George Somero

Title(s)Emeritus Professor, Marine Biology
SchoolVc-marine Sciences
Address9500 Gilman Drive #
La Jolla CA 92093
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    1. Tissue-specific temperature dependence of RNA editing levels in zebrafish. BMC Biol. 2023 11 20; 21(1):262. Li W, Bu M, Hu R, Jiang S, Chen L, Somero GN. PMID: 37981664; PMCID: PMC10659053.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Oxidative stress effects are not correlated with differences in heat tolerance among congeners of Mytilus. J Exp Biol. 2023 Aug 01; 226(15). Dowd WW, Somero GN. PMID: 37416965.
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    3. Turning a page: remaining a top competitor in an evolving publication ecosystem. J Exp Biol. 2023 01 15; 226(2). Somero GN. PMID: 36637438.
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    4. Solutions: how adaptive changes in cellular fluids enable marine life to cope with abiotic stressors. Mar Life Sci Technol. 2022 Aug; 4(3):389-413. Somero GN. PMID: 37073170; PMCID: PMC10077225.
      View in: PubMed   Mentions: 6  
    5. Effects of heat acclimation on cardiac function in the intertidal mussel Mytilus californianus: can laboratory-based indices predict survival in the field? J Exp Biol. 2022 05 01; 225(9). Moyen NE, Somero GN, Denny MW. PMID: 35388895; PMCID: PMC9163446.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    6. Thermal adaptation of mRNA secondary structure: stability versus lability. Proc Natl Acad Sci U S A. 2021 11 09; 118(45). Liao ML, Dong YW, Somero GN. PMID: 34728561; PMCID: PMC8609332.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    7. An integrated, multi-level analysis of thermal effects on intertidal molluscs for understanding species distribution patterns. Biol Rev Camb Philos Soc. 2022 04; 97(2):554-581. Dong YW, Liao ML, Han GD, Somero GN. PMID: 34713568.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    8. A tribute to Dr. Serge N. Timasheff, our mentor. Biophys Rev. 2021 Aug; 13(4):459-484. Aune K, Lee J, Prakash V, Bhat R, Andreu J, Monasterio O, Perez-Ramirez B, Shearwin K, Arakawa T, Carpenter J, Crowe J, Crowe L, Somero G, Gagnon P, Charles MT. PMID: 34471434; PMCID: PMC8355303.
      View in: PubMed   Mentions: 1  
    9. The Goldilocks Principle: A Unifying Perspective on Biochemical Adaptation to Abiotic Stressors in the Sea. Ann Rev Mar Sci. 2022 01 03; 14:1-23. Somero GN. PMID: 34102065.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    10. A single heat-stress bout induces rapid and prolonged heat acclimation in the California mussel, Mytilus californianus. Proc Biol Sci. 2020 12 09; 287(1940):20202561. Moyen NE, Crane RL, Somero GN, Denny MW. PMID: 33290677; PMCID: PMC7739924.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    11. Mussel acclimatization to high, variable temperatures is lost slowly upon transfer to benign conditions. J Exp Biol. 2020 07 01; 223(Pt 13). Moyen NE, Somero GN, Denny MW. PMID: 32457061.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    12. Introduction to the special issue: Comparative biology of cellular stress responses in animals. J Exp Zool A Ecol Integr Physiol. 2020 07; 333(6):345-349. Kültz D, Somero GN. PMID: 32588555.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    13. Establishing typical values for hemocyte mortality in individual California mussels, Mytilus californianus. Fish Shellfish Immunol. 2020 May; 100:70-79. Moyen NE, Bump PA, Somero GN, Denny MW. PMID: 32135339.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    14. The cellular stress response and temperature: Function, regulation, and evolution. J Exp Zool A Ecol Integr Physiol. 2020 07; 333(6):379-397. Somero GN. PMID: 31944627.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    15. Impact of heating rate on cardiac thermal tolerance in the California mussel, Mytilus californianus. J Exp Biol. 2019 09 03; 222(Pt 17). Moyen NE, Somero GN, Denny MW. PMID: 31395674.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    16. Comparing mutagenesis and simulations as tools for identifying functionally important sequence changes for protein thermal adaptation. Proc Natl Acad Sci U S A. 2019 01 08; 116(2):679-688. Liao ML, Somero GN, Dong YW. PMID: 30584112; PMCID: PMC6329985.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    17. RNA thermosensors: how might animals exploit their regulatory potential? J Exp Biol. 2018 02 22; 221(Pt 4). Somero GN. PMID: 29472490.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    18. Structural flexibility and protein adaptation to temperature: Molecular dynamics analysis of malate dehydrogenases of marine molluscs. Proc Natl Acad Sci U S A. 2018 02 06; 115(6):1274-1279. Dong YW, Liao ML, Meng XL, Somero GN. PMID: 29358381; PMCID: PMC5819447.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    19. Thermal history and gape of individual Mytilus californianus correlate with oxidative damage and thermoprotective osmolytes. J Exp Biol. 2017 11 15; 220(Pt 22):4292-4304. Gleason LU, Miller LP, Winnikoff JR, Somero GN, Yancey PH, Bratz D, Dowd WW. PMID: 29141883.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    20. Heat-resistant cytosolic malate dehydrogenases (cMDHs) of thermophilic intertidal snails (genus Echinolittorina): protein underpinnings of tolerance to body temperatures reaching 55°C. J Exp Biol. 2017 06 01; 220(Pt 11):2066-2075. Liao ML, Zhang S, Zhang GY, Chu YM, Somero GN, Dong YW. PMID: 28566358.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    21. Untangling the roles of microclimate, behaviour and physiological polymorphism in governing vulnerability of intertidal snails to heat stress. Proc Biol Sci. 2017 May 17; 284(1854). Dong YW, Li XX, Choi FMP, Williams GA, Somero GN, Helmuth B. PMID: 28469014; PMCID: PMC5443929.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    22. Adaptations of protein structure and function to temperature: there is more than one way to 'skin a cat'. J Exp Biol. 2015 Jun; 218(Pt 12):1801-11. Fields PA, Dong Y, Meng X, Somero GN. PMID: 26085658.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    23. Proteomic analysis of cardiac response to thermal acclimation in the eurythermal goby fish Gillichthys mirabilis. J Exp Biol. 2015 May; 218(Pt 9):1359-72. Jayasundara N, Tomanek L, Dowd WW, Somero GN. PMID: 25954043.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    24. Temporal patterning of thermal acclimation: from behavior to membrane biophysics. J Exp Biol. 2015 Feb 01; 218(Pt 3):500. Somero G. PMID: 25653424.
      View in: PubMed   Mentions: 2     Fields:    
    25. Temporal patterning of thermal acclimation: from behavior to membrane biophysics. J Exp Biol. 2015 Jan 15; 218(Pt 2):167-9. Somero G. PMID: 25609779.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    26. Master of all trades: thermal acclimation and adaptation of cardiac function in a broadly distributed marine invasive species, the European green crab, Carcinus maenas. J Exp Biol. 2014 Apr 01; 217(Pt 7):1129-38. Tepolt CK, Somero GN. PMID: 24671964.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    27. Physiological plasticity of cardiorespiratory function in a eurythermal marine teleost, the longjaw mudsucker, Gillichthys mirabilis. J Exp Biol. 2013 Jun 01; 216(Pt 11):2111-21. Jayasundara N, Somero GN. PMID: 23678101.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    28. A 1950s classic of thermal adaptation to cold. J Exp Biol. 2013 May 15; 216(Pt 10):1759-61. Somero GN. PMID: 23785104.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    29. Thermal stress and cellular signaling processes in hemocytes of native (Mytilus californianus) and invasive (M. galloprovincialis) mussels: cell cycle regulation and DNA repair. Comp Biochem Physiol A Mol Integr Physiol. 2013 Jun; 165(2):159-68. Yao CL, Somero GN. PMID: 23454628.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    30. Behavior and survival of Mytilus congeners following episodes of elevated body temperature in air and seawater. J Exp Biol. 2013 Feb 01; 216(Pt 3):502-14. Dowd WW, Somero GN. PMID: 23038732.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    31. The impact of acute temperature stress on hemocytes of invasive and native mussels (Mytilus galloprovincialis and Mytilus californianus): DNA damage, membrane integrity, apoptosis and signaling pathways. J Exp Biol. 2012 Dec 15; 215(Pt 24):4267-77. Yao CL, Somero GN. PMID: 22972891.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    32. Functional determinants of temperature adaptation in enzymes of cold- versus warm-adapted mussels (Genus Mytilus). Mol Biol Evol. 2012 Oct; 29(10):3061-70. Lockwood BL, Somero GN. PMID: 22491035.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    33. The physiology of global change: linking patterns to mechanisms. Ann Rev Mar Sci. 2012; 4:39-61. Somero GN. PMID: 22457968.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsPHPublic Health
    34. Bruce D. Sidell (20 March 1948-8 February 2011). Comp Biochem Physiol A Mol Integr Physiol. 2011 Nov; 160(3):440-2. Driedzic WR, Shick JM, Somero GN. PMID: 21980604.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    35. Bruce D. Sidell (20 March 1948-8 February 2011). Comp Biochem Physiol C Toxicol Pharmacol. 2011 Nov; 154(4):437-9. Driedzic WR, Shick JM, Somero GN. PMID: 22010291.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    36. Bruce D. Sidell (20 March 1948-8 February 2011). Comp Biochem Physiol B Biochem Mol Biol. 2011 Oct; 160(2-3):119-21. Driedzic WR, Shick JM, Somero GN. PMID: 21984995.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    37. Bruce D. Sidell. 20 March 1948 - 8 February 2011. J Exp Biol. 2011 Aug 01; 214(Pt 15):2453-4. Driedzic W, Shick JM, Somero GN. PMID: 21877336.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    38. Comparative physiology: a "crystal ball" for predicting consequences of global change. Am J Physiol Regul Integr Comp Physiol. 2011 Jul; 301(1):R1-14. Somero GN. PMID: 21430078.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    39. Effects of thermal acclimation on transcriptional responses to acute heat stress in the eurythermal fish Gillichthys mirabilis (Cooper). Am J Physiol Regul Integr Comp Physiol. 2011 Jun; 300(6):R1373-83. Logan CA, Somero GN. PMID: 21411771.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    40. Transcriptomic responses to salinity stress in invasive and native blue mussels (genus Mytilus). Mol Ecol. 2011 Feb; 20(3):517-29. Lockwood BL, Somero GN. PMID: 21199031.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    41. Transcriptomic responses to heat stress in invasive and native blue mussels (genus Mytilus): molecular correlates of invasive success. J Exp Biol. 2010 Oct 15; 213(Pt 20):3548-58. Lockwood BL, Sanders JG, Somero GN. PMID: 20889835.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    42. Phosphorylation events catalyzed by major cell signaling proteins differ in response to thermal and osmotic stress among native (Mytilus californianus and Mytilus trossulus) and invasive (Mytilus galloprovincialis) species of mussels. Physiol Biochem Zool. 2010 Nov-Dec; 83(6):984-96. Evans TG, Somero GN. PMID: 20946068.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    43. Transcriptional responses to thermal acclimation in the eurythermal fish Gillichthys mirabilis (Cooper 1864). Am J Physiol Regul Integr Comp Physiol. 2010 Sep; 299(3):R843-52. Logan CA, Somero GN. PMID: 20610827.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    44. The physiology of climate change: how potentials for acclimatization and genetic adaptation will determine 'winners' and 'losers'. J Exp Biol. 2010 Mar 15; 213(6):912-20. Somero GN. PMID: 20190116.
      View in: PubMed   Mentions: 332     Fields:    Translation:AnimalsCells
    45. Heterologous hybridization to a complementary DNA microarray reveals the effect of thermal acclimation in the endothermic bluefin tuna (Thunnus orientalis). Mol Ecol. 2009 May; 18(10):2092-102. Castilho PC, Buckley BA, Somero G, Block BA. PMID: 19389180.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    46. Protein-protein interactions enable rapid adaptive response to osmotic stress in fish gills. Commun Integr Biol. 2009; 2(2):94-6. Evans TG, Somero GN. PMID: 19704899; PMCID: PMC2686354.
      View in: PubMed   Mentions: 1  
    47. Temperature adaptation of cytosolic malate dehydrogenases of limpets (genus Lottia): differences in stability and function due to minor changes in sequence correlate with biogeographic and vertical distributions. J Exp Biol. 2009 Jan; 212(Pt 2):169-77. Dong Y, Somero GN. PMID: 19112135.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    48. A microarray-based transcriptomic time-course of hyper- and hypo-osmotic stress signaling events in the euryhaline fish Gillichthys mirabilis: osmosensors to effectors. J Exp Biol. 2008 Nov; 211(Pt 22):3636-49. Evans TG, Somero GN. PMID: 18978229.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    49. Rhythms of gene expression in a fluctuating intertidal environment. Curr Biol. 2008 Oct 14; 18(19):1501-7. Gracey AY, Chaney ML, Boomhower JP, Tyburczy WR, Connor K, Somero GN. PMID: 18848447.
      View in: PubMed   Mentions: 56     Fields:    Translation:Animals
    50. Heat-shock protein 70 (Hsp70) expression in four limpets of the genus Lottia: interspecific variation in constitutive and inducible synthesis correlates with in situ exposure to heat stress. Biol Bull. 2008 Oct; 215(2):173-81. Dong Y, Miller LP, Sanders JG, Somero GN. PMID: 18840778.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    51. Thermal limits and adaptation in marine Antarctic ectotherms: an integrative view. Philos Trans R Soc Lond B Biol Sci. 2007 Dec 29; 362(1488):2233-58. Pörtner HO, Peck L, Somero G. PMID: 17553776; PMCID: PMC2443174.
      View in: PubMed   Mentions: 60     Fields:    Translation:Animals
    52. Extreme anoxia tolerance in embryos of the annual killifish Austrofundulus limnaeus: insights from a metabolomics analysis. J Exp Biol. 2007 Jul; 210(Pt 13):2253-66. Podrabsky JE, Lopez JP, Fan TW, Higashi R, Somero GN. PMID: 17575031.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    53. Guest editors' introduction. J Exp Biol. 2007 May; 210(Pt 9):1491. Cossins A, Somero G. PMID: 17449813.
      View in: PubMed   Mentions: 2     Fields:    
    54. An inducible 70 kDa-class heat shock protein is constitutively expressed during early development and diapause in the annual killifish Austrofundulus limnaeus. Cell Stress Chaperones. 2007; 12(3):199-204. Podrabsky JE, Somero GN. PMID: 17915551; PMCID: PMC1971235.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    55. Biochemical adaptations of notothenioid fishes: comparisons between cold temperate South American and New Zealand species and Antarctic species. Comp Biochem Physiol A Mol Integr Physiol. 2007 Jul; 147(3):799-807. Coppes Petricorena ZL, Somero GN. PMID: 17293146.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    56. The cellular response to heat stress in the goby Gillichthys mirabilis: a cDNA microarray and protein-level analysis. J Exp Biol. 2006 Jul; 209(Pt 14):2660-77. Buckley BA, Gracey AY, Somero GN. PMID: 16809457.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    57. Following the heart: temperature and salinity effects on heart rate in native and invasive species of blue mussels (genus Mytilus). J Exp Biol. 2006 Jul; 209(Pt 13):2554-66. Braby CE, Somero GN. PMID: 16788038.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    58. Temperature sensitivities of cytosolic malate dehydrogenases from native and invasive species of marine mussels (genus Mytilus): sequence-function linkages and correlations with biogeographic distribution. J Exp Biol. 2006 Feb; 209(Pt 4):656-67. Fields PA, Rudomin EL, Somero GN. PMID: 16449560.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    59. Evolutionary and acclimation-induced variation in the thermal limits of heart function in congeneric marine snails (genus Tegula): implications for vertical zonation. Biol Bull. 2005 Apr; 208(2):138-44. Stenseng E, Braby CE, Somero GN. PMID: 15837963.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    60. Linking biogeography to physiology: Evolutionary and acclimatory adjustments of thermal limits. Front Zool. 2005 Jan 17; 2(1):1. Somero GN. PMID: 15679952; PMCID: PMC546413.
      View in: PubMed   Mentions: 77  
    61. Peter Hochachka: adventures in biochemical adaptation. Annu Rev Physiol. 2005; 67:25-37. Somero GN, Suarez RK. PMID: 15709951.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    62. Preface to Peter Hochachka memorial volume. Comp Biochem Physiol B Biochem Mol Biol. 2004 Nov; 139(3):311-5. Somero GN. PMID: 15544956.
      View in: PubMed   Mentions: 1     Fields:    
    63. Adaptation of enzymes to temperature: searching for basic "strategies". Comp Biochem Physiol B Biochem Mol Biol. 2004 Nov; 139(3):321-33. Somero GN. PMID: 15544958.
      View in: PubMed   Mentions: 74     Fields:    Translation:Animals
    64. Changes in gene expression associated with acclimation to constant temperatures and fluctuating daily temperatures in an annual killifish Austrofundulus limnaeus. J Exp Biol. 2004 Jun; 207(Pt 13):2237-54. Podrabsky JE, Somero GN. PMID: 15159429.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    65. Evolutionary convergence in adaptation of proteins to temperature: A4-lactate dehydrogenases of Pacific damselfishes (Chromis spp.). Mol Biol Evol. 2004 Feb; 21(2):314-20. Johns GC, Somero GN. PMID: 14660697.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    66. Protein adaptations to temperature and pressure: complementary roles of adaptive changes in amino acid sequence and internal milieu. Comp Biochem Physiol B Biochem Mol Biol. 2003 Dec; 136(4):577-91. Somero GN. PMID: 14662287.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    67. Influences of thermal acclimation and acute temperature change on the motility of epithelial wound-healing cells (keratocytes) of tropical, temperate and Antarctic fish. J Exp Biol. 2003 Dec; 206(Pt 24):4539-51. Ream RA, Theriot JA, Somero GN. PMID: 14610038.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    68. Local selection and latitudinal variation in a marine predator-prey interaction. Science. 2003 May 16; 300(5622):1135-7. Sanford E, Roth MS, Johns GC, Wares JP, Somero GN. PMID: 12750518.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    69. Base compositions of genes encoding alpha-actin and lactate dehydrogenase-A from differently adapted vertebrates show no temperature-adaptive variation in G + C content. Mol Biol Evol. 2003 Jan; 20(1):105-10. Ream RA, Johns GC, Somero GN. PMID: 12519912.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    70. Obituary: Peter W. Hochachka (1937-2002). Comp Biochem Physiol C Toxicol Pharmacol. 2002 Dec; 133(4):471-3. Somero GN. PMID: 12841218.
      View in: PubMed   Mentions:    Fields:    
    71. Thermal physiology and vertical zonation of intertidal animals: optima, limits, and costs of living. Integr Comp Biol. 2002 Aug; 42(4):780-9. Somero GN. PMID: 21708776.
      View in: PubMed   Mentions: 98     Fields:    
    72. Interspecific- and acclimation-induced variation in levels of heat-shock proteins 70 (hsp70) and 90 (hsp90) and heat-shock transcription factor-1 (HSF1) in congeneric marine snails (genus Tegula): implications for regulation of hsp gene expression. J Exp Biol. 2002 Mar; 205(Pt 5):677-85. Tomanek L, Somero GN. PMID: 11907057.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    73. Phylogenetic relationships and biochemical properties of the duplicated cytosolic and mitochondrial isoforms of malate dehydrogenase from a teleost fish, Sphyraena idiastes. J Mol Evol. 2002 Jan; 54(1):107-17. Lin JJ, Yang TH, Wahlstrand BD, Fields PA, Somero GN. PMID: 11734904.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    74. Hypoxia-induced gene expression profiling in the euryoxic fish Gillichthys mirabilis. Proc Natl Acad Sci U S A. 2001 Feb 13; 98(4):1993-8. Gracey AY, Troll JV, Somero GN. PMID: 11172064; PMCID: PMC29370.
      View in: PubMed   Mentions: 127     Fields:    Translation:AnimalsCells
    75. A comparative analysis of the evolutionary patterning and mechanistic bases of lactate dehydrogenase thermal stability in porcelain crabs, genus Petrolisthes. J Exp Biol. 2001 Feb; 204(Pt 4):767-76. Stillman JH, Somero GN. PMID: 11171359.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    76. Heat-shock protein expression is absent in the antarctic fish Trematomus bernacchii (family Nototheniidae). J Exp Biol. 2000 Aug; 203(Pt 15):2331-9. Hofmann GE, Buckley BA, Airaksinen S, Keen JE, Somero GN. PMID: 10887071.
      View in: PubMed   Mentions: 76     Fields:    Translation:Animals
    77. A comparative analysis of the upper thermal tolerance limits of eastern Pacific porcelain crabs, genus Petrolisthes: influences of latitude, vertical zonation, acclimation, and phylogeny. Physiol Biochem Zool. 2000 Mar-Apr; 73(2):200-8. Stillman JH, Somero GN. PMID: 10801398.
      View in: PubMed   Mentions: 59     Fields:    Translation:Animals
    78. Time course and magnitude of synthesis of heat-shock proteins in congeneric marine snails (Genus tegula) from different tidal heights. Physiol Biochem Zool. 2000 Mar-Apr; 73(2):249-56. Tomanek L, Somero GN. PMID: 10801403.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    79. Unity in diversity: a perspective on the methods, contributions, and future of comparative physiology. Annu Rev Physiol. 2000; 62:927-37. Somero GN. PMID: 10845117.
      View in: PubMed   Mentions: 5     Fields:    
    80. Hot spots in cold adaptation: localized increases in conformational flexibility in lactate dehydrogenase A4 orthologs of Antarctic notothenioid fishes. Proc Natl Acad Sci U S A. 1998 Sep 15; 95(19):11476-81. Fields PA, Somero GN. PMID: 9736762; PMCID: PMC21668.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    81. Heat-Shock Protein Expression in Mytilus californianus: Acclimatization (Seasonal and Tidal-Height Comparisons) and Acclimation Effects. Biol Bull. 1997 Apr; 192(2):309-320. Roberts DA, Hofmann GE, Somero GN. PMID: 28581871.
      View in: PubMed   Mentions: 27     Fields:    
    82. Evolution of lactate dehydrogenase-A homologs of barracuda fishes (genus Sphyraena) from different thermal environments: differences in kinetic properties and thermal stability are due to amino acid substitutions outside the active site. Biochemistry. 1997 Mar 18; 36(11):3207-15. Holland LZ, McFall-Ngai M, Somero GN. PMID: 9115998.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    83. Serge Timasheff: the man with a genius for solutions in biology. Biophys J. 1996 Oct; 71(4):1985-93. Schellman JA, Somero GN. PMID: 8889172; PMCID: PMC1233664.
      View in: PubMed   Mentions: 1     Fields:    
    84. Activity of lactate dehydrogenase but not its concentration of messenger RNA increases with body size in barred sand bass, Paralabrax nebulifer (Teleostei). Biol Bull. 1996 Oct; 191(2):155-8. Yang TH, Somero GN. PMID: 8916541.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    85. Differences in protein patterns of gill epithelial cells of the fish Gillichthys mirabilis after osmotic and thermal acclimation. J Comp Physiol B. 1996; 166(2):88-100. Kültz D, Somero GN. PMID: 8766907.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    86. Ion transport in gills of the euryhaline fish Gillichthys mirabilis is facilitated by a phosphocreatine circuit. Am J Physiol. 1995 Apr; 268(4 Pt 2):R1003-12. Kültz D, Somero GN. PMID: 7733382.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    87. Proteins and temperature. Annu Rev Physiol. 1995; 57:43-68. Somero GN. PMID: 7778874.
      View in: PubMed   Mentions: 165     Fields:    Translation:AnimalsCells
    88. Effects of expected global climate change on marine faunas. Trends Ecol Evol. 1993 Oct; 8(10):361-7. Fields PA, Graham JB, Rosenblatt RH, Somero GN. PMID: 21236196.
      View in: PubMed   Mentions: 11     Fields:    
    89. Respiratory, Blood, and Heart Enzymatic Adaptations of Sebastolobus alascanus (Scorpaenidae; Teleostei) to the Oxygen Minimum Zone: A Comparative Study. Biol Bull. 1992 Dec; 183(3):490-499. Yang TH, Lai NC, Graham JB, Somero GN. PMID: 29300502.
      View in: PubMed   Mentions: 2     Fields:    
    90. Biochemical ecology of deep-sea animals. Experientia. 1992 Jun 15; 48(6):537-43. Somero GN. PMID: 1319350.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    91. The threshold induction temperature of the 90-kDa heat shock protein is subject to acclimatization in eurythermal goby fishes (genus Gillichthys). Proc Natl Acad Sci U S A. 1992 Apr 15; 89(8):3389-93. Dietz TJ, Somero GN. PMID: 1565632; PMCID: PMC48873.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    92. Temperature- and concentration-dependence of compatibility of the organic osmolyte beta-dimethylsulfoniopropionate. Cryobiology. 1992 Feb; 29(1):118-24. Nishiguchi MK, Somero GN. PMID: 1295491.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    93. Adaptations to high hydrostatic pressure. Annu Rev Physiol. 1992; 54:557-77. Somero GN. PMID: 1314046.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    94. Pressure-Temperature Interactions on M4-Lactate Dehydrogenases From Hydrothermal Vent Fishes: Evidence for Adaptation to Elevated Temperatures by the Zoarcid Thermarces andersoni, but not by the Bythitid, Bythites hollisi. Biol Bull. 1990 Aug; 179(1):134-139. Dahlhoff E, Schneidemann S, Somero GN. PMID: 29314911.
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    95. Pressure adaptation of Na+/K+-ATPase in gills of marine teleosts. J Exp Biol. 1989 May; 143:475-92. Gibbs A, Somero GN. PMID: 2543729.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    96. Properties of the interaction between phosphofructokinase and actin. Arch Biochem Biophys. 1989 Feb 15; 269(1):284-94. Roberts SJ, Somero GN. PMID: 2521786.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    97. Regulation of binding of phosphofructokinase to myofibrils in the red and white muscle of the barred sand bass, Paralabrax nebulifer (Serranidae). J Exp Biol. 1988 Jul; 137:13-27. Roberts SJ, Lowery MS, Somero GN. PMID: 2974860.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    98. Binding of phosphofructokinase to filamentous actin. Biochemistry. 1987 Jun 16; 26(12):3437-42. Roberts SJ, Somero GN. PMID: 2958082.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    99. Protein adaptation and biogeography: Threshold effects on molecular evolution. Trends Ecol Evol. 1986 Nov; 1(5):124-7. Somero GN. PMID: 21227795.
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    100. Protons, osmolytes, and fitness of internal milieu for protein function. Am J Physiol. 1986 Aug; 251(2 Pt 2):R197-213. Somero GN. PMID: 3017133.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    101. Hydrogen Sulfide Oxidation Is Coupled to Oxidative Phosphorylation in Mitochondria of Solemya reidi. Science. 1986 Aug 01; 233(4763):563-6. Powell MA, Somero GN. PMID: 17820467.
      View in: PubMed   Mentions: 29     Fields:    
    102. Pressure effects on actin self-assembly: interspecific differences in the equilibrium and kinetics of the G to F transformation. Biochemistry. 1985 Feb 12; 24(4):852-60. Swezey RR, Somero GN. PMID: 3994993.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    103. Influence of osmolytes, thin filaments, and solubility state on elasmobranch phosphofructokinase in vitro. J Exp Zool. 1984 Aug; 231(2):297-302. Hand SC, Somero GN. PMID: 6237173.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    104. Blood Components Prevent Sulfide Poisoning of Respiration of the Hydrothermal Vent Tube Worm Riftia pachyptila. Science. 1983 Jan 21; 219(4582):297-9. Powell MA, Somero GN. PMID: 17798280.
      View in: PubMed   Mentions: 4     Fields:    
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    106. Environmental adaptation of proteins: strategies for the conservation of critical functional and structural traits. Comp Biochem Physiol A Comp Physiol. 1983; 76(3):621-33. Somero GN. PMID: 6139233.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    107. Living with water stress: evolution of osmolyte systems. Science. 1982 Sep 24; 217(4566):1214-22. Yancey PH, Clark ME, Hand SC, Bowlus RD, Somero GN. PMID: 7112124.
      View in: PubMed   Mentions: 750     Fields:    Translation:AnimalsCells
    108. Polymerization thermodynamics and structural stabilities of skeletal muscle actins from vertebrates adapted to different temperatures and hydrostatic pressures. Biochemistry. 1982 Aug 31; 21(18):4496-503. Swezey RR, Somero GN. PMID: 7126554.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    109. Urea and methylamine effects on rabbit muscle phosphofructokinase. Catalytic stability and aggregation state as a function of pH and temperature. J Biol Chem. 1982 Jan 25; 257(2):734-41. Hand SC, Somero GN. PMID: 6459323.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    110. Acid-base regulation and phospholipid adaptations to temperature: time courses and physiological significance of modifying the milieu for protein function. Physiol Rev. 1982 Jan; 62(1):40-90. White FN, Somero G. PMID: 7034010.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
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    112. Effects of anions on the activation thermodynamics and fluorescence emission spectrum of alkaline phosphatase: evidence for enzyme hydration changes during catalysis. Biochemistry. 1979 Nov 27; 18(24):5322-32. Greaney GS, Somero GN. PMID: 518838.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    113. Counteraction of urea destabilization of protein structure by methylamine osmoregulatory compounds of elasmobranch fishes. Biochem J. 1979 Nov 01; 183(2):317-23. Yancey PH, Somero GN. PMID: 534499; PMCID: PMC1161561.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    114. Inefficient lactate dehydrogenases of deep-sea fishes. Nature. 1979 Nov 01; 282(5734):100-2. Somero GN, Siebenaller JF. PMID: 503183.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    115. Solute compatibility with enzyme function and structure: rationales for the selection of osmotic agents and end-products of anaerobic metabolism in marine invertebrates. J Exp Zool. 1979 May; 208(2):137-51. Bowlus RD, Somero GN. PMID: 469480.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    116. Pressure-adaptive differences in lactate dehydrogenases of congeneric fishes living at different depths. Science. 1978 Jul 21; 201(4352):255-7. Siebenaller J, Somero GN. PMID: 208149.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    117. Protein water binding ability correlates with cellular osmolarity. Experientia. 1978 Mar 15; 34(3):314-5. Low PS, Hoffmann KH, Swezey R, Somero GN. PMID: 631253.
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    118. Neutral salt effects on the velocity and activation volume of the lactate dehydrogenase reaction: evidence for enzyme hydration changes during catalysis. Arch Biochem Biophys. 1977 Jun; 181(2):438-46. Somero GN, Neubauer M, Low PS. PMID: 900931.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    119. Enzyme hydration may explain catalytic efficiency differences among lactate dehydrogenase homologues. Nature. 1977 Mar 17; 266(5599):276-8. Somero GN, Low PS. PMID: 846575.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    120. Lead effects on tissue and whole organism respiration of the estuarine teleost fish, Gillichthys mirabilis. Arch Environ Contam Toxicol. 1977; 6(2-3):349-54. Somero GN, Yancey PH, Chow TJ, Snyder CB. PMID: 901013.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    121. Lead accumulation rates in tissues of the estuarine teleost fish, Gillichthys mirabilis: salinity and temperature effects. Arch Environ Contam Toxicol. 1977; 6(2-3):337-48. Somero GN, Chow TJ, Yancey PH, Snyder CB. PMID: 901012.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    122. Adaptation of muscle pyruvate kinases to environmental temperatures and pressures. J Exp Zool. 1976 Oct; 198(1):1-11. Low PS, Somero GN. PMID: 824400.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    123. Temperature: a "shaping force' in protein evolution. Biochem Soc Symp. 1976; (41):33-42. Somero GN, Low PS. PMID: 788719.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    124. Temperature as a selective factor in protein evolution: the adaptational strategy of "compromise". J Exp Zool. 1975 Oct; 194(1):175-88. Somero GN. PMID: 1104753.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    125. Pressure effects on enzyme structure and function in vitro and under simulated in vivo conditions. Comp Biochem Physiol B. 1975 Sep 15; 52(1):67-74. Low PS, Somero GN. PMID: 1183178.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    126. Protein hydration changes during catalysis: a new mechanism of enzymic rate-enhancement and ion activation/inhibition of catalysis. Proc Natl Acad Sci U S A. 1975 Sep; 72(9):3305-9. Low PS, Somero GN. PMID: 1059113; PMCID: PMC432980.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    127. Activation volumes in enzymic catalysis: their sources and modification by low-molecular-weight solutes. Proc Natl Acad Sci U S A. 1975 Aug; 72(8):3014-8. Low PS, Somero GN. PMID: 1059089; PMCID: PMC432909.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    128. Temperature adaptation of enzymes: a proposed molecular basis for the different catalytic efficiencies of enzymes from ectotherms and endotherms. Comp Biochem Physiol B. 1974 Oct 15; 49(2):307-12. Low PS, Somero GN. PMID: 4420155.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    129. Genetic variation in marine fishes as a test of the niche-variation hypothesis. Nature. 1974 Jun 14; 249(458):670-2. Somero GN, Soulé M. PMID: 4833808.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    130. Temperature and rates of protein degradation in the fish Gillichthys mirabilis. Comp Biochem Physiol B. 1973 Nov 15; 46(3):463-74. Somero GN, Doyle D. PMID: 4754763.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    131. Temperature adaptation of enzymes: roles of the free energy, the enthalpy, and the entropy of activation. Proc Natl Acad Sci U S A. 1973 Feb; 70(2):430-2. Low PS, Bada JL, Somero GN. PMID: 4510286; PMCID: PMC433275.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    132. Thermal modulation of pyruvate metabolism in the fish Gillichthys mirabilis: the role of lactate dehydrogenases. Comp Biochem Physiol B. 1973 Jan 15; 44(1):205-9. Somero GN. PMID: 4683999.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    133. Pyruvate kinase variants of the Alaskan king-crab. Evidence for a temperature-dependent interconversion between two forms having distinct and adaptive kinetic properties. Biochem J. 1969 Sep; 114(2):237-41. Somero GN. PMID: 5810080; PMCID: PMC1184848.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    134. Isoenzymes and short-term temperature compensation in poikilotherms: activation of lactate dehydrogenase isoenzymes by temperature decreases. Nature. 1969 Jul 12; 223(5202):194-5. Somero GN, Hochachka PW. PMID: 5791732.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    135. The effect of temperature on catalytic and regulatory functions of pyruvate kinases of the rainbow trout and the antarctic fish Trematomus bernacchii. Biochem J. 1968 Dec; 110(3):395-400. Somero GN, Hochachka PW. PMID: 5701664; PMCID: PMC1187363.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    136. The adaptation of enzymes to temperature. Comp Biochem Physiol. 1968 Dec; 27(3):659-68. Hochachka PW, Somero GN. PMID: 5710275.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    137. Temperature tolerance of some Antarctic fishes. Science. 1967 Apr 14; 156(3772):257-8. Somero GN, DeVries AL. PMID: 6021046.
      View in: PubMed   Mentions: 59     Fields:    Translation:Animals
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