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Wendy Huang
Title
Assistant Professor
School
University of California, San Diego
Department
Cellular and Molecular Medicine
Address
9500 Gilman Drive #0651
CA La Jolla 92093
Phone
858-246-2258
Email
wjh003@ucsd.edu
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Biography
Education and Training
New York University School of Medicine
Postdoctoral Fellowship
2016
Skirball Institute
University of California San Diego
Ph.D.
2010
Biomedical Sciences
University of California Berkeley
B.A.
2005
Molecular and Cellular Biology
Overview
Overview
To examine molecular mechanisms underlying immune-cell development and effector functions and to assess their contributions to immune pathologies in mouse models of colitis and multiple sclerosis.
Focus Area #1: To assess the contributions of RNA-helicases and their associated ncRNAs to host immune homeostasis and autoimmune pathologies.
Focus Area #2: To dissect non-canonical functions for nucleoporins in immunity.
Focus Area #3: To uncover the tissue-specific post-transcriptional and post-translational mechanisms that orchestrate local immune responses in animal autoimmune disease models of colitis and multiple sclerosis.
Interests
Autoimmunity, Th17, Transcription regulation, RNA binding protein, Non-coding RNA
Research
Research Activities and Funding
Post-translational modifications in RORgt-dependent immune cell functions
NIH/NIGMS
R01GM124494
Sep 1, 2017 - May 31, 2022
Role: Principal Investigator
Toll-like receptor 2 negative regulation of Liver X Receptors function
NIH/NIDDK
F31DK083913
Sep 1, 2009 - Oct 31, 2010
Role: Principal Investigator
ORNG Applications
Websites
Bibliographic
Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can
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Huang W
, Littman DR. Regulation of ROR?t in Inflammatory Lymphoid Cell Differentiation. Cold Spring Harb Symp Quant Biol. 2015; 80:257-63. PMID: 26968628.
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PubMed
Huang W
, Thomas B, Flynn RA, Gavzy SJ, Wu L, Kim SV, Hall JA, Miraldi ER, Ng CP, Rigo F, Rigo FW, Meadows S, Montoya NR, Herrera NG, Domingos AI, Rastinejad F, Myers RM, Fuller-Pace FV, Bonneau R, Chang HY, Acuto O, Littman DR. DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions. Nature. 2015 Dec 24; 528(7583):517-22. PMID: 26675721; PMCID: PMC4762670.
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PubMed
,
PubMed Central
Sano T,
Huang W
, Hall JA, Yang Y, Chen A, Gavzy SJ, Lee JY, Ziel JW, Miraldi ER, Domingos AI, Bonneau R, Littman DR. An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses. Cell. 2015 Oct 08; 163(2):381-93. PMID: 26411290; PMCID: PMC4621768 [Available on 10/08/16].
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PubMed
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PubMed Central
Wang VY,
Huang W
, Asagiri M, Spann N, Hoffmann A, Glass C, Ghosh G. The transcriptional specificity of NF-?B dimers is coded within the ?B DNA response elements. Cell Rep. 2012 Oct 25; 2(4):824-39. PMID: 23063365; PMCID: PMC4167904.
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PubMed
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PubMed Central
Ciofani M, Madar A, Galan C, Sellars M, Mace K, Pauli F, Agarwal A,
Huang W
, Parkhurst CN, Muratet M, Newberry KM, Meadows S, Greenfield A, Yang Y, Jain P, Kirigin FK, Birchmeier C, Wagner EF, Murphy KM, Myers RM, Bonneau R, Littman DR. A validated regulatory network for Th17 cell specification. Cell. 2012 Oct 12; 151(2):289-303. PMID: 23021777; PMCID: PMC3503487.
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PubMed Central
Garmire LX, Garmire DG,
Huang W
, Yao J, Glass CK, Subramaniam S. A global clustering algorithm to identify long intergenic non-coding RNA--with applications in mouse macrophages. PLoS One. 2011; 6(9):e24051. PMID: 21980340; PMCID: PMC3184070.
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PubMed Central
Huang W
, Ghisletti S, Saijo K, Gandhi M, Aouadi M, Tesz GJ, Zhang DX, Yao J, Czech MP, Goode BL, Rosenfeld MG, Glass CK. Coronin 2A mediates actin-dependent de-repression of inflammatory response genes. Nature. 2011 Feb 17; 470(7334):414-8. PMID: 21331046; PMCID: PMC3464905.
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PubMed Central
Sullivan AL, Benner C, Heinz S,
Huang W
, Xie L, Miano JM, Glass CK. Serum response factor utilizes distinct promoter- and enhancer-based mechanisms to regulate cytoskeletal gene expression in macrophages. Mol Cell Biol. 2011 Feb; 31(4):861-75. PMID: 21135125; PMCID: PMC3028656.
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PubMed
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PubMed Central
Huang W
, Glass CK. Nuclear receptors and inflammation control: molecular mechanisms and pathophysiological relevance. Arterioscler Thromb Vasc Biol. 2010 Aug; 30(8):1542-9. PMID: 20631355; PMCID: PMC2911147.
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PubMed
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PubMed Central
Wiesner P, Choi SH, Almazan F, Benner C,
Huang W
, Diehl CJ, Gonen A, Butler S, Witztum JL, Glass CK, Miller YI. Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor kappa B and activator protein-1: possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia. Circ Res. 2010 Jul 09; 107(1):56-65. PMID: 20489162; PMCID: PMC2904601.
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PubMed
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PubMed Central
Huang W
, Ghisletti S, Perissi V, Rosenfeld MG, Glass CK. Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint. Mol Cell. 2009 Jul 10; 35(1):48-57. PMID: 19595715; PMCID: PMC2759189.
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PubMed
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PubMed Central
Ghisletti S,
Huang W
, Jepsen K, Benner C, Hardiman G, Rosenfeld MG, Glass CK. Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways. Genes Dev. 2009 Mar 15; 23(6):681-93. PMID: 19299558; PMCID: PMC2661610.
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PubMed Central
Ghisletti S,
Huang W
, Ogawa S, Pascual G, Lin ME, Willson TM, Rosenfeld MG, Glass CK. Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma. Mol Cell. 2007 Jan 12; 25(1):57-70. PMID: 17218271; PMCID: PMC1850387.
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Year
Publications
2007
1
2009
2
2010
3
2011
2
2012
2
2015
2
2016
1
Wendy's Networks
Concepts
Derived automatically from this person's publications.
Inflammation Mediators
Th17 Cells
Receptors, Cytoplasmic and Nuclear
DEAD-box RNA Helicases
Inflammation
See all (115) concept(s)
_
Co-Authors
People in Profiles who have published with this person.
Glass, Christopher
Rosenfeld, Michael
Eichenfield, Dawn
Ghosh, Gourisankar
Subramaniam, Shankar
See all (10) people
_
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Same Department
Dixon, Jack
Perelis, Mark
Phan, Anne
Shaw, Laura
Van Nostrand, Eric
Search Department