Soumita Das

Title(s)Assistant Professor, Pathology
SchoolHealth Sciences
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    Collapse Overview 
    Collapse Overview
    My lab is interested in understanding the three-way crosstalk and interactions between gastro-intestinal epithelial cells, immune cells and microbe (beneficial as well as pathogenic). The host gut barrier is disrupted after encountering microbes/toxin/ microbial products linked to inflammation and chronic diseases. Inflammation following infection also leads to DNA damage, which predisposes the epithelium to neoplastic transformation and cancer progression. Our recently developed gut organoid/Gut-on-a-chip model with epithelial cells, immune cells and microbes will be utilized to investigate mechanisms for gastro-intestinal inflammatory diseases, both oncogenic and non-oncogenic. The model will be useful for the identification of new diagnostic and therapeutic targets, identification of beneficial vs harmful microbes and nutritional components and to screen efficacy of novel barrier-protective drugs to combat inflammation-linked diseases. The core expertise of the lab are biochemistry, molecular biology, cell biology, microbial pathogenesis and mucosal immunology.

    Collapse Research 
    Collapse Research Activities and Funding
    Transforming Crohn’s disease Therapeutics: Where precise and predictable network-based targets are personalized through Phase ‘0’ human trials
    Crohn’s Disease Project Grant (The Helmsley Charitable Trust and Foundation) Jan 1, 2019 - Dec 31, 2021
    Role: Co-Principal Investigator
    Modeling the Diabetic Gut: how microbes fuel metabolic disorders
    DiaComp Pilot & Feasibility award, NIH/NIDDK Oct 1, 2018 - Sep 30, 2019
    Role: Principal Investigator
    Stem-cell based approaches to develop gut barrier-protective therapies in IBD
    The Takeda-Sanford Innovation Alliance Sep 1, 2018 - Oct 1, 2020
    Role: Co-PI
    Innate responses following infection with enteric microbes
    NIH/NIDDK R01DK107585Sep 1, 2016 - Aug 31, 2021
    Role: Principal Investigator
    Engulfment of enteric bacteria and the consequences for intestinal inflammation
    NIH/NIDDK R56DK099275Sep 1, 2014 - Aug 31, 2015
    Role: Principal Investigator
    Targeting the Gut Barrier to Cure Inflammatory Bowel Diseases
    Role: PI

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Das B, Okamoto K, Rabalais J, Kozan PA, Marchelletta RR, McGeough MD, Durali N, Go M, Barrett KE, Das S, Sivagnanam M. Enteroids expressing a disease-associated mutant of EpCAM are a model for congenital tufting enteropathy. Am J Physiol Gastrointest Liver Physiol. 2019 Aug 21. PMID: 31433211.
      View in: PubMed
    2. Garcia-Carbonell R, Yao SJ, Das S, Guma M. Dysregulation of Intestinal Epithelial Cell RIPK Pathways Promotes Chronic Inflammation in the IBD Gut. Front Immunol. 2019; 10:1094. PMID: 31164887.
      View in: PubMed
    3. Garcia-Carbonell R, Wong J, Kim JY, Close LA, Boland BS, Wong TL, Harris PA, Ho SB, Das S, Ernst PB, Sasik R, Sandborn WJ, Bertin J, Gough PJ, Chang JT, Kelliher M, Boone D, Guma M, Karin M. Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death. Proc Natl Acad Sci U S A. 2018 09 25; 115(39):E9192-E9200. PMID: 30209212.
      View in: PubMed
    4. Sahan AZ, Hazra TK, Das S. The Pivotal Role of DNA Repair in Infection Mediated-Inflammation and Cancer. Front Microbiol. 2018; 9:663. PMID: 29696001.
      View in: PubMed
    5. Das S, Jayaratne R, Barrett KE. The Role of Ion Transporters in the Pathophysiology of Infectious Diarrhea. Cell Mol Gastroenterol Hepatol. 2018; 6(1):33-45. PMID: 29928670.
      View in: PubMed
    6. Das S, Angsantikul P, Le C, Bao D, Miyamoto Y, Gao W, Zhang L, Eckmann L. Neutralization of cholera toxin with nanoparticle decoys for treatment of cholera. PLoS Negl Trop Dis. 2018 02; 12(2):e0006266. PMID: 29470490.
      View in: PubMed
    7. Sarkar A, Tindle C, Pranadinata RF, Reed S, Eckmann L, Stappenbeck TS, Ernst PB, Das S. ELMO1 Regulates Autophagy Induction and Bacterial Clearance During Enteric Infection. J Infect Dis. 2017 12 19; 216(12):1655-1666. PMID: 29029244.
      View in: PubMed
    8. Hwang JH, Lyes M, Sladewski K, Enany S, McEachern E, Mathew DP, Das S, Moshensky A, Bapat S, Pride DT, Ongkeko WM, Crotty Alexander LE. Electronic cigarette inhalation alters innate immunity and airway cytokines while increasing the virulence of colonizing bacteria. J Mol Med (Berl). 2016 06; 94(6):667-79. PMID: 26804311.
      View in: PubMed
    9. den Hartog G, Chattopadhyay R, Ablack A, Hall EH, Butcher LD, Bhattacharyya A, Eckmann L, Harris PR, Das S, Ernst PB, Crowe SE. Regulation of Rac1 and Reactive Oxygen Species Production in Response to Infection of Gastrointestinal Epithelia. PLoS Pathog. 2016 Jan; 12(1):e1005382. PMID: 26761793.
      View in: PubMed
    10. Fox S, Ryan KA, Berger AH, Petro K, Das S, Crowe SE, Ernst PB. The role of C1q in recognition of apoptotic epithelial cells and inflammatory cytokine production by phagocytes during Helicobacter pylori infection. J Inflamm (Lond). 2015; 12:51. PMID: 26357509; PMCID: PMC4563842.
    11. Das S, Sarkar A, Choudhury SS, Owen KA, Castillo V, Fox S, Eckmann L, Elliott MR, Casanova JE, Ernst PB. ELMO1 has an essential role in the internalization of Salmonella Typhimurium into enteric macrophages that impacts disease outcome. Cell Mol Gastroenterol Hepatol. 2015 Apr 01; 1(3):311-324. PMID: 26878033.
      View in: PubMed
    12. Das S, Sarkar A, Ryan KA, Fox S, Berger AH, Juncadella IJ, Bimczok D, Smythies LE, Harris PR, Ravichandran KS, Crowe SE, Smith PD, Ernst PB. Brain angiogenesis inhibitor 1 is expressed by gastric phagocytes during infection with Helicobacter pylori and mediates the recognition and engulfment of human apoptotic gastric epithelial cells. FASEB J. 2014 May; 28(5):2214-24. PMID: 24509909; PMCID: PMC3986834.
    13. Bimczok D, Smythies LE, Waites KB, Grams JM, Stahl RD, Mannon PJ, Peter S, Wilcox CM, Harris PR, Das S, Ernst PB, Smith PD. Helicobacter pylori infection inhibits phagocyte clearance of apoptotic gastric epithelial cells. J Immunol. 2013 Jun 15; 190(12):6626-34. PMID: 23686492; PMCID: PMC3725581.
    14. Mauldin JP, Lu M, Das S, Park D, Ernst PB, Ravichandran KS. A link between the cytoplasmic engulfment protein Elmo1 and the Mediator complex subunit Med31. Curr Biol. 2013 Jan 21; 23(2):162-7. PMID: 23273896; PMCID: PMC3556191.
    15. Park D, Han CZ, Elliott MR, Kinchen JM, Trampont PC, Das S, Collins S, Lysiak JJ, Hoehn KL, Ravichandran KS. Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein. Nature. 2011 Aug 21; 477(7363):220-4. PMID: 21857682; PMCID: PMC3513690.
    16. Das S, Owen KA, Ly KT, Park D, Black SG, Wilson JM, Sifri CD, Ravichandran KS, Ernst PB, Casanova JE. Brain angiogenesis inhibitor 1 (BAI1) is a pattern recognition receptor that mediates macrophage binding and engulfment of Gram-negative bacteria. Proc Natl Acad Sci U S A. 2011 Feb 01; 108(5):2136-41. PMID: 21245295.
      View in: PubMed
    17. Banerjee D, Mandal SM, Das A, Hegde ML, Das S, Bhakat KK, Boldogh I, Sarkar PS, Mitra S, Hazra TK. Preferential repair of oxidized base damage in the transcribed genes of mammalian cells. J Biol Chem. 2011 Feb 25; 286(8):6006-16. PMID: 21169365; PMCID: PMC3057786.
    18. Alam MS, Kurtz CC, Rowlett RM, Reuter BK, Wiznerowicz E, Das S, Linden J, Crowe SE, Ernst PB. CD73 is expressed by human regulatory T helper cells and suppresses proinflammatory cytokine production and Helicobacter felis-induced gastritis in mice. J Infect Dis. 2009 Feb 15; 199(4):494-504. PMID: 19281303.
      View in: PubMed
    19. Chattopadhyay R, Das S, Maiti AK, Boldogh I, Xie J, Hazra TK, Kohno K, Mitra S, Bhakat KK. Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1. Mol Cell Biol. 2008 Dec; 28(23):7066-80. PMID: 18809583; PMCID: PMC2593380.
    20. Das S, Chattopadhyay R, Bhakat KK, Boldogh I, Kohno K, Prasad R, Wilson SH, Hazra TK. Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress. J Biol Chem. 2007 Sep 28; 282(39):28474-84. PMID: 17686777.
      View in: PubMed
    21. Beswick EJ, Pinchuk IV, Das S, Powell DW, Reyes VE. Expression of the programmed death ligand 1, B7-H1, on gastric epithelial cells after Helicobacter pylori exposure promotes development of CD4+ CD25+ FoxP3+ regulatory T cells. Infect Immun. 2007 Sep; 75(9):4334-41. PMID: 17562772; PMCID: PMC1951191.
    22. Hazra TK, Das A, Das S, Choudhury S, Kow YW, Roy R. Oxidative DNA damage repair in mammalian cells: a new perspective. DNA Repair (Amst). 2007 Apr 01; 6(4):470-80. PMID: 17116430; PMCID: PMC2702509.
    23. Das S, Suarez G, Beswick EJ, Sierra JC, Graham DY, Reyes VE. Expression of B7-H1 on gastric epithelial cells: its potential role in regulating T cells during Helicobacter pylori infection. J Immunol. 2006 Mar 01; 176(5):3000-9. PMID: 16493058.
      View in: PubMed
    24. Beswick EJ, Das S, Pinchuk IV, Adegboyega P, Suarez G, Yamaoka Y, Reyes VE. Helicobacter pylori-induced IL-8 production by gastric epithelial cells up-regulates CD74 expression. J Immunol. 2005 Jul 01; 175(1):171-6. PMID: 15972644.
      View in: PubMed
    25. Sarkar M, Das S, Bandyopadhaya A, Ray K, Chaudhuri K. Upregulation of human mitochondrial NADH dehydrogenase subunit 5 in intestinal epithelial cells is modulated by Vibrio cholerae pathogenesis. FEBS Lett. 2005 Jun 20; 579(16):3449-60. PMID: 15946665.
      View in: PubMed
    26. Nag S, Das S, Chaudhuri K. In vivo induced clpB1 gene of Vibrio cholerae is involved in different stress responses and affects in vivo cholera toxin production. Biochem Biophys Res Commun. 2005 Jun 17; 331(4):1365-73. PMID: 15883026.
      View in: PubMed
    27. Das S, Sierra JC, Soman KV, Suarez G, Mohammad AA, Dang TA, Luxon BA, Reyes VE. Differential protein expression profiles of gastric epithelial cells following Helicobacter pylori infection using ProteinChips. J Proteome Res. 2005 May-Jun; 4(3):920-30. PMID: 15952739.
      View in: PubMed
    28. Banerjee R, Das S, Mukhopadhyay K, Nag S, Chakrabortty A, Chaudhuri K. Involvement of in vivo induced cheY-4 gene of Vibrio cholerae in motility, early adherence to intestinal epithelial cells and regulation of virulence factors. FEBS Lett. 2002 Dec 04; 532(1-2):221-6. PMID: 12459494.
      View in: PubMed
    29. Das S, Chakrabortty A, Banerjee R, Chaudhuri K. Involvement of in vivo induced icmF gene of Vibrio cholerae in motility, adherence to epithelial cells, and conjugation frequency. Biochem Biophys Res Commun. 2002 Jul 26; 295(4):922-8. PMID: 12127983.
      View in: PubMed