Wendy Huang

Title(s)Assistant Professor, Cellular and Molecular Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0001-7425-8280 Additional info
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    Collapse Biography 
    Collapse Education and Training
    New York University School of MedicinePostdoctoral Fellowship2016Skirball Institute
    University of California San DiegoPh.D.2010Biomedical Sciences
    University of California BerkeleyB.A.2005Molecular and Cellular Biology

    Collapse Overview 
    Collapse Overview
    To examine molecular mechanisms underlying immune-cell development and effector functions and to assess their contributions to immune homeostasis and pathologies.

    Focus Area #1: To assess the contributions of RNA binding proteins, including RNA-helicases and RNA editing enzymes, to host immune homeostasis and autoimmune pathologies.

    Focus Area #2: To assess the identify and characterize contributions of chromatin associated non-coding RNAs to host immune homeostasis and autoimmune pathologies.

    Focus Area #3: To uncover the tissue-specific post-transcriptional and post-translational mechanisms that orchestrate local immune responses in models of mucosal inflammation, tumorigenesis, and autoimmunity.
    Collapse Websites

    Collapse Research 
    Collapse Research Activities and Funding
    Long non-coding RNAs in T cell lymphoma
    Gabrielle’s Angel Foundation for Cancer Research May 1, 2018 - Apr 30, 2021
    The role of RNA-structuralmodifying protein, DDX5, in intestinal cancer
    Edward Mallinckrodt, Jr. Foundation Oct 1, 2017 - Sep 30, 2020
    Post-translational modifications in RORgt-dependent immune cell functions
    NIH R01GM124494Sep 1, 2017 - May 31, 2022
    Role: Principal Investigator
    Toll-like receptor 2 negative regulation of Liver X Receptors function
    NIH F31DK083913Sep 1, 2009 - Oct 31, 2010
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. RNA binding protein DDX5 restricts ROR?t+ Treg suppressor function to promote intestine inflammation. Sci Adv. 2023 Feb 03; 9(5):eadd6165. Ma S, Yang Q, Chen N, Zheng A, Abbasi N, Wang G, Patel PR, Cho BS, Yee BA, Zhang L, Chu H, Evans SM, Yeo GW, Zheng Y, Huang WJM. PMID: 36724232.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Protocol to assess cell-intrinsic regulatory mechanisms using an ex vivo murine T cell polarization and co-culture system. STAR Protoc. 2022 09 16; 3(3):101543. Ma S, Hernandez JE, Huang WJM. PMID: 35839772; PMCID: PMC9294555.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    3. The long noncoding RNA Malat1 regulates CD8+ T cell differentiation by mediating epigenetic repression. J Exp Med. 2022 06 06; 219(6). Kanbar JN, Ma S, Kim ES, Kurd NS, Tsai MS, Tysl T, Widjaja CE, Limary AE, Yee B, He Z, Hao Y, Fu XD, Yeo GW, Huang WJ, Chang JT. PMID: 35593887; PMCID: PMC9127983.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    4. Chromatin-associated lncRNA Malat1 regulates Th17 effector program and promotes intestinal inflammation. bioRxiv. 2022. Shengyun Ma, Bing Zhou, Nicholas Chen, Claire Luo, Yuxin Li, Parth R. Patel, Anna Zheng, Shefali A. Patel, Yajing Hao, John T. Chang, Xiang-Dong Fu, Wendy Jia Men Huang. . View Publication.
    5. ROR?t phosphorylation protects against T�cell-mediated inflammation. Cell Rep. 2022 03 15; 38(11):110520. Ma S, Patel SA, Abe Y, Chen N, Patel PR, Cho BS, Abbasi N, Zeng S, Schnabl B, Chang JT, Huang WJM. PMID: 35294872; PMCID: PMC8982147.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    6. RNA binding protein DDX5 directs tuft cell specification and function to regulate microbial repertoire and disease susceptibility in the intestine. Gut. 2022 09; 71(9):1790-1802. Long T, Abbasi N, Hernandez JE, Li Y, Sayed IM, Ma S, Iemolo A, Yee BA, Yeo GW, Telese F, Ghosh P, Das S, Huang WJM. PMID: 34853057; PMCID: PMC9156727.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    7. RNA adenosine deaminase ADAR2 modulates T helper 17 cell effector function. bioRxiv. 2020. Shengyun Ma, Benjamin S. Cho, Yuxin Li, Nazia Abbasi, Brian A. Yee, Ge Sun, Claire Luo, John T. Chang, Bing Zhou, Xiang-dong Fu, Gene W. Yeo, Wendy Jia Men Huang. . View Publication.
    8. The DNA Glycosylase NEIL2 Suppresses Fusobacterium-Infection-Induced Inflammation and DNA Damage in Colonic Epithelial Cells. Cells. 2020 08 28; 9(9). Sayed IM, Chakraborty A, Abd El-Hafeez AA, Sharma A, Sahan AZ, Huang WJM, Sahoo D, Ghosh P, Hazra TK, Das S. PMID: 32872214; PMCID: PMC7565382.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    9. DDX5 promotes oncogene C3 and FABP1 expressions and drives intestinal inflammation and tumorigenesis. Life Sci Alliance. 2020 10; 3(10). Abbasi N, Long T, Li Y, Yee BA, Cho BS, Hernandez JE, Ma E, Patel PR, Sahoo D, Sayed IM, Varki N, Das S, Ghosh P, Yeo GW, Huang WJM. PMID: 32817263; PMCID: PMC7441524.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    10. Early precursors and molecular determinants of tissue-resident memory CD8+ T lymphocytes revealed by single-cell RNA sequencing. Sci Immunol. 2020 05 15; 5(47). Kurd NS, He Z, Louis TL, Milner JJ, Omilusik KD, Jin W, Tsai MS, Widjaja CE, Kanbar JN, Olvera JG, Tysl T, Quezada LK, Boland BS, Huang WJ, Murre C, Goldrath AW, Yeo GW, Chang JT. PMID: 32414833; PMCID: PMC7341730.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    11. Noncoding RNAs in inflammation and colorectal cancer. RNA Biol. 2020 11; 17(11):1628-1635. Ma S, Long T, Huang WJM. PMID: 31847691; PMCID: PMC7567496.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    12. Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice. Gut. 2019 08; 68(8):1504-1515. Hendrikx T, Duan Y, Wang Y, Oh JH, Alexander LM, Huang W, St?rkel P, Ho SB, Gao B, Fiehn O, Emond P, Sokol H, van Pijkeren JP, Schnabl B. PMID: 30448775; PMCID: PMC6387784.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    13. Regulation of ROR?t in Inflammatory Lymphoid Cell Differentiation. Cold Spring Harb Symp Quant Biol. 2015; 80:257-63. Huang W, Littman DR. PMID: 26968628; PMCID: PMC7156073.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    14. An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses. Cell. 2015 Oct 08; 163(2):381-93. Sano T, Huang W, Hall JA, Yang Y, Chen A, Gavzy SJ, Lee JY, Ziel JW, Miraldi ER, Domingos AI, Bonneau R, Littman DR. PMID: 26411290; PMCID: PMC4621768.
      View in: PubMed   Mentions: 240     Fields:    Translation:AnimalsCells
    15. The transcriptional specificity of NF-?B dimers is coded within the ?B DNA response elements. Cell Rep. 2012 Oct 25; 2(4):824-39. Wang VY, Huang W, Asagiri M, Spann N, Hoffmann A, Glass C, Ghosh G. PMID: 23063365; PMCID: PMC4167904.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    16. A validated regulatory network for Th17 cell specification. Cell. 2012 Oct 12; 151(2):289-303. Ciofani M, Madar A, Galan C, Sellars M, Mace K, Pauli F, Agarwal A, Huang W, Parkhurst CN, Muratet M, Newberry KM, Meadows S, Greenfield A, Yang Y, Jain P, Kirigin FK, Birchmeier C, Wagner EF, Murphy KM, Myers RM, Bonneau R, Littman DR. PMID: 23021777; PMCID: PMC3503487.
      View in: PubMed   Mentions: 562     Fields:    Translation:HumansAnimalsCells
    17. A global clustering algorithm to identify long intergenic non-coding RNA--with applications in mouse macrophages. PLoS One. 2011; 6(9):e24051. Garmire LX, Garmire DG, Huang W, Yao J, Glass CK, Subramaniam S. PMID: 21980340; PMCID: PMC3184070.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    18. Coronin 2A mediates actin-dependent de-repression of inflammatory response genes. Nature. 2011 Feb 17; 470(7334):414-8. Huang W, Ghisletti S, Saijo K, Gandhi M, Aouadi M, Tesz GJ, Zhang DX, Yao J, Czech MP, Goode BL, Rosenfeld MG, Glass CK. PMID: 21331046; PMCID: PMC3464905.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    19. Serum response factor utilizes distinct promoter- and enhancer-based mechanisms to regulate cytoskeletal gene expression in macrophages. Mol Cell Biol. 2011 Feb; 31(4):861-75. Sullivan AL, Benner C, Heinz S, Huang W, Xie L, Miano JM, Glass CK. PMID: 21135125; PMCID: PMC3028656.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    20. Nuclear receptors and inflammation control: molecular mechanisms and pathophysiological relevance. Arterioscler Thromb Vasc Biol. 2010 Aug; 30(8):1542-9. Huang W, Glass CK. PMID: 20631355; PMCID: PMC2911147.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    21. Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor kappa B and activator protein-1: possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia. Circ Res. 2010 Jul 09; 107(1):56-65. Wiesner P, Choi SH, Almazan F, Benner C, Huang W, Diehl CJ, Gonen A, Butler S, Witztum JL, Glass CK, Miller YI. PMID: 20489162; PMCID: PMC2904601.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    22. Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint. Mol Cell. 2009 Jul 10; 35(1):48-57. Huang W, Ghisletti S, Perissi V, Rosenfeld MG, Glass CK. PMID: 19595715; PMCID: PMC2759189.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    23. Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways. Genes Dev. 2009 Mar 15; 23(6):681-93. Ghisletti S, Huang W, Jepsen K, Benner C, Hardiman G, Rosenfeld MG, Glass CK. PMID: 19299558; PMCID: PMC2661610.
      View in: PubMed   Mentions: 136     Fields:    Translation:AnimalsCells
    24. Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma. Mol Cell. 2007 Jan 12; 25(1):57-70. Ghisletti S, Huang W, Ogawa S, Pascual G, Lin ME, Willson TM, Rosenfeld MG, Glass CK. PMID: 17218271; PMCID: PMC1850387.
      View in: PubMed   Mentions: 257     Fields:    Translation:HumansAnimalsCells
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