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Wendy Huang

Title(s)Assistant Professor, Cellular and Molecular Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #0651
La Jolla CA 92093
Phone8/2-46--2258
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    Collapse Biography 
    Collapse Education and Training
    New York University School of MedicinePostdoctoral Fellowship2016Skirball Institute
    University of California San DiegoPh.D.2010Biomedical Sciences
    University of California BerkeleyB.A.2005Molecular and Cellular Biology

    Collapse Overview 
    Collapse Overview
    To examine molecular mechanisms underlying immune-cell development and effector functions and to assess their contributions to immune pathologies in mouse models of colitis and multiple sclerosis.

    Focus Area #1: To assess the contributions of RNA-helicases and their associated ncRNAs to host immune homeostasis and autoimmune pathologies.

    Focus Area #2: To dissect non-canonical functions for nucleoporins in immunity.

    Focus Area #3: To uncover the tissue-specific post-transcriptional and post-translational mechanisms that orchestrate local immune responses in animal autoimmune disease models of colitis and multiple sclerosis.

    Collapse Research 
    Collapse Research Activities and Funding
    Post-translational modifications in RORgt-dependent immune cell functions
    NIH/NIGMS R01GM124494Sep 1, 2017 - May 31, 2022
    Role: Principal Investigator
    Toll-like receptor 2 negative regulation of Liver X Receptors function
    NIH/NIDDK F31DK083913Sep 1, 2009 - Sep 30, 2010
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The DNA Glycosylase NEIL2 Suppresses Fusobacterium-Infection-Induced Inflammation and DNA Damage in Colonic Epithelial Cells. Cells. 2020 Aug 28; 9(9). Sayed IM, Chakraborty A, Abd El-Hafeez AA, Sharma A, Sahan AZ, Huang WJM, Sahoo D, Ghosh P, Hazra TK, Das S. PMID: 32872214.
      View in: PubMed   Mentions:
    2. DDX5 promotes oncogene C3 and FABP1 expressions and drives intestinal inflammation and tumorigenesis. Life Sci Alliance. 2020 Oct; 3(10). Abbasi N, Long T, Li Y, Yee BA, Cho BS, Hernandez JE, Ma E, Patel PR, Sahoo D, Sayed IM, Varki N, Das S, Ghosh P, Yeo GW, Huang WJM. PMID: 32817263.
      View in: PubMed   Mentions:    Fields:    
    3. Early precursors and molecular determinants of tissue-resident memory CD8+ T lymphocytes revealed by single-cell RNA sequencing. Sci Immunol. 2020 05 15; 5(47). Kurd NS, He Z, Louis TL, Milner JJ, Omilusik KD, Jin W, Tsai MS, Widjaja CE, Kanbar JN, Olvera JG, Tysl T, Quezada LK, Boland BS, Huang WJ, Murre C, Goldrath AW, Yeo GW, Chang JT. PMID: 32414833.
      View in: PubMed   Mentions:    Fields:    
    4. Noncoding RNAs in inflammation and colorectal cancer. RNA Biol. 2019 Dec 26; 1-8. Ma S, Long T, Huang WJM. PMID: 31847691.
      View in: PubMed   Mentions:    Fields:    
    5. Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice. Gut. 2019 08; 68(8):1504-1515. Hendrikx T, Duan Y, Wang Y, Oh JH, Alexander LM, Huang W, Stärkel P, Ho SB, Gao B, Fiehn O, Emond P, Sokol H, van Pijkeren JP, Schnabl B. PMID: 30448775.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    6. Regulation of ROR?t in Inflammatory Lymphoid Cell Differentiation. Cold Spring Harb Symp Quant Biol. 2015; 80:257-63. Huang W, Littman DR. PMID: 26968628.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    7. An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses. Cell. 2015 Oct 08; 163(2):381-93. Sano T, Huang W, Hall JA, Yang Y, Chen A, Gavzy SJ, Lee JY, Ziel JW, Miraldi ER, Domingos AI, Bonneau R, Littman DR. PMID: 26411290.
      View in: PubMed   Mentions: 109     Fields:    Translation:AnimalsCells
    8. The transcriptional specificity of NF-?B dimers is coded within the ?B DNA response elements. Cell Rep. 2012 Oct 25; 2(4):824-39. Wang VY, Huang W, Asagiri M, Spann N, Hoffmann A, Glass C, Ghosh G. PMID: 23063365.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    9. A validated regulatory network for Th17 cell specification. Cell. 2012 Oct 12; 151(2):289-303. Ciofani M, Madar A, Galan C, Sellars M, Mace K, Pauli F, Agarwal A, Huang W, Parkhurst CN, Muratet M, Newberry KM, Meadows S, Greenfield A, Yang Y, Jain P, Kirigin FK, Birchmeier C, Wagner EF, Murphy KM, Myers RM, Bonneau R, Littman DR. PMID: 23021777.
      View in: PubMed   Mentions: 356     Fields:    Translation:HumansAnimalsCells
    10. A global clustering algorithm to identify long intergenic non-coding RNA--with applications in mouse macrophages. PLoS One. 2011; 6(9):e24051. Garmire LX, Garmire DG, Huang W, Yao J, Glass CK, Subramaniam S. PMID: 21980340.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    11. Coronin 2A mediates actin-dependent de-repression of inflammatory response genes. Nature. 2011 Feb 17; 470(7334):414-8. Huang W, Ghisletti S, Saijo K, Gandhi M, Aouadi M, Tesz GJ, Zhang DX, Yao J, Czech MP, Goode BL, Rosenfeld MG, Glass CK. PMID: 21331046.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    12. Serum response factor utilizes distinct promoter- and enhancer-based mechanisms to regulate cytoskeletal gene expression in macrophages. Mol Cell Biol. 2011 Feb; 31(4):861-75. Sullivan AL, Benner C, Heinz S, Huang W, Xie L, Miano JM, Glass CK. PMID: 21135125.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    13. Nuclear receptors and inflammation control: molecular mechanisms and pathophysiological relevance. Arterioscler Thromb Vasc Biol. 2010 Aug; 30(8):1542-9. Huang W, Glass CK. PMID: 20631355.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    14. Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor kappa B and activator protein-1: possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia. Circ Res. 2010 Jul 09; 107(1):56-65. Wiesner P, Choi SH, Almazan F, Benner C, Huang W, Diehl CJ, Gonen A, Butler S, Witztum JL, Glass CK, Miller YI. PMID: 20489162.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    15. Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint. Mol Cell. 2009 Jul 10; 35(1):48-57. Huang W, Ghisletti S, Perissi V, Rosenfeld MG, Glass CK. PMID: 19595715.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    16. Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways. Genes Dev. 2009 Mar 15; 23(6):681-93. Ghisletti S, Huang W, Jepsen K, Benner C, Hardiman G, Rosenfeld MG, Glass CK. PMID: 19299558.
      View in: PubMed   Mentions: 113     Fields:    Translation:AnimalsCells
    17. Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma. Mol Cell. 2007 Jan 12; 25(1):57-70. Ghisletti S, Huang W, Ogawa S, Pascual G, Lin ME, Willson TM, Rosenfeld MG, Glass CK. PMID: 17218271.
      View in: PubMed   Mentions: 198     Fields:    Translation:HumansAnimalsCells
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