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Xingyu Wu

Title(s)Assistant Project Scientist, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer. Cancer Res. 2025 Aug 15; 85(16):3032-3051. Koshizuka K, Wu X, Sato K, Vo PTT, Murawska GM, Ishikawa T, Wang Z, Molinolo AA, Dennis EA, Nathan CO, Mali P, Gutkind JS. PMID: 40479615; PMCID: PMC12327062.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Targeting YAP/TAZ-TEAD signaling as a therapeutic approach in head and neck squamous cell carcinoma. Cancer Lett. 2025 Mar 01; 612:217467. Sato K, Faraji F, Cervantes-Villagrana RD, Wu X, Koshizuka K, Ishikawa T, Iglesias-Bartolome R, Chen L, Miliani de Marval PL, Gwaltney SL, Adler B, Gutkind JS. PMID: 39826667; PMCID: PMC12044704.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    3. Oncogenic HRAS Induces Metformin Resistance in Head and Neck Cancer by Promoting Glycolytic Metabolism. Cancer Prev Res (Phila). 2024 Dec 03; 17(12):571-583. Wu X, Adame-Garcia SR, Koshizuka K, Vo PTT, Hoang TS, Sato K, Izumi H, Goto Y, Allevato MM, Wood KC, Lippman SM, Gutkind JS. PMID: 39463147; PMCID: PMC11969736.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. A genome-wide CRISPR screen reveals that antagonism of glutamine metabolism sensitizes head and neck squamous cell carcinoma to ferroptotic cell death. Cancer Lett. 2024 Aug 28; 598:217089. Allevato MM, Trinh S, Koshizuka K, Nachmanson D, Nguyen TC, Yokoyama Y, Wu X, Andres A, Wang Z, Watrous J, Molinolo AA, Mali P, Harismendy O, Jain M, Wild R, Gutkind JS. PMID: 38964731; PMCID: PMC12278720.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    5. A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC. Cancer Res Commun. 2024 07 01; 4(7):1850-1862. Goto Y, Koshizuka K, Ando T, Izumi H, Wu X, Sato K, Ishikawa T, Ford K, Feng X, Wang Z, Arang N, Allevato MM, Kishore A, Mali P, Gutkind JS. PMID: 38954773; PMCID: PMC11284272.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. Gαs is dispensable for β-arrestin coupling but dictates GRK selectivity and is predominant for gene expression regulation by β2-adrenergic receptor. J Biol Chem. 2023 11; 299(11):105293. Burghi V, Paradis JS, Officer A, Adame-Garcia SR, Wu X, Matthees ESF, Barsi-Rhyne B, Ramms DJ, Clubb L, Acosta M, Tamayo P, Bouvier M, Inoue A, von Zastrow M, Hoffmann C, Gutkind JS. PMID: 37774973; PMCID: PMC10641165.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    7. Inhibition of mTOR signaling and clinical activity of metformin in oral premalignant lesions. JCI Insight. 2021 09 08; 6(17). Gutkind JS, Molinolo AA, Wu X, Wang Z, Nachmanson D, Harismendy O, Alexandrov LB, Wuertz BR, Ondrey FG, Laronde D, Rock LD, Rosin M, Coffey C, Butler VD, Bengtson L, Hsu CH, Bauman JE, Hewitt SM, Cohen EE, Chow HS, Lippman SM, Szabo E. PMID: 34255745; PMCID: PMC8492350.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCellsCTClinical Trials
    8. Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma. Clin Cancer Res. 2021 06 01; 27(11):3190-3200. Paradis JS, Acosta M, Saddawi-Konefka R, Kishore A, Gomes F, Arang N, Tiago M, Coma S, Lubrano S, Wu X, Ford K, Day CP, Merlino G, Mali P, Pachter JA, Sato T, Aplin AE, Gutkind JS. PMID: 33568347; PMCID: PMC8895627.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    9. Pathway-Specific Genome Editing of PI3K/mTOR Tumor Suppressor Genes Reveals that PTEN Loss Contributes to Cetuximab Resistance in Head and Neck Cancer. Mol Cancer Ther. 2020 07; 19(7):1562-1571. Izumi H, Wang Z, Goto Y, Ando T, Wu X, Zhang X, Li H, Johnson DE, Grandis JR, Gutkind JS. PMID: 32430488; PMCID: PMC7357849.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    10. 4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer. Cancer Res. 2019 04 01; 79(7):1438-1450. Wang Z, Feng X, Molinolo AA, Martin D, Vitale-Cross L, Nohata N, Ando M, Wahba A, Amornphimoltham P, Wu X, Gilardi M, Allevato M, Wu V, Steffen DJ, Tofilon P, Sonenberg N, Califano J, Chen Q, Lippman SM, Gutkind JS. PMID: 30894372; PMCID: PMC6445709.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    11. Interaction Landscape of Inherited Polymorphisms with Somatic Events in Cancer. Cancer Discov. 2017 04; 7(4):410-423. Carter H, Marty R, Hofree M, Gross AM, Jensen J, Fisch KM, Wu X, DeBoever C, Van Nostrand EL, Song Y, Wheeler E, Kreisberg JF, Lippman SM, Yeo GW, Gutkind JS, Ideker T. PMID: 28188128; PMCID: PMC5460679.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
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