Tannishtha Reya
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Title(s) | Professor, Pharmacology and Medicine |
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School | Health Sciences |
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Phone | 858-534-6568 |
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vCard | Download vCard |
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Title(s) | Pharmacology and Medicine |
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Biography Williams College | B.A. | | Biology | University of Pennsylvania | Ph.D. | | Immunology | University of California San Francisco | Post-Doctoral Fellowship | | Immunology | Stanford University | Post-Doctoral Fellowship | | Stem Cell Biology |
| 2005 | | The Presidential Early Career Award for Scientists and Engineers (PECASE, US Govt.) | | 2007 | | Leukemia and Lymphoma Society Scholar Award | | 2008 | | Richard E Weitzman Award (Endocrine Society) | | 2009 | | NIH Director's Pioneer Award | | 2015 | | NCI Outstanding Investigator Award |
Overview The primary goal of our lab is to understand the signaling pathways that regulate the choice between stem cell renewal and commitment, and define how the same signals are subverted in cancer. The lab has three primary areas of interest: analyzing the role of developmental signals in stem cells and cancer, defining mechanisms that initiate stem cell regeneration after injury and developing high-resolution imaging strategies to visualize the behavior of living stem cells during growth, regeneration, and can¬cer formation. These studies have implications not only for understanding the basic mechanisms that regulate normal and oncogenic self-renewal, but also for enhancing stem cell based therapies for human disease.
Research ORNG Applications Bibliographic
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Lytle NK, Barber AG, Reya T. Stem cell fate in cancer growth, progression and therapy resistance. Nat Rev Cancer. 2018 Nov; 18(11):669-680. PMID: 30228301.
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Dravis C, Chung CY, Lytle NK, Herrera-Valdez J, Luna G, Trejo CL, Reya T, Wahl GM. Epigenetic and Transcriptomic Profiling of Mammary Gland Development and Tumor Models Disclose Regulators of Cell State Plasticity. Cancer Cell. 2018 Sep 10; 34(3):466-482.e6. PMID: 30174241.
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Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle NK, Dhar D, Banerjee S, Fagman JB, Browne CD, Umemura A, Valasek MA, Kessler H, Tarin D, Goggins M, Reya T, Diaz-Meco M, Moscat J, Karin M. Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. Cancer Cell. 2017 Dec 11; 32(6):824-839.e8. PMID: 29153842.
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Hui S, Ghergurovich JM, Morscher RJ, Jang C, Teng X, Lu W, Esparza LA, Reya T, Yanxiang Guo J, White E, Rabinowitz JD. Glucose feeds the TCA cycle via circulating lactate. Nature. 2017 11 02; 551(7678):115-118. PMID: 29045397.
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Bajaj J, Konuma T, Lytle NK, Kwon HY, Ablack JN, Cantor JM, Rizzieri D, Chuah C, Oehler VG, Broome EH, Ball ED, van der Horst EH, Ginsberg MH, Reya T. CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia. Cancer Cell. 2016 Nov 14; 30(5):792-805. PMID: 27908736.
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Haney S, Reya T, Bazhenov M. Delayed Onset of Symptoms Through Feedback Interference in Chronic Cancers. Converg Sci Phys Oncol. 2016; 2(4). PMID: 29744132.
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Koechlein CS, Harris JR, Lee TK, Weeks J, Fox RG, Zimdahl B, Ito T, Blevins A, Jung SH, Chute JP, Chourasia A, Covert MW, Reya T. High-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo. Nat Commun. 2016 07 18; 7:12169. PMID: 27425143.
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Fox RG, Lytle NK, Jaquish DV, Park FD, Ito T, Bajaj J, Koechlein CS, Zimdahl B, Yano M, Kopp J, Kritzik M, Sicklick J, Sander M, Grandgenett PM, Hollingsworth MA, Shibata S, Pizzo D, Valasek M, Sasik R, Scadeng M, Okano H, Kim Y, MacLeod AR, Lowy AM, Reya T. Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma. Nature. 2016 06 16; 534(7607):407-411. PMID: 27281208; PMCID: PMC4998062 [Available on 12/16/16].
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Kwon HY, Bajaj J, Ito T, Blevins A, Konuma T, Weeks J, Lytle NK, Koechlein CS, Rizzieri D, Chuah C, Oehler VG, Sasik R, Hardiman G, Reya T. Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia. Cell Stem Cell. 2015 Aug 06; 17(2):152-164. PMID: 26212080; PMCID: PMC4664079.
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Bajaj J, Zimdahl B, Reya T. Fearful symmetry: subversion of asymmetric division in cancer development and progression. Cancer Res. 2015 Mar 01; 75(5):792-7. PMID: 25681272; PMCID: PMC4784538.
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Fox RG, Park FD, Koechlein CS, Kritzik M, Reya T. Musashi signaling in stem cells and cancer. Annu Rev Cell Dev Biol. 2015; 31:249-67. PMID: 26566113.
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Wu X, Zhang W, Font-Burgada J, Palmer T, Hamil AS, Biswas SK, Poidinger M, Borcherding N, Xie Q, Ellies LG, Lytle NK, Wu LW, Fox RG, Yang J, Dowdy SF, Reya T, Karin M. Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade. Proc Natl Acad Sci U S A. 2014 Sep 23; 111(38):13870-5. PMID: 25189770; PMCID: PMC4183333.
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Lento W, Ito T, Zhao C, Harris JR, Huang W, Jiang C, Owzar K, Piryani S, Racioppi L, Chao N, Reya T. Loss of ß-catenin triggers oxidative stress and impairs hematopoietic regeneration. Genes Dev. 2014 May 01; 28(9):995-1004. PMID: 24788518; PMCID: PMC4018497.
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Zimdahl B, Ito T, Blevins A, Bajaj J, Konuma T, Weeks J, Koechlein CS, Kwon HY, Arami O, Rizzieri D, Broome HE, Chuah C, Oehler VG, Sasik R, Hardiman G, Reya T. Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia. Nat Genet. 2014 Mar; 46(3):245-52. PMID: 24487275; PMCID: PMC4267534.
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Lento W, Congdon K, Voermans C, Kritzik M, Reya T. Wnt signaling in normal and malignant hematopoiesis. Cold Spring Harb Perspect Biol. 2013 Feb 01; 5(2). PMID: 23378582; PMCID: PMC3552513.
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Himburg HA, Harris JR, Ito T, Daher P, Russell JL, Quarmyne M, Doan PL, Helms K, Nakamura M, Fixsen E, Herradon G, Reya T, Chao NJ, Harroch S, Chute JP. Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche. Cell Rep. 2012 Oct 25; 2(4):964-75. PMID: 23084748; PMCID: PMC3696585.
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Reya T. Tannishtha Reya: classic pathways, new views on cancer. Interview by Caitlin Sedwick. J Cell Biol. 2012 Sep 03; 198(5):766-7. PMID: 22945930; PMCID: PMC3432759.
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Fereshteh M, Ito T, Kovacs JJ, Zhao C, Kwon HY, Tornini V, Konuma T, Chen M, Lefkowitz RJ, Reya T. ß-Arrestin2 mediates the initiation and progression of myeloid leukemia. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12532-7. PMID: 22773819; PMCID: PMC3411976.
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Ito T, Zimdahl B, Reya T. aSIRTing control over cancer stem cells. Cancer Cell. 2012 Feb 14; 21(2):140-2. PMID: 22340585.
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Reya T. Illuminating immune privilege--a role for regulatory T cells in preventing rejection. N Engl J Med. 2011 Sep 08; 365(10):956-7. PMID: 21899457.
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Ito T, Kwon HY, Zimdahl B, Congdon KL, Blum J, Lento WE, Zhao C, Lagoo A, Gerrard G, Foroni L, Goldman J, Goh H, Kim SH, Kim DW, Chuah C, Oehler VG, Radich JP, Jordan CT, Reya T. Regulation of myeloid leukaemia by the cell-fate determinant Musashi. Nature. 2010 Aug 05; 466(7307):765-8. PMID: 20639863; PMCID: PMC2918284.
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Kim J, Tang JY, Gong R, Kim J, Lee JJ, Clemons KV, Chong CR, Chang KS, Fereshteh M, Gardner D, Reya T, Liu JO, Epstein EH, Stevens DA, Beachy PA. Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell. 2010 Apr 13; 17(4):388-99. PMID: 20385363; PMCID: PMC4039177.
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Himburg HA, Muramoto GG, Daher P, Meadows SK, Russell JL, Doan P, Chi JT, Salter AB, Lento WE, Reya T, Chao NJ, Chute JP. Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells. Nat Med. 2010 Apr; 16(4):475-82. PMID: 20305662; PMCID: PMC3689427.
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Zhao C, Chen A, Jamieson CH, Fereshteh M, Abrahamsson A, Blum J, Kwon HY, Kim J, Chute JP, Rizzieri D, Munchhof M, VanArsdale T, Beachy PA, Reya T. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature. 2009 Apr 09; 458(7239):776-9. PMID: 19169242; PMCID: PMC2946231.
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Kurokawa M, Zhao C, Reya T, Kornbluth S. Inhibition of apoptosome formation by suppression of Hsp90beta phosphorylation in tyrosine kinase-induced leukemias. Mol Cell Biol. 2008 Sep; 28(17):5494-506. PMID: 18591256; PMCID: PMC2519729.
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Congdon KL, Reya T. Divide and conquer: how asymmetric division shapes cell fate in the hematopoietic system. Curr Opin Immunol. 2008 Jun; 20(3):302-7. PMID: 18554882; PMCID: PMC2560983.
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Congdon KL, Voermans C, Ferguson EC, DiMascio LN, Uqoezwa M, Zhao C, Reya T. Activation of Wnt signaling in hematopoietic regeneration. Stem Cells. 2008 May; 26(5):1202-10. PMID: 18308947.
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Zhao C, Blum J, Chen A, Kwon HY, Jung SH, Cook JM, Lagoo A, Reya T. Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo. Cancer Cell. 2007 Dec; 12(6):528-41. PMID: 18068630; PMCID: PMC2262869.
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Wu M, Kwon HY, Rattis F, Blum J, Zhao C, Ashkenazi R, Jackson TL, Gaiano N, Oliver T, Reya T. Imaging hematopoietic precursor division in real time. Cell Stem Cell. 2007 Nov; 1(5):541-54. PMID: 18345353; PMCID: PMC2267762.
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Zhao Y, Altman BJ, Coloff JL, Herman CE, Jacobs SR, Wieman HL, Wofford JA, Dimascio LN, Ilkayeva O, Kelekar A, Reya T, Rathmell JC. Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. Mol Cell Biol. 2007 Jun; 27(12):4328-39. PMID: 17371841; PMCID: PMC1900055.
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Kitsos CM, Sankar U, Illario M, Colomer-Font JM, Duncan AW, Ribar TJ, Reya T, Means AR. Calmodulin-dependent protein kinase IV regulates hematopoietic stem cell maintenance. J Biol Chem. 2005 Sep 30; 280(39):33101-8. PMID: 16020540.
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Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature. 2005 Apr 14; 434(7035):843-50. PMID: 15829953.
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Duncan AW, Rattis FM, DiMascio LN, Congdon KL, Pazianos G, Zhao C, Yoon K, Cook JM, Willert K, Gaiano N, Reya T. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat Immunol. 2005 Mar; 6(3):314-22. PMID: 15665828.
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Ranheim EA, Kwan HC, Reya T, Wang YK, Weissman IL, Francke U. Frizzled 9 knock-out mice have abnormal B-cell development. Blood. 2005 Mar 15; 105(6):2487-94. PMID: 15572594.
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Pazianos G, Uqoezwa M, Reya T. The elements of stem cell self-renewal: a genetic perspective. Biotechniques. 2003 Dec; 35(6):1240-7. PMID: 14682059.
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Reya T, Duncan AW, Ailles L, Domen J, Scherer DC, Willert K, Hintz L, Nusse R, Weissman IL. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature. 2003 May 22; 423(6938):409-14. PMID: 12717450.
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Willert K, Brown JD, Danenberg E, Duncan AW, Weissman IL, Reya T, Yates JR, Nusse R. Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature. 2003 May 22; 423(6938):448-52. PMID: 12717451.
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Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature. 2001 Nov 01; 414(6859):105-11. PMID: 11689955.
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Reya T, O'Riordan M, Okamura R, Devaney E, Willert K, Nusse R, Grosschedl R. Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism. Immunity. 2000 Jul; 13(1):15-24. PMID: 10933391.
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Akashi K, Reya T, Dalma-Weiszhausz D, Weissman IL. Lymphoid precursors. Curr Opin Immunol. 2000 Apr; 12(2):144-50. PMID: 10712944.
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Reya T, Okamura R, Grosschedl R. Control of lymphocyte differentiation by the LEF-1/TCF family of transcription factors. Cold Spring Harb Symp Quant Biol. 1999; 64:133-40. PMID: 11232278.
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Reya T, Contractor NV, Couzens MS, Wasik MA, Emerson SG, Carding SR. Abnormal myelocytic cell development in interleukin-2 (IL-2)-deficient mice: evidence for the involvement of IL-2 in myelopoiesis. Blood. 1998 Apr 15; 91(8):2935-47. PMID: 9531604.
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Reya T, Grosschedl R. Transcriptional regulation of B-cell differentiation. Curr Opin Immunol. 1998 Apr; 10(2):158-65. PMID: 9602304.
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Reya T, Yang-Snyder JA, Rothenberg EV, Carding SR. Regulated expression and function of CD122 (interleukin-2/interleukin-15R-beta) during lymphoid development. Blood. 1996 Jan 01; 87(1):190-201. PMID: 8547641.
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1996 | 1 | 1998 | 2 | 1999 | 1 | 2000 | 2 | 2001 | 1 | 2003 | 3 | 2004 | 1 | 2005 | 3 | 2007 | 3 | 2008 | 3 | 2009 | 1 | 2010 | 3 | 2011 | 1 | 2012 | 4 | 2013 | 1 | 2014 | 3 | 2015 | 3 | 2016 | 4 | 2017 | 2 | 2018 | 2 |
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