Our site may be slower due to heavy traffic from automated "bots" and AI crawlers. We're working to fix this.

Christine Hrycyna

Title(s)Dean, Dean - Physical Sciences
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
vCardDownload vCard

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Photoswitchable Isoprenoid Lipids Enable Optical Control of Peptide Lipidation. ACS Chem Biol. 2022 10 21; 17(10):2945-2953. Morstein J, Bader T, Cardillo AL, Schackmann J, Ashok S, Hougland JL, Hrycyna CA, Trauner DH, Distefano MD. PMID: 36194691; PMCID: PMC9799063.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    2. The roles of the human ATP-binding cassette transporters P-glycoprotein and ABCG2 in multidrug resistance in cancer and at endogenous sites: future opportunities for structure-based drug design of inhibitors. Cancer Drug Resist. 2021; 4:784-804. Goebel J, Chmielewski J, Hrycyna CA. PMID: 34993424; PMCID: PMC8730335.
      View in: PubMed   Mentions: 34  
    3. Potential Tools for Eradicating HIV Reservoirs in the Brain: Development of Trojan Horse Prodrugs for the Inhibition of P-Glycoprotein with Anti-HIV-1 Activity. J Med Chem. 2020 03 12; 63(5):2131-2138. Agrawal N, Rowe J, Lan J, Yu Q, Hrycyna CA, Chmielewski J. PMID: 31505928; PMCID: PMC7073916.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    4. Methyltransferase-like 21c methylates and stabilizes the heat shock protein Hspa8 in type I myofibers in mice. J Biol Chem. 2019 09 13; 294(37):13718-13728. Wang C, Arrington J, Ratliff AC, Chen J, Horton HE, Nie Y, Yue F, Hrycyna CA, Tao WA, Kuang S. PMID: 31346037; PMCID: PMC6746458.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    5. Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers. FASEB J. 2019 08; 33(8):9672-9684. Wang C, Zhang B, Ratliff AC, Arrington J, Chen J, Xiong Y, Yue F, Nie Y, Hu K, Jin W, Tao WA, Hrycyna CA, Sun X, Kuang S. PMID: 31162944; PMCID: PMC6993925.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    6. A Quantitative FRET Assay for the Upstream Cleavage Activity of the Integral Membrane Proteases Human ZMPSTE24 and Yeast Ste24. Methods Mol Biol. 2019; 2009:279-293. Hsu ET, Vervacke JS, Distefano MD, Hrycyna CA. PMID: 31152411.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    7. ZMPSTE24 missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or protein stability. Dis Model Mech. 2018 07 13; 11(7). Spear ED, Hsu ET, Nie L, Carpenter EP, Hrycyna CA, Michaelis S. PMID: 29794150; PMCID: PMC6078402.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    8. a-Factor Analogues Containing Alkyne- and Azide-Functionalized Isoprenoids Are Efficiently Enzymatically Processed and Retain Wild-Type Bioactivity. Bioconjug Chem. 2018 02 21; 29(2):316-323. Diaz-Rodriguez V, Hsu ET, Ganusova E, Werst ER, Becker JM, Hrycyna CA, Distefano MD. PMID: 29188996; PMCID: PMC5824361.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    9. Dual inhibitors of the human blood-brain barrier drug efflux transporters P-glycoprotein and ABCG2 based on the antiviral azidothymidine. Bioorg Med Chem. 2017 10 01; 25(19):5128-5132. Namanja-Magliano HA, Bohn K, Agrawal N, Willoughby ME, Hrycyna CA, Chmielewski J. PMID: 28712845.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    10. Dual Modulation of Human P-Glycoprotein and ABCG2 with Prodrug Dimers of the Atypical Antipsychotic Agent Paliperidone in a Model of the Blood-Brain Barrier. Mol Pharm. 2017 04 03; 14(4):1107-1119. Bohn K, Lange A, Chmielewski J, Hrycyna CA. PMID: 28264565.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    11. AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity. Proc Natl Acad Sci U S A. 2016 08 09; 113(32):E4671-80. Di Micco A, Frera G, Lugrin J, Jamilloux Y, Hsu ET, Tardivel A, De Gassart A, Zaffalon L, Bujisic B, Siegert S, Quadroni M, Broz P, Henry T, Hrycyna CA, Martinon F. PMID: 27462105; PMCID: PMC4987819.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    12. Non-Substrate Based, Small Molecule Inhibitors of the Human Isoprenylcysteine Carboxyl Methyltransferase. Medchemcomm. 2016 May 01; 7(5):1016-1021. Butler KV, Bohn K, Hrycyna CA, Jin J. PMID: 27547295; PMCID: PMC4990076.
      View in: PubMed   Mentions: 2  
    13. Diazirine-containing photoactivatable isoprenoid: synthesis and application in studies with isoprenylcysteine carboxyl methyltransferase. J Org Chem. 2014 Mar 07; 79(5):1971-8. Vervacke JS, Funk AL, Wang YC, Strom M, Hrycyna CA, Distefano MD. PMID: 24502619; PMCID: PMC3985442.
      View in: PubMed   Mentions: 14     Fields:    
    14. Reversible dimers of the atypical antipsychotic quetiapine inhibit p-glycoprotein-mediated efflux in vitro with increased binding affinity and in situ at the blood-brain barrier. ACS Chem Neurosci. 2014 Apr 16; 5(4):305-17. Emmert D, Campos CR, Ward D, Lu P, Namanja HA, Bohn K, Miller DS, Sharom FJ, Chmielewski J, Hrycyna CA. PMID: 24483607; PMCID: PMC3990950.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    15. Quinine dimers are potent inhibitors of the Plasmodium falciparum chloroquine resistance transporter and are active against quinoline-resistant P. falciparum. ACS Chem Biol. 2014 Mar 21; 9(3):722-30. Hrycyna CA, Summers RL, Lehane AM, Pires MM, Namanja H, Bohn K, Kuriakose J, Ferdig M, Henrich PP, Fidock DA, Kirk K, Chmielewski J, Martin RE. PMID: 24369685; PMCID: PMC4068143.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    16. Homodimers of the Antiviral Abacavir as Modulators of P-glycoprotein Transport in Cell Culture: Probing Tether Length. Medchemcomm. 2013 Oct; 4(10). Namanja HA, Emmert D, Hrycyna CA, Chmielewski J. PMID: 24273637; PMCID: PMC3833348.
      View in: PubMed   Mentions: 5  
    17. Competency-based reforms of the undergraduate biology curriculum: integrating the physical and biological sciences. CBE Life Sci Educ. 2013 Jun 01; 12(2):162-9. Thompson KV, Chmielewski J, Gaines MS, Hrycyna CA, LaCourse WR. PMID: 23737624; PMCID: PMC3671644.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    18. Biochemistry. A protease for the ages. Science. 2013 Mar 29; 339(6127):1529-30. Michaelis S, Hrycyna CA. PMID: 23539586.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    19. Human ZMPSTE24 disease mutations: residual proteolytic activity correlates with disease severity. Hum Mol Genet. 2012 Sep 15; 21(18):4084-93. Barrowman J, Wiley PA, Hudon-Miller SE, Hrycyna CA, Michaelis S. PMID: 22718200; PMCID: PMC3428156.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    20. Tools for eradicating HIV in the brain: prodrug dimeric inhibitors of P-gp. Ther Deliv. 2012 Jun; 3(6):689-92. Chmielewski J, Hrycyna C. PMID: 22838065.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    21. Evaluation of substrate and inhibitor binding to yeast and human isoprenylcysteine carboxyl methyltransferases (Icmts) using biotinylated benzophenone-containing photoaffinity probes. Biochem Biophys Res Commun. 2012 Jun 22; 423(1):98-103. Hahne K, Vervacke JS, Shrestha L, Donelson JL, Gibbs RA, Distefano MD, Hrycyna CA. PMID: 22634004; PMCID: PMC3718205.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    22. Click chemistry-derived bivalent quinine inhibitors of P-glycoprotein-mediated cellular efflux. Bioorg Med Chem Lett. 2012 Jul 01; 22(13):4410-2. Kuriakose J, Hrycyna CA, Chmielewski J. PMID: 22632934.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    23. Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24. J Lipid Res. 2012 Jun; 53(6):1176-82. Chang SY, Hudon-Miller SE, Yang SH, Jung HJ, Lee JM, Farber E, Subramanian T, Andres DA, Spielmann HP, Hrycyna CA, Young SG, Fong LG. PMID: 22448028; PMCID: PMC3351824.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    24. S-Farnesyl-Thiopropionic Acid (FTPA) Triazoles as Potent Inhibitors of Isoprenylcysteine Carboxyl Methyltransferase. ACS Med Chem Lett. 2012 Jan 12; 3(1):15-19. Bergman JA, Hahne K, Song J, Hrycyna CA, Gibbs RA. PMID: 22754607; PMCID: PMC3387282.
      View in: PubMed   Mentions: 15  
    25. Amide-modified prenylcysteine based Icmt inhibitors: Structure-activity relationships, kinetic analysis and cellular characterization. Bioorg Med Chem. 2012 Jan 01; 20(1):283-95. Majmudar JD, Hodges-Loaiza HB, Hahne K, Donelson JL, Song J, Shrestha L, Harrison ML, Hrycyna CA, Gibbs RA. PMID: 22142613; PMCID: PMC3382068.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    26. Toward eradicating HIV reservoirs in the brain: inhibiting P-glycoprotein at the blood-brain barrier with prodrug abacavir dimers. J Am Chem Soc. 2012 Feb 15; 134(6):2976-80. Namanja HA, Emmert D, Davis DA, Campos C, Miller DS, Hrycyna CA, Chmielewski J. PMID: 21866921; PMCID: PMC3262104.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    27. Lipid and sulfur substituted prenylcysteine analogs as human Icmt inhibitors. Bioorg Med Chem Lett. 2011 Sep 15; 21(18):5616-9. Bergman JA, Hahne K, Hrycyna CA, Gibbs RA. PMID: 21782433; PMCID: PMC4037158.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    28. Recombinant synthesis of human ABCG2 expressed in the yeast Saccharomyces cerevisiae: an experimental methodological study. Protein J. 2011 Mar; 30(3):201-11. Jacobs A, Emmert D, Wieschrath S, Hrycyna CA, Wiese M. PMID: 21424391.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    29. Probing the isoprenylcysteine carboxyl methyltransferase (Icmt) binding pocket: sulfonamide modified farnesyl cysteine (SMFC) analogs as Icmt inhibitors. Bioorg Med Chem Lett. 2011 May 01; 21(9):2616-20. Majmudar JD, Hahne K, Hrycyna CA, Gibbs RA. PMID: 21334890; PMCID: PMC3401633.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    30. Functional oligomerization of the Saccharomyces cerevisiae isoprenylcysteine carboxyl methyltransferase, Ste14p. J Biol Chem. 2010 Apr 30; 285(18):13380-7. Griggs AM, Hahne K, Hrycyna CA. PMID: 20202940; PMCID: PMC2859497.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    31. Inhibition of human P-glycoprotein transport and substrate binding using a galantamine dimer. Biochem Biophys Res Commun. 2009 Oct 30; 388(4):672-6. Namanja HA, Emmert D, Pires MM, Hrycyna CA, Chmielewski J. PMID: 19683513; PMCID: PMC2764298.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    32. Solid-phase synthesis of prenylcysteine analogs. J Org Chem. 2009 Apr 17; 74(8):2975-81. Donelson JL, Hodges-Loaiza HB, Henriksen BS, Hrycyna CA, Gibbs RA. PMID: 19320430; PMCID: PMC2702710.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    33. Inhibition of P-glycoprotein-mediated paclitaxel resistance by reversibly linked quinine homodimers. Mol Pharmacol. 2009 Jan; 75(1):92-100. Pires MM, Emmert D, Hrycyna CA, Chmielewski J. PMID: 18945821; PMCID: PMC2685053.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    34. HIV-protease inhibitors block the enzymatic activity of purified Ste24p. Biochem Biophys Res Commun. 2008 Sep 19; 374(2):365-8. Hudon SE, Coffinier C, Michaelis S, Fong LG, Young SG, Hrycyna CA. PMID: 18639527; PMCID: PMC2543933.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    35. A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24 or lead to an accumulation of farnesyl-prelamin A in cells. J Biol Chem. 2008 Apr 11; 283(15):9797-804. Coffinier C, Hudon SE, Lee R, Farber EA, Nobumori C, Miner JH, Andres DA, Spielmann HP, Hrycyna CA, Fong LG, Young SG. PMID: 18230615; PMCID: PMC2442292.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    36. HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells. Proc Natl Acad Sci U S A. 2007 Aug 14; 104(33):13432-7. Coffinier C, Hudon SE, Farber EA, Chang SY, Hrycyna CA, Young SG, Fong LG. PMID: 17652517; PMCID: PMC1948915.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    37. Substrate overlap between Mrp4 and Abcg2/Bcrp affects purine analogue drug cytotoxicity and tissue distribution. Cancer Res. 2007 Jul 15; 67(14):6965-72. Takenaka K, Morgan JA, Scheffer GL, Adachi M, Stewart CF, Sun D, Leggas M, Ejendal KF, Hrycyna CA, Schuetz JD. PMID: 17638908.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    38. 9 Structure and function of isoprenylcysteine carboxylmethyltransferase (Icmt): A key enzyme in CaaX processing. Enzymes. 2006; 24:245-72. Anderson JL, Hrycyna CA. PMID: 26718043.
      View in: PubMed   Mentions: 2     Fields:    
    39. Functional reconstitution of the integral membrane enzyme, isoprenylcysteine carboxyl methyltransferase, in synthetic bolalipid membrane vesicles. Biochemistry. 2006 Dec 12; 45(49):14683-94. Febo-Ayala W, Morera-Félix SL, Hrycyna CA, Thompson DH. PMID: 17144661; PMCID: PMC2583143.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    40. Therapeutic intervention based on protein prenylation and associated modifications. Nat Chem Biol. 2006 Oct; 2(10):518-28. Gelb MH, Brunsveld L, Hrycyna CA, Michaelis S, Tamanoi F, Van Voorhis WC, Waldmann H. PMID: 16983387; PMCID: PMC2892741.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    41. Bivalent probes of the human multidrug transporter P-glycoprotein. Biochemistry. 2006 Sep 26; 45(38):11695-702. Pires MM, Hrycyna CA, Chmielewski J. PMID: 16981729.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    42. The nature of amino acid 482 of human ABCG2 affects substrate transport and ATP hydrolysis but not substrate binding. Protein Sci. 2006 Jul; 15(7):1597-607. Ejendal KF, Diop NK, Schweiger LC, Hrycyna CA. PMID: 16815914; PMCID: PMC2242565.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    43. Amide-substituted farnesylcysteine analogs as inhibitors of human isoprenylcysteine carboxyl methyltransferase. Bioorg Med Chem Lett. 2006 Aug 15; 16(16):4420-3. Donelson JL, Hodges HB, Macdougall DD, Henriksen BS, Hrycyna CA, Gibbs RA. PMID: 16777414; PMCID: PMC3401632.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    44. Cellular efflux of auxin catalyzed by the Arabidopsis MDR/PGP transporter AtPGP1. Plant J. 2005 Oct; 44(2):179-94. Geisler M, Blakeslee JJ, Bouchard R, Lee OR, Vincenzetti V, Bandyopadhyay A, Titapiwatanakun B, Peer WA, Bailly A, Richards EL, Ejendal KF, Smith AP, Baroux C, Grossniklaus U, Müller A, Hrycyna CA, Dudler R, Murphy AS, Martinoia E. PMID: 16212599.
      View in: PubMed   Mentions: 238     Fields:    Translation:HumansAnimalsCells
    45. Synthesis of desthio prenylcysteine analogs: sulfur is important for biological activity. Bioorg Med Chem Lett. 2005 Nov 15; 15(22):5080-3. Henriksen BS, Anderson JL, Hrycyna CA, Gibbs RA. PMID: 16183278; PMCID: PMC3401638.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    46. Oligomerization of the human ABC transporter ABCG2: evaluation of the native protein and chimeric dimers. Biochemistry. 2005 Aug 16; 44(32):10893-904. Bhatia A, Schäfer HJ, Hrycyna CA. PMID: 16086592.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    47. The isoprenoid substrate specificity of isoprenylcysteine carboxylmethyltransferase: development of novel inhibitors. J Biol Chem. 2005 Aug 19; 280(33):29454-61. Anderson JL, Henriksen BS, Gibbs RA, Hrycyna CA. PMID: 15946942; PMCID: PMC3401627.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    48. Transmembrane inhibitors of P-glycoprotein, an ABC transporter. J Med Chem. 2005 Jun 02; 48(11):3768-75. Tarasova NI, Seth R, Tarasov SG, Kosakowska-Cholody T, Hrycyna CA, Gottesman MM, Michejda CJ. PMID: 15916428.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    49. A general fluorescence-based coupled assay for S-adenosylmethionine-dependent methyltransferases. Biochem Biophys Res Commun. 2005 May 27; 331(1):351-6. Wang C, Leffler S, Thompson DH, Hrycyna CA. PMID: 15845399.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    50. Inhibition of membrane-associated methyltransferases by a cholesterol-based metal chelator. Bioconjug Chem. 2005 May-Jun; 16(3):490-3. Hodges HB, Zhou M, Haldar S, Anderson JL, Thompson DH, Hrycyna CA. PMID: 15898712.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    51. N-Linked glycosylation of the human ABC transporter ABCG2 on asparagine 596 is not essential for expression, transport activity, or trafficking to the plasma membrane. Biochemistry. 2005 Apr 12; 44(14):5420-9. Diop NK, Hrycyna CA. PMID: 15807535.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    52. Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24. Biochem J. 2005 Apr 01; 387(Pt 1):129-38. Corrigan DP, Kuszczak D, Rusinol AE, Thewke DP, Hrycyna CA, Michaelis S, Sinensky MS. PMID: 15479156; PMCID: PMC1134940.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    53. Purification, functional reconstitution, and characterization of the Saccharomyces cerevisiae isoprenylcysteine carboxylmethyltransferase Ste14p. J Biol Chem. 2005 Feb 25; 280(8):7336-45. Anderson JL, Frase H, Michaelis S, Hrycyna CA. PMID: 15611058.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    54. Differential sensitivities of the human ATP-binding cassette transporters ABCG2 and P-glycoprotein to cyclosporin A. Mol Pharmacol. 2005 Mar; 67(3):902-11. Ejendal KF, Hrycyna CA. PMID: 15598974.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    55. Multidrug resistance and cancer: the role of the human ABC transporter ABCG2. Curr Protein Pept Sci. 2002 Oct; 3(5):503-11. Ejendal KF, Hrycyna CA. PMID: 12369998.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    56. Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells. Cancer Res. 2001 Sep 15; 61(18):6635-9. Honjo Y, Hrycyna CA, Yan QW, Medina-Pérez WY, Robey RW, van de Laar A, Litman T, Dean M, Bates SE. PMID: 11559526.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansCells
    57. Molecular genetic analysis and biochemical characterization of mammalian P-glycoproteins involved in multidrug resistance. Semin Cell Dev Biol. 2001 Jun; 12(3):247-56. Hrycyna CA. PMID: 11428917.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    58. Functional characterization of glycosylation-deficient human P-glycoprotein using a vaccinia virus expression system. J Membr Biol. 2000 Feb 01; 173(3):203-14. Gribar JJ, Ramachandra M, Hrycyna CA, Dey S, Ambudkar SV. PMID: 10667916.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    59. Both ATP sites of human P-glycoprotein are essential but not symmetric. Biochemistry. 1999 Oct 19; 38(42):13887-99. Hrycyna CA, Ramachandra M, Germann UA, Cheng PW, Pastan I, Gottesman MM. PMID: 10529234.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    60. Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu Rev Pharmacol Toxicol. 1999; 39:361-98. Ambudkar SV, Dey S, Hrycyna CA, Ramachandra M, Pastan I, Gottesman MM. PMID: 10331089.
      View in: PubMed   Mentions: 543     Fields:    Translation:HumansAnimalsCells
    61. Contribution to substrate specificity and transport of nonconserved residues in transmembrane domain 12 of human P-glycoprotein. Biochemistry. 1998 Nov 17; 37(46):16400-9. Hafkemeyer P, Dey S, Ambudkar SV, Hrycyna CA, Pastan I, Gottesman MM. PMID: 9819232.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    62. P-glycoprotein plays an insignificant role in the presentation of antigenic peptides to CD8+ T cells. Cancer Res. 1998 Oct 15; 58(20):4688-93. Russ G, Ramachandra M, Hrycyna CA, Gottesman MM, Pastan I, Bennink JR, Yewdell JW. PMID: 9788623.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    63. Structural flexibility of the linker region of human P-glycoprotein permits ATP hydrolysis and drug transport. Biochemistry. 1998 Sep 29; 37(39):13660-73. Hrycyna CA, Airan LE, Germann UA, Ambudkar SV, Pastan I, Gottesman MM. PMID: 9753453.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    64. Mechanism of action of human P-glycoprotein ATPase activity. Photochemical cleavage during a catalytic transition state using orthovanadate reveals cross-talk between the two ATP sites. J Biol Chem. 1998 Jul 03; 273(27):16631-4. Hrycyna CA, Ramachandra M, Ambudkar SV, Ko YH, Pedersen PL, Pastan I, Gottesman MM. PMID: 9642211.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    65. Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state. Biochemistry. 1998 Apr 07; 37(14):5010-9. Ramachandra M, Ambudkar SV, Chen D, Hrycyna CA, Dey S, Gottesman MM, Pastan I. PMID: 9538020.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    66. Functional expression of human P-glycoprotein from plasmids using vaccinia virus-bacteriophage T7 RNA polymerase system. Methods Enzymol. 1998; 292:456-73. Hrycyna CA, Ramachandra M, Pastan I, Gottesman MM. PMID: 9711574.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    67. Multidrug ABC transporters from bacteria to man: an emerging hypothesis for the universality of molecular mechanism and function. Drug Resist Updat. 1998; 1(2):81-3. Hrycyna CA, Gottesman MM. PMID: 16904390.
      View in: PubMed   Mentions: 7     Fields:    
    68. Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system. Mol Biol Cell. 1996 Oct; 7(10):1485-98. Ramachandra M, Ambudkar SV, Gottesman MM, Pastan I, Hrycyna CA. PMID: 8898356; PMCID: PMC276000.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    69. Heterologous expression systems for P-glycoprotein: E. coli, yeast, and baculovirus. J Bioenerg Biomembr. 1995 Feb; 27(1):43-52. Evans GL, Ni B, Hrycyna CA, Chen D, Ambudkar SV, Pastan I, Germann UA, Gottesman MM. PMID: 7629051.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    70. Genetic analysis of the multidrug transporter. Annu Rev Genet. 1995; 29:607-49. Gottesman MM, Hrycyna CA, Schoenlein PV, Germann UA, Pastan I. PMID: 8825488.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansAnimalsCells
    71. Yeast STE14 methyltransferase, expressed as TrpE-STE14 fusion protein in Escherichia coli, for in vitro carboxylmethylation of prenylated polypeptides. Methods Enzymol. 1995; 250:251-66. Hrycyna CA, Wait SJ, Backlund PS, Michaelis S. PMID: 7651156.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    72. Protein carboxyl methylation in Saccharomyces cerevisiae: evidence for STE14-dependent and STE14-independent pathways. Biochemistry. 1994 Aug 16; 33(32):9806-12. Hrycyna CA, Yang MC, Clarke S. PMID: 8068661.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    73. Purification and characterization of a novel metalloendopeptidase from Saccharomyces cerevisiae. Biochemistry. 1993 Oct 26; 32(42):11293-301. Hrycyna CA, Clarke S. PMID: 8218194.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    74. Modification of eukaryotic signaling proteins by C-terminal methylation reactions. Pharmacol Ther. 1993 Sep; 59(3):281-300. Hrycyna CA, Clarke S. PMID: 8309992.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    75. Maturation of isoprenylated proteins in Saccharomyces cerevisiae. Multiple activities catalyze the cleavage of the three carboxyl-terminal amino acids from farnesylated substrates in vitro. J Biol Chem. 1992 May 25; 267(15):10457-64. Hrycyna CA, Clarke S. PMID: 1587828.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    76. The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that mediates C-terminal methylation of a-factor and RAS proteins. EMBO J. 1991 Jul; 10(7):1699-709. Hrycyna CA, Sapperstein SK, Clarke S, Michaelis S. PMID: 2050108; PMCID: PMC452841.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    77. Farnesyl cysteine C-terminal methyltransferase activity is dependent upon the STE14 gene product in Saccharomyces cerevisiae. Mol Cell Biol. 1990 Oct; 10(10):5071-6. Hrycyna CA, Clarke S. PMID: 2204804; PMCID: PMC361172.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    Christine's Networks
    Concepts (359)
    Derived automatically from this person's publications.
    Explore
    _
    Co-Authors (2)
    People in Profiles who have published with this person.
    Explore
    _
    Similar People (60)
    People who share similar concepts with this person.
    Explore
    _

    UCSD Profiles is managed by the UC San Diego Altman Clinical and Translational Research Institute (ACTRI).
    This site is running Profiles RNS version UCSF-v3.1.0-16-gff1bd585 on PROFILES-PWEB04. We use cookies to operate our website. We also use cookies to analyze our site’s performance and improve your experience on our site. For more information about how we use cookies, please see our Website Terms of Use.

    Copyright © The Regents of the University of California