Yujiro Hirose

Title(s)Postdoctoral Scholar, Pediatrics
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0001-6338-4767 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Hokkaido University Faculty of Dentistry, Sapporo, Hokkaido, JapanD. D. S03/2010Dentistry
    Nagoya University Graduate School of Medicine, Nagoya, Aichi, JapanPh. D.03/2016Medicine
    Collapse Awards and Honors
    Scholarship from Iwadare Scholarship Foundation2015  - 2016Iwadare Scholarship
    Japan Society for the Promotion of Science2016  - 2017Research Fellowship for Young Scientist
    Japan Society for the Promotion of Science2020  - 2022Overseas Research Fellowships

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Elucidation of the pathogenesis of necrotizing fasciitis caused by Streptococcus pyogenes
    Japan Society for the Promotion of Science 20K18474Apr 1, 2020 - Mar 31, 2022
    Role: Co-Investigator
    Investigation of cell surface proteins involved in the blood-brain barrier breakthrough of Streptococcus pneumoniae and elucidation of the breakthrough mechanism
    Sasakawa Scientific Research Grant from the Japan Science Society 2018-4001Apr 1, 2018 - Mar 31, 2019
    Role: Co-Investigator
    Analysis of the role of the interaction between Streptococcus pneumoniae and glycosaminoglycan in inflammatory response and infection establishment
    Japan Society for the Promotion of Science 17K11666Apr 1, 2017 - Mar 31, 2020
    Role: Co-Investigator
    Elucidation of the blood-brain barrier breakthrough mechanism by Streptococcus pneumoniae
    Japan Society for the Promotion of Science 16J02607Apr 1, 2016 - Mar 31, 2017
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pneumococcal BgaA Promotes Host Organ Bleeding and Coagulation in a Mouse Sepsis Model. Front Cell Infect Microbiol. 2022; 12:844000. Takemura M, Yamaguchi M, Kobayashi M, Sumitomo T, Hirose Y, Okuzaki D, Ono M, Motooka D, Goto K, Nakata M, Uzawa N, Kawabata S. PMID: 35846740; PMCID: PMC9284207.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. An M protein coiled coil unfurls and exposes its hydrophobic core to capture LL-37. Elife. 2022 06 21; 11. Kolesinski P, Wang KC, Hirose Y, Nizet V, Ghosh P. PMID: 35726694.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Contribution of Streptococcus pyogenes M87 protein to innate immune resistance and virulence. Microb Pathog. 2022 Jun 17; 105636. Hirose Y, Kolesinski P, Hiraoka M, Uchiyama S, Zurich RH, Kumaraswamy M, Bjanes E, Ghosh P, Kawabata S, Nizet V. PMID: 35724830.
      View in: PubMed   Mentions:    Fields:    
    4. Streptococcus pyogenes upregulates arginine catabolism to exert its pathogenesis on the skin surface. Cell Rep. 2021 03 30; 34(13):108924. Hirose Y, Yamaguchi M, Sumitomo T, Nakata M, Hanada T, Okuzaki D, Motooka D, Mori Y, Kawasaki H, Coady A, Uchiyama S, Hiraoka M, Zurich RH, Amagai M, Nizet V, Kawabata S. PMID: 33789094; PMCID: PMC9214650.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    5. Epidemiological Analysis of Pneumococcal Strains Isolated at Yangon Children's Hospital in Myanmar via Whole-genome Sequencing-based Methods. Microb. Genomics. 2021; (In press). Yamaguchi M., Myo Win H. P., Higashi K., Ono M., Hirose Y., Motooka D., Okuzaki D., Aye M. M., Htun M. M., Thu H. M., Kawabata S.
    6. Streptococcus pyogenes upregulates arginine catabolism to exert its pathogenesis on the skin surface. Cell Rep. 2021; (In press). Hirose Y., Yamaguchi M., Sumitomo T., Nakata M., Hanada T., Okuzaki D., Motooka D., Mori Y., Kawasaki H., Coady A., Uchiyama S., Hiraoka M., Zurich R.H., Amagai M., Nizet V., Kawabata S.
    7. Genetic characterization of Streptococcus pyogenes emm89 strains isolated in Japan from 2011 to 2019. Infect. Microbe Dis. 2021; 4(2):160-166. Hirose Y., Yamaguchi M., Takemoto N., Miyoshi-Akiyama T., Sumitomo T., Nakata M., Ikebe T., Hanada T., Yamaguchi T., Kawahara R., Okuno R., Otsuka H., Matsumoto Y., Terashima Y., Kazawa Y., Nakanishi N., Uchida K., Akiyama Y., Iwabuchi K., Nakagawa C., Yamamoto K., Nizet V., Kawabata S. View Publication.
    8. Epidemiological analysis of pneumococcal strains isolated at Yangon Children's Hospital in Myanmar via whole-genome sequencing-based methods. Microb Genom. 2021 02; 7(2). Yamaguchi M, Win HPM, Higashi K, Ono M, Hirose Y, Motooka D, Okuzaki D, Aye MM, Htun MM, Thu HM, Kawabata S. PMID: 33565958; PMCID: PMC8208701.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    9. Role of BgaA as a Pneumococcal Virulence Factor Elucidated by Molecular Evolutionary Analysis. Front Microbiol. 2020; 11:582437. Yamaguchi M, Takemura M, Higashi K, Goto K, Hirose Y, Sumitomo T, Nakata M, Uzawa N, Kawabata S. PMID: 33072054; PMCID: PMC7541833.
      View in: PubMed   Mentions: 3  
    10. Performance of a Biodegradable Composite with Hydroxyapatite as a Scaffold in Pulp Tissue Repair. Polymers (Basel). 2020 Apr 17; 12(4). Okamoto M, Matsumoto S, Sugiyama A, Kanie K, Watanabe M, Huang H, Ali M, Ito Y, Miura J, Hirose Y, Uto K, Ebara M, Kato R, Yamawaki-Ogata A, Narita Y, Kawabata S, Takahashi Y, Hayashi M. PMID: 32316615; PMCID: PMC7240495.
      View in: PubMed   Mentions: 2  
    11. Streptococcal H2O2 inhibits IgE-triggered degranulation of RBL-2H3 mast cell/basophil cell line by inducing cell death. PLoS One. 2020; 15(4):e0231101. Okahashi N, Nakata M, Hirose Y, Morisaki H, Kataoka H, Kuwata H, Kawabata S. PMID: 32302339; PMCID: PMC7164662.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    12. Streptococcus pyogenes Transcriptome Changes in the Inflammatory Environment of Necrotizing Fasciitis. Appl Environ Microbiol. 2019 11 01; 85(21). Hirose Y, Yamaguchi M, Okuzaki D, Motooka D, Hamamoto H, Hanada T, Sumitomo T, Nakata M, Kawabata S. PMID: 31471300; PMCID: PMC6803311.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    13. Surface Pre-Reacted Glass Filler Contributes to Tertiary Dentin Formation through a Mechanism Different Than That of Hydraulic Calcium-Silicate Cement. J Clin Med. 2019 Sep 11; 8(9). Okamoto M, Ali M, Komichi S, Watanabe M, Huang H, Ito Y, Miura J, Hirose Y, Mizuhira M, Takahashi Y, Okuzaki D, Kawabata S, Imazato S, Hayashi M. PMID: 31514356; PMCID: PMC6780685.
      View in: PubMed   Mentions: 3  
    14. Streptococcus pneumoniae Evades Host Cell Phagocytosis and Limits Host Mortality Through Its Cell Wall Anchoring Protein PfbA. Front Cell Infect Microbiol. 2019; 9:301. Yamaguchi M, Hirose Y, Takemura M, Ono M, Sumitomo T, Nakata M, Terao Y, Kawabata S. PMID: 31482074; PMCID: PMC6710382.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    15. Identification of evolutionarily conserved virulence factor by selective pressure analysis of Streptococcus pneumoniae. Commun Biol. 2019; 2:96. Yamaguchi M, Goto K, Hirose Y, Yamaguchi Y, Sumitomo T, Nakata M, Nakano K, Kawabata S. PMID: 30886906; PMCID: PMC6408437.
      View in: PubMed   Mentions: 15  Translation:Cells
    16. Comparison of trophic factors secreted from human adipose-derived stromal vascular fraction with those from adipose-derived stromal/stem cells in the same individuals. Cytotherapy. 2018 04; 20(4):589-591. Hirose Y, Funahashi Y, Matsukawa Y, Majima T, Yamaguchi M, Kawabata S, Gotoh M, Yamamoto T. PMID: 29503101.
      View in: PubMed   Mentions: 4     Fields:    
    17. Composition of salivary microbiota in elderly subjects. Sci Rep. 2018 01 11; 8(1):414. Ogawa T, Hirose Y, Honda-Ogawa M, Sugimoto M, Sasaki S, Kibi M, Kawabata S, Ikebe K, Maeda Y. PMID: 29323208; PMCID: PMC5765146.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    18. Competence-induced protein Ccs4 facilitates pneumococcal invasion into brain tissue and virulence in meningitis. Virulence. 2018; 9(1):1576-1587. Hirose Y, Yamaguchi M, Goto K, Sumitomo T, Nakata M, Kawabata S. PMID: 30251911; PMCID: PMC6177246.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    19. Zinc metalloproteinase ZmpC suppresses experimental pneumococcal meningitis by inhibiting bacterial invasion of central nervous systems. Virulence. 2017 11 17; 8(8):1516-1524. Yamaguchi M, Nakata M, Sumioka R, Hirose Y, Wada S, Akeda Y, Sumitomo T, Kawabata S. PMID: 28489958; PMCID: PMC5810488.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    20. Evolutionary inactivation of a sialidase in group B Streptococcus. Sci Rep. 2016 06 29; 6:28852. Yamaguchi M, Hirose Y, Nakata M, Uchiyama S, Yamaguchi Y, Goto K, Sumitomo T, Lewis AL, Kawabata S, Nizet V. PMID: 27352769; PMCID: PMC4926279.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    21. Therapeutic Potential of Dental Pulp Stem Cell Secretome for Alzheimer's Disease Treatment: An In Vitro Study. Stem Cells Int. 2016; 2016:8102478. Ahmed Nel-M, Murakami M, Hirose Y, Nakashima M. PMID: 27403169; PMCID: PMC4923581.
      View in: PubMed   Mentions: 30  
    22. Effects of Extracellular pH on Dental Pulp Cells In Vitro. J Endod. 2016 May; 42(5):735-41. Hirose Y, Yamaguchi M, Kawabata S, Murakami M, Nakashima M, Gotoh M, Yamamoto T. PMID: 26951958.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    23. Injection of Dental Pulp Stem Cells Promotes Healing of Damaged Bladder Tissue in a Rat Model of Chemically Induced Cystitis. Cell Transplant. 2016; 25(3):425-36. Hirose Y, Yamamoto T, Nakashima M, Funahashi Y, Matsukawa Y, Yamaguchi M, Kawabata S, Gotoh M. PMID: 26395427.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    24. Trophic Effects and Regenerative Potential of Mobilized Mesenchymal Stem Cells From Bone Marrow and Adipose Tissue as Alternative Cell Sources for Pulp/Dentin Regeneration. Cell Transplant. 2015; 24(9):1753-65. Murakami M, Hayashi Y, Iohara K, Osako Y, Hirose Y, Nakashima M. PMID: 25199044.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
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