capacity in anemic hemodialysis patients. Am J Kidney Dis. 1990 Apr; 15(4):325-32.
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      53. Adamson JW, Eschbach JW. Treatment of the anemia of chronic renal failure with recombinant human erythropoietin. Annu Rev Med. 1990; 41:349-60.
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      54. Adamson JW, Eschbach JW. The use of recombinant human erythropoietin [rHuEpo] in man. Prog Clin Biol Res. 1990; 352:505-17.
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      55. Eschbach JW, Haley NR, Adamson JW. The anemia of chronic renal failure: pathophysiology and effects of recombinant erythropoietin. Contrib Nephrol. 1990; 78:24-36; discussion 37.
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      56. Adamson JW, Eschbach JW. Management of the anaemia of chronic renal failure with recombinant erythropoietin. Q J Med. 1989 Dec; 73(272):1093-101.
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      57. Eschbach JW, Adamson JW. Guidelines for recombinant human erythropoietin therapy. Am J Kidney Dis. 1989 Aug; 14(2 Suppl 1):2-8.
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      58. Eschbach JW, Kelly MR, Haley NR, Abels RI, Adamson JW. Treatment of the anemia of progressive renal failure with recombinant human erythropoietin. N Engl J Med. 1989 Jul 20; 321(3):158-63.
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      59. Adamson JW. The promise of recombinant human erythropoietin. Semin Hematol. 1989 Apr; 26(2 Suppl 2):5-8.
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      60. Migliaccio G, Migliaccio AR, Kaushansky K, Adamson JW. Regulation of differentiation of murine progenitor cells derived from blast cell colonies under serum-deprived conditions. Exp Hematol. 1989 Feb; 17(2):110-5.
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      61. Eschbach JW, Downing MR, Egrie JC, Browne JK, Adamson JW. USA multicenter clinical trial with recombinant human erythropoietin (Amgen). Results in hemodialysis patients. Contrib Nephrol. 1989; 76:160-5; discussion 212-8.
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      62. Kaushansky K, Broudy VC, Harlan JM, Adamson JW. Tumor necrosis factor-alpha and tumor necrosis factor-beta (lymphotoxin) stimulate the production of granulocyte-macrophage colony-stimulating factor, macrophage colony-stimulating factor, and IL-1 in vivo. J Immunol. 1988 Nov 15; 141(10):3410-5.
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      63. Adamson JW. Erythropoietin: in vitro and in vivo studies of the regulation of erythropoiesis. Schweiz Med Wochenschr. 1988 Oct 22; 118(42):1501-6.
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      64. Broudy VC, Lin N, Egrie J, de Haën C, Weiss T, Papayannopoulou T, Adamson JW. Identification of the receptor for erythropoietin on human and murine erythroleukemia cells and modulation by phorbol ester and dimethyl sulfoxide. Proc Natl Acad Sci U S A. 1988 Sep; 85(17):6513-7.
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      65. Migliaccio G, Migliaccio AR, Adamson JW. In vitro differentiation of human granulocyte/macrophage and erythroid progenitors: comparative analysis of the influence of recombinant human erythropoietin, G-CSF, GM-CSF, and IL-3 in serum-supplemented and serum-deprived cultures. Blood. 1988 Jul; 72(1):248-56.
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      66. Abkowitz JL, Ott RM, Holly RD, Adamson JW. Clonal evolution following chemotherapy-induced stem cell depletion in cats heterozygous for glucose-6-phosphate dehydrogenase. Blood. 1988 Jun; 71(6):1687-92.
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      67. Segal GM, Eschbach JW, Egrie JC, Stueve T, Adamson JW. The anemia of end-stage renal disease: hematopoietic progenitor cell response. Kidney Int. 1988 May; 33(5):983-8.
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      68. Eschbach JW, Adamson JW. Recombinant human erythropoietin: implications for nephrology. Am J Kidney Dis. 1988 Mar; 11(3):203-9.
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      69. Adamson JW. Erythropoietin: in vitro and in vivo studies of the regulation of erythropoiesis. Soc Gen Physiol Ser. 1988; 43:57-65.
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      70. Kaushansky K, Lin N, Adamson JW. Interleukin 1 stimulates fibroblasts to synthesize granulocyte-macrophage and granulocyte colony-stimulating factors. Mechanism for the hematopoietic response to inflammation. J Clin Invest. 1988 Jan; 81(1):92-7.
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      71. Abkowitz JL, Holly RD, Adamson JW. Retrovirus-induced feline pure red cell aplasia: the kinetics of erythroid marrow failure. J Cell Physiol. 1987 Sep; 132(3):571-7.
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      72. Broudy VC, Kaushansky K, Harlan JM, Adamson JW. Interleukin 1 stimulates human endothelial cells to produce granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor. J Immunol. 1987 Jul 15; 139(2):464-8.
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      73. Eschbach JW, Egrie JC, Downing MR, Browne JK, Adamson JW. Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. Results of a combined phase I and II clinical trial. N Engl J Med. 1987 Jan 8; 316(2):73-8.
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      74. Abkowitz JL, Ott RL, Holly RD, Adamson JW. Lymphocytes and antibody in retrovirus-induced feline pure red cell aplasia. J Natl Cancer Inst. 1987 Jan; 78(1):135-9.
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      75. Abkowitz JL, Powell JS, Nakamura JM, Kadin ME, Adamson JW. Pure red cell aplasia: response to therapy with anti-thymocyte globulin. Am J Hematol. 1986 Dec; 23(4):363-71.
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      76. Wardrop KJ, Kramer JW, Abkowitz JL, Clemons G, Adamson JW. Quantitative studies of erythropoiesis in the clinically normal, phlebotomized, and feline leukemia virus-infected cat. Am J Vet Res. 1986 Oct; 47(10):2274-7.
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      77. Broudy VC, Kaushansky K, Segal GM, Harlan JM, Adamson JW. Tumor necrosis factor type alpha stimulates human endothelial cells to produce granulocyte/macrophage colony-stimulating factor. Proc Natl Acad Sci U S A. 1986 Oct; 83(19):7467-71.
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      78. Kaushansky K, O'Hara PJ, Berkner K, Segal GM, Hagen FS, Adamson JW. Genomic cloning, characterization, and multilineage growth-promoting activity of human granulocyte-macrophage colony-stimulating factor. Proc Natl Acad Sci U S A. 1986 May; 83(10):3101-5.
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      79. Abkowitz JL, Kadin ME, Powell JS, Adamson JW. Pure red cell aplasia: lymphocyte inhibition of erythropoiesis. Br J Haematol. 1986 May; 63(1):59-67.
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      80. Abkowitz JL, Holly RD, Segal GM, Adamson JW. Multilineage, non-species specific hematopoietic growth factor(s) elaborated by a feline fibroblast cell line: enhancement by virus infection. J Cell Physiol. 1986 Apr; 127(1):189-96.
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      81. Delwiche F, Segal GM, Eschbach JW, Adamson JW. Hematopoietic inhibitors in chronic renal failure: lack of in vitro specificity. Kidney Int. 1986 Mar; 29(3):641-8.
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      82. Eschbach JW, Adamson JW. Anemia of end-stage renal disease (ESRD). Kidney Int. 1985 Jul; 28(1):1-5.
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      83. Abkowitz JL, Ott RL, Nakamura JM, Steinmann L, Fialkow PJ, Adamson JW. Feline glucose-6-phosphate dehydrogenase cellular mosaicism. Application to the study of retrovirus-induced pure red cell aplasia. J Clin Invest. 1985 Jan; 75(1):133-40.
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      84. Eschbach JW, Mladenovic J, Garcia JF, Wahl PW, Adamson JW. The anemia of chronic renal failure in sheep. Response to erythropoietin-rich plasma in vivo. J Clin Invest. 1984 Aug; 74(2):434-41.
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      85. Abkowitz JL, Adamson JW. Clonal evolution in the pathogenesis of pancytopenia. Prog Clin Biol Res. 1984; 148:71-80.
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      86. Abkowitz JL, Fialkow PJ, Niebrugge DJ, Raskind WH, Adamson JW. Pancytopenia as a clonal disorder of a multipotent hematopoietic stem cell. J Clin Invest. 1984 Jan; 73(1):258-61.
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      87. Adamson JW. The polycythemias: diagnosis and treatment. Hosp Pract (Off Ed). 1983 Dec; 18(12):49-57.
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      88. Delwiche F, Garrity MJ, Powell JS, Robertson RP, Adamson JW. High levels of the circulating form of parathyroid hormone do not inhibit in vitro erythropoiesis. J Lab Clin Med. 1983 Oct; 102(4):613-20.
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      89. Singer JW, Adamson JW, Arlin ZA, Kempin SJ, Clarkson BD, Fialkow PJ. Chronic myelogenous leukemia: in vitro studies of hematopoietic regulation in a patient undergoing intensive chemotherapy. J Clin Invest. 1981 Jun; 67(6):1593-8.
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      90. Singer JW, Arlin ZA, Najfeld V, Adamson JW, Kempin SJ, Clarkson BD, Fialkow PJ. Restoration of nonclonal hematopoiesis in chronic myelogenous leukemia (CML) following a chemotherapy-induced loss of the Ph1 chromosome. Blood. 1980 Sep; 56(3):356-60.
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      91. Appelbaum FR, Fefer A, Cheever MA, Sanders JE, Singer JW, Adamson JW, Mickelson EM, Hansen JA, Greenberg PD, Thomas ED. Treatment of aplastic anemia by bone marrow transplantation in identical twins. Blood. 1980 Jun; 55(6):1033-9.
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      92. Torok-Storb BJ, Sieff C, Storb R, Adamson J, Thomas ED. In vitro tests for distinguishing possible immune-mediated aplastic anemia from transfusion-induced sensitization. Blood. 1980 Feb; 55(2):211-5.
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      93. Torok-Storb B, Deeg HJ, Atkinson K, Weiden PL, Adamson JW, Storb R. Erythroid colony stimulating and inhibiting cells in peripheral blood of transfused dogs: separation of function by velocity sedimentation. Blood. 1979 Oct; 54(4):955-8.
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      94. Torok-Storb BJ, Storb R, Deeg HJ, Graham TC, Wise C, Weiden PL, Adamson JW. Growth in vitro of donor marrow cultured with recipient lymphocytes predicts the fate of marrow grafts in transfused DLA-identical dogs. Blood. 1979 Jan; 53(1):104-8.
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      95. Torok-Storb BJ, Storb R, Graham TC, Prentice RL, Weiden PL, Adamson JW. Erythropoiesis in vitro: effect of normal versus "transfusion-sensitized" mononuclear cells. Blood. 1978 Oct; 52(4):706-11.
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      96. Prchal JF, Adamson JW, Murphy S, Steinmann L, Fialkow PJ. Polycythemia vera. The in vitro response of normal and abnormal stem cell lines to erythropoietin. J Clin Invest. 1978 Apr; 61(4):1044-7.
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      97. Lindner A, Douglas SW, Adamson JW. Propranolol effects in long-term hemodialysis patients with renin-dependent hypertension. Ann Intern Med. 1978 Apr; 88(4):457-62.
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      98. Brown JE, Adamson JW. Modulation of in vitro erythropoiesis: enhancement of erythroid colony growth by cyclic nucleotides. Cell Tissue Kinet. 1977 May; 10(3):289-98.
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      99. Brown JE, Adamson JW. Studies of the influence of cyclic nucleotides on in vitro haemoglobin synthesis. Br J Haematol. 1977 Feb; 35(2):193-208.
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      100. Prchal JF, Adamson JW, Steinmann L, Fialkow PJ. Human erythroid colony formation in vitro: evidence for clonal origin. J Cell Physiol. 1976 Nov; 89(3):489-92.
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      101. Adamson JW, Fialkow PJ, Murphy S, Prchal JF, Steinmann L. Polycythemia vera: stem-cell and probable clonal origin of the disease. N Engl J Med. 1976 Oct 21; 295(17):913-6.
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      102. Singer JW, Samuels AI, Adamson JW. Steroids and hematopoiesis. I. The effect of steroids on in vitro erythroid colony growth: structure/activity relationships. J Cell Physiol. 1976 Jun; 88(2):127-34.
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      103. Adamson JW. Familial polycythemia. Semin Hematol. 1975 Oct; 12(4):383-96.
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      104. Douglas SW, Adamson JW. The anemia of chronic disorders: studies of marrow regulation and iron metabolism. Blood. 1975 Jan; 45(1):55-65.
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      105. Adamson JW, Dale DC, Elin RJ. Hematopoiesis in the grey collie dog: studies of the regulation of erythropoiesis. J Clin Invest. 1974 Oct; 54(4):965-73.
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      106. Weiden PL, Robinett B, Graham TC, Adamson J, Storb R. Canine cyclic neutropenia. A stem cell defect. J Clin Invest. 1974 Mar; 53(3):950-3.
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      107. Adamson JW, Stamatoyannopoulos G, Kontras S, Lascari A, Detter J. Recessive familial erythrocytosis: aspects of marrow regulation in two families. Blood. 1973 May; 41(5):641-52.
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      108. Eschbach JW, Adamson JW. Improvement in the anemia of chronic renal failure with fluoxymesterone. Ann Intern Med. 1973 Apr; 78(4):527-32.
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      109. Adamson JW, Hayashi A, Stamatoyannopoulos G, Burger WF. Erythrocyte function and marrow regulation in hemoglobin Bethesda (beta-145 histidine). J Clin Invest. 1972 Nov; 51(11):2883-8.
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      110. Adamson JW, Storb R. The proliferative potential of frozen stored human marrow cells. Transplantation. 1972 Oct; 14(4):490-4.
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      111. Eschbach JW, Adamson JW, Anderson RG, Dennis MB. Anemia of chronic renal failure: studies of marrow regulation in the uremic sheep. Trans Am Soc Artif Intern Organs. 1972; 18(0):295-300.
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      112. Adamson JW, Finch CA. Erythropoietin and the regulation of erythropoiesis in DiGuglielmo's syndrome. Blood. 1970 Nov; 36(5):590-7.
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      113. Eschbach JW, Adamson JW, Cook JD. Disorders of red blood cell production in uremia. Arch Intern Med. 1970 Nov; 126(5):812-5.
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      114. Adamson JW, Parer JT, Stamatoyannopoulos G. Erythrocytosis associated with hemoglobin Rainier: oxygen equilibria and marrow regulation. J Clin Invest. 1969 Aug; 48(8):1376-86.
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      115. Adamson JW. The erythropoietin-hematocrit relationship in normal and polycythemic man: implications of marrow regulation. Blood. 1968 Oct; 32(4):597-609.
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      116. Adamson JW, Eschbach J, Finch CA. The kidney and erythropoiesis. Am J Med. 1968 May; 44(5):725-33.
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      117. Hillman RS, Adamson J, Burka E. Characteristics of vitamin B12 correction of the abnormal erythropoiesis of pernicious anemia. Blood. 1968 Apr; 31(4):419-32.
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      118. Eschbach JW, Funk D, Adamson J, Kuhn I, Scribner BH, Finch CA. Erythropoiesis in patients with renal failure undergoing chronic dialysis. N Engl J Med. 1967 Mar 23; 276(12):653-8.
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      119. Adamson JW, Finch CA. Mechanisms of erythroid marrow activation. Trans Assoc Am Physicians. 1966; 79:419-25.
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