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    Guy Salvesen

    TitleAdjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentPathology
    Address9500 Gilman Drive #0612
    CA La Jolla 92093
    Phone858-646-3114
    vCardDownload vCard

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Poreba M, Salvesen G, Drag M. Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity. Nat Protoc. 2017 Oct; 12(10):2189-2214. PMID: 28933778.
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      2. Poreba M, Salvesen G. Return of the Ice Age: Caspases Safeguard against Inflammatory Cell Death. Cell Chem Biol. 2017 May 18; 24(5):550-552. PMID: 28525771.
        View in: PubMed
      3. Poreba M, Szalek A, Rut W, Kasperkiewicz P, Rutkowska-Wlodarczyk I, Snipas SJ, Itoh Y, Turk D, Turk B, Overall CM, Kaczmarek L, Salvesen G, Drag M. Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families. Sci Rep. 2017 Feb 23; 7:43135. PMID: 28230157.
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      4. Lee P, Zhu Z, Hachmann J, Nojima T, Kitamura D, Salvesen G, Rickert RC. Differing Requirements for MALT1 Function in Peripheral B Cell Survival and Differentiation. J Immunol. 2017 Feb 01; 198(3):1066-1080. PMID: 28031341.
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      5. Fasci D, Anania V, Lill J, Salvesen G. Response to Comment on "SUMO deconjugation is required for arsenic-triggered ubiquitylation of PML". Sci Signal. 2016 Aug 09; 9(440):tc2. PMID: 27507652.
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      6. Poreba M, Solberg R, Rut W, Lunde NN, Kasperkiewicz P, Snipas SJ, Mihelic M, Turk D, Turk B, Salvesen G, Drag M. Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes. Cell Chem Biol. 2016 Aug 18; 23(8):1023-35. PMID: 27478158.
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      7. Brumatti G, Ma C, Lalaoui N, Nguyen NY, Navarro M, Tanzer MC, Richmond J, Ghisi M, Salmon JM, Silke N, Pomilio G, Glaser SP, de Valle E, Gugasyan R, Gurthridge MA, Condon SM, Johnstone RW, Lock R, Salvesen G, Wei A, Vaux DL, Ekert PG, Silke J. The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia. Sci Transl Med. 2016 May 18; 8(339):339ra69. PMID: 27194727.
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      8. Oroz-Parra I, Navarro M, Cervantes-Luevano KE, Álvarez-Delgado C, Salvesen G, Sanchez-Campos LN, Licea-Navarro AF. Apoptosis Activation in Human Lung Cancer Cell Lines by a Novel Synthetic Peptide Derived from Conus californicus Venom. Toxins (Basel). 2016 Feb 05; 8(2):38. PMID: 26861394; PMCID: PMC4773791.
      9. Metkar SS, Pardo J, Anderluh G, Salvesen G, Trapani JA, Simon MM. In memoriam: Prof Christopher J Froelich (1951-2015). Cell Death Differ. 2016 Jan; 23(1):3-4. PMID: 26639556; PMCID: PMC4815969 [Available on 01/01/17].
      10. Salvesen G, Hempel A, Coll NS. Protease signaling in animal and plant-regulated cell death. FEBS J. 2016 Jul; 283(14):2577-98. PMID: 26648190.
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      11. Park G, Tan J, Garcia G, Kang Y, Salvesen G, Zhang Z. Regulation of Histone Acetylation by Autophagy in Parkinson Disease. J Biol Chem. 2016 Feb 12; 291(7):3531-40. PMID: 26699403; PMCID: PMC4751393 [Available on 02/12/17].
      12. Poreba M, Szalek A, Kasperkiewicz P, Rut W, Salvesen G, Drag M. Small Molecule Active Site Directed Tools for Studying Human Caspases. Chem Rev. 2015 Nov 25; 115(22):12546-629. PMID: 26551511.
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      13. Rajkovic J, Poreba M, Caglic D, Vidmar R, Wilk A, Borowik A, Salvesen G, Turk V, Drag M, Turk B. Biochemical Characterization and Substrate Specificity of Autophagin-2 from the Parasite Trypanosoma cruzi. J Biol Chem. 2015 Nov 20; 290(47):28231-44. PMID: 26446788; PMCID: PMC4653680 [Available on 11/20/16].
      14. Kayagaki N, Stowe IB, Lee BL, O'Rourke K, Anderson K, Warming S, Cuellar T, Haley B, Roose-Girma M, Phung QT, Liu PS, Lill JR, Li H, Wu J, Kummerfeld S, Zhang J, Lee WP, Snipas SJ, Salvesen G, Morris LX, Fitzgerald L, Zhang Y, Bertram EM, Goodnow CC, Dixit VM. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature. 2015 Oct 29; 526(7575):666-71. PMID: 26375259.
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      15. Hachmann J, Salvesen G. The Paracaspase MALT1. Biochimie. 2016 Mar; 122:324-38. PMID: 26386283; PMCID: PMC4747852 [Available on 03/01/17].
      16. Kasperkiewicz P, Poreba M, Snipas SJ, Lin SJ, Kirchhofer D, Salvesen G, Drag M. Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4. PLoS One. 2015; 10(7):e0132818. PMID: 26172376; PMCID: PMC4501687.
      17. Fasci D, Anania VG, Lill JR, Salvesen G. SUMO deconjugation is required for arsenic-triggered ubiquitylation of PML. Sci Signal. 2015 Jun 09; 8(380):ra56. PMID: 26060329; PMCID: PMC4603552.
      18. Hachmann J, Edgington-Mitchell LE, Poreba M, Sanman LE, Drag M, Bogyo M, Salvesen G. Probes to monitor activity of the paracaspase MALT1. Chem Biol. 2015 Jan 22; 22(1):139-47. PMID: 25556944; PMCID: PMC4304901.
      19. Kumar S, van Raam BJ, Salvesen G, Cieplak P. Caspase cleavage sites in the human proteome: CaspDB, a database of predicted substrates. PLoS One. 2014; 9(10):e110539. PMID: 25330111; PMCID: PMC4201543.
      20. Ashkenazi A, Salvesen G. Regulated cell death: signaling and mechanisms. Annu Rev Cell Dev Biol. 2014; 30:337-56. PMID: 25150011.
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      21. Salvesen G, Walsh CM. Functions of caspase 8: the identified and the mysterious. Semin Immunol. 2014 Jun; 26(3):246-52. PMID: 24856110; PMCID: PMC4099255.
      22. Poreba M, Kasperkiewicz P, Snipas SJ, Fasci D, Salvesen G, Drag M. Unnatural amino acids increase sensitivity and provide for the design of highly selective caspase substrates. Cell Death Differ. 2014 Sep; 21(9):1482-92. PMID: 24832467; PMCID: PMC4131180.
      23. Pustelny K, Zdzalik M, Stach N, Stec-Niemczyk J, Cichon P, Czarna A, Popowicz G, Mak P, Drag M, Salvesen G, Wladyka B, Potempa J, Dubin A, Dubin G. Staphylococcal SplB serine protease utilizes a novel molecular mechanism of activation. J Biol Chem. 2014 May 30; 289(22):15544-53. PMID: 24713703; PMCID: PMC4140910.
      24. Byzia A, Haeggström JZ, Salvesen G, Drag M. A remarkable activity of human leukotriene A4 hydrolase (LTA4H) toward unnatural amino acids. Amino Acids. 2014 May; 46(5):1313-20. PMID: 24573245; PMCID: PMC3984412.
      25. Kasperkiewicz P, Poreba M, Snipas SJ, Parker H, Winterbourn CC, Salvesen G, Drag M. Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling. Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7):2518-23. PMID: 24550277; PMCID: PMC3932852.
      26. Salvesen G. Dying from within: granzyme B converts entosis to emperitosis. Cell Death Differ. 2014 Jan; 21(1):3-4. PMID: 24317271; PMCID: PMC3857627.
      27. Mace PD, Riedl SJ, Salvesen G. Caspase enzymology and activation mechanisms. Methods Enzymol. 2014; 544:161-78. PMID: 24974290.
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      28. Poreba M, Strózyk A, Salvesen G, Drag M. Caspase substrates and inhibitors. Cold Spring Harb Perspect Biol. 2013 Aug 01; 5(8):a008680. PMID: 23788633; PMCID: PMC3721276.
      29. Vamos M, Welsh K, Finlay D, Lee PS, Mace PD, Snipas SJ, Gonzalez ML, Ganji SR, Ardecky RJ, Riedl SJ, Salvesen G, Vuori K, Reed JC, Cosford ND. Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP. ACS Chem Biol. 2013 Apr 19; 8(4):725-32. PMID: 23323685; PMCID: PMC3953502.
      30. Aleshin AE, Drag M, Gombosuren N, Wei G, Mikolajczyk J, Satterthwait AC, Strongin AY, Liddington RC, Salvesen G. Activity, specificity, and probe design for the smallpox virus protease K7L. J Biol Chem. 2012 Nov 16; 287(47):39470-9. PMID: 23012361; PMCID: PMC3501048.
      31. Salvesen G, Bogyo M. Highlight: the universe of proteolytic networks and mechanisms. Biol Chem. 2012 Sep; 393(9):841. PMID: 22944685.
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      32. van Raam BJ, Ehrnhoefer DE, Hayden MR, Salvesen G. Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6. Cell Death Differ. 2013 Jan; 20(1):86-96. PMID: 22858542; PMCID: PMC3524638.
      33. Sivaraman KK, Oellig CA, Huynh K, Atkinson SC, Poreba M, Perugini MA, Trenholme KR, Gardiner DL, Salvesen G, Drag M, Dalton JP, Whisstock JC, McGowan S. X-ray crystal structure and specificity of the Plasmodium falciparum malaria aminopeptidase PfM18AAP. J Mol Biol. 2012 Sep 28; 422(4):495-507. PMID: 22709581.
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      34. Conus S, Pop C, Snipas SJ, Salvesen G, Simon HU. Cathepsin D primes caspase-8 activation by multiple intra-chain proteolysis. J Biol Chem. 2012 Jun 15; 287(25):21142-51. PMID: 22528489; PMCID: PMC3375537.
      35. Rickert RC, Salvesen G, Ware CF. Mousing around with caspases and IAPs. Biochem J. 2012 Apr 15; 443(2):e1-2. PMID: 22452818.
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      36. Hachmann J, Snipas SJ, van Raam BJ, Cancino EM, Houlihan EJ, Poreba M, Kasperkiewicz P, Drag M, Salvesen G. Mechanism and specificity of the human paracaspase MALT1. Biochem J. 2012 Apr 01; 443(1):287-95. PMID: 22309193; PMCID: PMC3304489.
      37. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, Garcia-Manero G, Garcia-Marcos M, Garmyn M, Gartel AL, Gatti E, Gautel M, Gawriluk TR, Gegg ME, Geng J, Germain M, Gestwicki JE, Gewirtz DA, Ghavami S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. PMID: 22966490; PMCID: PMC3404883.
      38. Edgington LE, van Raam BJ, Verdoes M, Wierschem C, Salvesen G, Bogyo M. An optimized activity-based probe for the study of caspase-6 activation. Chem Biol. 2012 Mar 23; 19(3):340-52. PMID: 22444589; PMCID: PMC3314226.
      39. Bender CE, Fitzgerald P, Tait SW, Llambi F, McStay GP, Tupper DO, Pellettieri J, Sánchez Alvarado A, Salvesen G, Green DR. Mitochondrial pathway of apoptosis is ancestral in metazoans. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):4904-9. PMID: 22416118; PMCID: PMC3324028.
      40. Poreba M, McGowan S, Skinner-Adams TS, Trenholme KR, Gardiner DL, Whisstock JC, To J, Salvesen G, Dalton JP, Drag M. Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum. PLoS One. 2012; 7(2):e31938. PMID: 22359643; PMCID: PMC3281095.
      41. Dobrota C, Fasci D, Hadade ND, Roiban GD, Pop C, Meier VM, Dumitru I, Matache M, Salvesen G, Funeriu DP. Glycine fluoromethylketones as SENP-specific activity based probes. Chembiochem. 2012 Jan 02; 13(1):80-4. PMID: 22134988.
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      42. Poreba M, Gajda A, Picha J, Jiracek J, Marschner A, Klein CD, Salvesen G, Drag M. S1 pocket fingerprints of human and bacterial methionine aminopeptidases determined using fluorogenic libraries of substrates and phosphorus based inhibitors. Biochimie. 2012 Mar; 94(3):704-10. PMID: 22085501.
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      43. Salvesen G, Ashkenazi A. Snapshot: caspases. Cell. 2011 Oct 14; 147(2):476-476.e1. PMID: 22000022.
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      44. Green DR, Oberst A, Dillon CP, Weinlich R, Salvesen G. RIPK-dependent necrosis and its regulation by caspases: a mystery in five acts. Mol Cell. 2011 Oct 07; 44(1):9-16. PMID: 21981915; PMCID: PMC3192321.
      45. Lu JV, Weist BM, van Raam BJ, Marro BS, Nguyen LV, Srinivas P, Bell BD, Luhrs KA, Lane TE, Salvesen G, Walsh CM. Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15312-7. PMID: 21876153; PMCID: PMC3174674.
      46. Ponder EL, Albrow VE, Leader BA, Békés M, Mikolajczyk J, Fonovic UP, Shen A, Drag M, Xiao J, Deu E, Campbell AJ, Powers JC, Salvesen G, Bogyo M. Functional characterization of a SUMO deconjugating protease of Plasmodium falciparum using newly identified small molecule inhibitors. Chem Biol. 2011 Jun 24; 18(6):711-21. PMID: 21700207; PMCID: PMC3131532.
      47. Albrow VE, Ponder EL, Fasci D, Békés M, Deu E, Salvesen G, Bogyo M. Development of small molecule inhibitors and probes of human SUMO deconjugating proteases. Chem Biol. 2011 Jun 24; 18(6):722-32. PMID: 21700208; PMCID: PMC3131534.
      48. van Raam BJ, Salvesen G. Proliferative versus apoptotic functions of caspase-8 Hetero or homo: the caspase-8 dimer controls cell fate. Biochim Biophys Acta. 2012 Jan; 1824(1):113-22. PMID: 21704196; PMCID: PMC3993904.
      49. Akpan N, Serrano-Saiz E, Zacharia BE, Otten ML, Ducruet AF, Snipas SJ, Liu W, Velloza J, Cohen G, Sosunov SA, Frey WH, Salvesen G, Connolly ES, Troy CM. Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke. J Neurosci. 2011 Jun 15; 31(24):8894-904. PMID: 21677173; PMCID: PMC3143191.
      50. Zervoudi E, Papakyriakou A, Georgiadou D, Evnouchidou I, Gajda A, Poreba M, Salvesen G, Drag M, Hattori A, Swevers L, Vourloumis D, Stratikos E. Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides. Biochem J. 2011 Apr 15; 435(2):411-20. PMID: 21314638; PMCID: PMC4000605.
      51. Oberst A, Dillon CP, Weinlich R, McCormick LL, Fitzgerald P, Pop C, Hakem R, Salvesen G, Green DR. Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature. 2011 Mar 17; 471(7338):363-7. PMID: 21368763; PMCID: PMC3077893.
      52. Békés M, Prudden J, Srikumar T, Raught B, Boddy MN, Salvesen G. The dynamics and mechanism of SUMO chain deconjugation by SUMO-specific proteases. J Biol Chem. 2011 Mar 25; 286(12):10238-47. PMID: 21247896; PMCID: PMC3060478.
      53. Petroski MD, Salvesen G, Wolf DA. Urm1 couples sulfur transfer to ubiquitin-like protein function in oxidative stress. Proc Natl Acad Sci U S A. 2011 Feb 01; 108(5):1749-50. PMID: 21245332; PMCID: PMC3033263.
      54. Timmer JC, Salvesen G. N-terminomics: a high-content screen for protease substrates and their cleavage sites. Methods Mol Biol. 2011; 753:243-55. PMID: 21604127.
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      55. Leyva MJ, Degiacomo F, Kaltenbach LS, Holcomb J, Zhang N, Gafni J, Park H, Lo DC, Salvesen G, Ellerby LM, Ellman JA. Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models. Chem Biol. 2010 Nov 24; 17(11):1189-200. PMID: 21095569; PMCID: PMC3035168.
      56. Shu CW, Drag M, Bekes M, Zhai D, Salvesen G, Reed JC. Synthetic substrates for measuring activity of autophagy proteases: autophagins (Atg4). Autophagy. 2010 Oct; 6(7):936-47. PMID: 20818167; PMCID: PMC3039740.
      57. Chekeni FB, Elliott MR, Sandilos JK, Walk SF, Kinchen JM, Lazarowski ER, Armstrong AJ, Penuela S, Laird DW, Salvesen G, Isakson BE, Bayliss DA, Ravichandran KS. Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis. Nature. 2010 Oct 14; 467(7317):863-7. PMID: 20944749; PMCID: PMC3006164.
      58. Bratton SB, Salvesen G. Regulation of the Apaf-1-caspase-9 apoptosome. J Cell Sci. 2010 Oct 01; 123(Pt 19):3209-14. PMID: 20844150; PMCID: PMC2939798.
      59. Wachmann K, Pop C, van Raam BJ, Drag M, Mace PD, Snipas SJ, Zmasek C, Schwarzenbacher R, Salvesen G, Riedl SJ. Activation and specificity of human caspase-10. Biochemistry. 2010 Sep 28; 49(38):8307-15. PMID: 20795673; PMCID: PMC2943529.
      60. Uhlmann F, Salvesen G. Divide and die another day. Curr Opin Cell Biol. 2010 Dec; 22(6):764-5. PMID: 20864325; PMCID: PMC2993833.
      61. Drag M, Salvesen G. Emerging principles in protease-based drug discovery. Nat Rev Drug Discov. 2010 Sep; 9(9):690-701. PMID: 20811381; PMCID: PMC2974563.
      62. Kolli N, Mikolajczyk J, Drag M, Mukhopadhyay D, Moffatt N, Dasso M, Salvesen G, Wilkinson KD. Distribution and paralogue specificity of mammalian deSUMOylating enzymes. Biochem J. 2010 Sep 01; 430(2):335-44. PMID: 20590526; PMCID: PMC3749516.
      63. Enoksson M, Salvesen G. Metacaspases are not caspases--always doubt. Cell Death Differ. 2010 Aug; 17(8):1221. PMID: 20622886.
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      64. Nakamura T, Wang L, Wong CC, Scott FL, Eckelman BP, Han X, Tzitzilonis C, Meng F, Gu Z, Holland EA, Clemente AT, Okamoto S, Salvesen G, Riek R, Yates JR, Lipton SA. Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death. Mol Cell. 2010 Jul 30; 39(2):184-95. PMID: 20670888; PMCID: PMC2924818.
      65. Leverrier S, Salvesen G, Walsh CM. Enzymatically active single chain caspase-8 maintains T-cell survival during clonal expansion. Cell Death Differ. 2011 Jan; 18(1):90-8. PMID: 20523353; PMCID: PMC3131867.
      66. Oberst A, Pop C, Tremblay AG, Blais V, Denault JB, Salvesen G, Green DR. Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation. J Biol Chem. 2010 May 28; 285(22):16632-42. PMID: 20308068; PMCID: PMC2878047.
      67. Staflin K, Krueger JS, Hachmann J, Forsyth JS, Lorger M, Steiniger SC, Mee J, Pop C, Salvesen G, Janda KD, Felding-Habermann B. Targeting activated integrin alphavbeta3 with patient-derived antibodies impacts late-stage multiorgan metastasis. Clin Exp Metastasis. 2010 Apr; 27(4):217-31. PMID: 20225083; PMCID: PMC4830478.
      68. van Raam BJ, Salvesen G. Transferring death: a role for tRNA in apoptosis regulation. Mol Cell. 2010 Mar 12; 37(5):591-2. PMID: 20227362.
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      69. Grzywa R, Oleksyszyn J, Salvesen G, Drag M. Identification of very potent inhibitor of human aminopeptidase N (CD13). Bioorg Med Chem Lett. 2010 Apr 15; 20(8):2497-9. PMID: 20307982.
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      70. Zhai D, Yu E, Jin C, Welsh K, Shiau CW, Chen L, Salvesen G, Liddington R, Reed JC. Vaccinia virus protein F1L is a caspase-9 inhibitor. J Biol Chem. 2010 Feb 19; 285(8):5569-80. PMID: 20022954; PMCID: PMC2820784.
      71. Walters J, Pop C, Scott FL, Drag M, Swartz P, Mattos C, Salvesen G, Clark AC. A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis. Biochem J. 2009 Dec 10; 424(3):335-45. PMID: 19788411; PMCID: PMC2805924.
      72. Drag M, Bogyo M, Ellman JA, Salvesen G. Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors. J Biol Chem. 2010 Jan 29; 285(5):3310-8. PMID: 19948737; PMCID: PMC2823418.
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      75. Cimadamore F, Curchoe CL, Alderson N, Scott F, Salvesen G, Terskikh AV. Nicotinamide rescues human embryonic stem cell-derived neuroectoderm from parthanatic cell death. Stem Cells. 2009 Aug; 27(8):1772-81. PMID: 19544437; PMCID: PMC4151857.
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      78. Zhu S, Goeres J, Sixt KM, Békés M, Zhang XD, Salvesen G, Matunis MJ. Protection from isopeptidase-mediated deconjugation regulates paralog-selective sumoylation of RanGAP1. Mol Cell. 2009 Mar 13; 33(5):570-80. PMID: 19285941; PMCID: PMC2668917.
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      80. Timmer AM, Timmer JC, Pence MA, Hsu LC, Ghochani M, Frey TG, Karin M, Salvesen G, Nizet V. Streptolysin O promotes group A Streptococcus immune evasion by accelerated macrophage apoptosis. J Biol Chem. 2009 Jan 09; 284(2):862-71. PMID: 19001420; PMCID: PMC2613605.
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      83. Drag M, Salvesen G. DeSUMOylating enzymes--SENPs. IUBMB Life. 2008 Nov; 60(11):734-42. PMID: 18666185.
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      84. Droga-Mazovec G, Bojic L, Petelin A, Ivanova S, Romih R, Repnik U, Salvesen G, Stoka V, Turk V, Turk B. Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues. J Biol Chem. 2008 Jul 04; 283(27):19140-50. PMID: 18469004.
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      86. Snipas SJ, Drag M, Stennicke HR, Salvesen G. Activation mechanism and substrate specificity of the Drosophila initiator caspase DRONC. Cell Death Differ. 2008 May; 15(5):938-45. PMID: 18309328.
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      87. Eckelman BP, Drag M, Snipas SJ, Salvesen G. The mechanism of peptide-binding specificity of IAP BIR domains. Cell Death Differ. 2008 May; 15(5):920-8. PMID: 18239672.
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      88. Drag M, Mikolajczyk J, Krishnakumar IM, Huang Z, Salvesen G. Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family. Biochem J. 2008 Jan 15; 409(2):461-9. PMID: 17916063.
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      89. Denault JB, Salvesen G. Apoptotic caspase activation and activity. Methods Mol Biol. 2008; 414:191-220. PMID: 18175821.
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      92. McStay GP, Salvesen G, Green DR. Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways. Cell Death Differ. 2008 Feb; 15(2):322-31. PMID: 17975551.
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      93. Wu YI, Munshi HG, Snipas SJ, Salvesen G, Fridman R, Stack MS. Activation-coupled membrane-type 1 matrix metalloproteinase membrane trafficking. Biochem J. 2007 Oct 15; 407(2):171-7. PMID: 17650075; PMCID: PMC2049019.
      94. Timmer JC, Enoksson M, Wildfang E, Zhu W, Igarashi Y, Denault JB, Ma Y, Dummitt B, Chang YH, Mast AE, Eroshkin A, Smith JW, Tao WA, Salvesen G. Profiling constitutive proteolytic events in vivo. Biochem J. 2007 Oct 01; 407(1):41-8. PMID: 17650073; PMCID: PMC2267409.
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      96. Truscott M, Denault JB, Goulet B, Leduy L, Salvesen G, Nepveu A. Carboxyl-terminal proteolytic processing of CUX1 by a caspase enables transcriptional activation in proliferating cells. J Biol Chem. 2007 Oct 12; 282(41):30216-26. PMID: 17681953.
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      97. Denault JB, Eckelman BP, Shin H, Pop C, Salvesen G. Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9. Biochem J. 2007 Jul 01; 405(1):11-9. PMID: 17437405; PMCID: PMC1925235.
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      99. Enoksson M, Li J, Ivancic MM, Timmer JC, Wildfang E, Eroshkin A, Salvesen G, Tao WA. Identification of proteolytic cleavage sites by quantitative proteomics. J Proteome Res. 2007 Jul; 6(7):2850-8. PMID: 17547438.
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      100. Salvesen G, Riedl SJ. Caspase inhibition, specifically. Structure. 2007 May; 15(5):513-4. PMID: 17502096.
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      103. Timmer JC, Salvesen G. Caspase substrates. Cell Death Differ. 2007 Jan; 14(1):66-72. PMID: 17082814.
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      104. Dobó J, Swanson R, Salvesen G, Olson ST, Gettins PG. Cytokine response modifier a inhibition of initiator caspases results in covalent complex formation and dissociation of the caspase tetramer. J Biol Chem. 2006 Dec 15; 281(50):38781-90. PMID: 17052983.
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      105. Eckelman BP, Salvesen G, Scott FL. Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family. EMBO Rep. 2006 Oct; 7(10):988-94. PMID: 17016456; PMCID: PMC1618369.
      106. Ekici OD, Li ZZ, Campbell AJ, James KE, Asgian JL, Mikolajczyk J, Salvesen G, Ganesan R, Jelakovic S, Grütter MG, Powers JC. Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and -10. J Med Chem. 2006 Sep 21; 49(19):5728-49. PMID: 16970398.
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      107. Berger AB, Witte MD, Denault JB, Sadaghiani AM, Sexton KM, Salvesen G, Bogyo M. Identification of early intermediates of caspase activation using selective inhibitors and activity-based probes. Mol Cell. 2006 Aug; 23(4):509-21. PMID: 16916639.
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      108. Denault JB, Békés M, Scott FL, Sexton KM, Bogyo M, Salvesen G. Engineered hybrid dimers: tracking the activation pathway of caspase-7. Mol Cell. 2006 Aug; 23(4):523-33. PMID: 16916640.
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      110. Stennicke HR, Salvesen G. Chemical ligation--an unusual paradigm in protease inhibition. Mol Cell. 2006 Mar 17; 21(6):727-8. PMID: 16543139.
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      111. Stuhr LE, Salnikov AV, Iversen VV, Salvesen G, Rubin K, Reed RK. High-dose, short-term, anti-inflammatory treatment with dexamethasone reduces growth and augments the effects of 5-fluorouracil on dimethyl-alpha-benzanthracene-induced mammary tumors in rats. Scand J Clin Lab Invest. 2006; 66(6):477-86. PMID: 17000555.
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      113. Pop C, Salvesen G. The nematode death machine in 3D. Cell. 2005 Oct 21; 123(2):192-3. PMID: 16239138.
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      114. Iversen VV, Nedrebø T, Borge BA, Salvesen G, Reed RK. Platelet activating factor (PAF) increases plasma protein extravasation and induces lowering of interstitial fluid pressure (P) in rat skin. Acta Physiol Scand. 2005 Sep; 185(1):5-12. PMID: 16128692.
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      115. Simonovic M, Denault JB, Salvesen G, Volz K, Gettins PG. Lack of involvement of strand s1'A of the viral serpin CrmA in anti-apoptotic or caspase-inhibitory functions. Arch Biochem Biophys. 2005 Aug 01; 440(1):1-9. PMID: 15993378.
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      116. Kato D, Boatright KM, Berger AB, Nazif T, Blum G, Ryan C, Chehade KA, Salvesen G, Bogyo M. Activity-based probes that target diverse cysteine protease families. Nat Chem Biol. 2005 Jun; 1(1):33-8. PMID: 16407991.
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      117. Gregorc U, Dobersek A, Salvesen G, Turk V, Turk B, Kopitar-Jerala N. A novel caspase-7 specific monoclonal antibody. Immunol Lett. 2005 Apr 15; 98(1):167-9. PMID: 15849872.
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      119. Bruckner S, Rhamouni S, Tautz L, Denault JB, Alonso A, Becattini B, Salvesen G, Mustelin T. Yersinia phosphatase induces mitochondrially dependent apoptosis of T cells. J Biol Chem. 2005 Mar 18; 280(11):10388-94. PMID: 15632192.
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      120. Shin H, Renatus M, Eckelman BP, Nunes VA, Sampaio CA, Salvesen G. The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition. Biochem J. 2005 Jan 01; 385(Pt 1):1-10. PMID: 15485395; PMCID: PMC1134667.
      121. Vucic D, Franklin MC, Wallweber HJ, Das K, Eckelman BP, Shin H, Elliott LO, Kadkhodayan S, Deshayes K, Salvesen G, Fairbrother WJ. Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP. Biochem J. 2005 Jan 01; 385(Pt 1):11-20. PMID: 15485396; PMCID: PMC1134668.
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      124. Krajewska M, Rosenthal RE, Mikolajczyk J, Stennicke HR, Wiesenthal T, Mai J, Naito M, Salvesen G, Reed JC, Fiskum G, Krajewski S. Early processing of Bid and caspase-6, -8, -10, -14 in the canine brain during cardiac arrest and resuscitation. Exp Neurol. 2004 Oct; 189(2):261-79. PMID: 15380478.
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      125. Wilkinson JC, Wilkinson AS, Scott FL, Csomos RA, Salvesen G, Duckett CS. Neutralization of Smac/Diablo by inhibitors of apoptosis (IAPs). A caspase-independent mechanism for apoptotic inhibition. J Biol Chem. 2004 Dec 03; 279(49):51082-90. PMID: 15371416.
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      126. Boatright KM, Deis C, Denault JB, Sutherlin DP, Salvesen G. Activation of caspases-8 and -10 by FLIP(L). Biochem J. 2004 Sep 01; 382(Pt 2):651-7. PMID: 15209560; PMCID: PMC1133822.
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      128. Dohi T, Okada K, Xia F, Wilford CE, Samuel T, Welsh K, Marusawa H, Zou H, Armstrong R, Matsuzawa S, Salvesen G, Reed JC, Altieri DC. An IAP-IAP complex inhibits apoptosis. J Biol Chem. 2004 Aug 13; 279(33):34087-90. PMID: 15218035.
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      129. Salvesen G, Abrams JM. Caspase activation - stepping on the gas or releasing the brakes? Lessons from humans and flies. Oncogene. 2004 Apr 12; 23(16):2774-84. PMID: 15077141.
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      131. James KE, Asgian JL, Li ZZ, Ekici OD, Rubin JR, Mikolajczyk J, Salvesen G, Powers JC. Design, synthesis, and evaluation of aza-peptide epoxides as selective and potent inhibitors of caspases-1, -3, -6, and -8. J Med Chem. 2004 Mar 11; 47(6):1553-74. PMID: 14998341.
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      132. Pedersen IM, Zapata JM, Samuel T, Scott FL, Salvesen G, Honda T, Gribble GW, Suh N, Sporn MB, Kipps TJ, Reed JC. Retraction: The triterpenoid CDDO-Imidazolide induces apoptosis and enhances fludarabine-induced apoptosis of CLL B-cells. Blood. 2004 Aug 15; 104(4):932. PMID: 14739219.
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      133. Schimmer AD, Welsh K, Pinilla C, Wang Z, Krajewska M, Bonneau MJ, Pedersen IM, Kitada S, Scott FL, Bailly-Maitre B, Glinsky G, Scudiero D, Sausville E, Salvesen G, Nefzi A, Ostresh JM, Houghten RA, Reed JC. Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity. Cancer Cell. 2004 Jan; 5(1):25-35. PMID: 14749124.
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      134. Wu YI, Munshi HG, Sen R, Snipas SJ, Salvesen G, Fridman R, Stack MS. Glycosylation broadens the substrate profile of membrane type 1 matrix metalloproteinase. J Biol Chem. 2004 Feb 27; 279(9):8278-89. PMID: 14670950.
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      135. Boatright KM, Salvesen G. Mechanisms of caspase activation. Curr Opin Cell Biol. 2003 Dec; 15(6):725-31. PMID: 14644197.
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      136. Cirman T, Oresic K, Mazovec GD, Turk V, Reed JC, Myers RM, Salvesen G, Turk B. Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins. J Biol Chem. 2004 Jan 30; 279(5):3578-87. PMID: 14581476.
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      137. Shin H, Okada K, Wilkinson JC, Solomon KM, Duckett CS, Reed JC, Salvesen G. Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein. Biochem J. 2003 Aug 01; 373(Pt 3):965-71. PMID: 12747801; PMCID: PMC1223557.
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      140. Reed JC, Doctor K, Rojas A, Zapata JM, Stehlik C, Fiorentino L, Damiano J, Roth W, Matsuzawa S, Newman R, Takayama S, Marusawa H, Xu F, Salvesen G, Godzik A. Comparative analysis of apoptosis and inflammation genes of mice and humans. Genome Res. 2003 Jun; 13(6B):1376-88. PMID: 12819136; PMCID: PMC403667.
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      143. Boatright KM, Renatus M, Scott FL, Sperandio S, Shin H, Pedersen IM, Ricci JE, Edris WA, Sutherlin DP, Green DR, Salvesen G. A unified model for apical caspase activation. Mol Cell. 2003 Feb; 11(2):529-41. PMID: 12620239.
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      144. Denault JB, Salvesen G. Expression, purification, and characterization of caspases. Curr Protoc Protein Sci. 2003 Feb; Chapter 21:Unit 21.13. PMID: 18429241.
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      146. Saklatvala J, Nagase H, Salvesen G. A tribute to Alan J. Barrett. Biochem Soc Symp. 2003; (70):ix-x. PMID: 14587277.
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      150. Ryan CA, Stennicke HR, Nava VE, Burch JB, Hardwick JM, Salvesen G. Inhibitor specificity of recombinant and endogenous caspase-9. Biochem J. 2002 Sep 01; 366(Pt 2):595-601. PMID: 12067274; PMCID: PMC1222808.
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      152. Salvesen G, Duckett CS. IAP proteins: blocking the road to death's door. Nat Rev Mol Cell Biol. 2002 Jun; 3(6):401-10. PMID: 12042762.
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      154. Okamoto S, Li Z, Ju C, Scholzke MN, Mathews E, Cui J, Salvesen G, Bossy-Wetzel E, Lipton SA. Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3974-9. PMID: 11904443; PMCID: PMC122633.
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      159. Lu C, Fu W, Salvesen G, Mattson MP. Direct cleavage of AMPA receptor subunit GluR1 and suppression of AMPA currents by caspase-3: implications for synaptic plasticity and excitotoxic neuronal death. Neuromolecular Med. 2002; 1(1):69-79. PMID: 12025817.
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      160. Turk B, Turk D, Salvesen G. Regulating cysteine protease activity: essential role of protease inhibitors as guardians and regulators. Curr Pharm Des. 2002; 8(18):1623-37. PMID: 12132995.
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      165. Snipas SJ, Stennicke HR, Riedl S, Potempa J, Travis J, Barrett AJ, Salvesen G. Inhibition of distant caspase homologues by natural caspase inhibitors. Biochem J. 2001 Jul 15; 357(Pt 2):575-80. PMID: 11439111; PMCID: PMC1221988.
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      167. Riedl SJ, Renatus M, Schwarzenbacher R, Zhou Q, Sun C, Fesik SW, Liddington RC, Salvesen G. Structural basis for the inhibition of caspase-3 by XIAP. Cell. 2001 Mar 09; 104(5):791-800. PMID: 11257232.
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      168. Katunuma N, Matsui A, Le QT, Utsumi K, Salvesen G, Ohashi A. Novel procaspase-3 activating cascade mediated by lysoapoptases and its biological significances in apoptosis. Adv Enzyme Regul. 2001; 41:237-50. PMID: 11384748.
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      169. Salvesen G. A lysosomal protease enters the death scene. J Clin Invest. 2001 Jan; 107(1):21-2. PMID: 11134173; PMCID: PMC198551.
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      171. Stoka V, Turk B, Schendel SL, Kim TH, Cirman T, Snipas SJ, Ellerby LM, Bredesen D, Freeze H, Abrahamson M, Bromme D, Krajewski S, Reed JC, Yin XM, Turk V, Salvesen G. Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route. J Biol Chem. 2001 Feb 02; 276(5):3149-57. PMID: 11073962.
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      174. Stennicke HR, Renatus M, Meldal M, Salvesen G. Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8. Biochem J. 2000 Sep 01; 350 Pt 2:563-8. PMID: 10947972; PMCID: PMC1221285.
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      176. Lu DC, Rabizadeh S, Chandra S, Shayya RF, Ellerby LM, Ye X, Salvesen G, Koo EH, Bredesen DE. A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor. Nat Med. 2000 Apr; 6(4):397-404. PMID: 10742146.
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      177. Stennicke HR, Salvesen G. Caspases - controlling intracellular signals by protease zymogen activation. Biochim Biophys Acta. 2000 Mar 07; 1477(1-2):299-306. PMID: 10708865.
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      178. Huang Q, Deveraux QL, Maeda S, Salvesen G, Stennicke HR, Hammock BD, Reed JC. Evolutionary conservation of apoptosis mechanisms: lepidopteran and baculoviral inhibitor of apoptosis proteins are inhibitors of mammalian caspase-9. Proc Natl Acad Sci U S A. 2000 Feb 15; 97(4):1427-32. PMID: 10677478; PMCID: PMC26450.
      179. Zhou Q, Salvesen G. Viral caspase inhibitors CrmA and p35. Methods Enzymol. 2000; 322:143-54. PMID: 10914011.
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      180. Stennicke HR, Salvesen G. Caspase assays. Methods Enzymol. 2000; 322:91-100. PMID: 10914007.
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      182. Deveraux QL, Stennicke HR, Salvesen G, Reed JC. Endogenous inhibitors of caspases. J Clin Immunol. 1999 Nov; 19(6):388-98. PMID: 10634212.
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      183. Salvesen G. Caspase 8: igniting the death machine. Structure. 1999 Oct 15; 7(10):R225-9. PMID: 10545333.
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      184. Deveraux QL, Leo E, Stennicke HR, Welsh K, Salvesen G, Reed JC. Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases. EMBO J. 1999 Oct 01; 18(19):5242-51. PMID: 10508158; PMCID: PMC1171595.
      185. Germain M, Affar EB, D'Amours D, Dixit VM, Salvesen G, Poirier GG. Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7. J Biol Chem. 1999 Oct 01; 274(40):28379-84. PMID: 10497198.
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      186. Salvesen G, Dixit VM. Caspase activation: the induced-proximity model. Proc Natl Acad Sci U S A. 1999 Sep 28; 96(20):10964-7. PMID: 10500109; PMCID: PMC34227.
      187. Wolf BB, Goldstein JC, Stennicke HR, Beere H, Amarante-Mendes GP, Salvesen G, Green DR. Calpain functions in a caspase-independent manner to promote apoptosis-like events during platelet activation. Blood. 1999 Sep 01; 94(5):1683-92. PMID: 10477693.
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      188. Krajewski S, Krajewska M, Ellerby LM, Welsh K, Xie Z, Deveraux QL, Salvesen G, Bredesen DE, Rosenthal RE, Fiskum G, Reed JC. Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia. Proc Natl Acad Sci U S A. 1999 May 11; 96(10):5752-7. PMID: 10318956; PMCID: PMC21932.
      189. Stennicke HR, Salvesen G. Caspases: preparation and characterization. Methods. 1999 Apr; 17(4):313-9. PMID: 10196102.
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      190. Stennicke HR, Deveraux QL, Humke EW, Reed JC, Dixit VM, Salvesen G. Caspase-9 can be activated without proteolytic processing. J Biol Chem. 1999 Mar 26; 274(13):8359-62. PMID: 10085063.
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      191. Ellerby LM, Andrusiak RL, Wellington CL, Hackam AS, Propp SS, Wood JD, Sharp AH, Margolis RL, Ross CA, Salvesen G, Hayden MR, Bredesen DE. Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity. J Biol Chem. 1999 Mar 26; 274(13):8730-6. PMID: 10085113.
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      192. Chou JJ, Li H, Salvesen G, Yuan J, Wagner G. Solution structure of BID, an intracellular amplifier of apoptotic signaling. Cell. 1999 Mar 05; 96(5):615-24. PMID: 10089877.
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      193. Salvesen G. Programmed cell death and the caspases. APMIS. 1999 Jan; 107(1):73-9. PMID: 10190282.
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      194. Ellerby LM, Hackam AS, Propp SS, Ellerby HM, Rabizadeh S, Cashman NR, Trifiro MA, Pinsky L, Wellington CL, Salvesen G, Hayden MR, Bredesen DE. Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity. J Neurochem. 1999 Jan; 72(1):185-95. PMID: 9886069.
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      195. Yang X, Stennicke HR, Wang B, Green DR, Jänicke RU, Srinivasan A, Seth P, Salvesen G, Froelich CJ. Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7. J Biol Chem. 1998 Dec 18; 273(51):34278-83. PMID: 9852092.
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      196. Miyashita T, Nagao K, Krajewski S, Salvesen G, Reed JC, Inoue T, Yamada M. Investigation of glucocorticoid-induced apoptotic pathway: processing of caspase-6 but not caspase-3. Cell Death Differ. 1998 Dec; 5(12):1034-41. PMID: 9894610.
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      197. Cardone MH, Roy N, Stennicke HR, Salvesen G, Franke TF, Stanbridge E, Frisch S, Reed JC. Regulation of cell death protease caspase-9 by phosphorylation. Science. 1998 Nov 13; 282(5392):1318-21. PMID: 9812896.
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      198. Hu S, Snipas SJ, Vincenz C, Salvesen G, Dixit VM. Caspase-14 is a novel developmentally regulated protease. J Biol Chem. 1998 Nov 06; 273(45):29648-53. PMID: 9792675.
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      199. Mehlen P, Rabizadeh S, Snipas SJ, Assa-Munt N, Salvesen G, Bredesen DE. The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis. Nature. 1998 Oct 22; 395(6704):801-4. PMID: 9796814.
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      200. Stennicke HR, Jürgensmeier JM, Shin H, Deveraux Q, Wolf BB, Yang X, Zhou Q, Ellerby HM, Ellerby LM, Bredesen D, Green DR, Reed JC, Froelich CJ, Salvesen G. Pro-caspase-3 is a major physiologic target of caspase-8. J Biol Chem. 1998 Oct 16; 273(42):27084-90. PMID: 9765224.
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      201. Stennicke HR, Salvesen G. Properties of the caspases. Biochim Biophys Acta. 1998 Sep 08; 1387(1-2):17-31. PMID: 9748481.
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      202. Zhou Q, Krebs JF, Snipas SJ, Price A, Alnemri ES, Tomaselli KJ, Salvesen G. Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex. Biochemistry. 1998 Jul 28; 37(30):10757-65. PMID: 9692966.
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      203. Deveraux QL, Roy N, Stennicke HR, Van Arsdale T, Zhou Q, Srinivasula SM, Alnemri ES, Salvesen G, Reed JC. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J. 1998 Apr 15; 17(8):2215-23. PMID: 9545235; PMCID: PMC1170566.
      204. Wellington CL, Ellerby LM, Hackam AS, Margolis RL, Trifiro MA, Singaraja R, McCutcheon K, Salvesen G, Propp SS, Bromm M, Rowland KJ, Zhang T, Rasper D, Roy S, Thornberry N, Pinsky L, Kakizuka A, Ross CA, Nicholson DW, Bredesen DE, Hayden MR. Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract. J Biol Chem. 1998 Apr 10; 273(15):9158-67. PMID: 9535906.
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      205. Takahashi R, Deveraux Q, Tamm I, Welsh K, Assa-Munt N, Salvesen G, Reed JC. A single BIR domain of XIAP sufficient for inhibiting caspases. J Biol Chem. 1998 Apr 03; 273(14):7787-90. PMID: 9525868.
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      206. Amarante-Mendes GP, Finucane DM, Martin SJ, Cotter TG, Salvesen G, Green DR. Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death. Cell Death Differ. 1998 Apr; 5(4):298-306. PMID: 10200475.
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      207. Zapata JM, Takahashi R, Salvesen G, Reed JC. Granzyme release and caspase activation in activated human T-lymphocytes. J Biol Chem. 1998 Mar 20; 273(12):6916-20. PMID: 9506996.
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      208. Muzio M, Stockwell BR, Stennicke HR, Salvesen G, Dixit VM. An induced proximity model for caspase-8 activation. J Biol Chem. 1998 Jan 30; 273(5):2926-30. PMID: 9446604.
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      209. Roy N, Deveraux QL, Takahashi R, Salvesen G, Reed JC. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J. 1997 Dec 01; 16(23):6914-25. PMID: 9384571; PMCID: PMC1170295.
      210. Salvesen G, Dixit VM. Caspases: intracellular signaling by proteolysis. Cell. 1997 Nov 14; 91(4):443-6. PMID: 9390553.
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      211. Stennicke HR, Salvesen G. Biochemical characteristics of caspases-3, -6, -7, and -8. J Biol Chem. 1997 Oct 10; 272(41):25719-23. PMID: 9325297.
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      212. Caulín C, Salvesen G, Oshima RG. Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis. J Cell Biol. 1997 Sep 22; 138(6):1379-94. PMID: 9298992; PMCID: PMC2132555.
      213. Ellerby HM, Martin SJ, Ellerby LM, Naiem SS, Rabizadeh S, Salvesen G, Casiano CA, Cashman NR, Green DR, Bredesen DE. Establishment of a cell-free system of neuronal apoptosis: comparison of premitochondrial, mitochondrial, and postmitochondrial phases. J Neurosci. 1997 Aug 15; 17(16):6165-78. PMID: 9236228; PMCID: PMC3913837.
      214. Cardone MH, Salvesen G, Widmann C, Johnson G, Frisch SM. The regulation of anoikis: MEKK-1 activation requires cleavage by caspases. Cell. 1997 Jul 25; 90(2):315-23. PMID: 9244305.
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      215. Perry DK, Smyth MJ, Stennicke HR, Salvesen G, Duriez P, Poirier GG, Hannun YA. Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis. J Biol Chem. 1997 Jul 25; 272(30):18530-3. PMID: 9228015.
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      216. Deveraux QL, Takahashi R, Salvesen G, Reed JC. X-linked IAP is a direct inhibitor of cell-death proteases. Nature. 1997 Jul 17; 388(6639):300-4. PMID: 9230442.
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      217. Zhou Q, Salvesen G. Activation of pro-caspase-7 by serine proteases includes a non-canonical specificity. Biochem J. 1997 Jun 01; 324 ( Pt 2):361-4. PMID: 9182691; PMCID: PMC1218439.
      218. Zhou Q, Snipas S, Orth K, Muzio M, Dixit VM, Salvesen G. Target protease specificity of the viral serpin CrmA. Analysis of five caspases. J Biol Chem. 1997 Mar 21; 272(12):7797-800. PMID: 9065443.
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      219. Muzio M, Salvesen G, Dixit VM. FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens. J Biol Chem. 1997 Jan 31; 272(5):2952-6. PMID: 9006941.
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      220. Salvesen G. Serpins and programmed cell death. Adv Exp Med Biol. 1997; 425:177-83. PMID: 9433500.
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      221. Koloczek H, Banbula A, Salvesen G, Potempa J. Serpin alpha 1proteinase inhibitor probed by intrinsic tryptophan fluorescence spectroscopy. Protein Sci. 1996 Nov; 5(11):2226-35. PMID: 8931141; PMCID: PMC2143291.
      222. Froelich CJ, Hanna WL, Poirier GG, Duriez PJ, D'Amours D, Salvesen G, Alnemri ES, Earnshaw WC, Shah GM. Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment. Biochem Biophys Res Commun. 1996 Oct 23; 227(3):658-65. PMID: 8885990.
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      223. Alnemri ES, Livingston DJ, Nicholson DW, Salvesen G, Thornberry NA, Wong WW, Yuan J. Human ICE/CED-3 protease nomenclature. Cell. 1996 Oct 18; 87(2):171. PMID: 8861900.
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      224. Orth K, O'Rourke K, Salvesen G, Dixit VM. Molecular ordering of apoptotic mammalian CED-3/ICE-like proteases. J Biol Chem. 1996 Aug 30; 271(35):20977-80. PMID: 8702858.
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      225. Komiyama T, Grøn H, Pemberton PA, Salvesen G. Interaction of subtilisins with serpins. Protein Sci. 1996 May; 5(5):874-82. PMID: 8732759; PMCID: PMC2143405.
      226. Quan LT, Tewari M, O'Rourke K, Dixit V, Snipas SJ, Poirier GG, Ray C, Pickup DJ, Salvesen G. Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B. Proc Natl Acad Sci U S A. 1996 Mar 05; 93(5):1972-6. PMID: 8700869; PMCID: PMC39893.
      227. Komiyama T, Quan LT, Salvesen G. Inhibition of cysteine and serine proteinases by the cowpox virus serpin CRMA. Adv Exp Med Biol. 1996; 389:173-6. PMID: 8861008.
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      228. Tewari M, Quan LT, O'Rourke K, Desnoyers S, Zeng Z, Beidler DR, Poirier GG, Salvesen G, Dixit VM. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell. 1995 Jun 02; 81(5):801-9. PMID: 7774019.
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      229. Quan LT, Caputo A, Bleackley RC, Pickup DJ, Salvesen G. Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A. J Biol Chem. 1995 May 05; 270(18):10377-9. PMID: 7737968.
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      230. Falkenberg C, Allhorn M, Thøgersen IB, Valnickova Z, Pizzo SV, Salvesen G, Akerström B, Enghild JJ. alpha 1-Microglobulin destroys the proteinase inhibitory activity of alpha 1-inhibitor-3 by complex formation. J Biol Chem. 1995 Mar 03; 270(9):4478-83. PMID: 7533162.
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      231. Falkenberg C, Enghild JJ, Thøgersen IB, Salvesen G, Akerström B. Isolation and characterization of fibronectin-alpha 1-microglobulin complex in rat plasma. Biochem J. 1994 Aug 01; 301 ( Pt 3):745-51. PMID: 7519849; PMCID: PMC1137050.
      232. Komiyama T, Ray CA, Pickup DJ, Howard AD, Thornberry NA, Peterson EP, Salvesen G. Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition. J Biol Chem. 1994 Jul 29; 269(30):19331-7. PMID: 8034697.
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      233. Strittmatter WJ, Weisgraber KH, Huang DY, Dong LM, Salvesen G, Pericak-Vance M, Schmechel D, Saunders AM, Goldgaber D, Roses AD. Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proc Natl Acad Sci U S A. 1993 Sep 01; 90(17):8098-102. PMID: 8367470; PMCID: PMC47295.
      234. Enghild JJ, Valnickova Z, Thøgersen IB, Pizzo SV, Salvesen G. An examination of the inhibitory mechanism of serpins by analysing the interaction of trypsin and chymotrypsin with alpha 2-antiplasmin. Biochem J. 1993 May 01; 291 ( Pt 3):933-8. PMID: 7683878; PMCID: PMC1132459.
      235. Enghild JJ, Salvesen G, Thøgersen IB, Valnickova Z, Pizzo SV, Hefta SA. Presence of the protein-glycosaminoglycan-protein covalent cross-link in the inter-alpha-inhibitor-related proteinase inhibitor heavy chain 2/bikunin. J Biol Chem. 1993 Apr 25; 268(12):8711-6. PMID: 7682553.
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      236. Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen G, Roses AD. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci U S A. 1993 Mar 01; 90(5):1977-81. PMID: 8446617; PMCID: PMC46003.
      237. Salvesen G, Enghild JJ. alpha-Macroglobulins: detection and characterization. Methods Enzymol. 1993; 223:121-41. PMID: 7505874.
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      238. Salvesen G, Quan LT, Enghild JJ, Snipas S, Fey GH, Pizzo SV. Expression of a functional alpha-macroglobulin receptor binding domain in Escherichia coli. FEBS Lett. 1992 Nov 23; 313(2):198-202. PMID: 1385222.
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      239. Thøgersen IB, Salvesen G, Brucato FH, Pizzo SV, Enghild JJ. Purification and characterization of an alpha-macroglobulin proteinase inhibitor from the mollusc Octopus vulgaris. Biochem J. 1992 Jul 15; 285 ( Pt 2):521-7. PMID: 1379044; PMCID: PMC1132819.
      240. Ray CA, Black RA, Kronheim SR, Greenstreet TA, Sleath PR, Salvesen G, Pickup DJ. Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme. Cell. 1992 May 15; 69(4):597-604. PMID: 1339309.
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      241. Mast AE, Enghild JJ, Salvesen G. Conformation of the reactive site loop of alpha 1-proteinase inhibitor probed by limited proteolysis. Biochemistry. 1992 Mar 17; 31(10):2720-8. PMID: 1547212.
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      242. Nagase H, Suzuki K, Morodomi T, Enghild JJ, Salvesen G. Activation mechanisms of the precursors of matrix metalloproteinases 1, 2 and 3. Matrix Suppl. 1992; 1:237-44. PMID: 1480033.
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      243. Mast AE, Enghild JJ, Nagase H, Suzuki K, Pizzo SV, Salvesen G. Kinetics and physiologic relevance of the inactivation of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, and antithrombin III by matrix metalloproteinases-1 (tissue collagenase), -2 (72-kDa gelatinase/type IV collagenase), and -3 (stromelysin). J Biol Chem. 1991 Aug 25; 266(24):15810-6. PMID: 1651920.
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      244. Nagase H, Ogata Y, Suzuki K, Enghild JJ, Salvesen G. Substrate specificities and activation mechanisms of matrix metalloproteinases. Biochem Soc Trans. 1991 Aug; 19(3):715-8. PMID: 1783204.
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      245. Mast AE, Enghild JJ, Pizzo SV, Salvesen G. Analysis of the plasma elimination kinetics and conformational stabilities of native, proteinase-complexed, and reactive site cleaved serpins: comparison of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, antithrombin III, alpha 2-antiplasmin, angiotensinogen, and ovalbumin. Biochemistry. 1991 Feb 12; 30(6):1723-30. PMID: 1704258.
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      246. Enghild JJ, Salvesen G, Hefta SA, Thøgersen IB, Rutherfurd S, Pizzo SV. Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor. J Biol Chem. 1991 Jan 15; 266(2):747-51. PMID: 1898736.
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      247. Salvesen G, Enghild JJ. Zymogen activation specificity and genomic structures of human neutrophil elastase and cathepsin G reveal a new branch of the chymotrypsinogen superfamily of serine proteinases. Biomed Biochim Acta. 1991; 50(4-6):665-71. PMID: 1801740.
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      248. Nagase H, Suzuki K, Enghild JJ, Salvesen G. Stepwise activation mechanisms of the precursors of matrix metalloproteinases 1 (tissue collagenase) and 3 (stromelysin). Biomed Biochim Acta. 1991; 50(4-6):749-54. PMID: 1666284.
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      249. Okada Y, Morodomi T, Enghild JJ, Suzuki K, Yasui A, Nakanishi I, Salvesen G, Nagase H. Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts. Purification and activation of the precursor and enzymic properties. Eur J Biochem. 1990 Dec 27; 194(3):721-30. PMID: 2269296.
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      250. Suzuki K, Enghild JJ, Morodomi T, Salvesen G, Nagase H. Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (stromelysin). Biochemistry. 1990 Nov 06; 29(44):10261-70. PMID: 2176865.
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      251. Enghild JJ, Thøgersen IB, Salvesen G, Fey GH, Figler NL, Gonias SL, Pizzo SV. Alpha-macroglobulin from Limulus polyphemus exhibits proteinase inhibitory activity and participates in a hemolytic system. Biochemistry. 1990 Oct 30; 29(43):10070-80. PMID: 1703001.
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      252. Mast AE, Salvesen G, Schnebli HP, Pizzo SV. Evaluation of the rapid plasma elimination of recombinant alpha 1-proteinase inhibitor: synthesis of polyethylene glycol conjugates with improved therapeutic potential. J Lab Clin Med. 1990 Jul; 116(1):58-65. PMID: 2376698.
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      253. Nagase H, Enghild JJ, Suzuki K, Salvesen G. Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl)mercuric acetate. Biochemistry. 1990 Jun 19; 29(24):5783-9. PMID: 2383557.
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      254. Salvesen G, Enghild JJ. An unusual specificity in the activation of neutrophil serine proteinase zymogens. Biochemistry. 1990 Jun 05; 29(22):5304-8. PMID: 2383548.
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      255. Mast AE, Salvesen G, Brucato FH, Schnebli HP, Pizzo SV. Polyethylene glycol modification of serpins improves therapeutic potential. Biol Chem Hoppe Seyler. 1990 May; 371 Suppl:101-9. PMID: 2400571.
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      256. Suzuki K, Nagase H, Ito A, Enghild JJ, Salvesen G. The role of matrix metalloproteinase 3 in the stepwise activation of human rheumatoid synovial procollagenase. Biol Chem Hoppe Seyler. 1990 May; 371 Suppl:305-10. PMID: 2169257.
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      257. Gebhard W, Hochstrasser K, Fritz H, Enghild JJ, Pizzo SV, Salvesen G. Structure of inter-alpha-inhibitor (inter-alpha-trypsin inhibitor) and pre-alpha-inhibitor: current state and proposition of a new terminology. Biol Chem Hoppe Seyler. 1990 May; 371 Suppl:13-22. PMID: 1698066.
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      258. Enghild JJ, Thøgersen IB, Pizzo SV, Salvesen G. Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan. J Biol Chem. 1989 Sep 25; 264(27):15975-81. PMID: 2476436.
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      259. Hohn PA, Popescu NC, Hanson RD, Salvesen G, Ley TJ. Genomic organization and chromosomal localization of the human cathepsin G gene. J Biol Chem. 1989 Aug 15; 264(23):13412-9. PMID: 2569462.
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      260. Enghild JJ, Salvesen G, Thøgersen IB, Pizzo SV. Proteinase binding and inhibition by the monomeric alpha-macroglobulin rat alpha 1-inhibitor-3. J Biol Chem. 1989 Jul 05; 264(19):11428-35. PMID: 2472396.
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      261. Farley D, Travis J, Salvesen G. The human neutrophil elastase gene. Analysis of the nucleotide sequence reveals three distinct classes of repetitive DNA. Biol Chem Hoppe Seyler. 1989 Jul; 370(7):737-44. PMID: 2775493.
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      262. Enghild JJ, Salvesen G, Brew K, Nagase H. Interaction of human rheumatoid synovial collagenase (matrix metalloproteinase 1) and stromelysin (matrix metalloproteinase 3) with human alpha 2-macroglobulin and chicken ovostatin. Binding kinetics and identification of matrix metalloproteinase cleavage sites. J Biol Chem. 1989 May 25; 264(15):8779-85. PMID: 2470748.
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      263. Pizzo SV, Mast AE, Feldman SR, Salvesen G. In vivo catabolism of alpha 1-antichymotrypsin is mediated by the Serpin receptor which binds alpha 1-proteinase inhibitor, antithrombin III and heparin cofactor II. Biochim Biophys Acta. 1988 Nov 17; 967(2):158-62. PMID: 3263884.
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      264. Roche PA, Salvesen G, Pizzo SV. Symmetry of the inhibitory unit of human alpha 2-macroglobulin. Biochemistry. 1988 Oct 04; 27(20):7876-81. PMID: 2462911.
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      265. Farley D, Salvesen G, Travis J. Molecular cloning of human neutrophil elastase. Biol Chem Hoppe Seyler. 1988 May; 369 Suppl:3-7. PMID: 2462434.
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      266. Watorek W, Farley D, Salvesen G, Travis J. Neutrophil elastase and cathepsin G: structure, function, and biological control. Adv Exp Med Biol. 1988; 240:23-31. PMID: 3266707.
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      267. Müller-Esterl W, Johnson DA, Salvesen G, Barrett AJ. Human kininogens. Methods Enzymol. 1988; 163:240-56. PMID: 3237076.
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      268. Johnson DA, Salvesen G, Brown MA, Barrett AJ. Rapid isolation of human kininogens. Thromb Res. 1987 Oct 15; 48(2):187-93. PMID: 3122358.
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      269. Salvesen G, Farley D, Shuman J, Przybyla A, Reilly C, Travis J. Molecular cloning of human cathepsin G: structural similarity to mast cell and cytotoxic T lymphocyte proteinases. Biochemistry. 1987 Apr 21; 26(8):2289-93. PMID: 3304423.
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