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Ulupi Jhala

Title(s)Associate Adjunct Professor, Pediatrics
SchoolHealth Sciences
Phone858-822-2072
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    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms of Pancreatic Beta Cell Dysfunction
    NIH/NIDDK R01DK116038Jul 10, 2018 - Jun 30, 2022
    Role: Principal Investigator
    Molecular Mechanisms Regulating Beta Cell Death
    NIH/NIDDK R56DK105443Apr 1, 2015 - Mar 31, 2017
    Role: Principal Investigator
    Signaling Cascades in Regulation of Pancreatic Beta cell mass.
    NIH/NIDDK R01DK080147Feb 1, 2010 - Nov 30, 2013
    Role: Principal Investigator
    Transcriptional Mechanisms of Beta Cell Gene Expression
    NIH/NIDDK R21DK066203Dec 15, 2003 - Nov 30, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Vinckier NK, Patel NA, Geusz RJ, Wang A, Wang J, Matta I, Harrington AR, Wortham M, Wetton N, Wang J, Jhala US, Rosenfeld MG, Benner CW, Shih HP, Sander M. LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development. Nat Commun. 2020 Apr 29; 11(1):2082. PMID: 32350257.
      View in: PubMed
    2. Bordone L, Motta MC, Picard F, Robinson A, Jhala US, Apfeld J, McDonagh T, Lemieux M, McBurney M, Szilvasi A, Easlon EJ, Lin SJ, Guarente L. Correction: Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic ß Cells. PLoS Biol. 2015 Dec; 13(12):e1002346. PMID: 26714029.
      View in: PubMed
    3. Humphrey RK, Ray A, Gonuguntla S, Hao E, Jhala US. Loss of TRB3 alters dynamics of MLK3-JNK signaling and inhibits cytokine-activated pancreatic beta cell death. J Biol Chem. 2014 Oct 24; 289(43):29994-30004. PMID: 25204656.
      View in: PubMed
    4. Lancman JJ, Zvenigorodsky N, Gates KP, Zhang D, Solomon K, Humphrey RK, Kuo T, Setiawan L, Verkade H, Chi YI, Jhala US, Wright CV, Stainier DY, Dong PD. Specification of hepatopancreas progenitors in zebrafish by hnf1ba and wnt2bb. Development. 2013 Jul; 140(13):2669-79. PMID: 23720049.
      View in: PubMed
    5. Ren W, Jhala US, Du K. Proteomic analysis of protein palmitoylation in adipocytes. Adipocyte. 2013; 2(1):17-28. PMID: 23599907.
      View in: PubMed
    6. Humphrey RK, Yu SM, Bellary A, Gonuguntla S, Yebra M, Jhala US. Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic ß cell death. J Biol Chem. 2013 Jan 25; 288(4):2428-40. PMID: 23172226.
      View in: PubMed
    7. Humphrey RK, Newcomb CJ, Yu SM, Hao E, Yu D, Krajewski S, Du K, Jhala US. Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells. J Biol Chem. 2010 Jul 16; 285(29):22426-36. PMID: 20421299.
      View in: PubMed
    8. Humphrey RK, Yu SM, Flores LE, Jhala US. Glucose regulates steady-state levels of PDX1 via the reciprocal actions of GSK3 and AKT kinases. J Biol Chem. 2010 Jan 29; 285(5):3406-16. PMID: 19833727.
      View in: PubMed
    9. Kato S, Ding J, Pisck E, Jhala US, Du K. COP1 functions as a FoxO1 ubiquitin E3 ligase to regulate FoxO1-mediated gene expression. J Biol Chem. 2008 Dec 19; 283(51):35464-73. PMID: 18815134.
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    10. Krajewska M, Banares S, Zhang EE, Huang X, Scadeng M, Jhala US, Feng GS, Krajewski S. Development of diabesity in mice with neuronal deletion of Shp2 tyrosine phosphatase. Am J Pathol. 2008 May; 172(5):1312-24. PMID: 18403587.
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    11. Serra C, Palacios D, Mozzetta C, Forcales SV, Morantte I, Ripani M, Jones DR, Du K, Jhala US, Simone C, Puri PL. Functional interdependence at the chromatin level between the MKK6/p38 and IGF1/PI3K/AKT pathways during muscle differentiation. Mol Cell. 2007 Oct 26; 28(2):200-13. PMID: 17964260.
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    12. Malecki MT, Lebrun P, Pezzolesi M, Warram JH, Krolewski AS, Jhala US. A newly identified mutation in an IPF1 binding site of the insulin gene promoter may predispose to type 2 diabetes mellitus. Diabetologia. 2006 Aug; 49(8):1985-7. PMID: 16741735.
      View in: PubMed
    13. Bordone L, Motta MC, Picard F, Robinson A, Jhala US, Apfeld J, McDonagh T, Lemieux M, McBurney M, Szilvasi A, Easlon EJ, Lin SJ, Guarente L. Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biol. 2006 Feb; 4(2):e31. PMID: 16366736.
      View in: PubMed
    14. Hennige AM, Ozcan U, Okada T, Jhala US, Schubert M, White MF, Kulkarni RN. Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells. Am J Physiol Endocrinol Metab. 2005 Aug; 289(2):E337-46. PMID: 15827066.
      View in: PubMed
    15. Kulkarni RN, Jhala US, Winnay JN, Krajewski S, Montminy M, Kahn CR. PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. J Clin Invest. 2004 Sep; 114(6):828-36. PMID: 15372107.
      View in: PubMed
    16. Jhala US, Canettieri G, Screaton RA, Kulkarni RN, Krajewski S, Reed J, Walker J, Lin X, White M, Montminy M. cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Genes Dev. 2003 Jul 01; 17(13):1575-80. PMID: 12842910.
      View in: PubMed
    17. Herzig S, Long F, Jhala US, Hedrick S, Quinn R, Bauer A, Rudolph D, Schutz G, Yoon C, Puigserver P, Spiegelman B, Montminy M. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature. 2001 Sep 13; 413(6852):179-83. PMID: 11557984.
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    18. Du K, Asahara H, Jhala US, Wagner BL, Montminy M. Characterization of a CREB gain-of-function mutant with constitutive transcriptional activity in vivo. Mol Cell Biol. 2000 Jun; 20(12):4320-7. PMID: 10825195.
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    19. Malecki MT, Jhala US, Antonellis A, Fields L, Doria A, Orban T, Saad M, Warram JH, Montminy M, Krolewski AS. Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus. Nat Genet. 1999 Nov; 23(3):323-8. PMID: 10545951.
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    20. Parker D, Jhala US, Radhakrishnan I, Yaffe MB, Reyes C, Shulman AI, Cantley LC, Wright PE, Montminy M. Analysis of an activator:coactivator complex reveals an essential role for secondary structure in transcriptional activation. Mol Cell. 1998 Sep; 2(3):353-9. PMID: 9774973.
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    21. Chung-Bok MI, Vincent N, Jhala U, Watford M. Rat hepatic glutaminase: identification of the full coding sequence and characterization of a functional promoter. Biochem J. 1997 May 15; 324 ( Pt 1):193-200. PMID: 9164856.
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    22. Sharma S, Jhala US, Johnson T, Ferreri K, Leonard J, Montminy M. Hormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1. Mol Cell Biol. 1997 May; 17(5):2598-604. PMID: 9111329.
      View in: PubMed
    23. Jhala U, Baly DL. Effect of chronic IL-1 beta infusion on glucose homeostasis and pancreatic insulin secretion. Life Sci. 1994; 54(6):413-22. PMID: 8295488.
      View in: PubMed
    24. Alexander-Bridges M, Mukhopadhyay NK, Jhala U, Denaro M, Kong XF, Avruch J, Maller J. Growth factor-activated kinases phosphorylate IRE-ABP. Biochem Soc Trans. 1992 Aug; 20(3):691-3. PMID: 1426612.
      View in: PubMed
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