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    Bruce Wheeler

    TitleAdjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentBioengineering
    Address9500 Gilman Drive #0412
    CA La Jolla 92093
    Phone858-534-6458
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      Cornell, Ithaca NYMS, PHD1981Electrical Engineering
      MIT, Cambridge MAS.B.,S.B.1971History/Science

      Collapse Overview 
      Collapse Overview
      Brain-on-a-chip, micropatterning neurons and microelectrode arrays, neural signal processing. Bioengineering Education.

      Prof. Wheeler is particularly interested in the future of our young biomedical engineers. To this end he is heavily involved in UCSDs's new undergraduate Bioengineering Systems major, teaching and developing courses in instrumentation, signal processing and design. In his work with the UCSD Bioengineering: Systems UG major he emphasizes classical systems engineering but is cognizant that this education needs to take place in a context of genomics/informatics and the wearable/sensor/physiologic revolutions, both of which are changing the practice of medicine.

      Capsule Bio:
      Before moving to UCSD he has championed within the IEEE Engineering and Medical Bioengineering Society the growing emphasis on Biomedical and Health Informatics, a field which offers rapidly expanding job opportunities for biomedical engineers due to its huge practical impacts on health care effectiveness and cost, in addition to exploiting the genomics revolution. He is bringing into his classes an awareness of the tremendous impact that the wearable/sensor/wireless device explosion is having on biomedical engineering practice.

      For new students, Prof. Wheeler strongly recommends his MOOC "So you want to be a biomedical engineer" which is available for free at https://www.edx.org/course/so-you-want-become-biomedical-engineer-ieeex-biomed01x-0. This course was created by the IEEE EMBS with substantial help from D2 Creative (Somerset NJ). [Prof. Wheeler is particularly indebted to Laura Vitez who helped craft a more meaningful message to young bioengineers.] This course is available for free.

      Before joining UC San Diego, Dr. Wheeler was a professor and Acting Department Chair at the University of Florida, co-authoring Florida's new BME BS degree program proposal. Previously he had been on faculty at the University of Illinois where he was the Founding Head of the Bioengineering Department, authored the proposals and shepherded to completion the programs for the BS, MS and PhD. He also served as ECE Associate Head for Undergraduate Education and Chair of the Neuroscience Program. He earned his Ph.D. and Master's from Cornell and his Bachelor's from MIT. He is a Fellow of the AAAS, IEEE, BMES, AIMBE and IAMBE. He was President of the IEEE Engineering in Medicine and Biology Society in 2012-2013 and Editor of its flagship journal the IEEE Transactions on Bomedical Engineering. He adds that IEEE TBME is the world's most influential general BME journal and that IEEE EMBS is the world's oldest, largest, and most global biomedical engineering. Also, EMBS is most closely aligned with the engineering, clinical and industrial expansion into health care.

      Prof. Wheeler came through the research ranks with his interest in the application of electrical engineering methodologies to neuroscience. His work and laboratory influenced the development of neural spike sorting technologies, demonstrated that micro electrode array technology was useful for brain slice recording, and developed multiple micro lithographic techniques for controlling cell growth in culture, especially of neurons. This work aims at basic science understanding of the behavior of small populations of neurons, in hopes of creating better insight into the functioning of the brain. More recent work, in collaboration with GJ Brewer of UC Irvine and T DeMarse of the University of North Carolina has involved very novel reconstructions in vitro of the hippocampus from which we are gaining new insights into how this structure, critical to memory, encodes information.


      Collapse Research 
      Collapse Research Activities and Funding
      Engineering Form and Function in Neuronal Networks
      NIH/NINDS R01NS052233May 3, 2006 - Jan 31, 2017
      Role: Principal Investigator
      REAL-TIME NOISE CANCELLATION FOR HEARING AIDS
      NIH/NIDCD R21DC004840Jul 1, 2000 - Jun 30, 2003
      Role: Principal Investigator
      MICROPATTERNED NEURAL NETWORKS
      NIH/NINDS R21NS038617Aug 24, 1999 - Jul 31, 2002
      Role: Principal Investigator
      MICROSTAMPING PROTEINS AND MICROPATTERNING NEURONS
      NIH/NCRR R55RR013320Sep 30, 1998 - Sep 29, 2001
      Role: Principal Investigator
      PATTERNED NEURONAL NETWORKS
      NIH/NCRR R03RR006870Apr 1, 1991 - Mar 31, 1993
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Narula U, Ruiz A, McQuaide M, DeMarse TB, Wheeler B, Brewer GJ. Narrow microtunnel technology for the isolation and precise identification of axonal communication among distinct hippocampal subregion networks. PLoS One. 2017; 12(5):e0176868. PMID: 28493886.
        View in: PubMed
      2. Poli D, Thiagarajan S, DeMarse TB, Wheeler B, Brewer GJ. Sparse and Specific Coding during Information Transmission between Co-cultured Dentate Gyrus and CA3 Hippocampal Networks. Front Neural Circuits. 2017; 11:13. PMID: 28321182.
        View in: PubMed
      3. Bhattacharya A, Desai H, DeMarse TB, Wheeler B, Brewer GJ. Repeating Spatial-Temporal Motifs of CA3 Activity Dependent on Engineered Inputs from Dentate Gyrus Neurons in Live Hippocampal Networks. Front Neural Circuits. 2016; 10:45. PMID: 27445701; PMCID: PMC4923256.
      4. DeMarse TB, Pan L, Alagapan S, Brewer GJ, Wheeler B. Feed-Forward Propagation of Temporal and Rate Information between Cortical Populations during Coherent Activation in Engineered In Vitro Networks. Front Neural Circuits. 2016; 10:32. PMID: 27147977; PMCID: PMC4840215.
      5. Alagapan S, Franca E, Pan L, Leondopulos S, Wheeler B, DeMarse TB. Structure, Function, and Propagation of Information across Living Two, Four, and Eight Node Degree Topologies. Front Bioeng Biotechnol. 2016; 4:15. PMID: 26973833; PMCID: PMC4770194.
      6. Franca E, Jao PF, Fang SP, Alagapan S, Pan L, Yoon JH, Yoon YK, Wheeler B. Scale of Carbon Nanomaterials Affects Neural Outgrowth and Adhesion. IEEE Trans Nanobioscience. 2016 Jan; 15(1):11-8. PMID: 26829799; PMCID: PMC4791169 [Available on 01/25/17].
      7. Pan L, Alagapan S, Franca E, Leondopulos SS, DeMarse TB, Brewer GJ, Wheeler B. An in vitro method to manipulate the direction and functional strength between neural populations. Front Neural Circuits. 2015; 9:32. PMID: 26236198; PMCID: PMC4500931.
      8. Dhawan AP, Heetderks WJ, Pavel M, Acharya S, Akay M, Mairal A, Wheeler B, Dacso CC, Sunder T, Lovell N, Gerber M, Shah M, Senthilvel SG, Wang MD, Bhargava B. Current and Future Challenges in Point-of-Care Technologies: A Paradigm-Shift in Affordable Global Healthcare With Personalized and Preventive Medicine. IEEE J Transl Eng Health Med. 2015; 3:2800110. PMID: 27170902; PMCID: PMC4848045.
      9. Pan L, Alagapan S, Franca E, DeMarse T, Brewer GJ, Wheeler B. Large extracellular spikes recordable from axons in microtunnels. IEEE Trans Neural Syst Rehabil Eng. 2014 May; 22(3):453-9. PMID: 24240004; PMCID: PMC4013201.
      10. Brewer GJ, Boehler MD, Leondopulos S, Pan L, Alagapan S, DeMarse TB, Wheeler B. Toward a self-wired active reconstruction of the hippocampal trisynaptic loop: DG-CA3. Front Neural Circuits. 2013; 7:165. PMID: 24155693; PMCID: PMC3800815.
      11. Leondopulos SS, Boehler MD, Wheeler B, Brewer GJ. Chronic stimulation of cultured neuronal networks boosts low-frequency oscillatory activity at theta and gamma with spikes phase-locked to gamma frequencies. J Neural Eng. 2012 Apr; 9(2):026015. PMID: 22361724; PMCID: PMC3376752.
      12. Dhawan AP, Wheeler B. Editorial: introducing TBME Letters special section on multiscale biomedical signal and image modeling and analysis. IEEE Trans Biomed Eng. 2012 Jan; 59(1):3. PMID: 22186182.
        View in: PubMed
      13. Boehler MD, Leondopulos SS, Wheeler B, Brewer GJ. Hippocampal networks on reliable patterned substrates. J Neurosci Methods. 2012 Jan 30; 203(2):344-53. PMID: 21985763; PMCID: PMC3246106.
      14. Pan L, Alagapan S, Franca E, Brewer GJ, Wheeler B. Propagation of action potential activity in a predefined microtunnel neural network. J Neural Eng. 2011 Aug; 8(4):046031. PMID: 21750372; PMCID: PMC3213028.
      15. Wheeler B, Thakor N, He B. Special section on Grand Challenges in Neuroengineering. IEEE Trans Biomed Eng. 2011 Jul; 58(7):1883. PMID: 21693386.
        View in: PubMed
      16. Fidel J, Lyons J, Tripp C, Houston R, Wheeler B, Ruiz A. Treatment of oral squamous cell carcinoma with accelerated radiation therapy and concomitant carboplatin in cats. J Vet Intern Med. 2011 May-Jun; 25(3):504-10. PMID: 21539605.
        View in: PubMed
      17. Nam Y, Wheeler B. In vitro microelectrode array technology and neural recordings. Crit Rev Biomed Eng. 2011; 39(1):45-61. PMID: 21488814.
        View in: PubMed
      18. Wheeler B, Brewer GJ. Designing Neural Networks in Culture: Experiments are described for controlled growth, of nerve cells taken from rats, in predesigned geometrical patterns on laboratory culture dishes. Proc IEEE Inst Electr Electron Eng. 2010 Mar 01; 98(3):398-406. PMID: 21625406.
        View in: PubMed
      19. Ide AN, Andruska A, Boehler M, Wheeler B, Brewer GJ. Chronic network stimulation enhances evoked action potentials. J Neural Eng. 2010 Feb; 7(1):16008. PMID: 20083862; PMCID: PMC3775841.
      20. Dhawan AP, Wheeler B. Introducing TBME letters and regular papers special issue on therapeutic ultrasound. IEEE Trans Biomed Eng. 2010 Jan; 57(1):3. PMID: 20064752.
        View in: PubMed
      21. Brewer GJ, Boehler MD, Ide AN, Wheeler B. Chronic electrical stimulation of cultured hippocampal networks increases spontaneous spike rates. J Neurosci Methods. 2009 Oct 30; 184(1):104-9. PMID: 19666055; PMCID: PMC2753692.
      22. Musick K, Khatami D, Wheeler B. Three-dimensional micro-electrode array for recording dissociated neuronal cultures. Lab Chip. 2009 Jul 21; 9(14):2036-42. PMID: 19568672; PMCID: PMC2818679.
      23. Brewer GJ, Boehler MD, Pearson RA, DeMaris AA, Ide AN, Wheeler B. Neuron network activity scales exponentially with synapse density. J Neural Eng. 2009 Feb; 6(1):014001. PMID: 19104141; PMCID: PMC2679226.
      24. Nam Y, Brown EA, Ross JD, Blum RA, Wheeler B, DeWeerth SP. A retrofitted neural recording system with a novel stimulation IC to monitor early neural responses from a stimulating electrode. J Neurosci Methods. 2009 Mar 30; 178(1):99-102. PMID: 19100770; PMCID: PMC2677620.
      25. Dworak BJ, Wheeler B. Novel MEA platform with PDMS microtunnels enables the detection of action potential propagation from isolated axons in culture. Lab Chip. 2009 Feb 07; 9(3):404-10. PMID: 19156289; PMCID: PMC2790813.
      26. Brown EA, Ross JD, Blum RA, Wheeler B, Deweerth SP. Stimulus-artifact elimination in a multi-electrode system. IEEE Trans Biomed Circuits Syst. 2008 Mar; 2(1):10-21. PMID: 23852629.
        View in: PubMed
      27. Brewer GJ, Boehler MD, Jones TT, Wheeler B. NbActiv4 medium improvement to Neurobasal/B27 increases neuron synapse densities and network spike rates on multielectrode arrays. J Neurosci Methods. 2008 May 30; 170(2):181-7. PMID: 18308400; PMCID: PMC2393548.
      28. Wheeler B. Building a brain on a chip. Conf Proc IEEE Eng Med Biol Soc. 2008; 2008:1604-6. PMID: 19162982.
        View in: PubMed
      29. Boehler MD, Wheeler B, Brewer GJ. Added astroglia promote greater synapse density and higher activity in neuronal networks. Neuron Glia Biol. 2007 May; 3(2):127-40. PMID: 18345351; PMCID: PMC2267743.
      30. Vieira M, Christensen BL, Wheeler B, Feng AS, Kollmar R. Survival and stimulation of neurite outgrowth in a serum-free culture of spiral ganglion neurons from adult mice. Hear Res. 2007 Aug; 230(1-2):17-23. PMID: 17521837.
        View in: PubMed
      31. Rowe L, Almasri M, Lee K, Fogleman N, Brewer GJ, Nam Y, Wheeler B, Vukasinovic J, Glezer A, Frazier AB. Active 3-D microscaffold system with fluid perfusion for culturing in vitro neuronal networks. Lab Chip. 2007 Apr; 7(4):475-82. PMID: 17389964.
        View in: PubMed
      32. Nam Y, Brewer GJ, Wheeler B. Development of astroglial cells in patterned neuronal cultures. J Biomater Sci Polym Ed. 2007; 18(8):1091-100. PMID: 17706000.
        View in: PubMed
      33. Nam Y, Musick K, Wheeler B. Application of a PDMS microstencil as a replaceable insulator toward a single-use planar microelectrode array. Biomed Microdevices. 2006 Dec; 8(4):375-81. PMID: 16799748.
        View in: PubMed
      34. Chang JC, Brewer GJ, Wheeler B. Neuronal network structuring induces greater neuronal activity through enhanced astroglial development. J Neural Eng. 2006 Sep; 3(3):217-26. PMID: 16921205.
        View in: PubMed
      35. Nam Y, Branch DW, Wheeler B. Epoxy-silane linking of biomolecules is simple and effective for patterning neuronal cultures. Biosens Bioelectron. 2006 Dec 15; 22(5):589-97. PMID: 16531038.
        View in: PubMed
      36. Nam Y, Wheeler B, Heuschkel MO. Neural recording and stimulation of dissociated hippocampal cultures using microfabricated three-dimensional tip electrode array. J Neurosci Methods. 2006 Sep 15; 155(2):296-9. PMID: 16494949.
        View in: PubMed
      37. Ewert D, Wheeler B, Doetkott C, Ionan C, Pantalos G, Koenig SC. The effect of heart rate, preload, and afterload on the viscoelastic properties of the swine myocardium. Ann Biomed Eng. 2004 Sep; 32(9):1211-22. PMID: 15493509.
        View in: PubMed
      38. Nam Y, Chang J, Khatami D, Brewer GJ, Wheeler B. Patterning to enhance activity of cultured neuronal networks. IEE Proc Nanobiotechnol. 2004 Jun; 151(3):109-15. PMID: 16475852.
        View in: PubMed
      39. Lockwood ME, Jones DL, Bilger RC, Lansing CR, O'Brien WD, Wheeler B, Feng AS. Performance of time- and frequency-domain binaural beamformers based on recorded signals from real rooms. J Acoust Soc Am. 2004 Jan; 115(1):379-91. PMID: 14759029.
        View in: PubMed
      40. Khatami D, Nam Y, Brewer G, Wheeler B. Effect of bicuculline on the spontaneous and evoked activity of patterned embryonic hippocampal neurons cultured in vitro. Conf Proc IEEE Eng Med Biol Soc. 2004; 6:4059-62. PMID: 17271191.
        View in: PubMed
      41. Wheeler B, Nam Y, Brewer GJ. Patterning to influence in vitro neuronal interfaces. Conf Proc IEEE Eng Med Biol Soc. 2004; 7:5337-9. PMID: 17271547.
        View in: PubMed
      42. Nam Y, Chang JC, Wheeler B, Brewer GJ. Gold-coated microelectrode array with thiol linked self-assembled monolayers for engineering neuronal cultures. IEEE Trans Biomed Eng. 2004 Jan; 51(1):158-65. PMID: 14723505.
        View in: PubMed
      43. Nam Y, Wheeler B. Multichannel recording and stimulation of neuronal cultures grown on microstamped poly-D-lysine. Conf Proc IEEE Eng Med Biol Soc. 2004; 6:4049-52. PMID: 17271188.
        View in: PubMed
      44. Ratnam R, Jones DL, Wheeler B, O'Brien WD, Lansing CR, Feng AS. Blind estimation of reverberation time. J Acoust Soc Am. 2003 Nov; 114(5):2877-92. PMID: 14650022.
        View in: PubMed
      45. Chang JC, Brewer GJ, Wheeler B. A modified microstamping technique enhances polylysine transfer and neuronal cell patterning. Biomaterials. 2003 Aug; 24(17):2863-70. PMID: 12742724.
        View in: PubMed
      46. Cornish T, Branch DW, Wheeler B, Campanelli JT. Microcontact printing: a versatile technique for the study of synaptogenic molecules. Mol Cell Neurosci. 2002 May; 20(1):140-53. PMID: 12056845.
        View in: PubMed
      47. Liu C, Wheeler B, O'Brien WD, Lansing CR, Bilger RC, Jones DL, Feng AS. A two-microphone dual delay-line approach for extraction of a speech sound in the presence of multiple interferers. J Acoust Soc Am. 2001 Dec; 110(6):3218-31. PMID: 11785823.
        View in: PubMed
      48. Chang JC, Brewer GJ, Wheeler B. Modulation of neural network activity by patterning. Biosens Bioelectron. 2001 Sep; 16(7-8):527-33. PMID: 11544046.
        View in: PubMed
      49. Branch DW, Wheeler B, Brewer GJ, Leckband DE. Long-term stability of grafted polyethylene glycol surfaces for use with microstamped substrates in neuronal cell culture. Biomaterials. 2001 May; 22(10):1035-47. PMID: 11352085.
        View in: PubMed
      50. Liu C, Wheeler B, O'Brien WD, Bilger RC, Lansing CR, Feng AS. Localization of multiple sound sources with two microphones. J Acoust Soc Am. 2000 Oct; 108(4):1888-905. PMID: 11051515.
        View in: PubMed
      51. Branch DW, Wheeler B, Brewer GJ, Leckband DE. Long-term maintenance of patterns of hippocampal pyramidal cells on substrates of polyethylene glycol and microstamped polylysine. IEEE Trans Biomed Eng. 2000 Mar; 47(3):290-300. PMID: 10743770.
        View in: PubMed
      52. Wheeler B, Corey JM, Brewer GJ, Branch DW. Microcontact printing for precise control of nerve cell growth in culture. J Biomech Eng. 1999 Feb; 121(1):73-8. PMID: 10080092.
        View in: PubMed
      53. Branch DW, Corey JM, Weyhenmeyer JA, Brewer GJ, Wheeler B. Microstamp patterns of biomolecules for high-resolution neuronal networks. Med Biol Eng Comput. 1998 Jan; 36(1):135-41. PMID: 9614762.
        View in: PubMed
      54. Corey JM, Brunette AL, Chen MS, Weyhenmeyer JA, Brewer GJ, Wheeler B. Differentiated B104 neuroblastoma cells are a high-resolution assay for micropatterned substrates. J Neurosci Methods. 1997 Jul 18; 75(1):91-7. PMID: 9262149.
        View in: PubMed
      55. Corey JM, Wheeler B, Brewer GJ. Micrometer resolution silane-based patterning of hippocampal neurons: critical variables in photoresist and laser ablation processes for substrate fabrication. IEEE Trans Biomed Eng. 1996 Sep; 43(9):944-55. PMID: 9214810.
        View in: PubMed
      56. Boppart SA, Wheeler B, Wallace CS. A flexible perforated microelectrode array for extended neural recordings. IEEE Trans Biomed Eng. 1992 Jan; 39(1):37-42. PMID: 1572679.
        View in: PubMed
      57. Corey JM, Wheeler B, Brewer GJ. Compliance of hippocampal neurons to patterned substrate networks. J Neurosci Res. 1991 Oct; 30(2):300-7. PMID: 1798054.
        View in: PubMed
      58. Willming DA, Wheeler B. Real-time multichannel neural spike recognition with DSPs. IEEE Eng Med Biol Mag. 1990; 9(1):37-9. PMID: 18238315.
        View in: PubMed
      59. Novak JL, Wheeler B. Two-dimensional current source density analysis of propagation delays for components of epileptiform bursts in rat hippocampal slices. Brain Res. 1989 Sep 18; 497(2):223-30. PMID: 2819422.
        View in: PubMed
      60. Novak JL, Wheeler B. A high-speed multichannel neural data acquisition system for IBM PC compatibles. J Neurosci Methods. 1989 Jan; 26(3):239-47. PMID: 2918748.
        View in: PubMed
      61. Smith SR, Wheeler B. A real-time multiprocessor system for acquisition of multichannel neural data. IEEE Trans Biomed Eng. 1988 Oct; 35(10):875-7. PMID: 3192237.
        View in: PubMed
      62. Novak JL, Wheeler B. Multisite hippocampal slice recording and stimulation using a 32 element microelectrode array. J Neurosci Methods. 1988 Mar; 23(2):149-59. PMID: 3357355.
        View in: PubMed
      63. Wheeler B, Smith SR. High-resolution alignment of action potential waveforms using cubic spline interpolation. J Biomed Eng. 1988 Jan; 10(1):47-53. PMID: 3347033.
        View in: PubMed
      64. Wheeler B, Novak JL. Current source density estimation using microelectrode array data from the hippocampal slice preparation. IEEE Trans Biomed Eng. 1986 Dec; 33(12):1204-12. PMID: 3817854.
        View in: PubMed
      65. Novak JL, Wheeler B. Recording from the Aplysia abdominal ganglion with a planar microelectrode array. IEEE Trans Biomed Eng. 1986 Feb; 33(2):196-202. PMID: 3007331.
        View in: PubMed
      66. Wheeler B, Valesano WR. Real-time digital-filter-based data-acquisition system for the detection of neural signals. Med Biol Eng Comput. 1985 May; 23(3):243-8. PMID: 3839551.
        View in: PubMed
      67. Wheeler B, Heetderks WJ. A comparison of techniques for classification of multiple neural signals. IEEE Trans Biomed Eng. 1982 Dec; 29(12):752-9. PMID: 7173942.
        View in: PubMed