Matteo Castelli

Title(s)Postdoctoral Scholar, Molecular Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-3673-0262 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Milan, Milan, ItalyB.Sc.10/2018Chemistry
    University of Pavia, Pavia, ItalyM.Sc.07/2020Chemistry
    University of Pavia, Pavia, ItalyPh.D.09/2023Computational Biophysics
    Collapse Awards and Honors
    Italian Chemistry Society2022Italian Chemistry Society oral presentation travel grant

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Molecular mechanisms of chaperone-directed protein folding: Insights from atomistic simulations. Protein Sci. 2023 Dec 25; 33(3):e4880. Castelli M, Magni A, Bonollo G, Pavoni S, Frigerio F, Oliveira ASF, Cinquini F, Serapian SA, Colombo G. PMID: 38145386; PMCID: PMC10895457.
      View in: PubMed   Mentions: 1     Fields:    
    2. Decrypting Allostery in Membrane-Bound K-Ras4B Using Complementary In Silico Approaches Based on Unbiased Molecular Dynamics Simulations. J Am Chem Soc. 2024 Jan 10; 146(1):901-919. Castelli M, Marchetti F, Osuna S, F Oliveira AS, Mulholland AJ, Serapian SA, Colombo G. PMID: 38116743; PMCID: PMC10785808.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    3. NLRP3 monomer functional dynamics: From the effects of allosteric binding to implications for drug design. Int J Biol Macromol. 2023 Aug 15; 246:125609. Casali E, Serapian SA, Gianquinto E, Castelli M, Bertinaria M, Spyrakis F, Colombo G. PMID: 37394218.
      View in: PubMed   Mentions:    Fields:    
    4. How aberrant N-glycosylation can alter protein functionality and ligand binding: An atomistic view. Structure. 2023 08 03; 31(8):987-1004.e8. Castelli M, Yan P, Rodina A, Digwal CS, Panchal P, Chiosis G, Moroni E, Colombo G. PMID: 37343552; PMCID: PMC10526633.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    5. PhosY-secretome profiling combined with kinase-substrate interaction screening defines active c-Src-driven extracellular signaling. Cell Rep. 2023 06 27; 42(6):112539. Backe SJ, Votra SD, Stokes MP, Sebestyén E, Castelli M, Torielli L, Colombo G, Woodford MR, Mollapour M, Bourboulia D. PMID: 37243593; PMCID: PMC10569185.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    6. AlphaFold predicted structure of the Hsp90-like domains of the neurodegeneration linked protein sacsin reveals key residues for ATPase activity. Front Mol Biosci. 2022; 9:1074714. Perna L, Castelli M, Frasnetti E, Romano LEL, Colombo G, Prodromou C, Chapple JP. PMID: 36710881; PMCID: PMC9880540.
      View in: PubMed   Mentions:
    7. Phosphorylation of the Hsp90 Co-Chaperone Hop Changes its Conformational Dynamics and Biological Function. J Mol Biol. 2023 02 01; 435(3):167931. Castelli M, Bhattacharya K, Abboud E, Serapian SA, Picard D, Colombo G. PMID: 36572238.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    8. Studying the Dynamics of a Complex G-Quadruplex System: Insights into the Comparison of MD and NMR Data. J Chem Theory Comput. 2022 Jul 12; 18(7):4515-4528. Castelli M, Doria F, Freccero M, Colombo G, Moroni E. PMID: 35666124; PMCID: PMC9281369.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    9. Protein Allostery and Ligand Design: Computational Design Meets Experiments to Discover Novel Chemical Probes. J Mol Biol. 2022 09 15; 434(17):167468. Triveri A, Sanchez-Martin C, Torielli L, Serapian SA, Marchetti F, D'Acerno G, Pirota V, Castelli M, Moroni E, Ferraro M, Quadrelli P, Rasola A, Colombo G. PMID: 35101454.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    10. The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect. Nat Struct Mol Biol. 2021 08; 28(8):662-670. Woodford MR, Baker-Williams AJ, Sager RA, Backe SJ, Blanden AR, Hashmi F, Kancherla P, Gori A, Loiselle DR, Castelli M, Serapian SA, Colombo G, Haystead TA, Jensen SM, Stetler-Stevenson WG, Loh SN, Schmidt LS, Linehan WM, Bah A, Bourboulia D, Bratslavsky G, Mollapour M. PMID: 34381247; PMCID: PMC9278990.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    11. New perspectives in cancer drug development: computational advances with an eye to design. RSC Med Chem. 2021 Sep 23; 12(9):1491-1502. Castelli M, Serapian SA, Marchetti F, Triveri A, Pirota V, Torielli L, Collina S, Doria F, Freccero M, Colombo G. PMID: 34671733; PMCID: PMC8459323.
      View in: PubMed   Mentions: 1  
    12. Exploiting Folding and Degradation Machineries To Target Undruggable Proteins: What Can a Computational Approach Tell Us? ChemMedChem. 2021 05 18; 16(10):1593-1599. Serapian SA, Triveri A, Marchetti F, Castelli M, Colombo G. PMID: 33443306.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
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