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Ulupi Jhala

Title(s)Associate Adjunct Professor, Pediatrics
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #0983
La Jolla CA 92093
Phone8/8-22--2072
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    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms of Pancreatic Beta Cell Dysfunction
    NIH/NIDDK R01DK116038Jul 10, 2018 - Jun 30, 2022
    Role: Principal Investigator
    Molecular Mechanisms Regulating Beta Cell Death
    NIH/NIDDK R56DK105443Apr 1, 2015 - Mar 31, 2017
    Role: Principal Investigator
    Signaling Cascades in Regulation of Pancreatic Beta cell mass.
    NIH/NIDDK R01DK080147Feb 1, 2010 - Nov 30, 2013
    Role: Principal Investigator
    Transcriptional Mechanisms of Beta Cell Gene Expression
    NIH/NIDDK R21DK066203Dec 15, 2003 - Nov 30, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development. Nat Commun. 2020 04 29; 11(1):2082. Vinckier NK, Patel NA, Geusz RJ, Wang A, Wang J, Matta I, Harrington AR, Wortham M, Wetton N, Wang J, Jhala US, Rosenfeld MG, Benner CW, Shih HP, Sander M. PMID: 32350257.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Correction: Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic ß Cells. PLoS Biol. 2015 Dec; 13(12):e1002346. Bordone L, Motta MC, Picard F, Robinson A, Jhala US, Apfeld J, McDonagh T, Lemieux M, McBurney M, Szilvasi A, Easlon EJ, Lin SJ, Guarente L. PMID: 26714029.
      View in: PubMed   Mentions: 4     Fields:    
    3. Loss of TRB3 alters dynamics of MLK3-JNK signaling and inhibits cytokine-activated pancreatic beta cell death. J Biol Chem. 2014 Oct 24; 289(43):29994-30004. Humphrey RK, Ray A, Gonuguntla S, Hao E, Jhala US. PMID: 25204656.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Specification of hepatopancreas progenitors in zebrafish by hnf1ba and wnt2bb. Development. 2013 Jul; 140(13):2669-79. Lancman JJ, Zvenigorodsky N, Gates KP, Zhang D, Solomon K, Humphrey RK, Kuo T, Setiawan L, Verkade H, Chi YI, Jhala US, Wright CV, Stainier DY, Dong PD. PMID: 23720049.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    5. Proteomic analysis of protein palmitoylation in adipocytes. Adipocyte. 2013; 2(1):17-28. Ren W, Jhala US, Du K. PMID: 23599907.
      View in: PubMed   Mentions: 30     Fields:    
    6. Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic ß cell death. J Biol Chem. 2013 Jan 25; 288(4):2428-40. Humphrey RK, Yu SM, Bellary A, Gonuguntla S, Yebra M, Jhala US. PMID: 23172226.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    7. Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells. J Biol Chem. 2010 Jul 16; 285(29):22426-36. Humphrey RK, Newcomb CJ, Yu SM, Hao E, Yu D, Krajewski S, Du K, Jhala US. PMID: 20421299.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    8. Glucose regulates steady-state levels of PDX1 via the reciprocal actions of GSK3 and AKT kinases. J Biol Chem. 2010 Jan 29; 285(5):3406-16. Humphrey RK, Yu SM, Flores LE, Jhala US. PMID: 19833727.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    9. COP1 functions as a FoxO1 ubiquitin E3 ligase to regulate FoxO1-mediated gene expression. J Biol Chem. 2008 Dec 19; 283(51):35464-73. Kato S, Ding J, Pisck E, Jhala US, Du K. PMID: 18815134.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    10. Development of diabesity in mice with neuronal deletion of Shp2 tyrosine phosphatase. Am J Pathol. 2008 May; 172(5):1312-24. Krajewska M, Banares S, Zhang EE, Huang X, Scadeng M, Jhala US, Feng GS, Krajewski S. PMID: 18403587.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    11. Functional interdependence at the chromatin level between the MKK6/p38 and IGF1/PI3K/AKT pathways during muscle differentiation. Mol Cell. 2007 Oct 26; 28(2):200-13. Serra C, Palacios D, Mozzetta C, Forcales SV, Morantte I, Ripani M, Jones DR, Du K, Jhala US, Simone C, Puri PL. PMID: 17964260.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    12. A newly identified mutation in an IPF1 binding site of the insulin gene promoter may predispose to type 2 diabetes mellitus. Diabetologia. 2006 Aug; 49(8):1985-7. Malecki MT, Lebrun P, Pezzolesi M, Warram JH, Krolewski AS, Jhala US. PMID: 16741735.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    13. Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biol. 2006 Feb; 4(2):e31. Bordone L, Motta MC, Picard F, Robinson A, Jhala US, Apfeld J, McDonagh T, Lemieux M, McBurney M, Szilvasi A, Easlon EJ, Lin SJ, Guarente L. PMID: 16366736.
      View in: PubMed   Mentions: 251     Fields:    Translation:AnimalsCells
    14. Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells. Am J Physiol Endocrinol Metab. 2005 Aug; 289(2):E337-46. Hennige AM, Ozcan U, Okada T, Jhala US, Schubert M, White MF, Kulkarni RN. PMID: 15827066.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    15. PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. J Clin Invest. 2004 Sep; 114(6):828-36. Kulkarni RN, Jhala US, Winnay JN, Krajewski S, Montminy M, Kahn CR. PMID: 15372107.
      View in: PubMed   Mentions: 101     Fields:    Translation:Animals
    16. cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Genes Dev. 2003 Jul 01; 17(13):1575-80. Jhala US, Canettieri G, Screaton RA, Kulkarni RN, Krajewski S, Reed J, Walker J, Lin X, White M, Montminy M. PMID: 12842910.
      View in: PubMed   Mentions: 171     Fields:    Translation:HumansAnimalsCells
    17. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature. 2001 Sep 13; 413(6852):179-83. Herzig S, Long F, Jhala US, Hedrick S, Quinn R, Bauer A, Rudolph D, Schutz G, Yoon C, Puigserver P, Spiegelman B, Montminy M. PMID: 11557984.
      View in: PubMed   Mentions: 473     Fields:    Translation:HumansAnimalsCells
    18. Characterization of a CREB gain-of-function mutant with constitutive transcriptional activity in vivo. Mol Cell Biol. 2000 Jun; 20(12):4320-7. Du K, Asahara H, Jhala US, Wagner BL, Montminy M. PMID: 10825195.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    19. Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus. Nat Genet. 1999 Nov; 23(3):323-8. Malecki MT, Jhala US, Antonellis A, Fields L, Doria A, Orban T, Saad M, Warram JH, Montminy M, Krolewski AS. PMID: 10545951.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansCells
    20. Analysis of an activator:coactivator complex reveals an essential role for secondary structure in transcriptional activation. Mol Cell. 1998 Sep; 2(3):353-9. Parker D, Jhala US, Radhakrishnan I, Yaffe MB, Reyes C, Shulman AI, Cantley LC, Wright PE, Montminy M. PMID: 9774973.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    21. Rat hepatic glutaminase: identification of the full coding sequence and characterization of a functional promoter. Biochem J. 1997 May 15; 324 ( Pt 1):193-200. Chung-Bok MI, Vincent N, Jhala U, Watford M. PMID: 9164856.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    22. Hormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1. Mol Cell Biol. 1997 May; 17(5):2598-604. Sharma S, Jhala US, Johnson T, Ferreri K, Leonard J, Montminy M. PMID: 9111329.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    23. Effect of chronic IL-1 beta infusion on glucose homeostasis and pancreatic insulin secretion. Life Sci. 1994; 54(6):413-22. Jhala U, Baly DL. PMID: 8295488.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    24. Growth factor-activated kinases phosphorylate IRE-ABP. Biochem Soc Trans. 1992 Aug; 20(3):691-3. Alexander-Bridges M, Mukhopadhyay NK, Jhala U, Denaro M, Kong XF, Avruch J, Maller J. PMID: 1426612.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
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