Tannishtha Reya

Title(s)Professor, Pharmacology and Medicine
SchoolHealth Sciences
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    Other Positions
    Title(s)Pharmacology and Medicine

    Collapse Biography 
    Collapse Education and Training
    Williams CollegeB.A.Biology
    University of PennsylvaniaPh.D.Immunology
    University of California San FranciscoPost-Doctoral FellowshipImmunology
    Stanford UniversityPost-Doctoral FellowshipStem Cell Biology
    Collapse Awards and Honors
    2005The Presidential Early Career Award for Scientists and Engineers (PECASE, US Govt.)
    2007Leukemia and Lymphoma Society Scholar Award
    2008Richard E Weitzman Award (Endocrine Society)
    2009NIH Director's Pioneer Award
    2015NCI Outstanding Investigator Award

    Collapse Overview 
    Collapse Overview
    The primary goal of our lab is to understand the signaling pathways that regulate the choice between stem cell renewal and commitment, and define how the same signals are subverted in cancer. The lab has three primary areas of interest: analyzing the role of developmental signals in stem cells and cancer, defining mechanisms that initiate stem cell regeneration after injury and developing high-resolution imaging strategies to visualize the behavior of living stem cells during growth, regeneration, and can¬cer formation. These studies have implications not only for understanding the basic mechanisms that regulate normal and oncogenic self-renewal, but also for enhancing stem cell based therapies for human disease.

    Collapse Research 
    Collapse Research Activities and Funding
    Reprogramming human stem cells for blood cell generation
    CIRM DISC1-10074Jul 1, 2017 - Jun 30, 2018
    Role: Principal Investigator
    Reprogramming Transcriptional Circuitry to Control Pancreatic Cancer
    Stand Up to Cancer/AACR/CRUK/Lustgarten Jan 31, 2016 - Dec 31, 2018
    Role: Senior Investigator
    Molecular strategies for early detection and targeting of cancer
    NIH/NCI R35CA197699Aug 12, 2015 - Jul 31, 2022
    Role: Principal Investigator
    Musashi-mediated control of pancreatic cancer growth and progression
    NIH/NCI R01CA186043Feb 1, 2015 - Jan 31, 2020
    Role: Principal Investigator
    Molecular Determinants of Asymmetric Division
    NIH/NIDDK R01DK099335Apr 1, 2014 - Mar 31, 2018
    Role: Principal Investigator
    Imaging self-renewal and transformation in hematopoietic stem cells
    NIH/NCI DP1CA174422Sep 30, 2009 - Jul 31, 2014
    Role: Principal Investigator
    Imaging self-renewal and transformation in hematopoietic stem cells
    NIH DP1OD006430Sep 30, 2009 - Jul 31, 2014
    Role: Principal Investigator
    Imaging the stem cell niche in regeneration and cancer
    NIH/NHLBI R01HL097767Sep 5, 2009 - Jul 31, 2013
    Role: Principal Investigator
    Damage and regeneration in the hematopoietic system
    NIH/NIDDK R01DK072234May 15, 2006 - Apr 30, 2010
    Role: Principal Investigator
    Centers for Medical Countermeasures Against Radiation
    NIH U19AI067798Aug 31, 2005 - Jul 31, 2020
    Role: Co-Investigator
    Regulation of Hematopoietic Stem Cell Self-Renewal
    NIH/NIDDK R01DK063031Apr 1, 2003 - Jul 31, 2012
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Lytle NK, Ferguson LP, Rajbhandari N, Gilroy K, Fox RG, Deshpande A, Schürch CM, Hamilton M, Robertson N, Lin W, Noel P, Wartenberg M, Zlobec I, Eichmann M, Galván JA, Karamitopoulou E, Gilderman T, Esparza LA, Shima Y, Spahn P, French R, Lewis NE, Fisch KM, Sasik R, Rosenthal SB, Kritzik M, Von Hoff D, Han H, Ideker T, Deshpande AJ, Lowy AM, Adams PD, Reya T. A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma. Cell. 2019 Mar 29. PMID: 30955884.
      View in: PubMed
    2. Lytle NK, Barber AG, Reya T. Stem cell fate in cancer growth, progression and therapy resistance. Nat Rev Cancer. 2018 Nov; 18(11):669-680. PMID: 30228301.
      View in: PubMed
    3. Dravis C, Chung CY, Lytle NK, Herrera-Valdez J, Luna G, Trejo CL, Reya T, Wahl GM. Epigenetic and Transcriptomic Profiling of Mammary Gland Development and Tumor Models Disclose Regulators of Cell State Plasticity. Cancer Cell. 2018 Sep 10; 34(3):466-482.e6. PMID: 30174241.
      View in: PubMed
    4. Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle NK, Dhar D, Banerjee S, Fagman JB, Browne CD, Umemura A, Valasek MA, Kessler H, Tarin D, Goggins M, Reya T, Diaz-Meco M, Moscat J, Karin M. Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. Cancer Cell. 2017 Dec 11; 32(6):824-839.e8. PMID: 29153842.
      View in: PubMed
    5. Hui S, Ghergurovich JM, Morscher RJ, Jang C, Teng X, Lu W, Esparza LA, Reya T, Yanxiang Guo J, White E, Rabinowitz JD. Glucose feeds the TCA cycle via circulating lactate. Nature. 2017 11 02; 551(7678):115-118. PMID: 29045397.
      View in: PubMed
    6. Bajaj J, Konuma T, Lytle NK, Kwon HY, Ablack JN, Cantor JM, Rizzieri D, Chuah C, Oehler VG, Broome EH, Ball ED, van der Horst EH, Ginsberg MH, Reya T. CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia. Cancer Cell. 2016 Nov 14; 30(5):792-805. PMID: 27908736.
      View in: PubMed
    7. Haney S, Reya T, Bazhenov M. Delayed Onset of Symptoms Through Feedback Interference in Chronic Cancers. Converg Sci Phys Oncol. 2016; 2(4). PMID: 29744132.
      View in: PubMed
    8. Koechlein CS, Harris JR, Lee TK, Weeks J, Fox RG, Zimdahl B, Ito T, Blevins A, Jung SH, Chute JP, Chourasia A, Covert MW, Reya T. High-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo. Nat Commun. 2016 07 18; 7:12169. PMID: 27425143.
      View in: PubMed
    9. Fox RG, Lytle NK, Jaquish DV, Park FD, Ito T, Bajaj J, Koechlein CS, Zimdahl B, Yano M, Kopp J, Kritzik M, Sicklick J, Sander M, Grandgenett PM, Hollingsworth MA, Shibata S, Pizzo D, Valasek M, Sasik R, Scadeng M, Okano H, Kim Y, MacLeod AR, Lowy AM, Reya T. Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma. Nature. 2016 06 16; 534(7607):407-411. PMID: 27281208; PMCID: PMC4998062 [Available on 12/16/16].
    10. Kwon HY, Bajaj J, Ito T, Blevins A, Konuma T, Weeks J, Lytle NK, Koechlein CS, Rizzieri D, Chuah C, Oehler VG, Sasik R, Hardiman G, Reya T. Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia. Cell Stem Cell. 2015 Aug 06; 17(2):152-164. PMID: 26212080; PMCID: PMC4664079.
    11. Bajaj J, Zimdahl B, Reya T. Fearful symmetry: subversion of asymmetric division in cancer development and progression. Cancer Res. 2015 Mar 01; 75(5):792-7. PMID: 25681272; PMCID: PMC4784538.
    12. Fox RG, Park FD, Koechlein CS, Kritzik M, Reya T. Musashi signaling in stem cells and cancer. Annu Rev Cell Dev Biol. 2015; 31:249-67. PMID: 26566113.
      View in: PubMed
    13. Wu X, Zhang W, Font-Burgada J, Palmer T, Hamil AS, Biswas SK, Poidinger M, Borcherding N, Xie Q, Ellies LG, Lytle NK, Wu LW, Fox RG, Yang J, Dowdy SF, Reya T, Karin M. Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade. Proc Natl Acad Sci U S A. 2014 Sep 23; 111(38):13870-5. PMID: 25189770; PMCID: PMC4183333.
    14. Lento W, Ito T, Zhao C, Harris JR, Huang W, Jiang C, Owzar K, Piryani S, Racioppi L, Chao N, Reya T. Loss of ß-catenin triggers oxidative stress and impairs hematopoietic regeneration. Genes Dev. 2014 May 01; 28(9):995-1004. PMID: 24788518; PMCID: PMC4018497.
    15. Zimdahl B, Ito T, Blevins A, Bajaj J, Konuma T, Weeks J, Koechlein CS, Kwon HY, Arami O, Rizzieri D, Broome HE, Chuah C, Oehler VG, Sasik R, Hardiman G, Reya T. Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia. Nat Genet. 2014 Mar; 46(3):245-52. PMID: 24487275; PMCID: PMC4267534.
    16. Lento W, Congdon K, Voermans C, Kritzik M, Reya T. Wnt signaling in normal and malignant hematopoiesis. Cold Spring Harb Perspect Biol. 2013 Feb 01; 5(2). PMID: 23378582; PMCID: PMC3552513.
    17. Himburg HA, Harris JR, Ito T, Daher P, Russell JL, Quarmyne M, Doan PL, Helms K, Nakamura M, Fixsen E, Herradon G, Reya T, Chao NJ, Harroch S, Chute JP. Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche. Cell Rep. 2012 Oct 25; 2(4):964-75. PMID: 23084748; PMCID: PMC3696585.
    18. Reya T. Tannishtha Reya: classic pathways, new views on cancer. Interview by Caitlin Sedwick. J Cell Biol. 2012 Sep 03; 198(5):766-7. PMID: 22945930; PMCID: PMC3432759.
    19. Fereshteh M, Ito T, Kovacs JJ, Zhao C, Kwon HY, Tornini V, Konuma T, Chen M, Lefkowitz RJ, Reya T. ß-Arrestin2 mediates the initiation and progression of myeloid leukemia. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12532-7. PMID: 22773819; PMCID: PMC3411976.
    20. Ito T, Zimdahl B, Reya T. aSIRTing control over cancer stem cells. Cancer Cell. 2012 Feb 14; 21(2):140-2. PMID: 22340585.
      View in: PubMed
    21. Reya T. Illuminating immune privilege--a role for regulatory T cells in preventing rejection. N Engl J Med. 2011 Sep 08; 365(10):956-7. PMID: 21899457.
      View in: PubMed
    22. Ito T, Kwon HY, Zimdahl B, Congdon KL, Blum J, Lento WE, Zhao C, Lagoo A, Gerrard G, Foroni L, Goldman J, Goh H, Kim SH, Kim DW, Chuah C, Oehler VG, Radich JP, Jordan CT, Reya T. Regulation of myeloid leukaemia by the cell-fate determinant Musashi. Nature. 2010 Aug 05; 466(7307):765-8. PMID: 20639863; PMCID: PMC2918284.
    23. Kim J, Tang JY, Gong R, Kim J, Lee JJ, Clemons KV, Chong CR, Chang KS, Fereshteh M, Gardner D, Reya T, Liu JO, Epstein EH, Stevens DA, Beachy PA. Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell. 2010 Apr 13; 17(4):388-99. PMID: 20385363; PMCID: PMC4039177.
    24. Himburg HA, Muramoto GG, Daher P, Meadows SK, Russell JL, Doan P, Chi JT, Salter AB, Lento WE, Reya T, Chao NJ, Chute JP. Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells. Nat Med. 2010 Apr; 16(4):475-82. PMID: 20305662; PMCID: PMC3689427.
    25. Zhao C, Chen A, Jamieson CH, Fereshteh M, Abrahamsson A, Blum J, Kwon HY, Kim J, Chute JP, Rizzieri D, Munchhof M, VanArsdale T, Beachy PA, Reya T. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature. 2009 Apr 09; 458(7239):776-9. PMID: 19169242; PMCID: PMC2946231.
    26. Kurokawa M, Zhao C, Reya T, Kornbluth S. Inhibition of apoptosome formation by suppression of Hsp90beta phosphorylation in tyrosine kinase-induced leukemias. Mol Cell Biol. 2008 Sep; 28(17):5494-506. PMID: 18591256; PMCID: PMC2519729.
    27. Congdon KL, Reya T. Divide and conquer: how asymmetric division shapes cell fate in the hematopoietic system. Curr Opin Immunol. 2008 Jun; 20(3):302-7. PMID: 18554882; PMCID: PMC2560983.
    28. Congdon KL, Voermans C, Ferguson EC, DiMascio LN, Uqoezwa M, Zhao C, Reya T. Activation of Wnt signaling in hematopoietic regeneration. Stem Cells. 2008 May; 26(5):1202-10. PMID: 18308947.
      View in: PubMed
    29. Zhao C, Blum J, Chen A, Kwon HY, Jung SH, Cook JM, Lagoo A, Reya T. Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo. Cancer Cell. 2007 Dec; 12(6):528-41. PMID: 18068630; PMCID: PMC2262869.
    30. Wu M, Kwon HY, Rattis F, Blum J, Zhao C, Ashkenazi R, Jackson TL, Gaiano N, Oliver T, Reya T. Imaging hematopoietic precursor division in real time. Cell Stem Cell. 2007 Nov; 1(5):541-54. PMID: 18345353; PMCID: PMC2267762.
    31. Zhao Y, Altman BJ, Coloff JL, Herman CE, Jacobs SR, Wieman HL, Wofford JA, Dimascio LN, Ilkayeva O, Kelekar A, Reya T, Rathmell JC. Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. Mol Cell Biol. 2007 Jun; 27(12):4328-39. PMID: 17371841; PMCID: PMC1900055.
    32. Kitsos CM, Sankar U, Illario M, Colomer-Font JM, Duncan AW, Ribar TJ, Reya T, Means AR. Calmodulin-dependent protein kinase IV regulates hematopoietic stem cell maintenance. J Biol Chem. 2005 Sep 30; 280(39):33101-8. PMID: 16020540.
      View in: PubMed
    33. Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature. 2005 Apr 14; 434(7035):843-50. PMID: 15829953.
      View in: PubMed
    34. Duncan AW, Rattis FM, DiMascio LN, Congdon KL, Pazianos G, Zhao C, Yoon K, Cook JM, Willert K, Gaiano N, Reya T. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat Immunol. 2005 Mar; 6(3):314-22. PMID: 15665828.
      View in: PubMed
    35. Ranheim EA, Kwan HC, Reya T, Wang YK, Weissman IL, Francke U. Frizzled 9 knock-out mice have abnormal B-cell development. Blood. 2005 Mar 15; 105(6):2487-94. PMID: 15572594.
      View in: PubMed
    36. Pazianos G, Uqoezwa M, Reya T. The elements of stem cell self-renewal: a genetic perspective. Biotechniques. 2003 Dec; 35(6):1240-7. PMID: 14682059.
      View in: PubMed
    37. Reya T, Duncan AW, Ailles L, Domen J, Scherer DC, Willert K, Hintz L, Nusse R, Weissman IL. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature. 2003 May 22; 423(6938):409-14. PMID: 12717450.
      View in: PubMed
    38. Willert K, Brown JD, Danenberg E, Duncan AW, Weissman IL, Reya T, Yates JR, Nusse R. Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature. 2003 May 22; 423(6938):448-52. PMID: 12717451.
      View in: PubMed
    39. Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature. 2001 Nov 01; 414(6859):105-11. PMID: 11689955.
      View in: PubMed
    40. Reya T, O'Riordan M, Okamura R, Devaney E, Willert K, Nusse R, Grosschedl R. Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism. Immunity. 2000 Jul; 13(1):15-24. PMID: 10933391.
      View in: PubMed
    41. Akashi K, Reya T, Dalma-Weiszhausz D, Weissman IL. Lymphoid precursors. Curr Opin Immunol. 2000 Apr; 12(2):144-50. PMID: 10712944.
      View in: PubMed
    42. Reya T, Okamura R, Grosschedl R. Control of lymphocyte differentiation by the LEF-1/TCF family of transcription factors. Cold Spring Harb Symp Quant Biol. 1999; 64:133-40. PMID: 11232278.
      View in: PubMed
    43. Reya T, Contractor NV, Couzens MS, Wasik MA, Emerson SG, Carding SR. Abnormal myelocytic cell development in interleukin-2 (IL-2)-deficient mice: evidence for the involvement of IL-2 in myelopoiesis. Blood. 1998 Apr 15; 91(8):2935-47. PMID: 9531604.
      View in: PubMed
    44. Reya T, Grosschedl R. Transcriptional regulation of B-cell differentiation. Curr Opin Immunol. 1998 Apr; 10(2):158-65. PMID: 9602304.
      View in: PubMed
    45. Reya T, Yang-Snyder JA, Rothenberg EV, Carding SR. Regulated expression and function of CD122 (interleukin-2/interleukin-15R-beta) during lymphoid development. Blood. 1996 Jan 01; 87(1):190-201. PMID: 8547641.
      View in: PubMed