Ulupi Jhala

Title(s)	Associate Adjunct Professor, Pediatrics
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Research

Research Activities and Funding

Mechanisms of Pancreatic Beta Cell Dysfunction
NIH R01DK116038Jul 10, 2018 - Jun 30, 2022
Role: Principal Investigator

Molecular Mechanisms Regulating Beta Cell Death
NIH R56DK105443Apr 1, 2015 - Mar 31, 2018
Role: Principal Investigator

Signaling Cascades in Regulation of Pancreatic Beta cell mass.
NIH R01DK080147Feb 5, 2008 - Nov 30, 2013
Role: Principal Investigator

Transcriptional Mechanisms of Beta Cell Gene Expression
NIH R21DK066203Dec 15, 2003 - Nov 30, 2006
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development. Nat Commun. 2020 04 29; 11(1):2082. Vinckier NK, Patel NA, Geusz RJ, Wang A, Wang J, Matta I, Harrington AR, Wortham M, Wetton N, Wang J, Jhala US, Rosenfeld MG, Benner CW, Shih HP, Sander M. PMID: 32350257; PMCID: PMC7190832.

View in: PubMed Mentions: 5 Fields:
Bio Biology Sci Science
Translation:Humans Animals Cells
Correction: Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells. PLoS Biol. 2015 Dec; 13(12):e1002346. Bordone L, Motta MC, Picard F, Robinson A, Jhala US, Apfeld J, McDonagh T, Lemieux M, McBurney M, Szilvasi A, Easlon EJ, Lin SJ, Guarente L. PMID: 26714029; PMCID: PMC4694709.

View in: PubMed Mentions: 7 Fields:
Bio Biology
Loss of TRB3 alters dynamics of MLK3-JNK signaling and inhibits cytokine-activated pancreatic beta cell death. J Biol Chem. 2014 Oct 24; 289(43):29994-30004. Humphrey RK, Ray A, Gonuguntla S, Hao E, Jhala US. PMID: 25204656; PMCID: PMC4208007.

View in: PubMed Mentions: 5 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Specification of hepatopancreas progenitors in zebrafish by hnf1ba and wnt2bb. Development. 2013 Jul; 140(13):2669-79. Lancman JJ, Zvenigorodsky N, Gates KP, Zhang D, Solomon K, Humphrey RK, Kuo T, Setiawan L, Verkade H, Chi YI, Jhala US, Wright CV, Stainier DY, Dong PD. PMID: 23720049; PMCID: PMC3678338.

View in: PubMed Mentions: 12 Fields:
Bio Biology Emb Embryology
Translation:Animals Cells
Proteomic analysis of protein palmitoylation in adipocytes. Adipocyte. 2013; 2(1):17-28. Ren W, Jhala US, Du K. PMID: 23599907; PMCID: PMC3627377.

View in: PubMed Mentions: 47 Fields:
Cel Cell Biology Met Metabolism Phy Physiology
Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic β cell death. J Biol Chem. 2013 Jan 25; 288(4):2428-40. Humphrey RK, Yu SM, Bellary A, Gonuguntla S, Yebra M, Jhala US. PMID: 23172226; PMCID: PMC3554912.

View in: PubMed Mentions: 11 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells. J Biol Chem. 2010 Jul 16; 285(29):22426-36. Humphrey RK, Newcomb CJ, Yu SM, Hao E, Yu D, Krajewski S, Du K, Jhala US. PMID: 20421299; PMCID: PMC2903363.

View in: PubMed Mentions: 22 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Glucose regulates steady-state levels of PDX1 via the reciprocal actions of GSK3 and AKT kinases. J Biol Chem. 2010 Jan 29; 285(5):3406-16. Humphrey RK, Yu SM, Flores LE, Jhala US. PMID: 19833727; PMCID: PMC2823452.

View in: PubMed Mentions: 37 Fields:
Bio Biochemistry
Translation:Humans Animals
COP1 functions as a FoxO1 ubiquitin E3 ligase to regulate FoxO1-mediated gene expression. J Biol Chem. 2008 Dec 19; 283(51):35464-73. Kato S, Ding J, Pisck E, Jhala US, Du K. PMID: 18815134; PMCID: PMC2602905.

View in: PubMed Mentions: 48 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Development of diabesity in mice with neuronal deletion of Shp2 tyrosine phosphatase. Am J Pathol. 2008 May; 172(5):1312-24. Krajewska M, Banares S, Zhang EE, Huang X, Scadeng M, Jhala US, Feng GS, Krajewski S. PMID: 18403587; PMCID: PMC2329840.

View in: PubMed Mentions: 28 Fields:
Pat Pathology
Translation:Animals Cells
Functional interdependence at the chromatin level between the MKK6/p38 and IGF1/PI3K/AKT pathways during muscle differentiation. Mol Cell. 2007 Oct 26; 28(2):200-13. Serra C, Palacios D, Mozzetta C, Forcales SV, Morantte I, Ripani M, Jones DR, Du K, Jhala US, Simone C, Puri PL. PMID: 17964260; PMCID: PMC2693200.

View in: PubMed Mentions: 98 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Animals Cells
A newly identified mutation in an IPF1 binding site of the insulin gene promoter may predispose to type 2 diabetes mellitus. Diabetologia. 2006 Aug; 49(8):1985-7. Malecki MT, Lebrun P, Pezzolesi M, Warram JH, Krolewski AS, Jhala US. PMID: 16741735.

View in: PubMed Mentions: 1 Fields:
End Endocrinology
Translation:Humans Cells
Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biol. 2006 Feb; 4(2):e31. Bordone L, Motta MC, Picard F, Robinson A, Jhala US, Apfeld J, McDonagh T, Lemieux M, McBurney M, Szilvasi A, Easlon EJ, Lin SJ, Guarente L. PMID: 16366736; PMCID: PMC1318478.

View in: PubMed Mentions: 298 Fields:
Bio Biology
Translation:Animals Cells
Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells. Am J Physiol Endocrinol Metab. 2005 Aug; 289(2):E337-46. Hennige AM, Ozcan U, Okada T, Jhala US, Schubert M, White MF, Kulkarni RN. PMID: 15827066.

View in: PubMed Mentions: 12 Fields:
End Endocrinology Met Metabolism Phy Physiology
Translation:Animals Cells
PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. J Clin Invest. 2004 Sep; 114(6):828-36. Kulkarni RN, Jhala US, Winnay JN, Krajewski S, Montminy M, Kahn CR. PMID: 15372107; PMCID: PMC516265.

View in: PubMed Mentions: 113 Fields:
Med Medicine (General)
Translation:Animals
cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Genes Dev. 2003 Jul 01; 17(13):1575-80. Jhala US, Canettieri G, Screaton RA, Kulkarni RN, Krajewski S, Reed J, Walker J, Lin X, White M, Montminy M. PMID: 12842910; PMCID: PMC196130.

View in: PubMed Mentions: 200 Fields:
Mol Molecular Biology
Translation:Humans Animals Cells
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature. 2001 Sep 13; 413(6852):179-83. Herzig S, Long F, Jhala US, Hedrick S, Quinn R, Bauer A, Rudolph D, Schutz G, Yoon C, Puigserver P, Spiegelman B, Montminy M. PMID: 11557984.

View in: PubMed Mentions: 572 Fields:
Sci Science
Translation:Humans Animals Cells
Characterization of a CREB gain-of-function mutant with constitutive transcriptional activity in vivo. Mol Cell Biol. 2000 Jun; 20(12):4320-7. Du K, Asahara H, Jhala US, Wagner BL, Montminy M. PMID: 10825195; PMCID: PMC85799.

View in: PubMed Mentions: 43 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Animals Cells
Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus. Nat Genet. 1999 Nov; 23(3):323-8. Malecki MT, Jhala US, Antonellis A, Fields L, Doria A, Orban T, Saad M, Warram JH, Montminy M, Krolewski AS. PMID: 10545951.

View in: PubMed Mentions: 154 Fields:
Gen Genetics
Translation:Humans Cells
Analysis of an activator:coactivator complex reveals an essential role for secondary structure in transcriptional activation. Mol Cell. 1998 Sep; 2(3):353-9. Parker D, Jhala US, Radhakrishnan I, Yaffe MB, Reyes C, Shulman AI, Cantley LC, Wright PE, Montminy M. PMID: 9774973.

View in: PubMed Mentions: 47 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Cells
Rat hepatic glutaminase: identification of the full coding sequence and characterization of a functional promoter. Biochem J. 1997 May 15; 324 ( Pt 1):193-200. Chung-Bok MI, Vincent N, Jhala U, Watford M. PMID: 9164856; PMCID: PMC1218416.

View in: PubMed Mentions: 12 Fields:
Bio Biochemistry
Translation:Animals Cells
Hormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1. Mol Cell Biol. 1997 May; 17(5):2598-604. Sharma S, Jhala US, Johnson T, Ferreri K, Leonard J, Montminy M. PMID: 9111329; PMCID: PMC232109.

View in: PubMed Mentions: 32 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals Cells
Effect of chronic IL-1 beta infusion on glucose homeostasis and pancreatic insulin secretion. Life Sci. 1994; 54(6):413-22. Jhala U, Baly DL. PMID: 8295488.

View in: PubMed Mentions: 3 Fields:
Bio Biochemistry Bio Biology Phy Physiology
Translation:Animals
Growth factor-activated kinases phosphorylate IRE-ABP. Biochem Soc Trans. 1992 Aug; 20(3):691-3. Alexander-Bridges M, Mukhopadhyay NK, Jhala U, Denaro M, Kong XF, Avruch J, Maller J. PMID: 1426612.

View in: PubMed Mentions: 1 Fields:
Bio Biochemistry
Translation:Animals Cells