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Xiaohua Huang

Title(s)Associate Professor, Bioengineering
SchoolAcademic Aff
Phone858-822-2155
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    Collapse Research 
    Collapse Research Activities and Funding
    Technology for measuring telomere length of individual chromosomes of single cancer cells
    NIH/NCI R21CA223727Mar 1, 2019 - Feb 28, 2021
    Role: Principal Investigator
    Nanopore Direct Single-Molecule Protein Sequencing
    NIH/NIGMS R01GM126013Aug 1, 2018 - Apr 30, 2022
    Role: Principal Investigator
    Single-stranded sequencing using microfluidic reactors (SISSOR)
    NIH/NHGRI R01HG007836Aug 1, 2014 - May 31, 2018
    Role: Principal Investigator
    Direct real-time single molecule DNA sequencing
    NIH/NHGRI R21HG005096Sep 1, 2010 - Jun 30, 2013
    Role: Principal Investigator
    Genome Sequencing by Natural DNA Synthesis on Amplified DNA Clones
    NIH/NHGRI R01HG004804Aug 19, 2008 - May 31, 2012
    Role: Principal Investigator
    Genome Sequencing by Ligation Using Nano-Arrays of Single DNA Molecules
    NIH/NHGRI R21HG004130Sep 29, 2006 - Sep 30, 2009
    Role: Principal Investigator
    Massively Parallel Cloning and Sequencing of DNA
    NIH/NHGRI R21HG003587Aug 1, 2005 - May 31, 2008
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Song Y, Kim S, Heller MJ, Huang X. DNA multi-bit non-volatile memory and bit-shifting operations using addressable electrode arrays and electric field-induced hybridization. Nat Commun. 2018 01 18; 9(1):281. PMID: 29348493.
      View in: PubMed
    2. Walsh MT, Huang X. Measurement of incorporation kinetics of non-fluorescent native nucleotides by DNA polymerases using fluorescence microscopy. Nucleic Acids Res. 2017 Dec 01; 45(21):e175. PMID: 29036327.
      View in: PubMed
    3. Chu WK, Edge P, Lee HS, Bansal V, Bafna V, Huang X, Zhang K. Ultraaccurate genome sequencing and haplotyping of single human cells. Proc Natl Acad Sci U S A. 2017 11 21; 114(47):12512-12517. PMID: 29078313.
      View in: PubMed
    4. Walsh MT, Hsiao AP, Lee HS, Liu Z, Huang X. Capture and enumeration of mRNA transcripts from single cells using a microfluidic device. Lab Chip. 2015 Jul 21; 15(14):2968-80. PMID: 26040942.
      View in: PubMed
    5. Walsh MT, Roller EE, Ko KS, Huang X. Measurement of DNA Polymerase Incorporation Kinetics of Dye-Labeled Nucleotides Using Total Internal Reflection Fluorescence Microscopy. Biochemistry. 2015 Jul 07; 54(26):4019-21. PMID: 26096371.
      View in: PubMed
    6. Lee HS, Chu WK, Zhang K, Huang X. Microfluidic devices with permeable polymer barriers for capture and transport of biomolecules and cells. Lab Chip. 2013 Sep 07; 13(17):3389-97. PMID: 23828542; PMCID: PMC3818112.
      View in: PubMed, PubMed Central
    7. Joneja A, Huang X. Linear nicking endonuclease-mediated strand-displacement DNA amplification. Anal Biochem. 2011 Jul 01; 414(1):58-69. PMID: 21342654.
      View in: PubMed
    8. Barbee KD, Chandrangsu M, Huang X. Fabrication of DNA polymer brush arrays by destructive micropatterning and rolling-circle amplification. Macromol Biosci. 2011 May 12; 11(5):607-17. PMID: 21305694; PMCID: PMC3092525.
      View in: PubMed, PubMed Central
    9. Barbee KD, Hsiao AP, Roller EE, Huang X. Multiplexed protein detection using antibody-conjugated microbead arrays in a microfabricated electrophoretic device. Lab Chip. 2010 Nov 21; 10(22):3084-93. PMID: 20820631; PMCID: PMC3092535.
      View in: PubMed, PubMed Central
    10. Hsiao AP, Barbee KD, Huang X. Microfluidic Device for Capture and Isolation of Single Cells. Proc SPIE Int Soc Opt Eng. 2010 Aug 01; 7759. PMID: 21614137.
      View in: PubMed
    11. Chen YJ, Roller EE, Huang X. DNA sequencing by denaturation: experimental proof of concept with an integrated fluidic device. Lab Chip. 2010 May 07; 10(9):1153-9. PMID: 20390134; PMCID: PMC2881221.
      View in: PubMed, PubMed Central
    12. Barbee KD, Hsiao AP, Heller MJ, Huang X. Electric field directed assembly of high-density microbead arrays. Lab Chip. 2009 Nov 21; 9(22):3268-74. PMID: 19865735.
      View in: PubMed
    13. Joneja A, Huang X. A device for automated hydrodynamic shearing of genomic DNA. Biotechniques. 2009 Jun; 46(7):553-6. PMID: 19594456.
      View in: PubMed
    14. Chen YJ, Huang X. DNA sequencing by denaturation: principle and thermodynamic simulations. Anal Biochem. 2009 Jan 01; 384(1):170-9. PMID: 18930015; PMCID: PMC2621085.
      View in: PubMed, PubMed Central
    15. Barbee KD, Huang X. Magnetic assembly of high-density DNA arrays for genomic analyses. Anal Chem. 2008 Mar 15; 80(6):2149-54. PMID: 18260655.
      View in: PubMed
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