Tanya Nguyen

Title(s)Associate Clinical Professor, Psychiatry
SchoolHealth Sciences
Address200 W. Arbor Drive #8484
San Diego CA 92103
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    Dr. Tanya Nguyen earned her undergraduate degree in Neuroscience from the University of Southern California and her Ph.D. in Clinical Psychology (with an emphasis in Neuropsychology) from the SDSU/UCSD Joint Doctoral Program in Clinical Psychology. She completed her clinical internship at the VA Palo Alto and her postdoctoral fellowship at the VA San Diego in the Mental Illness Research, Education, and Clinical Centers (MIRECC), with a focus on neuropsychological assessment and clinical research. She then joined the clinical faculty in the UCSD School of Medicine, as Program Director of the Senior Behavioral Health (SBH) Intensive Outpatient Program and an attending neuropsychologist on the SBH inpatient unit. Her clinical expertise is in conducting neuropsychological evaluations to help determine causes of neurological or cognitive problems. Dr. Nguyen is actively involved in clinical research. She has been the PI on several NIH and national/local foundation grants. Broadly, her research aims to identify mechanisms cognitive and biological aging in serious mental illnesses. Her current work is focused on the gut-brain axis and understanding the relationship between the gut microbiome and brain/behavior, particularly as it pertains to accelerated aging in mental illness but also in healthy aging. Dr. Nguyen was awarded an NIMH K23 Career Development Award to investigate the role of inflammation and the gut microbiome in schizophrenia and how imbalance of the gut ecosystem can alter immune responses, leading to alterations to brain and behavioral function.

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    Characterizing the gut microbiome in schizophrenia: Relationship to age, cognition, & disease-related factors
    NIH K23MH118435Jul 1, 2019 - Jun 30, 2023
    Role: Principal Investigator
    Inflammatory Correlates of Cognitive and Neural Heterogeneity in Schizophrenia
    APA Society for Clinical Neuropsychology Early Career Pilot Study Award Jul 1, 2016 - Jun 30, 2017
    Role: Principal Investigator
    Choline Intervention in Children with Fetal Alcohol Spectrum Disorders
    NIH F31AA021630Sep 10, 2012 - Sep 9, 2016
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Associations between inflammatory marker profiles and neurocognitive functioning in people with schizophrenia and non-psychiatric comparison subjects. J Psychiatr Res. 2022 Mar 02; 149:106-113. Adamowicz DH, Shilling PD, Palmer BW, Nguyen TT, Wang E, Liu C, Tu X, Jeste DV, Irwin MR, Lee EE. PMID: 35259663.
      View in: PubMed   Mentions:
    2. The Microbiota-Gut-Brain Axis in Alzheimer's Disease: A Review of Taxonomic Alterations and Potential Avenues for Interventions. Arch Clin Neuropsychol. 2022 Feb 24. Murray ER, Kemp M, Nguyen TT. PMID: 35202456.
      View in: PubMed   Mentions:
    3. Partial least squares regression and principal component analysis: similarity and differences between two popular variable reduction approaches. Gen Psychiatr. 2022; 35(1):e100662. Liu C, Zhang X, Nguyen TT, Liu J, Wu T, Lee E, Tu XM. PMID: 35146334; PMCID: PMC8796256.
      View in: PubMed   Mentions:
    4. The Fecal Microbiome and Metabolome of Pitt Hopkins Syndrome, a Severe Autism Spectrum Disorder. mSystems. 2021 Dec 21; 6(6):e0100621. Dilmore AH, McDonald D, Nguyen TT, Adams JB, Krajmalnik-Brown R, Elijah E, Dorrestein PC, Knight R. PMID: 34846164; PMCID: PMC8631314.
      View in: PubMed   Mentions:
    5. Multi-omics of human plasma reveals molecular features of dysregulated inflammation and accelerated aging in schizophrenia. Mol Psychiatry. 2022 Feb; 27(2):1217-1225. Campeau A, Mills RH, Stevens T, Rossitto LA, Meehan M, Dorrestein P, Daly R, Nguyen TT, Gonzalez DJ, Jeste DV, Hook V. PMID: 34741130.
      View in: PubMed   Mentions:
    6. Neurobiology of loneliness: a systematic review. Neuropsychopharmacology. 2021 10; 46(11):1873-1887. Lam JA, Murray ER, Yu KE, Ramsey M, Nguyen TT, Mishra J, Martis B, Thomas ML, Lee EE. PMID: 34230607; PMCID: PMC8258736.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Physical and Mental Health Characteristics of 2,962 Adults With Subjective Cognitive Complaints. Int J Aging Hum Dev. 2022 Jun; 94(4):459-477. Van Patten R, Nguyen TT, Mahmood Z, Lee EE, Daly RE, Palmer BW, Wu TC, Tu X, Jeste DV, Twamley EW. PMID: 34192887; PMCID: PMC8842563.
      View in: PubMed   Mentions:    Fields:    
    8. Ageism: The Brain Strikes Back. Cerebrum. 2021 Jul-Aug; 2021. Nguyen TT, Jeste DV. PMID: 34650669; PMCID: PMC8493820.
      View in: PubMed   Mentions:
    9. Physical frailty as an important indicator of accelerated biological aging in serious mental illnesses. Int Psychogeriatr. 2021 Jun 15; 1-3. Graham SA, Nguyen TT. PMID: 34127170.
      View in: PubMed   Mentions:    Fields:    
    10. A semiparametric model for between-subject attributes: Applications to beta-diversity of microbiome data. Biometrics. 2021 May 19. Liu J, Zhang X, Chen T, Wu T, Lin T, Jiang L, Lang S, Liu L, Natarajan L, Tu JX, Kosciolek T, Morton J, Nguyen TT, Schnabl B, Knight R, Feng C, Zhong Y, Tu XM. PMID: 34010477; PMCID: PMC8602427.
      View in: PubMed   Mentions:    Fields:    
    11. Wisdom as a potential antidote to loneliness in aging. Int Psychogeriatr. 2021 05; 33(5):429-431. Nguyen TT. PMID: 34057066; PMCID: PMC8247117.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Microbes and geriatric mental health: past, present, and future. Int Psychogeriatr. 2022 Jan; 34(1):3-5. Vaccariello ED, Nguyen TT, Vaccariello ED, Nguyen TT. PMID: 33926593; PMCID: PMC8556388.
      View in: PubMed   Mentions:    Fields:    
    13. Chemokine MCP1 is associated with cognitive flexibility in schizophrenia: A preliminary analysis. J Psychiatr Res. 2021 06; 138:139-145. Klaus F, Mitchell K, Liou SC, Eyler LT, Nguyen TT. PMID: 33852994; PMCID: PMC8192469.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Association of Loneliness and Wisdom With Gut Microbial Diversity and Composition: An Exploratory Study. Front Psychiatry. 2021; 12:648475. Nguyen TT, Zhang X, Wu TC, Liu J, Le C, Tu XM, Knight R, Jeste DV. PMID: 33841213; PMCID: PMC8029068.
      View in: PubMed   Mentions: 2  
    15. Rates of Cognitive and Functional Impairments in Older Adults Residing in a Continuing Care Senior Housing Community. J Int Neuropsychol Soc. 2022 01; 28(1):62-73. Van Patten R, Mahmood Z, Nguyen TT, Maye JE, Kim HC, Jeste DV, Twamley EW. PMID: 33749570; PMCID: PMC8455703.
      View in: PubMed   Mentions:    Fields:    
    16. Exposure to Epstein Barr virus and cognitive functioning in individuals with schizophrenia. Schizophr Res. 2021 02; 228:193-197. Dickerson F, Katsafanas E, Origoni A, Squire A, Khushalani S, Newman T, Rowe K, Stallings C, Savage CLG, Sweeney K, Nguyen TT, Breier A, Goff D, Ford G, Jones-Brando L, Yolken R. PMID: 33450604; PMCID: PMC8023564.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    17. The Gut Microbiome, Aging, and Longevity: A Systematic Review. Nutrients. 2020 Dec 07; 12(12). Badal VD, Vaccariello ED, Murray ER, Yu KE, Knight R, Jeste DV, Nguyen TT. PMID: 33297486; PMCID: PMC7762384.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    18. Predictors of Loneliness by Age Decade: Study of Psychological and Environmental Factors in 2,843 Community-Dwelling Americans Aged 20-69 Years. J Clin Psychiatry. 2020 11 10; 81(6). Nguyen TT, Lee EE, Daly RE, Wu TC, Tang Y, Tu X, Van Patten R, Jeste DV, Palmer BW. PMID: 33176072; PMCID: PMC7953851.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    19. Gut microbiome in Schizophrenia: Altered functional pathways related to immune modulation and atherosclerotic risk. Brain Behav Immun. 2021 01; 91:245-256. Nguyen TT, Kosciolek T, Daly RE, Vázquez-Baeza Y, Swafford A, Knight R, Jeste DV. PMID: 33098964; PMCID: PMC8023565.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    20. Study of loneliness and wisdom in 482 middle-aged and oldest-old adults: a comparison between people in Cilento, Italy and San Diego, USA. Aging Ment Health. 2021 11; 25(11):2149-2159. Jeste DV, Di Somma S, Lee EE, Nguyen TT, Scalcione M, Biaggi A, Daly R, Liu J, Tu X, Ziedonis D, Glorioso D, Antonini P, Brenner D. PMID: 33000647; PMCID: PMC8012404.
      View in: PubMed   Mentions: 5     Fields:    
    21. Beyond artificial intelligence: exploring artificial wisdom. Int Psychogeriatr. 2020 08; 32(8):993-1001. Jeste DV, Graham SA, Nguyen TT, Depp CA, Lee EE, Kim HC. PMID: 32583762; PMCID: PMC7942180.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    22. Gut microbiome in serious mental illnesses: A systematic review and critical evaluation. Schizophr Res. 2021 08; 234:24-40. Nguyen TT, Hathaway H, Kosciolek T, Knight R, Jeste DV. PMID: 31495702; PMCID: PMC7056547.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    23. Quantitative Imaging Biomarkers of Damage to Critical Memory Regions Are Associated With Post-Radiation Therapy Memory Performance in Brain Tumor Patients. Int J Radiat Oncol Biol Phys. 2019 11 15; 105(4):773-783. Tringale KR, Nguyen TT, Karunamuni R, Seibert T, Huynh-Le MP, Connor M, Moiseenko V, Gorman MK, Marshall A, Tibbs MD, Farid N, Simpson D, Sanghvi P, McDonald CR, Hattangadi-Gluth JA. PMID: 31408667; PMCID: PMC6876859.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansPHPublic Health
    24. Positive light on schizophrenia and aging: Commentary on course and predictors of symptomatic remission in schizophrenia: A 5-year follow-up study in a Dutch psychiatric catchment area, by Lange et al. Schizophr Res. 2019 09; 211:32-33. Nguyen TT, Jeste DV. PMID: 31377051; PMCID: PMC6718309.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. Identifying early diffusion imaging biomarkers of regional white matter injury as indicators of executive function decline following brain radiotherapy: A prospective clinical trial in primary brain tumor patients. Radiother Oncol. 2019 03; 132:27-33. Tringale KR, Nguyen T, Bahrami N, Marshall DC, Leyden KM, Karunamuni R, Seibert TM, Kay Gorman M, Connor M, Burkeen J, Piccioni DE, Farid N, Hattangadi-Gluth JA, McDonald CR. PMID: 30825966; PMCID: PMC6400307.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansPHPublic Health
    26. Differences in gut microbiome composition between persons with chronic schizophrenia and healthy comparison subjects. Schizophr Res. 2019 02; 204:23-29. Nguyen TT, Kosciolek T, Maldonado Y, Daly RE, Martin AS, McDonald D, Knight R, Jeste DV. PMID: 30268819; PMCID: PMC6755901.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    27. American Gut: an Open Platform for Citizen Science Microbiome Research. mSystems. 2018 May-Jun; 3(3). McDonald D, Hyde E, Debelius JW, Morton JT, Gonzalez A, Ackermann G, Aksenov AA, Behsaz B, Brennan C, Chen Y, DeRight Goldasich L, Dorrestein PC, Dunn RR, Fahimipour AK, Gaffney J, Gilbert JA, Gogul G, Green JL, Hugenholtz P, Humphrey G, Huttenhower C, Jackson MA, Janssen S, Jeste DV, Jiang L, Kelley ST, Knights D, Kosciolek T, Ladau J, Leach J, Marotz C, Meleshko D, Melnik AV, Metcalf JL, Mohimani H, Montassier E, Navas-Molina J, Nguyen TT, Peddada S, Pevzner P, Pollard KS, Rahnavard G, Robbins-Pianka A, Sangwan N, Shorenstein J, Smarr L, Song SJ, Spector T, Swafford AD, Thackray VG, Thompson LR, Tripathi A, Vázquez-Baeza Y, Vrbanac A, Wischmeyer P, Wolfe E, Zhu Q, American Gut Consortium , Knight R. PMID: 29795809; PMCID: PMC5954204.
      View in: PubMed   Mentions: 146  
    28. Systemic Biomarkers of Accelerated Aging in Schizophrenia: A Critical Review and Future Directions. Schizophr Bull. 2018 02 15; 44(2):398-408. Nguyen TT, Eyler LT, Jeste DV. PMID: 29462455; PMCID: PMC5815075.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    29. Overview and systematic review of studies of microbiome in schizophrenia and bipolar disorder. J Psychiatr Res. 2018 04; 99:50-61. Nguyen TT, Kosciolek T, Eyler LT, Knight R, Jeste DV. PMID: 29407287; PMCID: PMC5849533.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    30. Abnormal levels of vascular endothelial biomarkers in schizophrenia. Eur Arch Psychiatry Clin Neurosci. 2018 Dec; 268(8):849-860. Nguyen TT, Dev SI, Chen G, Liou SC, Martin AS, Irwin MR, Carroll JE, Tu X, Jeste DV, Eyler LT. PMID: 28942562; PMCID: PMC8023592.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    31. Successful Aging of Physicians. Am J Geriatr Psychiatry. 2018 02; 26(2):209-211. Jeste DV, Nguyen TT. PMID: 28935514; PMCID: PMC8023569.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    32. Steeper Slope of Age-Related Changes in White Matter Microstructure and Processing Speed in Bipolar Disorder. Am J Geriatr Psychiatry. 2017 Jul; 25(7):744-752. Dev SI, Nguyen TT, McKenna BS, Sutherland AN, Bartsch H, Theilmann RJ, Eyler LT. PMID: 28342644; PMCID: PMC5479871.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    33. Cerebral Cortex Regions Selectively Vulnerable to Radiation Dose-Dependent Atrophy. Int J Radiat Oncol Biol Phys. 2017 04 01; 97(5):910-918. Seibert TM, Karunamuni R, Kaifi S, Burkeen J, Connor M, Krishnan AP, White NS, Farid N, Bartsch H, Murzin V, Nguyen TT, Moiseenko V, Brewer JB, McDonald CR, Dale AM, Hattangadi-Gluth JA. PMID: 28333012; PMCID: PMC5403140.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansPHPublic Health
    34. Randomized, double-blind, placebo-controlled clinical trial of choline supplementation in school-aged children with fetal alcohol spectrum disorders. Am J Clin Nutr. 2016 12; 104(6):1683-1692. Nguyen TT, Risbud RD, Mattson SN, Chambers CD, Thomas JD. PMID: 27806977; PMCID: PMC5118735.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    35. Dynamic functional connectivity in bipolar disorder is associated with executive function and processing speed: A preliminary study. Neuropsychology. 2017 01; 31(1):73-83. Nguyen TT, Kovacevic S, Dev SI, Lu K, Liu TT, Eyler LT. PMID: 27775400; PMCID: PMC5471616.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    36. Dietary Nutrient Intake in School-Aged Children With Heavy Prenatal Alcohol Exposure. Alcohol Clin Exp Res. 2016 05; 40(5):1075-82. Nguyen TT, Risbud RD, Chambers CD, Thomas JD. PMID: 27012806; PMCID: PMC4844832.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    37. The Use of Open- and Closed-Loop Control During Goal-Directed Force Responses by Children with Heavy Prenatal Alcohol Exposure. Alcohol Clin Exp Res. 2015 Sep; 39(9):1814-22. Simmons RW, Nguyen TT, Thomas JD, Riley EP. PMID: 26248225; PMCID: PMC4558327.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    38. Objective assessment of ADHD core symptoms in children with heavy prenatal alcohol exposure. Physiol Behav. 2015 Sep 01; 148:45-50. Infante MA, Moore EM, Nguyen TT, Fourligas N, Mattson SN, Riley EP. PMID: 25447751; PMCID: PMC4408220.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    39. The clinical utility and specificity of parent report of executive function among children with prenatal alcohol exposure. J Int Neuropsychol Soc. 2014 Aug; 20(7):704-16. Nguyen TT, Glass L, Coles CD, Kable JA, May PA, Kalberg WO, Sowell ER, Jones KL, Riley EP, Mattson SN, CIFASD. PMID: 25033032; PMCID: PMC4228981.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    40. Children with heavy prenatal alcohol exposure have different frequency domain signal characteristics when producing isometric force. Neurotoxicol Teratol. 2013 Jan-Feb; 35:14-20. Nguyen TT, Ashrafi A, Thomas JD, Riley EP, Simmons RW. PMID: 23238099; PMCID: PMC3603370.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    41. Children with heavy prenatal alcohol exposure experience reduced control of isotonic force. Alcohol Clin Exp Res. 2013 Feb; 37(2):315-24. Nguyen TT, Levy SS, Riley EP, Thomas JD, Simmons RW. PMID: 22834891; PMCID: PMC3752030.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    42. Children with heavy prenatal alcohol exposure exhibit deficits when regulating isometric force. Alcohol Clin Exp Res. 2012 Feb; 36(2):302-9. Simmons RW, Nguyen TT, Levy SS, Thomas JD, Mattson SN, Riley EP. PMID: 22014260; PMCID: PMC3578740.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    43. Fetal alcohol spectrum disorders: neuropsychological and behavioral features. Neuropsychol Rev. 2011 Jun; 21(2):81-101. Mattson SN, Crocker N, Nguyen TT. PMID: 21503685; PMCID: PMC3410672.
      View in: PubMed   Mentions: 197     Fields:    Translation:Humans
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