Lynn Ten Eyck

TitleRecall Non-faculty Academic
InstitutionUniversity of California San Diego
DepartmentChemistry and Biochemistry
Address9500 Gilman Drive #0505
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Computation and Mass Spec: Predicting Protein Complexes
    NIH/NIGMS R01GM070996May 1, 2004 - Apr 30, 2009
    Role: Principal Investigator
    Improved Macromolecular Refinement Methods
    NIH/NIGMS R01GM069758Feb 1, 2004 - Jan 31, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Fedosyuk S, Bezerra GA, Radakovics K, Smith TK, Sammito M, Bobik N, Round A, Ten Eyck L, Djinovic-Carugo K, Usón I, Skern T. Vaccinia Virus Immunomodulator A46: A Lipid and Protein-Binding Scaffold for Sequestering Host TIR-Domain Proteins. PLoS Pathog. 2016 Dec; 12(12):e1006079. PMID: 27973613.
      View in: PubMed
    2. Roberts VA, Pique ME, Ten Eyck L, Li S. Predicting protein-DNA interactions by full search computational docking. Proteins. 2013 Dec; 81(12):2106-18. PMID: 23966176; PMCID: PMC4045845.
    3. Roberts VA, Pique ME, Hsu S, Li S, Slupphaug G, Rambo RP, Jamison JW, Liu T, Lee JH, Tainer JA, Ten Eyck L, Woods VL. Combining H/D exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase. Nucleic Acids Res. 2012 Jul; 40(13):6070-81. PMID: 22492624; PMCID: PMC3401472.
    4. Levisson M, Han GW, Deller MC, Xu Q, Biely P, Hendriks S, Ten Eyck L, Flensburg C, Roversi P, Miller MD, McMullan D, von Delft F, Kreusch A, Deacon AM, van der Oost J, Lesley SA, Elsliger MA, Kengen SW, Wilson IA. Functional and structural characterization of a thermostable acetyl esterase from Thermotoga maritima. Proteins. 2012 Jun; 80(6):1545-59. PMID: 22411095; PMCID: PMC3348966.
    5. Trinh MH, Odorico M, Pique ME, Teulon JM, Roberts VA, Ten Eyck L, Getzoff ED, Parot P, Chen SW, Pellequer JL. Computational reconstruction of multidomain proteins using atomic force microscopy data. Structure. 2012 Jan 11; 20(1):113-20. PMID: 22244760; PMCID: PMC3264848.
    6. Thompson EE, Kornev AP, Kannan N, Kim C, Ten Eyck L, Taylor SS. Comparative surface geometry of the protein kinase family. Protein Sci. 2009 Oct; 18(10):2016-26. PMID: 19610074; PMCID: PMC2786965.
    7. Kornev AP, Taylor SS, Ten Eyck L. A helix scaffold for the assembly of active protein kinases. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14377-82. PMID: 18787129; PMCID: PMC2533684.
    8. Kornev AP, Taylor SS, Ten Eyck L. A generalized allosteric mechanism for cis-regulated cyclic nucleotide binding domains. PLoS Comput Biol. 2008 Apr 11; 4(4):e1000056. PMID: 18404204; PMCID: PMC2275311.
    9. Ten Eyck L, Taylor SS, Kornev AP. Conserved spatial patterns across the protein kinase family. Biochim Biophys Acta. 2008 Jan; 1784(1):238-43. PMID: 18067871.
      View in: PubMed
    10. Anand GS, Hotchko M, Brown SH, Ten Eyck L, Komives EA, Taylor SS. R-subunit isoform specificity in protein kinase A: distinct features of protein interfaces in PKA types I and II by amide H/2H exchange mass spectrometry. J Mol Biol. 2007 Nov 23; 374(2):487-99. PMID: 17942118; PMCID: PMC3419600.
    11. Weis DD, Wales TE, Engen JR, Hotchko M, Ten Eyck L. Identification and characterization of EX1 kinetics in H/D exchange mass spectrometry by peak width analysis. J Am Soc Mass Spectrom. 2006 Nov; 17(11):1498-1509. PMID: 16875839.
      View in: PubMed
    12. Hotchko M, Anand GS, Komives EA, Ten Eyck L. Automated extraction of backbone deuteration levels from amide H/2H mass spectrometry experiments. Protein Sci. 2006 Mar; 15(3):583-601. PMID: 16501228; PMCID: PMC2249778.
    13. Wu J, Yang J, Kannan N. Crystal structure of the E230Q mutant of cAMP-dependent protein kinase reveals an unexpected apoenzyme conformation and an extended N-terminal A helix. Protein Sci. 2005 Nov; 14(11):2871-9. PMID: 16253959; PMCID: PMC2253214.
    14. Law D, Hotchko M, Ten Eyck L. Progress in computation and amide hydrogen exchange for prediction of protein-protein complexes. Proteins. 2005 Aug 01; 60(2):302-7. PMID: 15981246.
      View in: PubMed
    15. Cerutti DS, Ten Eyck L, McCammon JA. Rapid Estimation of Solvation Energy for Simulations of Protein-Protein Association. J Chem Theory Comput. 2005 Jan; 1(1):143-52. PMID: 26641125.
      View in: PubMed
    16. Berman HM, Ten Eyck L, Goodsell DS, Haste NM, Kornev A, Taylor SS. The cAMP binding domain: an ancient signaling module. Proc Natl Acad Sci U S A. 2005 Jan 04; 102(1):45-50. PMID: 15618393; PMCID: PMC544069.
    17. Wu J, Jones JM, Nguyen-Huu X, Ten Eyck L, Taylor SS. Crystal structures of RIalpha subunit of cyclic adenosine 5'-monophosphate (cAMP)-dependent protein kinase complexed with (Rp)-adenosine 3',5'-cyclic monophosphothioate and (Sp)-adenosine 3',5'-cyclic monophosphothioate, the phosphothioate analogues of cAMP. Biochemistry. 2004 Jun 01; 43(21):6620-9. PMID: 15157095.
      View in: PubMed
    18. Yang J, Ten Eyck L, Xuong NH, Taylor SS. Crystal structure of a cAMP-dependent protein kinase mutant at 1.26A: new insights into the catalytic mechanism. J Mol Biol. 2004 Feb 13; 336(2):473-87. PMID: 14757059.
      View in: PubMed
    19. Anand GS, Law D, Mandell JG, Snead AN, Tsigelny I, Taylor SS, Ten Eyck L, Komives EA. Identification of the protein kinase A regulatory RIalpha-catalytic subunit interface by amide H/2H exchange and protein docking. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23):13264-9. PMID: 14583592; PMCID: PMC263775.
    20. Kotlovyi V, Nichols WL, Ten Eyck L. Protein structural alignment for detection of maximally conserved regions. Biophys Chem. 2003 Sep; 105(2-3):595-608. PMID: 14499921.
      View in: PubMed
    21. Law DS, Ten Eyck L, Katzenelson O, Tsigelny I, Roberts VA, Pique ME, Mitchell JC. Finding needles in haystacks: Reranking DOT results by using shape complementarity, cluster analysis, and biological information. Proteins. 2003 Jul 01; 52(1):33-40. PMID: 12784365.
      View in: PubMed
    22. Akamine P. Dynamic features of cAMP-dependent protein kinase revealed by apoenzyme crystal structure. J Mol Biol. 2003 Mar 14; 327(1):159-71. PMID: 12614615.
      View in: PubMed
    23. Ten Eyck L. Full matrix refinement as a tool to discover the quality of a refined structure. Methods Enzymol. 2003; 374:345-69. PMID: 14696381.
      View in: PubMed
    24. Tsigelny I, Sharikov Y, Ten Eyck L. Hidden Markov models-based system (HMMSPECTR) for detecting structural homologies on the basis of sequential information. Protein Eng. 2002 May; 15(5):347-52. PMID: 12034853.
      View in: PubMed