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A Highly Accurate Ensemble Classifier for the Molecular Diagnosis of ASD at Ages 1 to 4 Years. medRxiv. 2021.
Bao B., Gazestani V.H., Xiao Y., Kim R., Chiang A.W.T., Nalabolu S., Pierce K., Robasky K., Lewis N.E., Courchesne E. View Publication.
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Optimal balancing of clinical factors in large scale clinical RNA-Seq studies. bioRxiv. 2021.
Chiang A.W.T., Gazestani V.H., Altieri M.G., Courchesne E., Lewis N.E. View Publication.
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Transfer learning improves outcome predictions for ASD from gene expression in blood. bioRxiv. 2021.
Robasky K., Kim R., Yi H., Xu H., Bao B., Chiang A.W.T., Courchesne E., Lewis N.E. View Publication.
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Systems glycobiology for discovering drug targets, biomarkers, and rational designs for glyco-immunotherapy. J Biomed Sci. 2021 Jun 22; 28(1):50.
Chiang AWT, Baghdassarian HM, Kellman BP, Bao B, Sorrentino JT, Liang C, Kuo CC, Masson HO, Lewis NE. PMID: 34158025.
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Dysregulation of the secretory pathway connects Alzheimer's disease genetics to aggregate formation. Cell Syst. 2021 Jun 18.
Kuo CC, Chiang AWT, Baghdassarian HM, Lewis NE. PMID: 34171228.
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The Human Milk Oligosaccharide 3’Sialyllactose Promotes Inflammation Resolution and Reduces Atherosclerosis Development in Mice. bioRxiv. 2021.
Pessentheiner AR, Spann NJ, Autran CA, Ramms B, Chiang AW, Grunddal KV, Wang Y, Quach A, Booshehri LM, Hammond A, Tognaccini C, Latasiewicz J, Witztum JL, Hoffman HM, Lewis NE, Glass CK, Bode L, Gordts PL. View Publication.
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Elucidating Human Milk Oligosaccharide biosynthetic genes through network-based multiomics integration. bioRxiv. 2021.
Kellman BP, Richelle A, Yang J, Chapla D, Chiang AW, Najera J, Bao B, Koga N, Mohammad MA, Bruntse A, Haymond MW, Moremen KW, Bode L, Lewis NE. View Publication.
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Autism genetics perturb prenatal neurodevelopment through a hierarchy of broadly-expressed and brain-specific genes. bioRxiv. 2021.
Gazestani VH, Chiang AW, Courchesne E, Lewis NE. View Publication.
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Model-based assessment of mammalian cells metabolic functionalities using omics data. Cell Reports Methods (accepted). 2021.
Richelle A, Kellman BP, Wenzel AT, Chiang AW, Reagan T, Gutierrez JM, Joshi C, Li S, Liu JK, Masson H, Lee J, Li Z, Heirendt L, Trefois C, Juarez EF, Bath T, Borland D, Mesirov JP, Robasky K, Lewis NE. View Publication.
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Methods of Designing Carbohydrates. 2021.
Lewis NE, Liang C, Chiang AW. . View Publication.
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Method of Measuring Complex Carbohydrates at the Nano-Scale. 2021.
Lewis NE, Chiang AW, Liang C, Sorrentino JT.
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Glycoengineered Vaccines and Methods of Making the Same. 2021.
Fuerst TR, Toth EA, Lewis NE, Voldborg BG, Chiang AW. .
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Type 2 Immunity and Age Modify Gene Expression of Coronavirus-induced Disease 2019 Receptors in Eosinophilic Gastrointestinal Disorders. J Pediatr Gastroenterol Nutr. 2021 05 01; 72(5):718-722.
Chiang AWT, Duong LD, Shoda T, Nhu QM, Ruffner M, Hara T, Aaron B, Joplin E, Manresa MC, Abonia JP, Dellon ES, Hirano I, Gonsalves N, Gupta SK, Furuta GT, Rothenberg ME, Lewis NE, Muir AB, Aceves SS, CEGIR Investigator Group . PMID: 33394891.
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2 Fields:
Translation:
Humans
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Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate. Nat Chem Biol. 2021 06; 17(6):684-692.
Weiss RJ, Spahn PN, Chiang AWT, Liu Q, Li J, Hamill KM, Rother S, Clausen TM, Hoeksema MA, Timm BM, Godula K, Glass CK, Tor Y, Gordts PLSM, Lewis NE, Esko JD. PMID: 33846619.
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HumansCells
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A unique esophageal extracellular matrix proteome alters normal fibroblast function in severe eosinophilic esophagitis. J Allergy Clin Immunol. 2021 Aug; 148(2):486-494.
Hsieh LY, Chiang AWT, Duong LD, Kuo CC, Dong SX, Dohil R, Kurten R, Lewis NE, Aceves SS. PMID: 33556465.
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A consensus-based and readable extension of Linear Code for Reaction Rules (LiCoRR). Beilstein J Org Chem. 2020; 16:2645-2662.
Kellman BP, Zhang Y, Logomasini E, Meinhardt E, Godinez-Macias KP, Chiang AWT, Sorrentino JT, Liang C, Bao B, Zhou Y, Akase S, Sogabe I, Kouka T, Winzeler EA, Wilson IBH, Campbell MP, Neelamegham S, Krambeck FJ, Aoki-Kinoshita KF, Lewis NE. PMID: 33178355.
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Increased Production of LIGHT by T Cells in Eosinophilic Esophagitis Promotes Differentiation of Esophageal Fibroblasts Toward an Inflammatory Phenotype. Gastroenterology. 2020 11; 159(5):1778-1792.e13.
Manresa MC, Chiang AWT, Kurten RC, Dohil R, Brickner H, Dohil L, Herro R, Akuthota P, Lewis NE, Croft M, Aceves SS. PMID: 32712105.
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Translation:
HumansCells
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Method to Suppress Viral Infection of Mammalian Cells. 2020.
Lewis NE, Chiang AWT, Puig M, Zhang Y, Rosenberg AS. View Publication.
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Multiplex secretome engineering enhances recombinant protein production and purity. Nat Commun. 2020 04 20; 11(1):1908.
Kol S, Ley D, Wulff T, Decker M, Arnsdorf J, Schoffelen S, Hansen AH, Jensen TL, Gutierrez JM, Chiang AWT, Masson HO, Palsson BO, Voldborg BG, Pedersen LE, Kildegaard HF, Lee GM, Lewis NE. PMID: 32313013.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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ZNF263 is a transcriptional regulator of heparin and heparan sulfate biosynthesis. Proc Natl Acad Sci U S A. 2020 04 28; 117(17):9311-9317.
Weiss RJ, Spahn PN, Toledo AG, Chiang AWT, Kellman BP, Li J, Benner C, Glass CK, Gordts PLSM, Lewis NE, Esko JD. PMID: 32277030.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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A Markov model of glycosylation elucidates isozyme specificity and glycosyltransferase interactions for glycoengineering. Curr Res Biotechnol. 2020 Nov; 2:22-36.
Liang C, Chiang AWT, Hansen AH, Arnsdorf J, Schoffelen S, Sorrentino JT, Kellman BP, Bao B, Voldborg BG, Lewis NE. PMID: 32285041.
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Combating viral contaminants in CHO cells by engineering innate immunity. Sci Rep. 2019 06 20; 9(1):8827.
Chiang AWT, Li S, Kellman BP, Chattopadhyay G, Zhang Y, Kuo CC, Gutierrez JM, Ghazi F, Schmeisser H, Ménard P, Bjørn SP, Voldborg BG, Rosenberg AS, Puig M, Lewis NE. PMID: 31222165.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Increasing consensus of context-specific metabolic models by integrating data-inferred cell functions. PLoS Comput Biol. 2019 04; 15(4):e1006867.
Richelle A, Chiang AWT, Kuo CC, Lewis NE. PMID: 30986217.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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The emerging role of systems biology for engineering protein production in CHO cells. Curr Opin Biotechnol. 2018 06; 51:64-69.
Kuo CC, Chiang AW, Shamie I, Samoudi M, Gutierrez JM, Lewis NE. PMID: 29223005.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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A proteome view of structural, functional, and taxonomic characteristics of major protein domain clusters. Sci Rep. 2017 10 27; 7(1):14210.
Sun CT, Chiang AWT, Hwang MJ. PMID: 29079755.
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Translation:
Cells
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Identification of Entry Factors Involved in Hepatitis C Virus Infection Based on Host-Mimicking Short Linear Motifs. PLoS Comput Biol. 2017 01; 13(1):e1005368.
Chiang AW, Wu WY, Wang T, Hwang MJ. PMID: 28129350.
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Translation:
HumansCells
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Modulating carbohydrate-protein interactions through glycoengineering of monoclonal antibodies to impact cancer physiology. Curr Opin Struct Biol. 2016 10; 40:104-111.
Chiang AW, Li S, Spahn PN, Richelle A, Kuo CC, Samoudi M, Lewis NE. PMID: 27639240.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimals
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Proteins with Highly Evolvable Domain Architectures Are Nonessential but Highly Retained. Mol Biol Evol. 2016 05; 33(5):1219-30.
Hsu CH, Chiang AW, Hwang MJ, Liao BY. PMID: 26769031.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Understanding system dynamics of an adaptive enzyme network from globally profiled kinetic parameters. BMC Syst Biol. 2014 Jan 15; 8:4.
Chiang AW, Liu WC, Charusanti P, Hwang MJ. PMID: 24428922.
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3 Fields:
Translation:
Cells
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Partitioning the human transcriptome using HKera, a novel classifier of housekeeping and tissue-specific genes. PLoS One. 2013; 8(12):e83040.
Chiang AW, Shaw GT, Hwang MJ. PMID: 24376628.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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A computational pipeline for identifying kinetic motifs to aid in the design and improvement of synthetic gene circuits. BMC Bioinformatics. 2013; 14 Suppl 16:S5.
Chiang AW, Hwang MJ. PMID: 24564638.
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3 Fields: