Sumit Handa

TitleAssistant Project Scientist
InstitutionUniversity of California San Diego
DepartmentChemistry and Biochemistry
Address9500 Gilman Drive #0375
La Jolla CA 92093
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    1. Handa S, Jiang Y, Tao S, Foreman R, Schinazi RF, Miller JF, Ghosh P. Template-assisted synthesis of adenine-mutagenized cDNA by a retroelement protein complex. Nucleic Acids Res. 2018 Jul 11. PMID: 30007279.
      View in: PubMed
    2. Handa S, Dempsey DR, Ramamoorthy D, Cook N, Guida WC, Spradling TJ, White JK, Woodcock HL, Merkler DJ. Mechanistic Studies of 1-Deoxy-D-Xylulose-5-Phosphate Synthase from Deinococcus radiodurans. Biochem Mol Biol J. 2018; 4(1). PMID: 29552677.
      View in: PubMed
    3. Wu L, Gingery M, Abebe M, Arambula D, Czornyj E, Handa S, Khan H, Liu M, Pohlschroder M, Shaw KL, Du A, Guo H, Ghosh P, Miller JF, Zimmerly S. Diversity-generating retroelements: natural variation, classification and evolution inferred from a large-scale genomic survey. Nucleic Acids Res. 2018 Jan 09; 46(1):11-24. PMID: 29186518.
      View in: PubMed
    4. Paul BG, Burstein D, Castelle CJ, Handa S, Arambula D, Czornyj E, Thomas BC, Ghosh P, Miller JF, Banfield JF, Valentine DL. Retroelement-guided protein diversification abounds in vast lineages of Bacteria and Archaea. Nat Microbiol. 2017 Apr 03; 2:17045. PMID: 28368387.
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    5. White JK, Handa S, Vankayala SL, Merkler DJ, Woodcock HL. Thiamin Diphosphate Activation in 1-Deoxy-d-xylulose 5-Phosphate Synthase: Insights into the Mechanism and Underlying Intermolecular Interactions. J Phys Chem B. 2016 09 22; 120(37):9922-34. PMID: 27537621.
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    6. Handa S, Paul BG, Miller JF, Valentine DL, Ghosh P. Conservation of the C-type lectin fold for accommodating massive sequence variation in archaeal diversity-generating retroelements. BMC Struct Biol. 2016 08 31; 16(1):13. PMID: 27578274.
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    7. Battistini MR, Shoji C, Handa S, Breydo L, Merkler DJ. Mechanistic binding insights for 1-deoxy-D-Xylulose-5-Phosphate synthase, the enzyme catalyzing the first reaction of isoprenoid biosynthesis in the malaria-causing protists, Plasmodium falciparum and Plasmodium vivax. Protein Expr Purif. 2016 Apr; 120:16-27. PMID: 26699947; PMCID: PMC4729580 [Available on 04/01/17].
    8. Dempsey DR, Jeffries KA, Handa S, Carpenter AM, Rodriguez-Ospina S, Breydo L, Merkler DJ. Mechanistic and Structural Analysis of a Drosophila melanogaster Enzyme, Arylalkylamine N-Acetyltransferase Like 7, an Enzyme That Catalyzes the Formation of N-Acetylarylalkylamides and N-Acetylhistamine. Biochemistry. 2015 Apr 28; 54(16):2644-58. PMID: 25850002; PMCID: PMC4749145.
    9. Paul BG, Bagby SC, Czornyj E, Arambula D, Handa S, Sczyrba A, Ghosh P, Miller JF, Valentine DL. Targeted diversity generation by intraterrestrial archaea and archaeal viruses. Nat Commun. 2015 Mar 23; 6:6585. PMID: 25798780; PMCID: PMC4372165.
    10. Handa S, Ramamoorthy D, Spradling TJ, Guida WC, Adams JH, Bendinskas KG, Merkler DJ. Production of recombinant 1-deoxy-d-xylulose-5-phosphate synthase from Plasmodium vivax in Escherichia coli. FEBS Open Bio. 2013; 3:124-9. PMID: 23772383; PMCID: PMC3668541.
    11. Handa S, Spradling TJ, Dempsey DR, Merkler DJ. Production of the catalytic core of human peptidylglycine a-hydroxylating monooxygenase (hPHMcc) in Escherichia coli. Protein Expr Purif. 2012 Jul; 84(1):9-13. PMID: 22554821; PMCID: PMC3614408.
    12. Ivkovic M, Dempsey DR, Handa S, Hilton JH, Lowe EW, Merkler DJ. N-acylethanolamines as novel alcohol dehydrogenase 3 substrates. Arch Biochem Biophys. 2011 Feb 15; 506(2):157-64. PMID: 21144815; PMCID: PMC3030644.
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