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Gαs is dispensable for β-arrestin coupling but dictates GRK selectivity and is predominant for gene expression regulation by β2-adrenergic receptor. J Biol Chem. 2023 11; 299(11):105293.
Burghi V, Paradis JS, Officer A, Adame-Garcia SR, Wu X, Matthees ESF, Barsi-Rhyne B, Ramms DJ, Clubb L, Acosta M, Tamayo P, Bouvier M, Inoue A, von Zastrow M, Hoffmann C, Gutkind JS. PMID: 37774973; PMCID: PMC10641165.
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HumansCells
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A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAFV600E colorectal tumors. Nat Cancer. 2023 02; 4(2):240-256.
Ruiz-Saenz A, Atreya CE, Wang C, Pan B, Dreyer CA, Brunen D, Prahallad A, Muñoz DP, Ramms DJ, Burghi V, Spassov DS, Fewings E, Hwang YC, Cowdrey C, Moelders C, Schwarzer C, Wolf DM, Hann B, VandenBerg SR, Shokat K, Moasser MM, Bernards R, Gutkind JS, van 't Veer LJ, Coppé JP. PMID: 36759733; PMCID: PMC9970872.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Insulin signaling in the heart is impaired by growth hormone: a direct and early event. J Mol Endocrinol. 2022 08 01; 69(2):357-376.
Muñoz MC, Piazza VG, Burghi V, Giani JF, Martinez CS, Cicconi NS, Muia NV, Fang Y, Lavandero S, Sotelo AI, Bartke A, Pennisi PA, Dominici FP, Miquet JG. PMID: 35608964; PMCID: PMC9339477.
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AnimalsCells
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Biased agonism at histamine H1 receptor: Desensitization, internalization and MAPK activation triggered by antihistamines. Eur J Pharmacol. 2021 Apr 05; 896:173913.
Burghi V, Echeverría EB, Zappia CD, Díaz Nebreda A, Ripoll S, Gómez N, Shayo C, Davio CA, Monczor F, Fernández NC. PMID: 33508282.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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The Regulator of G Protein Signaling Homologous Domain of G Protein-Coupled Receptor Kinase 2 Mediates Short-Term Desensitization of β3-Adrenergic Receptor. Front Pharmacol. 2020; 11:113.
Echeverría E, Cabrera M, Burghi V, Sosa M, Ripoll S, Yaneff A, Monczor F, Davio C, Shayo C, Fernández N. PMID: 32153413; PMCID: PMC7047201.
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PubMed Mentions:
3
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Identification of inhibitors of the RGS homology domain of GRK2 by docking-based virtual screening. Life Sci. 2019 Dec 15; 239:116872.
Echeverría E, Velez Rueda AJ, Cabrera M, Juritz E, Burghi V, Fabián L, Davio C, Lorenzano Menna P, Fernández NC. PMID: 31525427.
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PubMed Mentions:
2 Fields:
Translation:
HumansCellsPHPublic Health
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Participation of Gαi-Adenylate Cyclase and ERK1/2 in Mas Receptor Signaling Pathways. Front Pharmacol. 2019; 10:146.
Burghi V, Echeverría EB, Sosa MH, Quiroga DT, Muñoz MC, Davio C, Monczor F, Fernández NC, Dominici FP. PMID: 30853914; PMCID: PMC6395383.
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PubMed Mentions:
3
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Involvement of histamine H1 and H2 receptor inverse agonists in receptor's crossregulation. Eur J Pharmacol. 2019 Mar 15; 847:42-52.
Díaz Nebreda A, Zappia CD, Rodríguez González A, Sahores A, Sosa M, Burghi V, Monczor F, Davio C, Fernández N, Shayo C. PMID: 30685431.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Validation of commercial Mas receptor antibodies for utilization in Western Blotting, immunofluorescence and immunohistochemistry studies. PLoS One. 2017; 12(8):e0183278.
Burghi V, Fernández NC, Gándola YB, Piazza VG, Quiroga DT, Guilhen Mario É, Felix Braga J, Bader M, Santos RAS, Dominici FP, Muñoz MC. PMID: 28813513; PMCID: PMC5558983.
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PubMed Mentions:
11 Fields:
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HumansAnimalsCells
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Chronic blockade of the AT2 receptor with PD123319 impairs insulin signaling in C57BL/6 mice. Peptides. 2017 02; 88:37-45.
Muñoz MC, Burghi V, Miquet JG, Cervino IA, Quiroga DT, Mazziotta L, Dominici FP. PMID: 27979738.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Modulation of the action of insulin by angiotensin-(1-7). Clin Sci (Lond). 2014 May; 126(9):613-30.
Dominici FP, Burghi V, Muñoz MC, Giani JF. PMID: 24450744.
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PubMed Mentions:
21 Fields:
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HumansAnimalsCells
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Downregulation of the ACE2/Ang-(1-7)/Mas axis in transgenic mice overexpressing GH. J Endocrinol. 2014 May; 221(2):215-27.
Muñoz MC, Burghi V, Miquet JG, Giani JF, Banegas RD, Toblli JE, Fang Y, Wang F, Bartke A, Dominici FP. PMID: 24756097; PMCID: PMC5987768.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Oral administration of angiotensin-(1-7) ameliorates type 2 diabetes in rats. J Mol Med (Berl). 2014 Mar; 92(3):255-65.
Santos SH, Giani JF, Burghi V, Miquet JG, Qadri F, Braga JF, Todiras M, Kotnik K, Alenina N, Dominici FP, Santos RA, Bader M. PMID: 24162089.
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PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
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Upregulation of the angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas receptor axis in the heart and the kidney of growth hormone receptor knock-out mice. Growth Horm IGF Res. 2012 Dec; 22(6):224-33.
Giani JF, Miquet JG, Muñoz MC, Burghi V, Toblli JE, Masternak MM, Kopchick JJ, Bartke A, Turyn D, Dominici FP. PMID: 22947377; PMCID: PMC3698955.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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The Mas receptor mediates modulation of insulin signaling by angiotensin-(1-7). Regul Pept. 2012 Aug 20; 177(1-3):1-11.
Muñoz MC, Giani JF, Burghi V, Mayer MA, Carranza A, Taira CA, Dominici FP. PMID: 22561450.
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PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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Angiotensin-(1-7) attenuates diabetic nephropathy in Zucker diabetic fatty rats. Am J Physiol Renal Physiol. 2012 Jun 15; 302(12):F1606-15.
Giani JF, Burghi V, Veiras LC, Tomat A, Muñoz MC, Cao G, Turyn D, Toblli JE, Dominici FP. PMID: 22492942.
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PubMed Mentions:
30 Fields:
Translation:
Animals