Martin Hetzer

TitleAssociate Adjunct Professor
InstitutionUniversity of California San Diego
DepartmentCell and Developmental Biology
Address9500 Gilman Drive #0932
La Jolla CA 92093
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    1. Franks TM, McCloskey A, Shokirev MN, Benner C, Rathore A, Hetzer MW. Nup98 recruits the Wdr82-Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation in hematopoietic progenitor cells. Genes Dev. 2017 11 15; 31(22):2222-2234. PMID: 29269482.
      View in: PubMed
    2. Toda T, Hsu JY, Linker SB, Hu L, Schafer ST, Mertens J, Jacinto FV, Hetzer MW, Gage FH. Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells. Cell Stem Cell. 2017 Nov 02; 21(5):618-634.e7. PMID: 28919367.
      View in: PubMed
    3. Buchwalter A, Hetzer MW. Nucleolar expansion and elevated protein translation in premature aging. Nat Commun. 2017 08 30; 8(1):328. PMID: 28855503.
      View in: PubMed
    4. Franks TM, Benner C, Narvaiza I, Marchetto MCN, Young JM, Malik HS, Gage FH, Hetzer MW. Corrigendum: Evolution of a transcriptional regulator from a transmembrane nucleoporin. Genes Dev. 2017 04 15; 31(8):845. PMID: 28512238.
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    5. van de Ven RA, de Groot JS, Park D, van Domselaar R, de Jong D, Szuhai K, van der Wall E, Rueda OM, Ali HR, Caldas C, van Diest PJ, Hetzer MW, Sahai E, Derksen PW. p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis. Nat Commun. 2016 Dec 22; 7:13874. PMID: 28004812.
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    6. Ibarra A, Benner C, Tyagi S, Cool J, Hetzer MW. Nucleoporin-mediated regulation of cell identity genes. Genes Dev. 2016 Oct 15; 30(20):2253-2258. PMID: 27807035.
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    7. Hatch EM, Hetzer MW. Nuclear envelope rupture is induced by actin-based nucleus confinement. J Cell Biol. 2016 Oct 10; 215(1):27-36. PMID: 27697922.
      View in: PubMed
    8. Franks TM, Benner C, Narvaiza I, Marchetto MC, Young JM, Malik HS, Gage FH, Hetzer MW. Evolution of a transcriptional regulator from a transmembrane nucleoporin. Genes Dev. 2016 05 15; 30(10):1155-71. PMID: 27198230; PMCID: PMC4888837.
    9. Mertens J, Paquola ACM, Ku M, Hatch E, Böhnke L, Ladjevardi S, McGrath S, Campbell B, Lee H, Herdy JR, Gonçalves JT, Toda T, Kim Y, Winkler J, Yao J, Hetzer MW, Gage FH. Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects. Cell Stem Cell. 2015 Dec 03; 17(6):705-718. PMID: 26456686.
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    10. Ori A, Toyama BH, Harris MS, Bock T, Iskar M, Bork P, Ingolia NT, Hetzer MW, Beck M. Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats. Cell Syst. 2015 Sep 23; 1(3):224-37. PMID: 27135913; PMCID: PMC4802414.
    11. Hatch EM, Hetzer MW. Linking Micronuclei to Chromosome Fragmentation. Cell. 2015 Jun 18; 161(7):1502-4. PMID: 26091034.
      View in: PubMed
    12. Jacinto FV, Benner C, Hetzer MW. The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing. Genes Dev. 2015 Jun 15; 29(12):1224-38. PMID: 26080816; PMCID: PMC4495395.
    13. Hatch EM, Hetzer MW. Chromothripsis. Curr Biol. 2015 May 18; 25(10):R397-9. PMID: 25989073.
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    14. Gomez-Cavazos JS, Hetzer MW. The nucleoporin gp210/Nup210 controls muscle differentiation by regulating nuclear envelope/ER homeostasis. J Cell Biol. 2015 Mar 16; 208(6):671-81. PMID: 25778917; PMCID: PMC4362455.
    15. Ibarra A, Hetzer MW. Nuclear pore proteins and the control of genome functions. Genes Dev. 2015 Feb 15; 29(4):337-49. PMID: 25691464; PMCID: PMC4335290.
    16. Buchwalter AL, Liang Y, Hetzer MW. Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics. Mol Biol Cell. 2014 Aug 15; 25(16):2472-84. PMID: 24943837; PMCID: PMC4142618.
    17. Hatch E, Hetzer M. Breaching the nuclear envelope in development and disease. J Cell Biol. 2014 Apr 28; 205(2):133-41. PMID: 24751535; PMCID: PMC4003239.
    18. Buchwalter A, Hetzer MW. Nuclear pores set the speed limit for mitosis. Cell. 2014 Feb 27; 156(5):868-9. PMID: 24581486; PMCID: PMC4008093.
    19. Toyama BH, Savas JN, Park SK, Harris MS, Ingolia NT, Yates JR, Hetzer MW. Identification of long-lived proteins reveals exceptional stability of essential cellular structures. Cell. 2013 Aug 29; 154(5):971-982. PMID: 23993091.
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    20. Dollendorf C, Hetzer M, Ritter H. Polymeric redox-responsive delivery systems bearing ammonium salts cross-linked via disulfides. Beilstein J Org Chem. 2013; 9:1652-1662. PMID: 24062825; PMCID: PMC3778402.
    21. Schmidt BV, Hetzer M, Ritter H, Barner-Kowollik C. Modulation of the thermoresponsive behavior of poly(N,N-diethylacrylamide) via cyclodextrin host/guest interactions. Macromol Rapid Commun. 2013 Aug; 34(16):1306-11. PMID: 23881563.
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    22. Hatch EM, Fischer AH, Deerinck TJ, Hetzer MW. Catastrophic nuclear envelope collapse in cancer cell micronuclei. Cell. 2013 Jul 03; 154(1):47-60. PMID: 23827674; PMCID: PMC3749778.
    23. Regner BM, Vucinic D, Domnisoru C, Bartol TM, Hetzer MW, Tartakovsky DM, Sejnowski TJ. Anomalous diffusion of single particles in cytoplasm. Biophys J. 2013 Apr 16; 104(8):1652-60. PMID: 23601312; PMCID: PMC3627875.
    24. Liang Y, Franks TM, Marchetto MC, Gage FH, Hetzer MW. Dynamic association of NUP98 with the human genome. PLoS Genet. 2013; 9(2):e1003308. PMID: 23468646; PMCID: PMC3585015.
    25. Toyama BH, Hetzer MW. Protein homeostasis: live long, won't prosper. Nat Rev Mol Cell Biol. 2013 Jan; 14(1):55-61. PMID: 23258296; PMCID: PMC3570024.
    26. Franks TM, Hetzer MW. The role of Nup98 in transcription regulation in healthy and diseased cells. Trends Cell Biol. 2013 Mar; 23(3):112-7. PMID: 23246429; PMCID: PMC3622213.
    27. Gomez-Cavazos JS, Hetzer MW. Outfits for different occasions: tissue-specific roles of Nuclear Envelope proteins. Curr Opin Cell Biol. 2012 Dec; 24(6):775-83. PMID: 22995343; PMCID: PMC3587307.
    28. Hatch EM, Hetzer MW. RNP export by nuclear envelope budding. Cell. 2012 May 11; 149(4):733-5. PMID: 22579277.
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    29. Savas JN, Toyama BH, Xu T, Yates JR, Hetzer MW. Extremely long-lived nuclear pore proteins in the rat brain. Science. 2012 Feb 24; 335(6071):942. PMID: 22300851; PMCID: PMC3296478.
    30. D'Angelo MA, Gomez-Cavazos JS, Mei A, Lackner DH, Hetzer MW. A change in nuclear pore complex composition regulates cell differentiation. Dev Cell. 2012 Feb 14; 22(2):446-58. PMID: 22264802; PMCID: PMC3288503.
    31. Vargas JD, Hatch EM, Anderson DJ, Hetzer MW. Transient nuclear envelope rupturing during interphase in human cancer cells. Nucleus. 2012 Jan-Feb; 3(1):88-100. PMID: 22567193; PMCID: PMC3342953.
    32. Talamas JA, Hetzer MW. POM121 and Sun1 play a role in early steps of interphase NPC assembly. J Cell Biol. 2011 Jul 11; 194(1):27-37. PMID: 21727197; PMCID: PMC3135402.
    33. Hetzer M, Cavalli G. Eukaryotic cells. Curr Opin Cell Biol. 2011 Jun; 23(3):255-7. PMID: 21592757.
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    34. Liang Y, Hetzer MW. Functional interactions between nucleoporins and chromatin. Curr Opin Cell Biol. 2011 Feb; 23(1):65-70. PMID: 21030234; PMCID: PMC3753814.
    35. Gonsior N, Hetzer M, Kulicke WM, Ritter H. First studies on the influence of methylated ß-cyclodextrin on the rheological behavior of 1-ethyl-3-methyl imidazolium acetate. J Phys Chem B. 2010 Oct 07; 114(39):12468-72. PMID: 20836509.
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    36. Hetzer M. Martin Hetzer: taking the nuclear membrane beyond the barrier. J Cell Biol. 2010 Aug 23; 190(4):484-5. PMID: 20733048; PMCID: PMC2928019.
    37. Doucet CM, Hetzer MW. Nuclear pore biogenesis into an intact nuclear envelope. Chromosoma. 2010 Oct; 119(5):469-77. PMID: 20721671.
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    38. Doucet CM, Talamas JA, Hetzer MW. Cell cycle-dependent differences in nuclear pore complex assembly in metazoa. Cell. 2010 Jun 11; 141(6):1030-41. PMID: 20550937; PMCID: PMC2887351.
    39. Hetzer MW. The role of the nuclear pore complex in aging of post-mitotic cells. Aging (Albany NY). 2010 Mar 20; 2(2):74-5. PMID: 20354266; PMCID: PMC2850141.
    40. Hetzer MW. The nuclear envelope. Cold Spring Harb Perspect Biol. 2010 Mar; 2(3):a000539. PMID: 20300205; PMCID: PMC2829960.
    41. Hetzer M, Chen G, Barner-Kowollik C, Stenzel MH. Neoglycopolymers based on 4-vinyl-1,2,3-triazole monomers prepared by click chemistry. Macromol Biosci. 2010 Feb 11; 10(2):119-26. PMID: 19731270.
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    42. Capelson M, Liang Y, Schulte R, Mair W, Wagner U, Hetzer MW. Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes. Cell. 2010 Feb 05; 140(3):372-83. PMID: 20144761; PMCID: PMC2821818.
    43. Hetzer MW, Wente SR. Border control at the nucleus: biogenesis and organization of the nuclear membrane and pore complexes. Dev Cell. 2009 Nov; 17(5):606-16. PMID: 19922866; PMCID: PMC3746554.
    44. Anderson DJ, Vargas JD, Hsiao JP, Hetzer MW. Recruitment of functionally distinct membrane proteins to chromatin mediates nuclear envelope formation in vivo. J Cell Biol. 2009 Jul 27; 186(2):183-91. PMID: 19620630; PMCID: PMC2717638.
    45. Capelson M, Hetzer MW. The role of nuclear pores in gene regulation, development and disease. EMBO Rep. 2009 Jul; 10(7):697-705. PMID: 19543230; PMCID: PMC2727434.
    46. Dawson TR, Lazarus MD, Hetzer MW, Wente SR. ER membrane-bending proteins are necessary for de novo nuclear pore formation. J Cell Biol. 2009 Mar 09; 184(5):659-75. PMID: 19273614; PMCID: PMC2686408.
    47. D'Angelo MA, Raices M, Panowski SH, Hetzer MW. Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells. Cell. 2009 Jan 23; 136(2):284-95. PMID: 19167330; PMCID: PMC2805151.
    48. Kutay U, Hetzer MW. Reorganization of the nuclear envelope during open mitosis. Curr Opin Cell Biol. 2008 Dec; 20(6):669-77. PMID: 18938243; PMCID: PMC2713602.
    49. D'Angelo MA, Hetzer MW. Structure, dynamics and function of nuclear pore complexes. Trends Cell Biol. 2008 Oct; 18(10):456-66. PMID: 18786826; PMCID: PMC2697926.
    50. Anderson DJ, Hetzer MW. Reshaping of the endoplasmic reticulum limits the rate for nuclear envelope formation. J Cell Biol. 2008 Sep 08; 182(5):911-24. PMID: 18779370; PMCID: PMC2528577.
    51. Anderson DJ, Hetzer MW. The life cycle of the metazoan nuclear envelope. Curr Opin Cell Biol. 2008 Aug; 20(4):386-92. PMID: 18495454; PMCID: PMC2676173.
    52. Schulte R, Talamas J, Doucet C, Hetzer MW. Single bead affinity detection (SINBAD) for the analysis of protein-protein interactions. PLoS One. 2008 Apr 30; 3(4):e2061. PMID: 18446240; PMCID: PMC2329591.
    53. Anderson DJ, Hetzer MW. Shaping the endoplasmic reticulum into the nuclear envelope. J Cell Sci. 2008 Jan 15; 121(Pt 2):137-42. PMID: 18187447.
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    54. Anderson DJ, Hetzer MW. Nuclear envelope formation by chromatin-mediated reorganization of the endoplasmic reticulum. Nat Cell Biol. 2007 Oct; 9(10):1160-6. PMID: 17828249.
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    55. Franz C, Walczak R, Yavuz S, Santarella R, Gentzel M, Askjaer P, Galy V, Hetzer M, Mattaj IW, Antonin W. MEL-28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly. EMBO Rep. 2007 Feb; 8(2):165-72. PMID: 17235358; PMCID: PMC1796766.
    56. D'Angelo MA, Anderson DJ, Richard E, Hetzer MW. Nuclear pores form de novo from both sides of the nuclear envelope. Science. 2006 Apr 21; 312(5772):440-3. PMID: 16627745.
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    57. Hetzer MW, Walther TC, Mattaj IW. Pushing the envelope: structure, function, and dynamics of the nuclear periphery. Annu Rev Cell Dev Biol. 2005; 21:347-80. PMID: 16212499.
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    58. Walther TC, Askjaer P, Gentzel M, Habermann A, Griffiths G, Wilm M, Mattaj IW, Hetzer M. RanGTP mediates nuclear pore complex assembly. Nature. 2003 Aug 07; 424(6949):689-94. PMID: 12894213.
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    59. Walther TC, Alves A, Pickersgill H, Loïodice I, Hetzer M, Galy V, Hülsmann BB, Köcher T, Wilm M, Allen T, Mattaj IW, Doye V. The conserved Nup107-160 complex is critical for nuclear pore complex assembly. Cell. 2003 Apr 18; 113(2):195-206. PMID: 12705868.
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    60. Bilbao-Cortés D, Hetzer M, Längst G, Becker PB, Mattaj IW. Ran binds to chromatin by two distinct mechanisms. Curr Biol. 2002 Jul 09; 12(13):1151-6. PMID: 12121625.
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    61. Hetzer M, Gruss OJ, Mattaj IW. The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly. Nat Cell Biol. 2002 Jul; 4(7):E177-84. PMID: 12105431.
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