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    Wendy Huang

    TitleAssistant Professor
    SchoolUniversity of California, San Diego
    DepartmentCellular and Molecular Medicine
    Address9500 Gilman Drive #0651
    CA La Jolla 92093
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      Collapse Biography 
      Collapse Education and Training
      New York University School of MedicinePostdoctoral Fellowship2016Skirball Institute
      University of California San DiegoPh.D.2010Biomedical Sciences
      University of California BerkeleyB.A.2005Molecular and Cellular Biology

      Collapse Overview 
      Collapse Overview
      To examine molecular mechanisms underlying immune-cell development and effector functions and to assess their contributions to immune pathologies in mouse models of colitis and multiple sclerosis.

      Focus Area #1: To assess the contributions of RNA-helicases and their associated ncRNAs to host immune homeostasis and autoimmune pathologies.

      Focus Area #2: To dissect non-canonical functions for nucleoporins in immunity.

      Focus Area #3: To uncover the tissue-specific post-transcriptional and post-translational mechanisms that orchestrate local immune responses in animal autoimmune disease models of colitis and multiple sclerosis.

      Collapse Research 
      Collapse Research Activities and Funding
      Post-translational modifications in RORgt-dependent immune cell functions
      NIH/NIGMS R01GM124494Sep 1, 2017 - May 31, 2022
      Role: Principal Investigator
      Toll-like receptor 2 negative regulation of Liver X Receptors function
      NIH/NIDDK F31DK083913Sep 1, 2009 - Oct 31, 2010
      Role: Principal Investigator

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Huang W, Littman DR. Regulation of ROR?t in Inflammatory Lymphoid Cell Differentiation. Cold Spring Harb Symp Quant Biol. 2015; 80:257-63. PMID: 26968628.
        View in: PubMed
      2. Huang W, Thomas B, Flynn RA, Gavzy SJ, Wu L, Kim SV, Hall JA, Miraldi ER, Ng CP, Rigo F, Rigo FW, Meadows S, Montoya NR, Herrera NG, Domingos AI, Rastinejad F, Myers RM, Fuller-Pace FV, Bonneau R, Chang HY, Acuto O, Littman DR. DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions. Nature. 2015 Dec 24; 528(7583):517-22. PMID: 26675721; PMCID: PMC4762670.
      3. Sano T, Huang W, Hall JA, Yang Y, Chen A, Gavzy SJ, Lee JY, Ziel JW, Miraldi ER, Domingos AI, Bonneau R, Littman DR. An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses. Cell. 2015 Oct 08; 163(2):381-93. PMID: 26411290; PMCID: PMC4621768 [Available on 10/08/16].
      4. Wang VY, Huang W, Asagiri M, Spann N, Hoffmann A, Glass C, Ghosh G. The transcriptional specificity of NF-?B dimers is coded within the ?B DNA response elements. Cell Rep. 2012 Oct 25; 2(4):824-39. PMID: 23063365; PMCID: PMC4167904.
      5. Ciofani M, Madar A, Galan C, Sellars M, Mace K, Pauli F, Agarwal A, Huang W, Parkhurst CN, Muratet M, Newberry KM, Meadows S, Greenfield A, Yang Y, Jain P, Kirigin FK, Birchmeier C, Wagner EF, Murphy KM, Myers RM, Bonneau R, Littman DR. A validated regulatory network for Th17 cell specification. Cell. 2012 Oct 12; 151(2):289-303. PMID: 23021777; PMCID: PMC3503487.
      6. Garmire LX, Garmire DG, Huang W, Yao J, Glass CK, Subramaniam S. A global clustering algorithm to identify long intergenic non-coding RNA--with applications in mouse macrophages. PLoS One. 2011; 6(9):e24051. PMID: 21980340; PMCID: PMC3184070.
      7. Huang W, Ghisletti S, Saijo K, Gandhi M, Aouadi M, Tesz GJ, Zhang DX, Yao J, Czech MP, Goode BL, Rosenfeld MG, Glass CK. Coronin 2A mediates actin-dependent de-repression of inflammatory response genes. Nature. 2011 Feb 17; 470(7334):414-8. PMID: 21331046; PMCID: PMC3464905.
      8. Sullivan AL, Benner C, Heinz S, Huang W, Xie L, Miano JM, Glass CK. Serum response factor utilizes distinct promoter- and enhancer-based mechanisms to regulate cytoskeletal gene expression in macrophages. Mol Cell Biol. 2011 Feb; 31(4):861-75. PMID: 21135125; PMCID: PMC3028656.
      9. Huang W, Glass CK. Nuclear receptors and inflammation control: molecular mechanisms and pathophysiological relevance. Arterioscler Thromb Vasc Biol. 2010 Aug; 30(8):1542-9. PMID: 20631355; PMCID: PMC2911147.
      10. Wiesner P, Choi SH, Almazan F, Benner C, Huang W, Diehl CJ, Gonen A, Butler S, Witztum JL, Glass CK, Miller YI. Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor kappa B and activator protein-1: possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia. Circ Res. 2010 Jul 09; 107(1):56-65. PMID: 20489162; PMCID: PMC2904601.
      11. Huang W, Ghisletti S, Perissi V, Rosenfeld MG, Glass CK. Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint. Mol Cell. 2009 Jul 10; 35(1):48-57. PMID: 19595715; PMCID: PMC2759189.
      12. Ghisletti S, Huang W, Jepsen K, Benner C, Hardiman G, Rosenfeld MG, Glass CK. Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways. Genes Dev. 2009 Mar 15; 23(6):681-93. PMID: 19299558; PMCID: PMC2661610.
      13. Ghisletti S, Huang W, Ogawa S, Pascual G, Lin ME, Willson TM, Rosenfeld MG, Glass CK. Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma. Mol Cell. 2007 Jan 12; 25(1):57-70. PMID: 17218271; PMCID: PMC1850387.