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    Vishal Nigam

    TitleAssociate Professor In Residence
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0731
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      A Multiscale Modeling Approach to Hypoplastic Left Heart Syndrome
      NIH/NHLBI R01HL128630Apr 15, 2016 - Mar 31, 2020
      Role: Principal Investigator
      Mechanisms of Notch1 in Aortic Valve Calcification
      NIH/NHLBI K08HL086775Aug 15, 2007 - Apr 30, 2013
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Wang RM, Johnson TD, He J, Rong Z, Wong M, Nigam V, Behfar A, Xu Y, Christman KL. Humanized mouse model for assessing the human immune response to xenogeneic and allogeneic decellularized biomaterials. Biomaterials. 2017 Jun; 129:98-110. PMID: 28334641.
        View in: PubMed
      2. Dewan S, Krishnamurthy A, Kole D, Conca G, Kerckhoffs R, Puchalski MD, Omens JH, Sun H, Nigam V, McCulloch AD. Model of Human Fetal Growth in Hypoplastic Left Heart Syndrome: Reduced Ventricular Growth Due to Decreased Ventricular Filling and Altered Shape. Front Pediatr. 2017; 5:25. PMID: 28275592.
        View in: PubMed
      3. Lathen C, Zhang Y, Chow J, Singh M, Lin G, Nigam V, Ashraf YA, Yuan JX, Robbins IM, Thistlethwaite PA. Response to Letter Regarding Article, "The ERG-APLNR Axis Controls Pulmonary Venule Endothelial Proliferation in Pulmonary Veno-Occlusive Disease". Circulation. 2015 Jul 14; 132(2):e17. PMID: 26169652; PMCID: PMC4624330.
      4. Patel V, Carrion K, Hollands A, Hinton A, Gallegos T, Dyo J, Sasik R, Leire E, Hardiman G, Mohamed SA, Nigam S, King CC, Nizet V, Nigam V. The stretch responsive microRNA miR-148a-3p is a novel repressor of IKBKB, NF-?B signaling, and inflammatory gene expression in human aortic valve cells. FASEB J. 2015 May; 29(5):1859-68. PMID: 25630970; PMCID: PMC4771066.
      5. Banerjee I, Carrion K, Serrano R, Dyo J, Sasik R, Lund S, Willems E, Aceves S, Meili R, Mercola M, Chen J, Zambon A, Hardiman G, Doherty TA, Lange S, del Álamo JC, Nigam V. Cyclic stretch of embryonic cardiomyocytes increases proliferation, growth, and expression while repressing Tgf-ß signaling. J Mol Cell Cardiol. 2015 Feb; 79:133-44. PMID: 25446186; PMCID: PMC4302020.
      6. Lathen C, Zhang Y, Chow J, Singh M, Lin G, Nigam V, Ashraf YA, Yuan JX, Robbins IM, Thistlethwaite PA. ERG-APLNR axis controls pulmonary venule endothelial proliferation in pulmonary veno-occlusive disease. Circulation. 2014 Sep 30; 130(14):1179-91. PMID: 25062690; PMCID: PMC4182129.
      7. Carrion K, Dyo J, Patel V, Sasik R, Mohamed SA, Hardiman G, Nigam V. The long non-coding HOTAIR is modulated by cyclic stretch and WNT/ß-CATENIN in human aortic valve cells and is a novel repressor of calcification genes. PLoS One. 2014; 9(5):e96577. PMID: 24788418; PMCID: PMC4006892.
      8. Johnson TD, Dequach JA, Gaetani R, Ungerleider J, Elhag D, Nigam V, Behfar A, Christman KL. Human versus porcine tissue sourcing for an injectable myocardial matrix hydrogel. Biomater Sci. 2014; 2014:60283D. PMID: 24634775.
        View in: PubMed
      9. Szeto K, Pastuszko P, del Álamo JC, Lasheras J, Nigam V. Bicuspid aortic valves experience increased strain as compared to tricuspid aortic valves. World J Pediatr Congenit Heart Surg. 2013 Oct; 4(4):362-6. PMID: 24327628.
        View in: PubMed
      10. Krishnamurthy A, Villongco CT, Chuang J, Frank LR, Nigam V, Belezzuoli E, Stark P, Krummen DE, Narayan S, Omens JH, McCulloch AD, Kerckhoffs RC. Patient-Specific Models of Cardiac Biomechanics. J Comput Phys. 2013 Jul 01; 244:4-21. PMID: 23729839.
        View in: PubMed
      11. Kwon C, Cheng P, King IN, Andersen P, Shenje L, Nigam V, Srivastava D. Notch post-translationally regulates ß-catenin protein in stem and progenitor cells. Nat Cell Biol. 2011 Aug 14; 13(10):1244-51. PMID: 21841793; PMCID: PMC3187850.
      12. Belge G, Radtke A, Meyer A, Stegen I, Richardt D, Nimzyk R, Nigam V, Dendorfer A, Sievers HH, Tiemann M, Buchwalow I, Bullerdiek J, Mohamed SA. Upregulation of the high mobility group AT-hook 2 gene in acute aortic dissection is potentially associated with endothelial-mesenchymal transition. Histol Histopathol. 2011 08; 26(8):1029-37. PMID: 21692035.
        View in: PubMed
      13. Nigam V, Sievers HH, Jensen BC, Sier HA, Simpson PC, Srivastava D, Mohamed SA. Altered microRNAs in bicuspid aortic valve: a comparison between stenotic and insufficient valves. J Heart Valve Dis. 2010 Jul; 19(4):459-65. PMID: 20845893; PMCID: PMC4242684.
      14. Nigam V, Srivastava D. Notch1 represses osteogenic pathways in aortic valve cells. J Mol Cell Cardiol. 2009 Dec; 47(6):828-34. PMID: 19695258; PMCID: PMC2783189.
      15. Kwon C, Qian L, Cheng P, Nigam V, Arnold J, Srivastava D. A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate. Nat Cell Biol. 2009 Aug; 11(8):951-7. PMID: 19620969; PMCID: PMC2748816.