 Yuan Chen
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| Title(s) | Professor, Surgery |
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| School | Vc-health Sciences-schools |
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| Address | 9500 Gilman Drive #
La Jolla CA 92093
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| vCard | Download vCard |
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 Biography | Rutgers University, New Jersey | Ph.D. | 12/1991 | Biochemistry | | The Scripps Research Institute, La Jolla, CA | post-doctoral training | 11/1993 | Structural and Molecular Biology |
Overview The long-term objective of the Chen laboratory is to identify novel mechanisms that can be targeted for developing innovative treatments for cancer and other recalcitrant human diseases. Their research focus for two decades has been on ubiquitin-like (Ubl) modifications, the regulation of which influences major oncogenic pathways and anti-tumor immunity. Even though more than 1000 enzymes/proteins are involved, Ubl modifications have been poorly addressed by FDA approved drugs, and thus are an untapped resource for new therapeutic development. The Chen laboratory has made major contributions to the discovery of new chemical and biochemical approaches to target Ubl modifications and to the elucidation of small ubiquitin-like modification (SUMO)-mediated cellular regulatory mechanisms. Her research program is transdisciplinary involving collaborations with other academic laboratories, clinicians and biotech industry.
Research Bibliographic
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Allosteric Inhibition of Ubiquitin-like Modifications by a Class of Inhibitor of SUMO-Activating Enzyme. Cell Chem Biol. 2019 02 21; 26(2):278-288.e6.
Li YJ, Du L, Wang J, Vega R, Lee TD, Miao Y, Aldana-Masangkay G, Samuels ER, Li B, Ouyang SX, Colayco SA, Bobkova EV, Divlianska DB, Sergienko E, Chung TDY, Fakih M, Chen Y. PMID: 30581133.
View in: PubMed Mentions: Fields: Translation: HumansAnimalsCells
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Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme. Nat Commun. 2018 12 04; 9(1):5145.
Lv Z, Yuan L, Atkison JH, Williams KM, Vega R, Sessions EH, Divlianska DB, Davies C, Chen Y, Olsen SK. PMID: 30514846.
View in: PubMed Mentions: 1 Fields: Translation: HumansCells
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Sumoylation of ROR?t regulates TH17 differentiation and thymocyte development. Nat Commun. 2018 11 19; 9(1):4870.
He Z, Zhang J, Huang Z, Du Q, Li N, Zhang Q, Chen Y, Sun Z. PMID: 30451821.
View in: PubMed Mentions: 1 Fields: Translation: AnimalsCells
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Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal. Nat Commun. 2016 07 28; 7:12326.
Du L, Li YJ, Fakih M, Wiatrek RL, Duldulao M, Chen Z, Chu P, Garcia-Aguilar J, Chen Y. PMID: 27465491.
View in: PubMed Mentions: 16 Fields: Translation: HumansAnimalsCells
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Identification of a SUMO-binding motif that recognizes SUMO-modified proteins. Proc Natl Acad Sci U S A. 2004 Oct 05; 101(40):14373-8.
Song J, Durrin LK, Wilkinson TA, Krontiris TG, Chen Y. PMID: 15388847.
View in: PubMed Mentions: 227 Fields: Translation: HumansCells
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| Year | Publications |
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| 2004 | 1 | | 2016 | 1 | | 2018 | 3 |
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