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    Ulupi Jhala

    TitleAssociate Adjunct Professor
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0983
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Molecular Mechanisms Regulating Beta Cell Death
      NIH/NIDDK R56DK105443Apr 1, 2015 - Mar 31, 2017
      Role: Principal Investigator
      Signaling Cascades in Regulation of Pancreatic Beta cell mass.
      NIH/NIDDK R01DK080147Feb 5, 2008 - Nov 30, 2013
      Role: Principal Investigator
      Transcriptional Mechanisms of Beta Cell Gene Expression
      NIH/NIDDK R21DK066203Dec 15, 2003 - Nov 30, 2006
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Bordone L, Motta MC, Picard F, Robinson A, Jhala U, Apfeld J, McDonagh T, Lemieux M, McBurney M, Szilvasi A, Easlon EJ, Lin SJ, Guarente L. Correction: Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic ß Cells. PLoS Biol. 2015 Dec; 13(12):e1002346. PMID: 26714029; PMCID: PMC4694709.
      2. Humphrey RK, Ray A, Gonuguntla S, Hao E, Jhala U. Loss of TRB3 alters dynamics of MLK3-JNK signaling and inhibits cytokine-activated pancreatic beta cell death. J Biol Chem. 2014 Oct 24; 289(43):29994-30004. PMID: 25204656; PMCID: PMC4208007.
      3. Lancman JJ, Zvenigorodsky N, Gates KP, Zhang D, Solomon K, Humphrey RK, Kuo T, Setiawan L, Verkade H, Chi YI, Jhala U, Wright CV, Stainier DY, Dong PD. Specification of hepatopancreas progenitors in zebrafish by hnf1ba and wnt2bb. Development. 2013 Jul; 140(13):2669-79. PMID: 23720049; PMCID: PMC3678338.
      4. Ren W, Jhala U, Du K. Proteomic analysis of protein palmitoylation in adipocytes. Adipocyte. 2013; 2(1):17-28. PMID: 23599907.
        View in: PubMed
      5. Humphrey RK, Yu SM, Bellary A, Gonuguntla S, Yebra M, Jhala U. Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic ß cell death. J Biol Chem. 2013 Jan 25; 288(4):2428-40. PMID: 23172226; PMCID: PMC3554912.
      6. Humphrey RK, Newcomb CJ, Yu SM, Hao E, Yu D, Krajewski S, Du K, Jhala U. Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells. J Biol Chem. 2010 Jul 16; 285(29):22426-36. PMID: 20421299; PMCID: PMC2903363.
      7. Humphrey RK, Yu SM, Flores LE, Jhala U. Glucose regulates steady-state levels of PDX1 via the reciprocal actions of GSK3 and AKT kinases. J Biol Chem. 2010 Jan 29; 285(5):3406-16. PMID: 19833727; PMCID: PMC2823452.
      8. Kato S, Ding J, Pisck E, Jhala U, Du K. COP1 functions as a FoxO1 ubiquitin E3 ligase to regulate FoxO1-mediated gene expression. J Biol Chem. 2008 Dec 19; 283(51):35464-73. PMID: 18815134; PMCID: PMC2602905.
      9. Krajewska M, Banares S, Zhang EE, Huang X, Scadeng M, Jhala U, Feng GS, Krajewski S. Development of diabesity in mice with neuronal deletion of Shp2 tyrosine phosphatase. Am J Pathol. 2008 May; 172(5):1312-24. PMID: 18403587; PMCID: PMC2329840.
      10. Serra C, Palacios D, Mozzetta C, Forcales SV, Morantte I, Ripani M, Jones DR, Du K, Jhala U, Simone C, Puri PL. Functional interdependence at the chromatin level between the MKK6/p38 and IGF1/PI3K/AKT pathways during muscle differentiation. Mol Cell. 2007 Oct 26; 28(2):200-13. PMID: 17964260; PMCID: PMC2693200.
      11. Malecki MT, Lebrun P, Pezzolesi M, Warram JH, Krolewski AS, Jhala U. A newly identified mutation in an IPF1 binding site of the insulin gene promoter may predispose to type 2 diabetes mellitus. Diabetologia. 2006 Aug; 49(8):1985-7. PMID: 16741735.
        View in: PubMed
      12. Bordone L, Motta MC, Picard F, Robinson A, Jhala U, Apfeld J, McDonagh T, Lemieux M, McBurney M, Szilvasi A, Easlon EJ, Lin SJ, Guarente L. Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biol. 2006 Feb; 4(2):e31. PMID: 16366736; PMCID: PMC1318478.
      13. Hennige AM, Ozcan U, Okada T, Jhala U, Schubert M, White MF, Kulkarni RN. Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells. Am J Physiol Endocrinol Metab. 2005 Aug; 289(2):E337-46. PMID: 15827066.
        View in: PubMed
      14. Kulkarni RN, Jhala U, Winnay JN, Krajewski S, Montminy M, Kahn CR. PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. J Clin Invest. 2004 Sep; 114(6):828-36. PMID: 15372107; PMCID: PMC516265.
      15. Jhala U, Canettieri G, Screaton RA, Kulkarni RN, Krajewski S, Reed J, Walker J, Lin X, White M, Montminy M. cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Genes Dev. 2003 Jul 01; 17(13):1575-80. PMID: 12842910; PMCID: PMC196130.
      16. Herzig S, Long F, Jhala U, Hedrick S, Quinn R, Bauer A, Rudolph D, Schutz G, Yoon C, Puigserver P, Spiegelman B, Montminy M. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature. 2001 Sep 13; 413(6852):179-83. PMID: 11557984.
        View in: PubMed
      17. Du K, Asahara H, Jhala U, Wagner BL, Montminy M. Characterization of a CREB gain-of-function mutant with constitutive transcriptional activity in vivo. Mol Cell Biol. 2000 Jun; 20(12):4320-7. PMID: 10825195; PMCID: PMC85799.
      18. Malecki MT, Jhala U, Antonellis A, Fields L, Doria A, Orban T, Saad M, Warram JH, Montminy M, Krolewski AS. Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus. Nat Genet. 1999 Nov; 23(3):323-8. PMID: 10545951.
        View in: PubMed
      19. Parker D, Jhala U, Radhakrishnan I, Yaffe MB, Reyes C, Shulman AI, Cantley LC, Wright PE, Montminy M. Analysis of an activator:coactivator complex reveals an essential role for secondary structure in transcriptional activation. Mol Cell. 1998 Sep; 2(3):353-9. PMID: 9774973.
        View in: PubMed
      20. Chung-Bok MI, Vincent N, Jhala U, Watford M. Rat hepatic glutaminase: identification of the full coding sequence and characterization of a functional promoter. Biochem J. 1997 May 15; 324 ( Pt 1):193-200. PMID: 9164856; PMCID: PMC1218416.
      21. Sharma S, Jhala U, Johnson T, Ferreri K, Leonard J, Montminy M. Hormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1. Mol Cell Biol. 1997 May; 17(5):2598-604. PMID: 9111329; PMCID: PMC232109.
      22. Jhala U, Baly DL. Effect of chronic IL-1 beta infusion on glucose homeostasis and pancreatic insulin secretion. Life Sci. 1994; 54(6):413-22. PMID: 8295488.
        View in: PubMed
      23. Alexander-Bridges M, Mukhopadhyay NK, Jhala U, Denaro M, Kong XF, Avruch J, Maller J. Growth factor-activated kinases phosphorylate IRE-ABP. Biochem Soc Trans. 1992 Aug; 20(3):691-3. PMID: 1426612.
        View in: PubMed
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