William Cain

Title(s)Emeritus Professor, Surgery
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Human Sensory Irritation From Volitile Organic Compounds
    NIH R01DC005602Aug 4, 2003 - Jul 31, 2008
    Role: Principal Investigator
    CLINICAL OLFACTORY PSYCHOPHYSICS
    NIH R01DC000284Dec 1, 1984 - Mar 31, 2001
    Role: Principal Investigator
    CLINICAL OLFACTORY PSYCHOPHYSICS
    NIH R01NS021644Dec 1, 1984 - Nov 30, 1991
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. An algorithm for 353 odor detection thresholds in humans. Chem Senses. 2012 Mar; 37(3):207-18. Abraham MH, Sánchez-Moreno R, Cometto-Muñiz JE, Cain WS. PMID: 21976369; PMCID: PMC3278675.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    2. Human chemosensory perception of methyl isothiocyanate: chemesthesis and odor. Regul Toxicol Pharmacol. 2010 Nov; 58(2):173-80. Cain WS, Dourson ML, Kohrman-Vincent MJ, Allen BC. PMID: 20633589.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    3. Making scents: dynamic olfactometry for threshold measurement. Chem Senses. 2010 Feb; 35(2):109-20. Schmidt R, Cain WS. PMID: 19965900; PMCID: PMC2805809.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    4. The biological and toxicological activity of gases and vapors. Toxicol In Vitro. 2010 Mar; 24(2):357-62. Abraham MH, Sánchez-Moreno R, Gil-Lostes J, Acree WE, Cometto-Muñiz JE, Cain WS. PMID: 19913608; PMCID: PMC2935277.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    5. Concentration-detection functions for the odor of homologous n-acetate esters. Physiol Behav. 2008 Dec 15; 95(5):658-67. Cometto-Muñiz JE, Cain WS, Abraham MH, Gil-Lostes J. PMID: 18950650; PMCID: PMC2639399.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    6. Solvation parameters for mercury and mercury(II) compounds: calculation of properties of environmental interest. J Environ Monit. 2008 Apr; 10(4):435-42. Abraham MH, Gil-Lostes J, Acree WE, Cometto-Muñiz JE, Cain WS. PMID: 18385864.
      View in: PubMed   Mentions:    Fields:    Translation:PHPublic Health
    7. Olfactory detection of ozone and D-limonene: reactants in indoor spaces. Indoor Air. 2007 Oct; 17(5):337-47. Cain WS, Schmidt R, Wolkoff P. PMID: 17880630.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansPHPublic Health
    8. Chemesthetic responses to airborne mineral dusts: boric acid compared to alkaline materials. Int Arch Occup Environ Health. 2008 Jan; 81(3):337-45. Cain WS, Jalowayski AA, Schmidt R, Kleinman M, Magruder K, Lee KC, Culver BD. PMID: 17609973.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    9. A quantitative structure activity analysis on the relative sensitivity of the olfactory and the nasal trigeminal chemosensory systems. Chem Senses. 2007 Sep; 32(7):711-9. Abraham MH, Sánchez-Moreno R, Cometto-Muñiz JE, Cain WS. PMID: 17573355.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    10. Concentration-detection functions for eye irritation evoked by homologous n-alcohols and acetates approaching a cut-off point. Exp Brain Res. 2007 Sep; 182(1):71-9. Cometto-Muñiz JE, Cain WS, Abraham MH, Sánchez-Moreno R. PMID: 17503026.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    11. Odor and chemesthesis from exposures to glutaraldehyde vapor. Int Arch Occup Environ Health. 2007 Aug; 80(8):721-31. Cain WS, Schmidt R, Jalowayski AA. PMID: 17429675.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansPHPublic Health
    12. Cutoff in detection of eye irritation from vapors of homologous carboxylic acids and aliphatic aldehydes. Neuroscience. 2007 Mar 30; 145(3):1130-7. Cometto-Muñiz JE, Cain WS, Abraham MH, Sánchez-Moreno R. PMID: 17270354; PMCID: PMC1993913.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    13. Chemesthesis from volatile organic compounds: Psychophysical and neural responses. Physiol Behav. 2006 Jul 30; 88(4-5):317-24. Cain WS, Lee NS, Wise PM, Schmidt R, Ahn BH, Cometto-Muñiz JE, Abraham MH. PMID: 16806320.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    14. Chemical boundaries for detection of eye irritation in humans from homologous vapors. Toxicol Sci. 2006 Jun; 91(2):600-9. Cometto-Muñiz JE, Cain WS, Abraham MH, Sánchez-Moreno R. PMID: 16543295.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    15. Odor and chemesthesis from brief exposures to TXIB. Indoor Air. 2005 Dec; 15(6):445-57. Cain WS, de Wijk RA, Jalowayski AA, Pilla Caminha G, Schmidt R. PMID: 16268834.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansPHPublic Health
    16. Molecular restrictions for human eye irritation by chemical vapors. Toxicol Appl Pharmacol. 2005 Sep 15; 207(3):232-43. Cometto-Muñiz JE, Cain WS, Abraham MH. PMID: 16129116.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansPHPublic Health
    17. Determinants for nasal trigeminal detection of volatile organic compounds. Chem Senses. 2005 Oct; 30(8):627-42. Cometto-Muñiz JE, Cain WS, Abraham MH. PMID: 16141291.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    18. Odor detection of single chemicals and binary mixtures. Behav Brain Res. 2005 Jan 06; 156(1):115-23. Cometto-Muñiz JE, Cain WS, Abraham MH. PMID: 15474656.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    19. Chemosensory additivity in trigeminal chemoreception as reflected by detection of mixtures. Exp Brain Res. 2004 Sep; 158(2):196-206. Cometto-Muñiz JE, Cain WS, Abraham MH. PMID: 15112117; PMCID: PMC1388341.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    20. Sensory and associated reactions to mineral dusts: sodium borate, calcium oxide, and calcium sulfate. J Occup Environ Hyg. 2004 Apr; 1(4):222-36. Cain WS, Jalowayski AA, Kleinman M, Lee NS, Lee BR, Ahn BH, Magruder K, Schmidt R, Hillen BK, Warren CB, Culver BD. PMID: 15204861.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansPHPublic Health
    21. Detection of single and mixed VOCs by smell and by sensory irritation. Indoor Air. 2004; 14 Suppl 8:108-17. Cometto-Muñiz JE, Cain WS, Abraham MH. PMID: 15663466.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCellsPHPublic Health
    22. Draize rabbit eye test compatibility with eye irritation thresholds in humans: a quantitative structure-activity relationship analysis. Toxicol Sci. 2003 Dec; 76(2):384-91. Abraham MH, Hassanisadi M, Jalali-Heravi M, Ghafourian T, Cain WS, Cometto-Muniz JE. PMID: 14514959.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    23. Quantification of chemical vapors in chemosensory research. Chem Senses. 2003 Jul; 28(6):467-77. Cometto-Muñiz JE, Cain WS, Abraham MH. PMID: 12907584.
      View in: PubMed   Mentions: 40     Fields:    Translation:Cells
    24. Dose-addition of individual odorants in the odor detection of binary mixtures. Behav Brain Res. 2003 Jan 06; 138(1):95-105. Cometto-Muñiz JE, Cain WS, Abraham MH. PMID: 12493633.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    25. Implicit and explicit memory for odors: hemispheric differences. Mem Cognit. 2003 Jan; 31(1):44-50. Olsson MJ, Cain WS. PMID: 12699142.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    26. Improving the health of workers in indoor environments: priority research needs for a national occupational research agenda. Am J Public Health. 2002 Sep; 92(9):1430-40. Mendell MJ, Fisk WJ, Kreiss K, Levin H, Alexander D, Cain WS, Girman JR, Hines CJ, Jensen PA, Milton DK, Rexroat LP, Wallingford KM. PMID: 12197969; PMCID: PMC1447254.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansPHPublic Health
    27. Sensory detection of glutaraldehyde in drinking water-emergence of sensitivity and specific anosmia. Chem Senses. 2002 Jun; 27(5):425-33. Cain WS, Schmidt R. PMID: 12052779.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    28. A model for odour thresholds. Chem Senses. 2002 Feb; 27(2):95-104. Abraham MH, Gola JM, Cometto-Muniz JE, Cain WS. PMID: 11839607.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    29. Psychometric functions for the olfactory and trigeminal detectability of butyl acetate and toluene. J Appl Toxicol. 2002 Jan-Feb; 22(1):25-30. Cometto-Muñiz JE, Cain WS, Abraham MH, Gola JM. PMID: 11807926.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCellsCTClinical Trials
    30. Ocular and nasal trigeminal detection of butyl acetate and toluene presented singly and in mixtures. Toxicol Sci. 2001 Oct; 63(2):233-44. Cometto-Muñiz JE, Cain WS, Abraham MH, Gola JM. PMID: 11568367.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    31. Orbital response indicates nasal pungency: analysis of biomechanical strain on the skin. Chem Senses. 2001 Oct; 26(8):1005-13. Jalowayski AA, Johnson BN, Wise PM, Schmid-Schönbein GW, Cain WS. PMID: 11595677.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    32. Quantification of odor quality. Chem Senses. 2000 Aug; 25(4):429-43. Wise PM, Olsson MJ, Cain WS. PMID: 10944507.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    33. Comparison of two stimulus-delivery systems for measurement of nasal pungency thresholds. Chem Senses. 2000 Jun; 25(3):285-91. Cometto-Muñiz JE, Cain WS, Hiraishi T, Abraham MH, Gola JM. PMID: 10866987.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    34. Latency and accuracy of discriminations of odor quality between binary mixtures and their components. Chem Senses. 2000 Jun; 25(3):247-65. Wise PM, Cain WS. PMID: 10866984.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    35. Chemosensory detectability of 1-butanol and 2-heptanone singly and in binary mixtures. Physiol Behav. 1999 Aug; 67(2):269-76. Cometto-Muñiz JE, Cain WS, Abraham MH, Gola JM. PMID: 10477059.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    36. Sensory properties of selected terpenes. Thresholds for odor, nasal pungency, nasal localization, and eye irritation. Ann N Y Acad Sci. 1998 Nov 30; 855:648-51. Cometto-Muñiz JE, Cain WS, Abraham MH, Kumarsingh R. PMID: 9929666.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    37. Trigeminal and olfactory chemosensory impact of selected terpenes. Pharmacol Biochem Behav. 1998 Jul; 60(3):765-70. Cometto-Muñiz JE, Cain WS, Abraham MH, Kumarsingh R. PMID: 9678663.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCellsCTClinical Trials
    38. Odor identification: perceptual and semantic dimensions. Chem Senses. 1998 Jun; 23(3):309-26. Cain WS, de Wijk R, Lulejian C, Schiet F, See LC. PMID: 9669044.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    39. Trigeminal and olfactory sensitivity: comparison of modalities and methods of measurement. Int Arch Occup Environ Health. 1998 Mar; 71(2):105-10. Cometto-Muñiz JE, Cain WS. PMID: 9580447.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansPHPublic Health
    40. Nasal pungency and odor of homologous aldehydes and carboxylic acids. Exp Brain Res. 1998 Jan; 118(2):180-8. Cometto-Muñiz JE, Cain WS, Abraham MH. PMID: 9580061.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    41. Perceptual and mental mixtures in odor and in taste: are there similarities and differences between experiments or between modalities? Reply to Schifferstein (1997) J Exp Psychol Hum Percept Perform. 1997 Oct; 23(5):1588-93. Cain WS, Algom D. PMID: 9336966.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    42. Agonistic sensory effects of airborne chemicals in mixtures: odor, nasal pungency, and eye irritation. Percept Psychophys. 1997 Jul; 59(5):665-74. Cometto-Muñiz JE, Cain WS, Hudnell HK. PMID: 9259635.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    43. Switch and bait: probing the discriminative basis of odor identification via recognition memory. Chem Senses. 1996 Feb; 21(1):35-44. Cain WS, Potts BC. PMID: 8646490.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    44. Irritation and odor as indicators of indoor pollution. Occup Med. 1995 Jan-Mar; 10(1):133-45. Cain WS, Cometto-Muñiz JE. PMID: 7792671.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansPHPublic Health
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