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    Gen-sheng Feng

    SchoolUniversity of California, San Diego
    DepartmentMolecular Biology
    Address9500 Gilman Drive #0864
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Shp2 and Pten in Leukemia and Anemia
      NIH/NHLBI R01HL129763Sep 1, 2015 - Mar 31, 2019
      Role: Principal Investigator
      Dissection of Pten-regulated signals in hepatopathogenesis
      NIH/NCI R01CA188506Jul 1, 2015 - Jun 30, 2020
      Role: Principal Investigator
      Molecular and cellular communications in liver tumorigenesis
      NIH/NCI R01CA176012Mar 1, 2014 - Feb 28, 2019
      Role: Principal Investigator
      Tyrosine Dephosphorylation and Blood Cell Development
      NIH/NHLBI R01HL096125Aug 17, 2009 - Jul 31, 2014
      Role: Principal Investigator
      Coordinated regulation of signaling events for insulin biosynthesis and secretion
      NIH/NIDDK R01DK075916Jan 15, 2009 - Nov 30, 2013
      Role: Principal Investigator
      Regulation of Leptin Signaling
      NIH/NIDDK R01DK073945Jul 1, 2007 - Jun 30, 2011
      Role: Principal Investigator
      Signaling Interactions in Cell Survival and Invasion
      NIH P01CA102583Sep 22, 2004 - Aug 31, 2010
      Role: Co-Investigator
      NIH/NHLBI R01HL066208Jan 1, 2001 - Nov 30, 2005
      Role: Principal Investigator
      Tyrosine dephosphorylation and blood cell development
      NIH/NCI R01CA078606May 1, 1999 - Feb 28, 2009
      Role: Principal Investigator
      Role of the Shp-2 tyrosine phosphatase in signal transdu
      NIH/NIGMS R01GM053660Mar 1, 1996 - Jun 30, 2006
      Role: Principal Investigator
      NIH/NIGMS R29GM053660Mar 1, 1996 - Feb 28, 2001
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Lee J, Liao R, Wang G, Yang BH, Luo X, Varki NM, Qiu SJ, Ren B, Fu W, Feng G. Preventive Inhibition of Liver Tumorigenesis by Systemic Activation of Innate Immune Functions. Cell Rep. 2017 Nov 14; 21(7):1870-1882. PMID: 29141219.
        View in: PubMed
      2. Cheng J, Zhong Y, Chen S, Sun Y, Huang L, Kang Y, Chen B, Chen G, Wang F, Tian Y, Liu W, Feng G, Lu Z. Gab2 mediates hepatocellular carcinogenesis by integrating multiple signaling pathways. FASEB J. 2017 Aug 21. PMID: 28842424.
        View in: PubMed
      3. Ran H, Kong S, Zhang S, Cheng J, Zhou C, He B, Xin Q, Lydon JP, DeMayo FJ, Feng G, Xia G, Lu Z, Wang C, Wang H. Nuclear Shp2 directs normal embryo implantation via facilitating the ERa tyrosine phosphorylation by the Src kinase. Proc Natl Acad Sci U S A. 2017 May 02; 114(18):4816-4821. PMID: 28424251.
        View in: PubMed
      4. Liu W, Guo W, Shen L, Chen Z, Luo Q, Luo X, Feng G, Shu Y, Gu Y, Xu Q, Sun Y. T lymphocyte SHP2-deficiency triggers anti-tumor immunity to inhibit colitis-associated cancer in mice. Oncotarget. 2017 Jan 31; 8(5):7586-7597. PMID: 27935860.
        View in: PubMed
      5. Liao R, Fu YP, Wang T, Deng ZG, Li DW, Fan J, Zhou J, Feng G, Qiu SJ, Du CY. Metavir and FIB-4 scores are associated with patient prognosis after curative hepatectomy in hepatitis B virus-related hepatocellular carcinoma: a retrospective cohort study at two centers in China. Oncotarget. 2017 Jan 03; 8(1):1774-1787. PMID: 27662665.
        View in: PubMed
      6. Luo X, Liao R, Hanley KL, Zhu HH, Malo KN, Hernandez C, Wei X, Varki NM, Alderson N, Chu C, Li S, Fan J, Loomba R, Qiu SJ, Feng G. Dual Shp2 and Pten Deficiencies Promote Non-alcoholic Steatohepatitis and Genesis of Liver Tumor-Initiating Cells. Cell Rep. 2016 Dec 13; 17(11):2979-2993. PMID: 27974211.
        View in: PubMed
      7. Chen S, Kang Y, Sun Y, Zhong Y, Li Y, Deng L, Tao J, Li Y, Tian Y, Zhao Y, Cheng J, Liu W, Feng G, Lu Z. Deletion of Gab2 in mice protects against hepatic steatosis and steatohepatitis: a novel therapeutic target for fatty liver disease. J Mol Cell Biol. 2016 Dec; 8(6):492-504. PMID: 27282405.
        View in: PubMed
      8. Maeshima K, Stanford SM, Hammaker D, Sacchetti C, Zeng LF, Ai R, Zhang V, Boyle DL, Aleman Muench GR, Feng G, Whitaker JW, Zhang ZY, Wang W, Bottini N, Firestein GS. Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation. JCI Insight. 2016 May 19; 1(7). PMID: 27275015.
        View in: PubMed
      9. Ma X, Qu X, Zhu W, Li YS, Yuan S, Zhang H, Liu J, Wang P, Lai CS, Zanella F, Feng G, Sheikh F, Chien S, Chen S. Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting. Proc Natl Acad Sci U S A. 2016 Feb 23; 113(8):2206-11. PMID: 26858399; PMCID: PMC4776497.
      10. Chen WS, Zhu HH, Feng G. Treating leukemia at the risk of inducing severe anemia. Exp Hematol. 2016 May; 44(5):329-31. PMID: 26826310.
        View in: PubMed
      11. Zhu HH, Luo X, Zhang K, Cui J, Zhao H, Ji Z, Zhou Z, Yao J, Zeng L, Ji K, Gao WQ, Zhang ZY, Feng G. Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals. Proc Natl Acad Sci U S A. 2015 Oct 27; 112(43):13342-7. PMID: 26460004; PMCID: PMC4629356.
      12. Hu X, Tang Z, Li Y, Liu W, Zhang S, Wang B, Tian Y, Zhao Y, Ran H, Liu W, Feng G, Shuai J, Wang H, Lu Z. Deletion of the tyrosine phosphatase Shp2 in Sertoli cells causes infertility in mice. Sci Rep. 2015 Aug 12; 5:12982. PMID: 26265072; PMCID: PMC4533007.
      13. Kamiya N, Shen J, Noda K, Kitami M, Feng G, Chen D, Komatsu Y. SHP2-Deficiency in Chondrocytes Deforms Orofacial Cartilage and Ciliogenesis in Mice. J Bone Miner Res. 2015 Nov; 30(11):2028-32. PMID: 25919282.
        View in: PubMed
      14. Hanley KL, Feng G. A new VETC in hepatocellular carcinoma metastasis. Hepatology. 2015 Aug; 62(2):343-5. PMID: 25902918.
        View in: PubMed
      15. Deng Z, Ma S, Zhou H, Zang A, Fang Y, Li T, Shi H, Liu M, Du M, Taylor PR, Zhu HH, Chen J, Meng G, Li F, Chen C, Zhang Y, Jia XM, Lin X, Zhang X, Pearlman E, Li X, Feng G, Xiao H. Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses. Nat Immunol. 2015 Jun; 16(6):642-52. PMID: 25915733; PMCID: PMC4439382.
      16. Luo T, Fu J, Xu A, Su B, Ren Y, Li N, Zhu J, Zhao X, Dai R, Cao J, Wang B, Qin W, Jiang J, Li J, Wu M, Feng G, Chen Y, Wang H. PSMD10/gankyrin induces autophagy to promote tumor progression through cytoplasmic interaction with ATG7 and nuclear transactivation of ATG7 expression. Autophagy. 2016 Aug 02; 12(8):1355-71. PMID: 25905985; PMCID: PMC4968225.
      17. Han T, Xiang DM, Sun W, Liu N, Sun HL, Wen W, Shen WF, Wang RY, Chen C, Wang X, Cheng Z, Li HY, Wu MC, Cong WM, Feng G, Ding J, Wang HY. PTPN11/Shp2 overexpression enhances liver cancer progression and predicts poor prognosis of patients. J Hepatol. 2015 Sep; 63(3):651-60. PMID: 25865556.
        View in: PubMed
      18. Su B, Luo T, Zhu J, Fu J, Zhao X, Chen L, Zhang H, Ren Y, Yu L, Yang X, Wu M, Feng G, Li S, Chen Y, Wang H. Interleukin-1ß/Iinterleukin-1 receptor-associated kinase 1 inflammatory signaling contributes to persistent Gankyrin activation during hepatocarcinogenesis. Hepatology. 2015 Feb; 61(2):585-97. PMID: 25294684.
        View in: PubMed
      19. Li XJ, Goodwin CB, Nabinger SC, Richine BM, Yang Z, Hanenberg H, Ohnishi H, Matozaki T, Feng G, Chan RJ. Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst. J Biol Chem. 2015 Feb 13; 290(7):3894-909. PMID: 25538234; PMCID: PMC4326800.
      20. Li S, Ni A, Feng G. Bridging cell surface receptor with nuclear receptors in control of bile acid homeostasis. Acta Pharmacol Sin. 2015 Jan; 36(1):113-8. PMID: 25500873; PMCID: PMC4571317.
      21. Li J, Kang Y, Wei L, Liu W, Tian Y, Chen B, Lin X, Li Y, Feng G, Lu Z. Tyrosine phosphatase Shp2 mediates the estrogen biological action in breast cancer via interaction with the estrogen extranuclear receptor. PLoS One. 2014; 9(7):e102847. PMID: 25048202; PMCID: PMC4105620.
      22. Li S, Hsu DD, Li B, Luo X, Alderson N, Qiao L, Ma L, Zhu HH, He Z, Suino-Powell K, Ji K, Li J, Shao J, Xu HE, Li T, Feng G. Cytoplasmic tyrosine phosphatase Shp2 coordinates hepatic regulation of bile acid and FGF15/19 signaling to repress bile acid synthesis. Cell Metab. 2014 Aug 05; 20(2):320-32. PMID: 24981838; PMCID: PMC4365973.
      23. Lee B, Qiao L, Kinney B, Feng G, Shao J. Macrophage depletion disrupts immune balance and energy homeostasis. PLoS One. 2014; 9(6):e99575. PMID: 24911652; PMCID: PMC4049836.
      24. Luo X, Feng G. VEGFA genomic amplification tailors treatment of HCCs with sorafenib. Cancer Discov. 2014 Jun; 4(6):640-1. PMID: 24891362; PMCID: PMC4633301.
      25. Liu CY, Feng G. NCOA5, a molecular link between type 2 diabetes and liver cancer. Hepatobiliary Surg Nutr. 2014 Jun; 3(3):106-8. PMID: 25019069; PMCID: PMC4073315.
      26. Yoo HS, Qiao L, Bosco C, Leong LH, Lytle N, Feng G, Chi NW, Shao J. Intermittent cold exposure enhances fat accumulation in mice. PLoS One. 2014; 9(5):e96432. PMID: 24789228; PMCID: PMC4008632.
      27. Lee B, Qiao L, Lu M, Yoo HS, Cheung W, Mak R, Schaack J, Feng G, Chi NW, Olefsky JM, Shao J. C/EBPa regulates macrophage activation and systemic metabolism. Am J Physiol Endocrinol Metab. 2014 May 15; 306(10):E1144-54. PMID: 24691027; PMCID: PMC4025063.
      28. Lajiness JD, Snider P, Wang J, Feng G, Krenz M, Conway SJ. SHP-2 deletion in postmigratory neural crest cells results in impaired cardiac sympathetic innervation. Proc Natl Acad Sci U S A. 2014 Apr 08; 111(14):E1374-82. PMID: 24706815; PMCID: PMC3986121.
      29. Puri P, Phillips BT, Suzuki H, Orwig KE, Rajkovic A, Lapinski PE, King PD, Feng G, Walker WH. The transition from stem cell to progenitor spermatogonia and male fertility requires the SHP2 protein tyrosine phosphatase. Stem Cells. 2014 Mar; 32(3):741-53. PMID: 24123360.
        View in: PubMed
      30. Kim HK, Feng G, Chen D, King PD, Kamiya N. Targeted disruption of Shp2 in chondrocytes leads to metachondromatosis with multiple cartilaginous protrusions. J Bone Miner Res. 2014 Mar; 29(3):761-9. PMID: 23929766; PMCID: PMC4081537.
      31. Qiao L, Yoo Hs, Bosco C, Lee B, Feng G, Schaack J, Chi NW, Shao J. Adiponectin reduces thermogenesis by inhibiting brown adipose tissue activation in mice. Diabetologia. 2014 May; 57(5):1027-36. PMID: 24531262; PMCID: PMC4077285.
      32. Chen E, Swift RV, Alderson N, Feher VA, Feng G, Amaro RE. Computation-guided discovery of influenza endonuclease inhibitors. ACS Med Chem Lett. 2014 Jan 09; 5(1):61-64. PMID: 24490002.
        View in: PubMed
      33. Ng GY, Yeh LK, Zhang Y, Liu H, Feng G, Kao WW, Liu CY. Role of SH2-containing tyrosine phosphatase Shp2 in mouse corneal epithelial stratification. Invest Ophthalmol Vis Sci. 2013 Dec 03; 54(13):7933-42. PMID: 24204042; PMCID: PMC3850669.
      34. He Z, Feng G. Control of body weight versus tumorigenesis by concerted action of leptin and estrogen. Rev Endocr Metab Disord. 2013 Dec; 14(4):339-45. PMID: 24142297.
        View in: PubMed
      35. Li H, Tao C, Cai Z, Hertzler-Schaefer K, Collins TN, Wang F, Feng G, Gotoh N, Zhang X. Frs2a and Shp2 signal independently of Gab to mediate FGF signaling in lens development. J Cell Sci. 2014 Feb 01; 127(Pt 3):571-82. PMID: 24284065; PMCID: PMC4007765.
      36. Kim HK, Aruwajoye O, Sucato D, Richards BS, Feng G, Chen D, King PD, Kamiya N. Induction of SHP2 deficiency in chondrocytes causes severe scoliosis and kyphosis in mice. Spine (Phila Pa 1976). 2013 Oct 01; 38(21):E1307-12. PMID: 23873233; PMCID: PMC3864111.
      37. Lapinski PE, Meyer MF, Feng G, Kamiya N, King PD. Deletion of SHP-2 in mesenchymal stem cells causes growth retardation, limb and chest deformity, and calvarial defects in mice. Dis Model Mech. 2013 Nov; 6(6):1448-58. PMID: 24077964; PMCID: PMC3820267.
      38. Zheng L, Yang W, Wu F, Wang C, Yu L, Tang L, Qiu B, Li Y, Guo L, Wu M, Feng G, Zou D, Wang H. Prognostic significance of AMPK activation and therapeutic effects of metformin in hepatocellular carcinoma. Clin Cancer Res. 2013 Oct 01; 19(19):5372-80. PMID: 23942093.
        View in: PubMed
      39. Wen W, Han T, Chen C, Huang L, Sun W, Wang X, Chen SZ, Xiang DM, Tang L, Cao D, Feng G, Wu MC, Ding J, Wang HY. Cyclin G1 expands liver tumor-initiating cells by Sox2 induction via Akt/mTOR signaling. Mol Cancer Ther. 2013 Sep; 12(9):1796-804. PMID: 23804702.
        View in: PubMed
      40. Cai Z, Tao C, Li H, Ladher R, Gotoh N, Feng G, Wang F, Zhang X. Deficient FGF signaling causes optic nerve dysgenesis and ocular coloboma. Development. 2013 Jul; 140(13):2711-23. PMID: 23720040; PMCID: PMC3678341.
      41. Coulombe G, Leblanc C, Cagnol S, Maloum F, Lemieux E, Perreault N, Feng G, Boudreau F, Rivard N. Epithelial tyrosine phosphatase SHP-2 protects against intestinal inflammation in mice. Mol Cell Biol. 2013 Jun; 33(11):2275-84. PMID: 23530062; PMCID: PMC3648065.
      42. Chen H, Luo Z, Dong L, Tan Y, Yang J, Feng G, Wu M, Li Z, Wang H. CD133/prominin-1-mediated autophagy and glucose uptake beneficial for hepatoma cell survival. PLoS One. 2013; 8(2):e56878. PMID: 23437259; PMCID: PMC3577658.
      43. Shi ZQ, Sunico CR, McKercher SR, Cui J, Feng G, Nakamura T, Lipton SA. S-nitrosylated SHP-2 contributes to NMDA receptor-mediated excitotoxicity in acute ischemic stroke. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):3137-42. PMID: 23382182; PMCID: PMC3581884.
      44. Yu J, Deng R, Zhu HH, Zhang SS, Zhu C, Montminy M, Davis R, Feng G. Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1, and SH2-tyrosine phosphatase Shp2. J Biol Chem. 2013 Feb 08; 288(6):3823-30. PMID: 23269672; PMCID: PMC3567637.
      45. Broxmeyer HE, Etienne-Julan M, Gotoh A, Braun SE, Lu L, Cooper S, Feng G, Li XJ, Chan RJ. Hematopoietic colony formation from human growth factor-dependent TF1 cells and human cord blood myeloid progenitor cells depends on SHP2 phosphatase function. Stem Cells Dev. 2013 Mar 15; 22(6):998-1006. PMID: 23082805; PMCID: PMC3585482.
      46. He Z, Zhu HH, Bauler TJ, Wang J, Ciaraldi T, Alderson N, Li S, Raquil MA, Ji K, Wang S, Shao J, Henry RR, King PD, Feng G. Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase. Proc Natl Acad Sci U S A. 2013 Jan 02; 110(1):E79-88. PMID: 23236157; PMCID: PMC3538237.
      47. Wu K, Ding J, Chen C, Sun W, Ning BF, Wen W, Huang L, Han T, Yang W, Wang C, Li Z, Wu MC, Feng G, Xie WF, Wang HY. Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development. Hepatology. 2012 Dec; 56(6):2255-67. PMID: 22898879.
        View in: PubMed
      48. Haglund E, Sulkowska JI, He Z, Feng G, Jennings PA, Onuchic JN. The unique cysteine knot regulates the pleotropic hormone leptin. PLoS One. 2012; 7(9):e45654. PMID: 23029163; PMCID: PMC3454405.
      49. Li S, Hsu DD, Wang H, Feng G. Dual faces of SH2-containing protein-tyrosine phosphatase Shp2/PTPN11 in tumorigenesis. Front Med. 2012 Sep; 6(3):275-9. PMID: 22869052.
        View in: PubMed
      50. Mali RS, Ma P, Zeng LF, Martin H, Ramdas B, He Y, Sims E, Nabinger S, Ghosh J, Sharma N, Munugalavadla V, Chatterjee A, Li S, Sandusky G, Craig AW, Bunting KD, Feng G, Chan RJ, Zhang ZY, Kapur R. Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT. Blood. 2012 Sep 27; 120(13):2669-78. PMID: 22806893; PMCID: PMC3460688.
      51. Huang H, Woo AJ, Waldon Z, Schindler Y, Moran TB, Zhu HH, Feng G, Steen H, Cantor AB. A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation. Genes Dev. 2012 Jul 15; 26(14):1587-601. PMID: 22759635; PMCID: PMC3404386.
      52. Huang J, Yan J, Zhang J, Zhu S, Wang Y, Shi T, Zhu C, Chen C, Liu X, Cheng J, Mustelin T, Feng G, Chen G, Yu J. SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane. Nat Commun. 2012 Jun 19; 3:911. PMID: 22713753.
        View in: PubMed
      53. Yang W, Wang C, Lin Y, Liu Q, Yu LX, Tang L, Yan HX, Fu J, Chen Y, Zhang HL, Tang L, Zheng LY, He YQ, Li YQ, Wu FQ, Zou SS, Li Z, Wu MC, Feng G, Wang HY. OV6? tumor-initiating cells contribute to tumor progression and invasion in human hepatocellular carcinoma. J Hepatol. 2012 Sep; 57(3):613-20. PMID: 22612999.
        View in: PubMed
      54. Sharma N, Kumar V, Everingham S, Mali RS, Kapur R, Zeng LF, Zhang ZY, Feng G, Hartmann K, Roers A, Craig AW. SH2 domain-containing phosphatase 2 is a critical regulator of connective tissue mast cell survival and homeostasis in mice. Mol Cell Biol. 2012 Jul; 32(14):2653-63. PMID: 22566685; PMCID: PMC3416204.
      55. Wen W, Ding J, Sun W, Fu J, Chen Y, Wu K, Ning B, Han T, Huang L, Chen C, Xie D, Li Z, Feng G, Wu M, Xie W, Wang H. Cyclin G1-mediated epithelial-mesenchymal transition via phosphoinositide 3-kinase/Akt signaling facilitates liver cancer progression. Hepatology. 2012 Jun; 55(6):1787-98. PMID: 22271581.
        View in: PubMed
      56. He Z, Zhang SS, Meng Q, Li S, Zhu HH, Raquil MA, Alderson N, Zhang H, Wu J, Rui L, Cai D, Feng G. Shp2 controls female body weight and energy balance by integrating leptin and estrogen signals. Mol Cell Biol. 2012 May; 32(10):1867-78. PMID: 22431513; PMCID: PMC3347413.
      57. Qian YW, Chen Y, Yang W, Fu J, Cao J, Ren YB, Zhu JJ, Su B, Luo T, Zhao XF, Dai RY, Li JJ, Sun W, Wu MC, Feng G, Wang HY. p28(GANK) prevents degradation of Oct4 and promotes expansion of tumor-initiating cells in hepatocarcinogenesis. Gastroenterology. 2012 Jun; 142(7):1547-58.e14. PMID: 22387393.
        View in: PubMed
      58. Zhang X, Zhang Y, Tao B, Teng L, Li Y, Cao R, Gui Q, Ye M, Mou X, Cheng H, Hu H, Zhou R, Wu X, Xie Q, Ning W, Lai M, Shen H, Feng G, Ke Y. Loss of Shp2 in alveoli epithelia induces deregulated surfactant homeostasis, resulting in spontaneous pulmonary fibrosis. FASEB J. 2012 Jun; 26(6):2338-50. PMID: 22362894.
        View in: PubMed
      59. Feng G. Conflicting roles of molecules in hepatocarcinogenesis: paradigm or paradox. Cancer Cell. 2012 Feb 14; 21(2):150-4. PMID: 22340589; PMCID: PMC3285429.
      60. Matsuura S, Yan M, Lo MC, Ahn EY, Weng S, Dangoor D, Matin M, Higashi T, Feng G, Zhang DE. Negative effects of GM-CSF signaling in a murine model of t(8;21)-induced leukemia. Blood. 2012 Mar 29; 119(13):3155-63. PMID: 22223820; PMCID: PMC3321875.
      61. Sun W, Ding J, Wu K, Ning BF, Wen W, Sun HY, Han T, Huang L, Dong LW, Yang W, Deng X, Li Z, Wu MC, Feng G, Xie WF, Wang HY. Gankyrin-mediated dedifferentiation facilitates the tumorigenicity of rat hepatocytes and hepatoma cells. Hepatology. 2011 Oct; 54(4):1259-72. PMID: 21735473.
        View in: PubMed
      62. Liu D, Kong G, Chen QC, Wang G, Li J, Xu Y, lin T, Tian Y, Zhang X, Yao X, Feng G, Lu Z, Chen H. Fatty acids as natural specific inhibitors of the proto-oncogenic protein Shp2. Bioorg Med Chem Lett. 2011 Nov 15; 21(22):6833-7. PMID: 21962577.
        View in: PubMed
      63. Li L, Chen L, Hu L, Liu Y, Sun HY, Tang J, Hou YJ, Chang YX, Tu QQ, Feng G, Shen F, Wu MC, Wang HY. Nuclear factor high-mobility group box1 mediating the activation of Toll-like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice. Hepatology. 2011 Nov; 54(5):1620-30. PMID: 21809356.
        View in: PubMed
      64. Zhu HH, Feng G. The dynamic interplay between a PTK (Kit) and a PTP (Shp2) in hematopoietic stem and progenitor cells. Cell Cycle. 2011 Jul 15; 10(14):2241-2. PMID: 21701261; PMCID: PMC3322470.
      65. Futami M, Zhu QS, Whichard ZL, Xia L, Ke Y, Neel BG, Feng G, Corey SJ. G-CSF receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase. Blood. 2011 Jul 28; 118(4):1077-86. PMID: 21636860; PMCID: PMC3148159.
      66. Bard-Chapeau EA, Li S, Ding J, Zhang SS, Zhu HH, Princen F, Fang DD, Han T, Bailly-Maitre B, Poli V, Varki NM, Wang H, Feng G. Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis. Cancer Cell. 2011 May 17; 19(5):629-39. PMID: 21575863; PMCID: PMC3098128.
      67. Cai Z, Simons DL, Fu XY, Feng G, Wu SM, Zhang X. Loss of Shp2-mediated mitogen-activated protein kinase signaling in Muller glial cells results in retinal degeneration. Mol Cell Biol. 2011 Jul; 31(14):2973-83. PMID: 21576358; PMCID: PMC3133408.
      68. Ruan X, Li Z, Zhang Y, Yang L, Pan Y, Wang Z, Feng G, Chen Y. Apolipoprotein A-I possesses an anti-obesity effect associated with increase of energy expenditure and up-regulation of UCP1 in brown fat. J Cell Mol Med. 2011 Apr; 15(4):763-72. PMID: 20193037; PMCID: PMC3922665.
      69. Zhu HH, Ji K, Alderson N, He Z, Li S, Liu W, Zhang DE, Li L, Feng G. Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool. Blood. 2011 May 19; 117(20):5350-61. PMID: 21450902; PMCID: PMC3109710.
      70. Zhao J, Wang W, Ha CH, Kim JY, Wong C, Redmond EM, Hamik A, Jain MK, Feng G, Jin ZG. Endothelial Grb2-associated binder 1 is crucial for postnatal angiogenesis. Arterioscler Thromb Vasc Biol. 2011 May; 31(5):1016-23. PMID: 21372298; PMCID: PMC3094153.
      71. Lu Y, Xiong Y, Huo Y, Han J, Yang X, Zhang R, Zhu DS, Klein-Hessling S, Li J, Zhang X, Han X, Li Y, Shen B, He Y, Shibuya M, Feng G, Luo J. Grb-2-associated binder 1 (Gab1) regulates postnatal ischemic and VEGF-induced angiogenesis through the protein kinase A-endothelial NOS pathway. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):2957-62. PMID: 21282639; PMCID: PMC3041066.
      72. Fu J, Chen Y, Cao J, Luo T, Qian YW, Yang W, Ren YB, Su B, Cao GW, Yang Y, Yan YQ, Shen F, Wu MC, Feng G, Wang HY. p28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1a pathways. Hepatology. 2011 Jan; 53(1):181-92. PMID: 21254169.
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      73. Bu Y, Shi T, Meng M, Kong G, Tian Y, Chen Q, Yao X, Feng G, Chen H, Cheng H, Lu Z. A novel screening model for the molecular drug for diabetes and obesity based on tyrosine phosphatase Shp2. Bioorg Med Chem Lett. 2011 Jan 15; 21(2):874-8. PMID: 21169016.
        View in: PubMed
      74. Bauler TJ, Kamiya N, Lapinski PE, Langewisch E, Mishina Y, Wilkinson JE, Feng G, King PD. Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations. Dis Model Mech. 2011 Mar; 4(2):228-39. PMID: 21068439; PMCID: PMC3046097.
      75. Zhu Y, Park J, Hu X, Zheng K, Li H, Cao Q, Feng G, Qiu M. Control of oligodendrocyte generation and proliferation by Shp2 protein tyrosine phosphatase. Glia. 2010 Sep; 58(12):1407-14. PMID: 20648636; PMCID: PMC3762492.
      76. Zheng Y, An H, Yao M, Hou J, Yu Y, Feng G, Cao X. Scaffolding adaptor protein Gab1 is required for TLR3/4- and RIG-I-mediated production of proinflammatory cytokines and type I IFN in macrophages. J Immunol. 2010 Jun 01; 184(11):6447-56. PMID: 20435932.
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      77. Pan Y, Carbe C, Powers A, Feng G, Zhang X. Sprouty2-modulated Kras signaling rescues Shp2 deficiency during lens and lacrimal gland development. Development. 2010 Apr; 137(7):1085-93. PMID: 20215346; PMCID: PMC2835324.
      78. Cai Z, Feng G, Zhang X. Temporal requirement of the protein tyrosine phosphatase Shp2 in establishing the neuronal fate in early retinal development. J Neurosci. 2010 Mar 17; 30(11):4110-9. PMID: 20237281; PMCID: PMC2845916.
      79. Weng T, Mao F, Wang Y, Sun Q, Li R, Yang G, Zhang X, Luo J, Feng G, Yang X. Osteoblastic molecular scaffold Gab1 is required for maintaining bone homeostasis. J Cell Sci. 2010 Mar 01; 123(Pt 5):682-9. PMID: 20124419.
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