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Encorafenib, Cetuximab, and mFOLFOX6 in BRAF-Mutated Colorectal Cancer. N Engl J Med. 2025 May 30.
Elez E, Yoshino T, Shen L, Lonardi S, Van Cutsem E, Eng C, Kim TW, Wasan HS, Desai J, Ciardiello F, Yaeger R, Maughan TS, Morris VK, Wu C, Usari T, Laliberte R, Dychter SS, Zhang X, Tabernero J, Kopetz S, BREAKWATER Trial Investigators. PMID: 40444708.
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Safety and Efficacy of a Third Dose of BNT162b2 Covid-19 Vaccine. N Engl J Med. 2022 05 19; 386(20):1910-1921.
Moreira ED, Kitchin N, Xu X, Dychter SS, Lockhart S, Gurtman A, Perez JL, Zerbini C, Dever ME, Jennings TW, Brandon DM, Cannon KD, Koren MJ, Denham DS, Berhe M, Fitz-Patrick D, Hammitt LL, Klein NP, Nell H, Keep G, Wang X, Koury K, Swanson KA, Cooper D, Lu C, Türeci Ö, Lagkadinou E, Tresnan DB, Dormitzer PR, Sahin U, Gruber WC, Jansen KU, C4591031 Clinical Trial Group. PMID: 35320659; PMCID: PMC9006787.
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Efficacy and safety of the BNT162b2 mRNA COVID-19 vaccine in participants with a history of cancer: subgroup analysis of a global phase 3 randomized clinical trial. Vaccine. 2022 03 01; 40(10):1483-1492.
Thomas SJ, Perez JL, Lockhart SP, Hariharan S, Kitchin N, Bailey R, Liau K, Lagkadinou E, Türeci Ö, Sahin U, Xu X, Koury K, Dychter SS, Lu C, Gentile TC, Gruber WC. PMID: 35131133; PMCID: PMC8702495.
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Avelumab alone or in combination with chemotherapy versus chemotherapy alone in platinum-resistant or platinum-refractory ovarian cancer (JAVELIN Ovarian 200): an open-label, three-arm, randomised, phase 3 study. Lancet Oncol. 2021 07; 22(7):1034-1046.
Pujade-Lauraine E, Fujiwara K, Ledermann JA, Oza AM, Kristeleit R, Ray-Coquard IL, Richardson GE, Sessa C, Yonemori K, Banerjee S, Leary A, Tinker AV, Jung KH, Madry R, Park SY, Anderson CK, Zohren F, Stewart RA, Wei C, Dychter SS, Monk BJ. PMID: 34143970.
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147 Fields:
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HumansCTClinical Trials
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A real-world study on characteristics, treatments and outcomes in US patients with advanced stage ovarian cancer. J Ovarian Res. 2020 Aug 31; 13(1):101.
Beachler DC, Lamy FX, Russo L, Taylor DH, Dinh J, Yin R, Jamal-Allial A, Dychter S, Lanes S, Verpillat P. PMID: 32867806; PMCID: PMC7461260.
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4 Fields:
Translation:
Humans
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A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Recombinant Human Hyaluronidase PH20 Administered Intravenously in Healthy Volunteers. Curr Ther Res Clin Exp. 2020; 93:100604.
Printz MA, Dychter SS, DeNoia EP, Harrigan R, Sugarman BJ, Zepeda M, Souratha J, Kang DW, Maneval DC. PMID: 32963641; PMCID: PMC7490523.
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9 Fields:
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Avelumab (anti-PD-L1) in platinum-resistant/refractory ovarian cancer: JAVELIN Ovarian 200 Phase III study design. Future Oncol. 2018 Sep; 14(21):2103-2113.
Pujade-Lauraine E, Fujiwara K, Dychter SS, Devgan G, Monk BJ. PMID: 29584456.
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PubMed Mentions:
36 Fields:
Translation:
HumansCTClinical Trials
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Phase 1 trials of PEGylated recombinant human hyaluronidase PH20 in patients with advanced solid tumours. Br J Cancer. 2018 01; 118(2):e3.
Infante JR, Korn RL, Rosen LS, LoRusso P, Dychter SS, Zhu J, Maneval DC, Jiang P, Shepard HM, Frost G, Von Hoff DD, Borad MJ, Ramanathan RK. PMID: 29361630; PMCID: PMC5785755.
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PubMed Mentions:
5 Fields:
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Phase 1 trials of PEGylated recombinant human hyaluronidase PH20 in patients with advanced solid tumours. Br J Cancer. 2018 01; 118(2):153-161.
Infante JR, Korn RL, Rosen LS, LoRusso P, Dychter SS, Zhu J, Maneval DC, Jiang P, Shepard HM, Frost G, Von Hoff DD, Borad MJ, Ramanathan RK. PMID: 28949957; PMCID: PMC5785735.
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PubMed Mentions:
34 Fields:
Translation:
HumansCTClinical Trials
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Phase Ib Study of PEGylated Recombinant Human Hyaluronidase and Gemcitabine in Patients with Advanced Pancreatic Cancer. Clin Cancer Res. 2016 06 15; 22(12):2848-54.
Hingorani SR, Harris WP, Beck JT, Berdov BA, Wagner SA, Pshevlotsky EM, Tjulandin SA, Gladkov OA, Holcombe RF, Korn R, Raghunand N, Dychter S, Jiang P, Shepard HM, Devoe CE. PMID: 26813359; PMCID: PMC7787348.
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PubMed Mentions:
152 Fields:
Translation:
HumansCTClinical Trials
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Erratum to: Clinical Immunogenicity of rHuPH20, a Hyaluronidase Enabling Subcutaneous Drug Administration. AAPS J. 2015 Nov; 17(6):1523-4.
Rosengren S, Dychter SS, Printz MA, Huang L, Schiff RI, Schwarz HP, McVey JK, Drake FH, Maneval DC, Kennard DA, Frost GI, Sugarman BJ, Muchmore DB. PMID: 26340861; PMCID: PMC4627462.
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1 Fields:
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Clinical Immunogenicity of rHuPH20, a Hyaluronidase Enabling Subcutaneous Drug Administration. AAPS J. 2015 Sep; 17(5):1144-56.
Rosengren S, Dychter SS, Printz MA, Huang L, Schiff RI, Schwarz HP, McVey JK, Drake FH, Maneval DC, Kennard DA, Frost GI, Sugarman BJ, Muchmore DB. PMID: 25967925; PMCID: PMC4540732.
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24 Fields:
Translation:
Humans
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Tolerability and pharmacokinetic properties of ondansetron administered subcutaneously with recombinant human hyaluronidase in minipigs and healthy volunteers. Clin Ther. 2014 Feb 01; 36(2):211-24.
Dychter SS, Harrigan R, Bahn JD, Printz MA, Sugarman BJ, DeNoia E, Haughey DB, Fellows D, Maneval DC. PMID: 24486335.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCTClinical Trials
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Subcutaneous drug delivery: a route to increased safety, patient satisfaction, and reduced costs. J Infus Nurs. 2012 May-Jun; 35(3):154-60.
Dychter SS, Gold DA, Haller MF. PMID: 22498485.
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18 Fields:
Translation:
Humans
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Intravenous therapy: a review of complications and economic considerations of peripheral access. J Infus Nurs. 2012 Mar-Apr; 35(2):84-91.
Dychter SS, Gold DA, Carson D, Haller M. PMID: 22382792.
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PubMed Mentions:
48 Fields:
Translation:
Humans
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Comparison of the tolerability of recombinant human hyaluronidase + normal saline and recombinant human hyaluronidase + lactated ringer's solution administered subcutaneously: A phase IV, double-blind, randomized pilot study in healthy volunteers. Curr Ther Res Clin Exp. 2009 Dec; 70(6):421-38.
Dychter SS, Ebel D, Mead TR, Yocum RC. PMID: 24692835; PMCID: PMC3969977.
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PubMed Mentions:
5 Fields:
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Hypothyroidism after sunitinib treatment for patients with gastrointestinal stromal tumors. Ann Intern Med. 2006 Nov 07; 145(9):660-4.
Desai J, Yassa L, Marqusee E, George S, Frates MC, Chen MH, Morgan JA, Dychter SS, Larsen PR, Demetri GD, Alexander EK. PMID: 17088579.
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PubMed Mentions:
89 Fields:
Translation:
HumansCTClinical Trials