Lawrence Frank

InstitutionUniversity of California San Diego
Address9500 Gilman Drive #0854
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    MIT - Massachusetts Institute of TechnologyPh.D.Physics
    University of California, BerkeleyB.S.Physics and English

    Collapse Research 
    Collapse Research Activities and Funding
    New Quantitative Neuroimaging Metrics of Structural and Functional Connectivity of the Locus Coeruleus as a Novel Biomarker of Alzheimer's Disease Pathogenesis and Progression
    NIH/NIA R01AG054049Sep 15, 2017 - Apr 30, 2022
    Role: Principal Investigator
    Non invasive measurements of muscle microstructure assessed by diffusion tensor imaging
    NIH/NIAMS R01AR070830Aug 11, 2017 - Jul 31, 2022
    Role: Co-Principal Investigator
    Diffusion Imaging in Gray Matter
    NIH/NIMH R01MH096100Jun 1, 2012 - Mar 31, 2017
    Role: Principal Investigator
    Software for the Analysis and Visualization of High Angular Resolution DTI Data
    NIH/NIMH R01MH075870Aug 1, 2006 - Jul 31, 2011
    Role: Principal Investigator
    High Angular Resolution Diffusion Imaging with MRI
    NIH/NIMH R01MH064729Dec 1, 2003 - Nov 30, 2009
    Role: Principal Investigator
    NIH P41RR008605Apr 15, 1994 - Apr 30, 2014
    Role: Co-Investigator
    SAMHSA/CSAP H86SP003935Aug 21, 1991 - Apr 30, 1996
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Galinsky VL, Frank LR. Symplectomorphic registration with phase space regularization by entropy spectrum pathways. Magn Reson Med. 2018 Sep 19. PMID: 30230014.
      View in: PubMed
    2. Galinsky VL, Martinez A, Paulus MP, Frank LR. Joint Estimation of Effective Brain Wave Activation Modes Using EEG/MEG Sensor Arrays and Multimodal MRI Volumes. Neural Comput. 2018 Apr 13; 1-25. PMID: 29652588.
      View in: PubMed
    3. Lewalle A, Land S, Carruth E, Frank LR, Lamata P, Omens JH, McCulloch AD, Niederer SA, Smith NP. Decreasing Compensatory Ability of Concentric Ventricular Hypertrophy in Aortic-Banded Rat Hearts. Front Physiol. 2018; 9:37. PMID: 29527171.
      View in: PubMed
    4. Berry DB, Regner B, Galinsky V, Ward SR, Frank LR. Relationships between tissue microstructure and the diffusion tensor in simulated skeletal muscle. Magn Reson Med. 2018 Jul; 80(1):317-329. PMID: 29090480.
      View in: PubMed
    5. Berry DB, You S, Warner J, Frank LR, Chen S, Ward SR. * A 3D Tissue-Printing Approach for Validation of Diffusion Tensor Imaging in Skeletal Muscle. Tissue Eng Part A. 2017 Sep; 23(17-18):980-988. PMID: 28338417.
      View in: PubMed
    6. Galinsky VL, Frank LR. A Unified Theory of Neuro-MRI Data Shows Scale-Free Nature of Connectivity Modes. Neural Comput. 2017 Jun; 29(6):1441-1467. PMID: 28333589.
      View in: PubMed
    7. Galinsky VL, Frank LR. The Lamellar Structure of the Brain Fiber Pathways. Neural Comput. 2016 Sep 14; 1-24. PMID: 27626966.
      View in: PubMed
    8. Frank LR, Galinsky VL. Detecting Spatio-Temporal Modes in Multivariate Data by Entropy Field Decomposition. J Phys A Math Theor. 2016 Sep 30; 49(39). PMID: 27695512.
      View in: PubMed
    9. Sorg SF, Schiehser DM, Bondi MW, Luc N, Clark AL, Jacobson MW, Frank LR, Delano-Wood L. White Matter Microstructural Compromise Is Associated With Cognition But Not Posttraumatic Stress Disorder Symptoms in Military Veterans With Traumatic Brain Injury. J Head Trauma Rehabil. 2016 Sep-Oct; 31(5):297-308. PMID: 26360008.
      View in: PubMed
    10. Yopak KE, Galinsky VL, Berquist RM, Frank LR. Quantitative Classification of Cerebellar Foliation in Cartilaginous Fishes (Class: Chondrichthyes) Using Three-Dimensional Shape Analysis and Its Implications for Evolutionary Biology. Brain Behav Evol. 2016; 87(4):252-64. PMID: 27450795; PMCID: PMC5023489 [Available on 07/23/17].
    11. Frank LR, Galinsky VL. Dynamic Multiscale Modes of Resting State Brain Activity Detected by Entropy Field Decomposition. Neural Comput. 2016 Sep; 28(9):1769-811. PMID: 27391678.
      View in: PubMed
    12. Berquist RM, Galinsky VL, Kajiura SM, Frank LR. The coelacanth rostral organ is a unique low-resolution electro-detector that facilitates the feeding strike. Sci Rep. 2015 Mar 11; 5:8962. PMID: 25758410; PMCID: PMC4355723.
    13. Galinsky VL, Frank LR. Simultaneous multi-scale diffusion estimation and tractography guided by entropy spectrum pathways. IEEE Trans Med Imaging. 2015 May; 34(5):1177-93. PMID: 25532167; PMCID: PMC4417445.
    14. Frank LR, Galinsky VL. Information pathways in a disordered lattice. Phys Rev E Stat Nonlin Soft Matter Phys. 2014 Mar; 89(3):032142. PMID: 24730824; PMCID: PMC4319715.
    15. Galinsky VL, Frank LR. Automated segmentation and shape characterization of volumetric data. Neuroimage. 2014 May 15; 92:156-68. PMID: 24521852; PMCID: PMC4324567.
    16. Sorg SF, Delano-Wood L, Luc N, Schiehser DM, Hanson KL, Nation DA, Lanni E, Jak AJ, Lu K, Meloy MJ, Frank LR, Lohr JB, Bondi MW. White matter integrity in veterans with mild traumatic brain injury: associations with executive function and loss of consciousness. J Head Trauma Rehabil. 2014 Jan-Feb; 29(1):21-32. PMID: 23640539; PMCID: PMC4300196.
    17. Graham JB, Wegner NC, Miller LA, Jew CJ, Lai NC, Berquist RM, Frank LR, Long JA. Spiracular air breathing in polypterid fishes and its implications for aerial respiration in stem tetrapods. Nat Commun. 2014; 5:3022. PMID: 24451680.
      View in: PubMed
    18. Krishnamurthy A, Villongco CT, Chuang J, Frank LR, Nigam V, Belezzuoli E, Stark P, Krummen DE, Narayan S, Omens JH, McCulloch AD, Kerckhoffs RC. Patient-Specific Models of Cardiac Biomechanics. J Comput Phys. 2013 Jul 01; 244:4-21. PMID: 23729839.
      View in: PubMed
    19. Rodríguez-Soto AE, Jaworski R, Jensen A, Niederberger B, Hargens AR, Frank LR, Kelly KR, Ward SR. Effect of load carriage on lumbar spine kinematics. Spine (Phila Pa 1976). 2013 Jun 01; 38(13):E783-91. PMID: 23524870.
      View in: PubMed
    20. Tangney JR, Chuang JS, Janssen MS, Krishnamurthy A, Liao P, Hoshijima M, Wu X, Meininger GA, Muthuchamy M, Zemljic-Harpf A, Ross RS, Frank LR, McCulloch AD, Omens JH. Novel role for vinculin in ventricular myocyte mechanics and dysfunction. Biophys J. 2013 Apr 02; 104(7):1623-33. PMID: 23561539; PMCID: PMC3617425.
    21. Baxter GT, Frank LR. A computational model for diffusion weighted imaging of myelinated white matter. Neuroimage. 2013 Jul 15; 75:204-12. PMID: 23507381; PMCID: PMC3683096.
    22. Zhang Y, Liang X, Ma J, Jing Y, Gonzales MJ, Villongco C, Krishnamurthy A, Frank LR, Nigam V, Stark P, Narayan SM, McCulloch AD. An atlas-based geometry pipeline for cardiac Hermite model construction and diffusion tensor reorientation. Med Image Anal. 2012 Aug; 16(6):1130-41. PMID: 22841777; PMCID: PMC3443263.
    23. Jacobus J, Thayer RE, Trim RS, Bava S, Frank LR, Tapert SF. White matter integrity, substance use, and risk taking in adolescence. Psychol Addict Behav. 2013 Jun; 27(2):431-42. PMID: 22564204.
      View in: PubMed
    24. Berquist RM, Gledhill KM, Peterson MW, Doan AH, Baxter GT, Yopak KE, Kang N, Walker HJ, Hastings PA, Frank LR. The Digital Fish Library: using MRI to digitize, database, and document the morphological diversity of fish. PLoS One. 2012; 7(4):e34499. PMID: 22493695; PMCID: PMC3321017.
    25. Lieber R, Ward S, Frank L, Schenk S. New opportunities and novel paradigms to support neuromuscular research. Phys Med Rehabil Clin N Am. 2012 Feb; 23(1):95-105, xi. PMID: 22239877.
      View in: PubMed
    26. Delano-Wood L, Stricker NH, Sorg SF, Nation DA, Jak AJ, Woods SP, Libon DJ, Delis DC, Frank LR, Bondi MW. Posterior cingulum white matter disruption and its associations with verbal memory and stroke risk in mild cognitive impairment. J Alzheimers Dis. 2012; 29(3):589-603. PMID: 22466061; PMCID: PMC3341099.
    27. Sorg SF, Taylor MJ, Alhassoon OM, Gongvatana A, Theilmann RJ, Frank LR, Grant I. Frontal white matter integrity predictors of adult alcohol treatment outcome. Biol Psychiatry. 2012 Feb 01; 71(3):262-8. PMID: 22047719; PMCID: PMC4208753.
    28. Rowe T, Frank LR. The disappearing third dimension. Science. 2011 Feb 11; 331(6018):712-4. PMID: 21311010.
      View in: PubMed
    29. Chuang JS, Zemljic-Harpf A, Ross RS, Frank LR, McCulloch AD, Omens JH. Determination of three-dimensional ventricular strain distributions in gene-targeted mice using tagged MRI. Magn Reson Med. 2010 Nov; 64(5):1281-8. PMID: 20981782; PMCID: PMC3272305.
    30. Kerr J, Norman GJ, Adams MA, Ryan S, Frank L, Sallis JF, Calfas KJ, Patrick K. Do neighborhood environments moderate the effect of physical activity lifestyle interventions in adults? Health Place. 2010 Sep; 16(5):903-8. PMID: 20510642; PMCID: PMC2918657.
    31. Frank LR, Jung Y, Inati S, Tyszka JM, Wong EC. High efficiency, low distortion 3D diffusion tensor imaging with variable density spiral fast spin echoes (3D DW VDS RARE). Neuroimage. 2010 Jan 15; 49(2):1510-23. PMID: 19778618; PMCID: PMC2791091.
    32. Yopak KE, Frank LR. Brain size and brain organization of the whale shark, Rhincodon typus, using magnetic resonance imaging. Brain Behav Evol. 2009; 74(2):121-42. PMID: 19729899.
      View in: PubMed
    33. Balls GT, Frank LR. A simulation environment for diffusion weighted MR experiments in complex media. Magn Reson Med. 2009 Sep; 62(3):771-8. PMID: 19488991; PMCID: PMC3820418.
    34. Bava S, Frank LR, McQueeny T, Schweinsburg BC, Schweinsburg AD, Tapert SF. Altered white matter microstructure in adolescent substance users. Psychiatry Res. 2009 Sep 30; 173(3):228-37. PMID: 19699064; PMCID: PMC2734872.
    35. McQueeny T, Schweinsburg BC, Schweinsburg AD, Jacobus J, Bava S, Frank LR, Tapert SF. Altered white matter integrity in adolescent binge drinkers. Alcohol Clin Exp Res. 2009 Jul; 33(7):1278-85. PMID: 19389185; PMCID: PMC2825379.
    36. Bava S, Theilmann RJ, Sach M, May SJ, Frank LR, Hesselink JR, Vu D, Trauner DA. Developmental changes in cerebral white matter microstructure in a disorder of lysosomal storage. Cortex. 2010 Feb; 46(2):206-16. PMID: 19427638; PMCID: PMC3351112.
    37. Gongvatana A, Schweinsburg BC, Taylor MJ, Theilmann RJ, Letendre SL, Alhassoon OM, Jacobus J, Woods SP, Jernigan TL, Ellis RJ, Frank LR, Grant I. White matter tract injury and cognitive impairment in human immunodeficiency virus-infected individuals. J Neurovirol. 2009 Apr; 15(2):187-95. PMID: 19306228.
      View in: PubMed
    38. Tyszka JM, Frank LR. High-field diffusion MR histology: image-based correction of eddy-current ghosts in diffusion-weighted rapid acquisition with relaxation enhancement (DW-RARE). Magn Reson Med. 2009 Mar; 61(3):728-33. PMID: 19097246; PMCID: PMC4319701.
    39. Runcie RM, Dewar H, Hawn DR, Frank LR, Dickson KA. Evidence for cranial endothermy in the opah (Lampris guttatus). J Exp Biol. 2009 Feb; 212(Pt 4):461-70. PMID: 19181893; PMCID: PMC2726851.
    40. Fryer SL, Schweinsburg BC, Bjorkquist OA, Frank LR, Mattson SN, Spadoni AD, Riley EP. Characterization of white matter microstructure in fetal alcohol spectrum disorders. Alcohol Clin Exp Res. 2009 Mar; 33(3):514-21. PMID: 19120066; PMCID: PMC2651988.
    41. Frank LR, Lu K, Wong EC. Perfusion tensor imaging. Magn Reson Med. 2008 Dec; 60(6):1284-91. PMID: 19030161; PMCID: PMC4319714.
    42. Delano-Wood L, Bondi MW, Jak AJ, Horne NR, Schweinsburg BC, Frank LR, Wierenga CE, Delis DC, Theilmann RJ, Salmon DP. Stroke risk modifies regional white matter differences in mild cognitive impairment. Neurobiol Aging. 2010 Oct; 31(10):1721-31. PMID: 19004528; PMCID: PMC2946939.
    43. Schulteis G, Archer C, Tapert SF, Frank LR. Intermittent binge alcohol exposure during the periadolescent period induces spatial working memory deficits in young adult rats. Alcohol. 2008 Sep; 42(6):459-67. PMID: 18760715; PMCID: PMC2562042.
    44. Fryer SL, Frank LR, Spadoni AD, Theilmann RJ, Nagel BJ, Schweinsburg AD, Tapert SF. Microstructural integrity of the corpus callosum linked with neuropsychological performance in adolescents. Brain Cogn. 2008 Jul; 67(2):225-33. PMID: 18346830; PMCID: PMC2491343.
    45. Buracas GT, Liu TT, Buxton RB, Frank LR, Wong EC. Imaging periodic currents using alternating balanced steady-state free precession. Magn Reson Med. 2008 Jan; 59(1):140-8. PMID: 18050317.
      View in: PubMed
    46. Tapert SF, Schweinsburg AD, Drummond SP, Paulus MP, Brown SA, Yang TT, Frank LR. Functional MRI of inhibitory processing in abstinent adolescent marijuana users. Psychopharmacology (Berl). 2007 Oct; 194(2):173-83. PMID: 17558500; PMCID: PMC2269705.
    47. Perry CN, Cartamil DP, Bernal D, Sepulveda CA, Theilmann RJ, Graham JB, Frank LR. Quantification of red myotomal muscle volume and geometry in the shortfin mako shark (Isurus oxyrinchus) and the salmon shark (Lamna ditropis) using T1-weighted magnetic resonance imaging. J Morphol. 2007 Apr; 268(4):284-92. PMID: 17299779.
      View in: PubMed
    48. Costandi PN, McCulloch AD, Omens JH, Frank LR. High-resolution longitudinal MRI of the transition to heart failure. Magn Reson Med. 2007 Apr; 57(4):714-20. PMID: 17390366; PMCID: PMC4482467.
    49. Costandi PN, Frank LR, McCulloch AD, Omens JH. Role of diastolic properties in the transition to failure in a mouse model of the cardiac dilatation. Am J Physiol Heart Circ Physiol. 2006 Dec; 291(6):H2971-9. PMID: 16861693; PMCID: PMC3334322.
    50. Wong EC, Cronin M, Wu WC, Inglis B, Frank LR, Liu TT. Velocity-selective arterial spin labeling. Magn Reson Med. 2006 Jun; 55(6):1334-41. PMID: 16700025.
      View in: PubMed
    51. Paulus MP, Frank LR. Anterior cingulate activity modulates nonlinear decision weight function of uncertain prospects. Neuroimage. 2006 Apr 01; 30(2):668-77. PMID: 16321546.
      View in: PubMed
    52. Clark CP, Brown GG, Frank L, Thomas L, Sutherland AN, Gillin JC. Improved anatomic delineation of the antidepressant response to partial sleep deprivation in medial frontal cortex using perfusion-weighted functional MRI. Psychiatry Res. 2006 Apr 30; 146(3):213-22. PMID: 16545553; PMCID: PMC2468216.
    53. Tapert SF, Schweinsburg AD, Barlett VC, Brown SA, Frank LR, Brown GG, Meloy MJ. Blood oxygen level dependent response and spatial working memory in adolescents with alcohol use disorders. Alcohol Clin Exp Res. 2004 Oct; 28(10):1577-86. PMID: 15597092.
      View in: PubMed
    54. Caligiuri MP, Brown GG, Meloy MJ, Eyler LT, Kindermann SS, Eberson S, Frank LR, Lohr JB. A functional magnetic resonance imaging study of cortical asymmetry in bipolar disorder. Bipolar Disord. 2004 Jun; 6(3):183-96. PMID: 15117397.
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    55. Obata T, Liu TT, Miller KL, Luh WM, Wong EC, Frank LR, Buxton RB. Discrepancies between BOLD and flow dynamics in primary and supplementary motor areas: application of the balloon model to the interpretation of BOLD transients. Neuroimage. 2004 Jan; 21(1):144-53. PMID: 14741651.
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    56. Liu TT, Frank LR. Efficiency, power, and entropy in event-related FMRI with multiple trial types. Part I: theory. Neuroimage. 2004 Jan; 21(1):387-400. PMID: 14741676.
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    57. Paulus MP, Frank LR. Ventromedial prefrontal cortex activation is critical for preference judgments. Neuroreport. 2003 Jul 18; 14(10):1311-5. PMID: 12876463.
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    58. Tapert SF, Cheung EH, Brown GG, Frank LR, Paulus MP, Schweinsburg AD, Meloy MJ, Brown SA. Neural response to alcohol stimuli in adolescents with alcohol use disorder. Arch Gen Psychiatry. 2003 Jul; 60(7):727-35. PMID: 12860777.
      View in: PubMed
    59. Frank LR, Wong EC, Liu TT, Buxton RB. Increased diffusion sensitivity with hyperechos. Magn Reson Med. 2003 Jun; 49(6):1098-105. PMID: 12768588.
      View in: PubMed
    60. Verney SP, Brown GG, Frank L, Paulus MP. Error-rate-related caudate and parietal cortex activation during decision making. Neuroreport. 2003 May 23; 14(7):923-8. PMID: 12802176.
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    61. Stiles J, Moses P, Roe K, Akshoomoff NA, Trauner D, Hesselink J, Wong EC, Frank LR, Buxton RB. Alternative brain organization after prenatal cerebral injury: convergent fMRI and cognitive data. J Int Neuropsychol Soc. 2003 May; 9(4):604-22. PMID: 12755173.
      View in: PubMed
    62. Paulus MP, Hozack N, Frank L, Brown GG, Schuckit MA. Decision making by methamphetamine-dependent subjects is associated with error-rate-independent decrease in prefrontal and parietal activation. Biol Psychiatry. 2003 Jan 01; 53(1):65-74. PMID: 12513946.
      View in: PubMed
    63. Paulus MP, Frank L, Brown GG, Braff DL. Schizophrenia subjects show intact success-related neural activation but impaired uncertainty processing during decision-making. Neuropsychopharmacology. 2003 Apr; 28(4):795-806. PMID: 12655327.
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    64. Paulus MP, Hozack NE, Zauscher BE, Frank L, Brown GG, McDowell J, Braff DL. Parietal dysfunction is associated with increased outcome-related decision-making in schizophrenia patients. Biol Psychiatry. 2002 Jun 15; 51(12):995-1004. PMID: 12062884.
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    65. Frank LR. Characterization of anisotropy in high angular resolution diffusion-weighted MRI. Magn Reson Med. 2002 Jun; 47(6):1083-99. PMID: 12111955.
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    66. Moses P, Roe K, Buxton RB, Wong EC, Frank LR, Stiles J. Functional MRI of global and local processing in children. Neuroimage. 2002 Jun; 16(2):415-24. PMID: 12030826.
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    67. Liu TT, Wong EC, Frank LR, Buxton RB. Analysis and design of perfusion-based event-related fMRI experiments. Neuroimage. 2002 May; 16(1):269-82. PMID: 11969334.
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    68. Paulus MP, Hozack N, Frank L, Brown GG. Error rate and outcome predictability affect neural activation in prefrontal cortex and anterior cingulate during decision-making. Neuroimage. 2002 Apr; 15(4):836-46. PMID: 11906224.
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    69. Paulus MP, Hozack NE, Zauscher BE, Frank L, Brown GG, Braff DL, Schuckit MA. Behavioral and functional neuroimaging evidence for prefrontal dysfunction in methamphetamine-dependent subjects. Neuropsychopharmacology. 2002 Jan; 26(1):53-63. PMID: 11751032.
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