 Takuya Ohkubo
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| Title(s) | Visiting Assistant Project Scientist, Neurosciences |
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| School | Health Sciences |
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| vCard | Download vCard |
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 Overview ORNG Applications Bibliographic
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Aladesuyi Arogundade O, Stauffer JE, Saberi S, Diaz-Garcia S, Malik S, Basilim H, Rodriguez MJ, Ohkubo T, Ravits J. Antisense RNA foci are associated with nucleoli and TDP-43 mislocalization in C9orf72-ALS/FTD: a quantitative study. Acta Neuropathol. 2019 Jan 21. PMID: 30666413.
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Melamed Z, López-Erauskin J, Baughn MW, Zhang O, Drenner K, Sun Y, Freyermuth F, McMahon MA, Beccari MS, Artates JW, Ohkubo T, Rodriguez M, Lin N, Wu D, Bennett CF, Rigo F, Da Cruz S, Ravits J, Lagier-Tourenne C, Cleveland DW. Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration. Nat Neurosci. 2019 Jan 14. PMID: 30643298.
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Ozaki K, Ohkubo T, Yamada T, Yoshioka K, Ichijo M, Majima T, Kudo S, Akashi T, Honda K, Ito E, Watanabe M, Sekine M, Hamagaki M, Eishi Y, Sanjo N, Ishibashi S, Mizusawa H, Yokota T. Progressive Encephalomyelitis with Rigidity and Myoclonus Resolving after Thymectomy with Subsequent Anasarca: An Autopsy Case. Intern Med. 2018 Dec 01; 57(23):3451-3458. PMID: 29984771.
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Neuwirth C, Braun N, Claeys KG, Bucelli R, Fournier C, Bromberg M, Petri S, Goedee S, Lenglet T, Leppanen R, Canosa A, Goodman I, Al-Lozi M, Ohkubo T, Hübers A, Atassi N, Abrahao A, Funke A, Appelfeller M, Tümmler A, Finegan E, Glass JD, Babu S, Ladha SS, Kwast-Rabben O, Juntas-Morales R, Coffey A, Chaudhry V, Vu T, Saephanh C, Newhard C, Zakrzewski M, Rosier E, Hamel N, Raheja D, Raaijman J, Ferguson T, Weber M. Implementing Motor Unit Number Index (MUNIX) in a large clinical trial: Real world experience from 27 centres. Clin Neurophysiol. 2018 Aug; 129(8):1756-1762. PMID: 29803404.
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Amano E, Ozaki K, Egawa S, Suzuki M, Hirai T, Ishibashi S, Ohkubo T, Yoshii T, Okawa A, Yokota T. Dynamic spinal compression revealed by computed tomography myelography in overshunting-associated myelopathy: A case report. Medicine (Baltimore). 2018 Mar; 97(10):e0082. PMID: 29517672.
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Ohara M, Ozaki K, Ohkubo T, Yamada A, Numasawa Y, Tanaka K, Tomii S, Ishibashi S, Sanjo N, Yokota T. Myasthenia Gravis Complicated with Peripheral T-cell Lymphoma, Not Otherwise Specified (PTCL-NOS), Following Thymectomy and Longstanding Tacrolimus Therapy. Intern Med. 2018 Feb 15; 57(4):601-604. PMID: 29269644.
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Saberi S, Stauffer JE, Jiang J, Garcia SD, Taylor AE, Schulte D, Ohkubo T, Schloffman CL, Maldonado M, Baughn M, Rodriguez MJ, Pizzo D, Cleveland D, Ravits J. Sense-encoded poly-GR dipeptide repeat proteins correlate to neurodegeneration and uniquely co-localize with TDP-43 in dendrites of repeat-expanded C9orf72 amyotrophic lateral sclerosis. Acta Neuropathol. 2018 Mar; 135(3):459-474. PMID: 29196813.
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Iwasawa E, Ohkubo T, Kanouchi T, Kanda T, Mizusawa H, Yokota T. Long-term Effects of Intravenous Cyclophosphamide in Combination with Mesna Provided Intravenously and via Bladder Perfusion in a Patient with Severe Multifocal Motor Neuropathy. Intern Med. 2017; 56(14):1893-1896. PMID: 28717088.
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Ohyagi M, Ishibashi S, Ohkubo T, Kobayashi Z, Mizusawa H, Yokota T, Emoto H, Kiyosawa M. Subacute Supranuclear Palsy in anti-Hu Paraneoplastic Encephalitis. Can J Neurol Sci. 2017 Jul; 44(4):444-446. PMID: 28767032.
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Sato N, Toide N, Kizawa M, Ohkubo T, Ishibashi S, Sanjo N, Yokota T. Methotrexate-associated lymphoproliferative disorder in a patient with neuromyelitis optica spectrum disorder: An implication for pathogenesis mediated by Epstein-Barr virus. J Neurol Sci. 2017 08 15; 379:219-221. PMID: 28716244.
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Abe K, Ohkubo T, Yokota T. TDP-43 in the skin of amyotrophic lateral sclerosis patients. J Med Dent Sci. 2017; 64(1):9-17. PMID: 28367944.
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Yagi Y, Ohkubo T, Kawaji H, Machida A, Miyata H, Goda S, Roy S, Hayashizaki Y, Suzuki H, Yokota T. Next-generation sequencing-based small RNA profiling of cerebrospinal fluid exosomes. Neurosci Lett. 2017 01 01; 636:48-57. PMID: 27780738.
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Yamada K, Kobayashi H, Bo R, Takahashi T, Purevsuren J, Hasegawa Y, Taketani T, Fukuda S, Ohkubo T, Yokota T, Watanabe M, Tsunemi T, Mizusawa H, Takuma H, Shioya A, Ishii A, Tamaoka A, Shigematsu Y, Sugie H, Yamaguchi S. Clinical, biochemical and molecular investigation of adult-onset glutaric acidemia type II: Characteristics in comparison with pediatric cases. Brain Dev. 2016 Mar; 38(3):293-301. PMID: 26403312.
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Ohkubo T. [Antiphospholipid syndrome]. Nihon Rinsho. 2015 Sep; 73 Suppl 7:706-10. PMID: 26480781.
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Ichijo M, Ishibashi S, Ohkubo T, Nomura S, Sanjo N, Yokota T, Mizusawa H. Elevated platelet microparticle levels after acute ischemic stroke with concurrent idiopathic thrombocytopenic purpura. J Stroke Cerebrovasc Dis. 2014 Mar; 23(3):587-9. PMID: 23747179.
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Machida A, Ohkubo T, Yokota T. Circulating microRNAs in the cerebrospinal fluid of patients with brain diseases. Methods Mol Biol. 2013; 1024:203-9. PMID: 23719953.
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Ohyagi M, Ohkubo T, Yagi Y, Ishibashi S, Akiyama J, Nagahori M, Watanabe M, Yokota T, Mizusawa H. Chronic inflammatory demyelinating polyradiculoneuropathy in a patient with Crohn's disease. Intern Med. 2013; 52(1):125-8. PMID: 23291687.
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Kanouchi T, Ohkubo T, Yokota T. Can regional spreading of amyotrophic lateral sclerosis motor symptoms be explained by prion-like propagation? J Neurol Neurosurg Psychiatry. 2012 Jul; 83(7):739-45. PMID: 22544947; PMCID: PMC3368493.
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Ohyagi M, Ohkubo T, Taniyama T, Tomizawa S, Okawa A, Yokota T, Mizusawa H. Spinal epidural abscess caused by bacteroides fragilis group after dilation and curettage for incomplete abortion. J Glob Infect Dis. 2012 Apr; 4(2):132-4. PMID: 22754250; PMCID: PMC3385204.
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Uchida A, Sasaguri H, Kimura N, Tajiri M, Ohkubo T, Ono F, Sakaue F, Kanai K, Hirai T, Sano T, Shibuya K, Kobayashi M, Yamamoto M, Yokota S, Kubodera T, Tomori M, Sakaki K, Enomoto M, Hirai Y, Kumagai J, Yasutomi Y, Mochizuki H, Kuwabara S, Uchihara T, Mizusawa H, Yokota T. Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43. Brain. 2012 Mar; 135(Pt 3):833-46. PMID: 22252998; PMCID: PMC3286326.
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Furuki M, Ohkubo T, Ota K, Ishikawa K, Yokota T, Mizusawa H. [Optic nerve swelling and gadolinium contrast enhancement on magnetic resonance imaging in the subacute stage of Leber's hereditary optic neuropathy: a case report]. Rinsho Shinkeigaku. 2012; 52(2):102-5. PMID: 22354234.
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Kinoshita H, Ohkubo T, Yasuda M, Yakushiji F. Serotonin syndrome induced by dextromethorphan (Medicon) administrated at the conventional dose. Geriatr Gerontol Int. 2011 Jan; 11(1):121-2. PMID: 21166968.
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Kinoshita H, Ohkubo T, Kaneko M, Satoh N, Mizutani S, Yasuda M, Machida A, Ishikawa K, Kamata T, Yakushiji F. Tremor in Klinefelter's syndrome improved by testosterone administration. J Neurol. 2009 Nov; 256(11):1924-5. PMID: 19597693.
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Kinoshita H, Okabayashi M, Kaneko M, Yasuda M, Abe K, Machida A, Ohkubo T, Kamata T, Yakushiji F. Shakuyaku-kanzo-to induces pseudoaldosteronism characterized by hypokalemia, rhabdomyolysis, metabolic alkalosis with respiratory compensation, and increased urinary cortisol levels. J Altern Complement Med. 2009 Apr; 15(4):439-43. PMID: 19388868.
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Noma T, Ikebukuro K, Sode K, Ohkubo T, Sakasegawa Y, Hachiya N, Kaneko K. A screening method for DNA aptamers that bind to a specific, unidentified protein in tissue samples. Biotechnol Lett. 2006 Sep; 28(17):1377-81. PMID: 16819584.
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Ohkubo T, Sakasegawa Y, Toda H, Kishida H, Arima K, Yamada M, Takahashi H, Mizusawa H, Hachiya NS, Kaneko K. Three-repeat Tau 69 is a major tau isoform in laser-microdissected Pick bodies. Amyloid. 2006 Mar; 13(1):1-5. PMID: 16690493.
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Hachiya NS, Ohkubo T, Kozuka Y, Yamazaki M, Mori O, Mizusawa H, Sakasegawa Y, Kaneko K. More than a 100-fold increase in immunoblot signals of laser-microdissected inclusion bodies with an excessive aggregation property by oligomeric actin interacting protein 2/D-lactate dehydrogenase protein 2. Anal Biochem. 2005 Dec 01; 347(1):106-11. PMID: 16229812.
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Hachiya NS, Yamada M, Watanabe K, Jozuka A, Ohkubo T, Sano K, Takeuchi Y, Kozuka Y, Sakasegawa Y, Kaneko K. Mitochondrial localization of cellular prion protein (PrPC) invokes neuronal apoptosis in aged transgenic mice overexpressing PrPC. Neurosci Lett. 2005 Feb 10; 374(2):98-103. PMID: 15644272.
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Noma T, Ikebukuro K, Sode K, Ohkubo T, Sakasegawa Y, Hachiya N, Kaneko K. Screening of DNA aptamers against multiple proteins in tissue. Nucleic Acids Symp Ser (Oxf). 2005; (49):357-8. PMID: 17150781.
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Ohkubo T, Shiojiri T, Matsunaga T. Severe diffuse white matter lesions in a patient with pancreatic encephalopathy. J Neurol. 2004 Apr; 251(4):476-8. PMID: 15083296.
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Ohkubo T, Mizusawa H, Kaneko K. [Variant Creutzfeldt-Jakob disease]. Nihon Rinsho. 2004 Jan; 62 Suppl:252-6. PMID: 15011360.
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Ohkubo T, Sakasegawa Y, Asada T, Kinoshita T, Goto Y, Kimura H, Mizusawa H, Hachiya NS, Kaneko K. Absence of association between codon 129/219 polymorphisms of the prion protein gene and Alzheimer's disease in Japan. Ann Neurol. 2003 Oct; 54(4):553-4; author reply 555. PMID: 14520676.
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