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Soumita Das

Title(s)Associate Professor, Pathology
SchoolHealth Sciences
Address 9500 Gilman Drive BRFII Room 4A21
La Jolla CA 92093
Phone858-246-2062
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    Collapse Overview 
    Collapse Overview
    My lab is interested in understanding the three-way crosstalk and interactions between gastro-intestinal epithelial cells, immune cells and microbe (beneficial as well as pathogenic). The host gut barrier is disrupted after encountering microbes/toxin/ microbial products linked to inflammation and chronic diseases. Inflammation following infection also leads to DNA damage, which predisposes the epithelium to neoplastic transformation and cancer progression. Our recently developed gut organoid/Gut-on-a-chip model with epithelial cells, immune cells and microbes will be utilized to investigate mechanisms for gastro-intestinal inflammatory diseases, both oncogenic and non-oncogenic. The model will be useful for the identification of new diagnostic and therapeutic targets, identification of beneficial vs harmful microbes and nutritional components and to screen efficacy of novel barrier-protective drugs to combat inflammation-linked diseases. The core expertise of the lab are biochemistry, molecular biology, cell biology, microbial pathogenesis and mucosal immunology.

    Collapse Research 
    Collapse Research Activities and Funding
    Network-Based Novel Therapeutics in Colorectal Cancers
    NIH/NCATS UG3TR002968Sep 11, 2019 - Jul 31, 2022
    Role: Co-Principal Investigator
    Transforming Crohn’s disease Therapeutics: Where precise and predictable network-based targets are personalized through Phase ‘0’ human trials
    Crohn’s Disease Project Grant (The Helmsley Charitable Trust and Foundation) Jan 1, 2019 - Dec 31, 2021
    Role: Co-Principal Investigator
    Modeling the Diabetic Gut: how microbes fuel metabolic disorders
    DiaComp Pilot & Feasibility award, NIH/NIDDK Oct 1, 2018 - Sep 30, 2019
    Role: Principal Investigator
    Stem-cell based approaches to develop gut barrier-protective therapies in IBD
    The Takeda-Sanford Innovation Alliance Sep 1, 2018 - Oct 1, 2020
    Role: Co-PI
    Innate responses following infection with enteric microbes
    NIH/NIDDK R01DK107585Sep 1, 2016 - Aug 31, 2021
    Role: Principal Investigator
    Engulfment of enteric bacteria and the consequences for intestinal inflammation
    NIH/NIDDK R56DK099275Sep 1, 2014 - Aug 31, 2015
    Role: Principal Investigator
    Targeting the Gut Barrier to Cure Inflammatory Bowel Diseases
    NIH/NCATS
    Role: PI

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Helicobacter pylori infection down-regulates the DNA glycosylase NEIL2,  resulting in increased genome damage and inflammation in gastric epithelial cells. J Biol Chem. 2020 Jun 09. Sayed IM, Sahan AZ, Venkova T, Chakraborty A, Mukhopadhyay D, Bimczok D, Beswick EJ, Reyes VE, Pinchuk I, Sahoo D, Ghosh P, Hazra TK, Das S. PMID: 32518160.
      View in: PubMed   Mentions:    Fields:    
    2. Congenital Tufting Enteropathy-Associated Mutant of Epithelial Cell Adhesion Molecule Activates the Unfolded Protein Response in a Murine Model of the Disease. Cells. 2020 Apr 11; 9(4). Das B, Okamoto K, Rabalais J, Marchelletta RR, Barrett KE, Das S, Niwa M, Sivagnanam M. PMID: 32290509.
      View in: PubMed   Mentions:    Fields:    
    3. Computational Approach to Identifying Universal Macrophage Biomarkers. Front Physiol. 2020; 11:275. Dang D, Taheri S, Das S, Ghosh P, Prince LS, Sahoo D. PMID: 32322218.
      View in: PubMed   Mentions:
    4. The stress polarity signaling (SPS) pathway serves as a marker and a target in the leaky gut barrier: implications in aging and cancer. Life Sci Alliance. 2020 03; 3(3). Ghosh P, Swanson L, Sayed IM, Mittal Y, Lim BB, Ibeawuchi SR, Foretz M, Viollet B, Sahoo D, Das S. PMID: 32041849.
      View in: PubMed   Mentions:    Fields:    
    5. Host engulfment pathway controls inflammation in inflammatory bowel disease. FEBS J. 2020 Jan 30. Sayed IM, Suarez K, Lim E, Singh S, Pereira M, Ibeawuchi SR, Katkar G, Dunkel Y, Mittal Y, Chattopadhyay R, Guma M, Boland BS, Dulai PS, Sandborn WJ, Ghosh P, Das S. PMID: 32003126.
      View in: PubMed   Mentions:    Fields:    
    6. RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-?B Activation. Cell Mol Gastroenterol Hepatol. 2020; 9(2):295-312. Wong J, Garcia-Carbonell R, Zelic M, Ho SB, Boland BS, Yao SJ, Desai SA, Das S, Planell N, Harris PA, Font-Burgada J, Taniguchi K, Bertin J, Salas A, Pasparakis M, Gough PJ, Kelliher M, Karin M, Guma M. PMID: 31606566.
      View in: PubMed   Mentions:    Fields:    
    7. Enteroids expressing a disease-associated mutant of EpCAM are a model for congenital tufting enteropathy. Am J Physiol Gastrointest Liver Physiol. 2019 11 01; 317(5):G580-G591. Das B, Okamoto K, Rabalais J, Kozan PA, Marchelletta RR, McGeough MD, Durali N, Go M, Barrett KE, Das S, Sivagnanam M. PMID: 31433211.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    8. Dysregulation of Intestinal Epithelial Cell RIPK Pathways Promotes Chronic Inflammation in the IBD Gut. Front Immunol. 2019; 10:1094. Garcia-Carbonell R, Yao SJ, Das S, Guma M. PMID: 31164887.
      View in: PubMed   Mentions:    Fields:    
    9. Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death. Proc Natl Acad Sci U S A. 2018 09 25; 115(39):E9192-E9200. Garcia-Carbonell R, Wong J, Kim JY, Close LA, Boland BS, Wong TL, Harris PA, Ho SB, Das S, Ernst PB, Sasik R, Sandborn WJ, Bertin J, Gough PJ, Chang JT, Kelliher M, Boone D, Guma M, Karin M. PMID: 30209212.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    10. The Pivotal Role of DNA Repair in Infection Mediated-Inflammation and Cancer. Front Microbiol. 2018; 9:663. Sahan AZ, Hazra TK, Das S. PMID: 29696001.
      View in: PubMed   Mentions:
    11. The Role of Ion Transporters in the Pathophysiology of Infectious Diarrhea. Cell Mol Gastroenterol Hepatol. 2018; 6(1):33-45. Das S, Jayaratne R, Barrett KE. PMID: 29928670.
      View in: PubMed   Mentions:    Fields:    
    12. Neutralization of cholera toxin with nanoparticle decoys for treatment of cholera. PLoS Negl Trop Dis. 2018 02; 12(2):e0006266. Das S, Angsantikul P, Le C, Bao D, Miyamoto Y, Gao W, Zhang L, Eckmann L. PMID: 29470490.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    13. ELMO1 Regulates Autophagy Induction and Bacterial Clearance During Enteric Infection. J Infect Dis. 2017 12 19; 216(12):1655-1666. Sarkar A, Tindle C, Pranadinata RF, Reed S, Eckmann L, Stappenbeck TS, Ernst PB, Das S. PMID: 29029244.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    14. Electronic cigarette inhalation alters innate immunity and airway cytokines while increasing the virulence of colonizing bacteria. J Mol Med (Berl). 2016 06; 94(6):667-79. Hwang JH, Lyes M, Sladewski K, Enany S, McEachern E, Mathew DP, Das S, Moshensky A, Bapat S, Pride DT, Ongkeko WM, Crotty Alexander LE. PMID: 26804311.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    15. Regulation of Rac1 and Reactive Oxygen Species Production in Response to Infection of Gastrointestinal Epithelia. PLoS Pathog. 2016 Jan; 12(1):e1005382. den Hartog G, Chattopadhyay R, Ablack A, Hall EH, Butcher LD, Bhattacharyya A, Eckmann L, Harris PR, Das S, Ernst PB, Crowe SE. PMID: 26761793.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    16. The role of C1q in recognition of apoptotic epithelial cells and inflammatory cytokine production by phagocytes during Helicobacter pylori infection. J Inflamm (Lond). 2015; 12:51. Fox S, Ryan KA, Berger AH, Petro K, Das S, Crowe SE, Ernst PB. PMID: 26357509.
      View in: PubMed   Mentions:
    17. ELMO1 has an essential role in the internalization of Salmonella Typhimurium into enteric macrophages that impacts disease outcome. Cell Mol Gastroenterol Hepatol. 2015 Apr 01; 1(3):311-324. Das S, Sarkar A, Choudhury SS, Owen KA, Castillo V, Fox S, Eckmann L, Elliott MR, Casanova JE, Ernst PB. PMID: 26878033.
      View in: PubMed   Mentions: 4     Fields:    
    18. Brain angiogenesis inhibitor 1 is expressed by gastric phagocytes during infection with Helicobacter pylori and mediates the recognition and engulfment of human apoptotic gastric epithelial cells. FASEB J. 2014 May; 28(5):2214-24. Das S, Sarkar A, Ryan KA, Fox S, Berger AH, Juncadella IJ, Bimczok D, Smythies LE, Harris PR, Ravichandran KS, Crowe SE, Smith PD, Ernst PB. PMID: 24509909.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    19. Helicobacter pylori infection inhibits phagocyte clearance of apoptotic gastric epithelial cells. J Immunol. 2013 Jun 15; 190(12):6626-34. Bimczok D, Smythies LE, Waites KB, Grams JM, Stahl RD, Mannon PJ, Peter S, Wilcox CM, Harris PR, Das S, Ernst PB, Smith PD. PMID: 23686492.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    20. A link between the cytoplasmic engulfment protein Elmo1 and the Mediator complex subunit Med31. Curr Biol. 2013 Jan 21; 23(2):162-7. Mauldin JP, Lu M, Das S, Park D, Ernst PB, Ravichandran KS. PMID: 23273896.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    21. Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein. Nature. 2011 Aug 21; 477(7363):220-4. Park D, Han CZ, Elliott MR, Kinchen JM, Trampont PC, Das S, Collins S, Lysiak JJ, Hoehn KL, Ravichandran KS. PMID: 21857682.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    22. Brain angiogenesis inhibitor 1 (BAI1) is a pattern recognition receptor that mediates macrophage binding and engulfment of Gram-negative bacteria. Proc Natl Acad Sci U S A. 2011 Feb 01; 108(5):2136-41. Das S, Owen KA, Ly KT, Park D, Black SG, Wilson JM, Sifri CD, Ravichandran KS, Ernst PB, Casanova JE. PMID: 21245295.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    23. Preferential repair of oxidized base damage in the transcribed genes of mammalian cells. J Biol Chem. 2011 Feb 25; 286(8):6006-16. Banerjee D, Mandal SM, Das A, Hegde ML, Das S, Bhakat KK, Boldogh I, Sarkar PS, Mitra S, Hazra TK. PMID: 21169365.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    24. CD73 is expressed by human regulatory T helper cells and suppresses proinflammatory cytokine production and Helicobacter felis-induced gastritis in mice. J Infect Dis. 2009 Feb 15; 199(4):494-504. Alam MS, Kurtz CC, Rowlett RM, Reuter BK, Wiznerowicz E, Das S, Linden J, Crowe SE, Ernst PB. PMID: 19281303.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    25. Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1. Mol Cell Biol. 2008 Dec; 28(23):7066-80. Chattopadhyay R, Das S, Maiti AK, Boldogh I, Xie J, Hazra TK, Kohno K, Mitra S, Bhakat KK. PMID: 18809583.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    26. Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress. J Biol Chem. 2007 Sep 28; 282(39):28474-84. Das S, Chattopadhyay R, Bhakat KK, Boldogh I, Kohno K, Prasad R, Wilson SH, Hazra TK. PMID: 17686777.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    27. Expression of the programmed death ligand 1, B7-H1, on gastric epithelial cells after Helicobacter pylori exposure promotes development of CD4+ CD25+ FoxP3+ regulatory T cells. Infect Immun. 2007 Sep; 75(9):4334-41. Beswick EJ, Pinchuk IV, Das S, Powell DW, Reyes VE. PMID: 17562772.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    28. Oxidative DNA damage repair in mammalian cells: a new perspective. DNA Repair (Amst). 2007 Apr 01; 6(4):470-80. Hazra TK, Das A, Das S, Choudhury S, Kow YW, Roy R. PMID: 17116430.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    29. Expression of B7-H1 on gastric epithelial cells: its potential role in regulating T cells during Helicobacter pylori infection. J Immunol. 2006 Mar 01; 176(5):3000-9. Das S, Suarez G, Beswick EJ, Sierra JC, Graham DY, Reyes VE. PMID: 16493058.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    30. Helicobacter pylori-induced IL-8 production by gastric epithelial cells up-regulates CD74 expression. J Immunol. 2005 Jul 01; 175(1):171-6. Beswick EJ, Das S, Pinchuk IV, Adegboyega P, Suarez G, Yamaoka Y, Reyes VE. PMID: 15972644.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    31. Upregulation of human mitochondrial NADH dehydrogenase subunit 5 in intestinal epithelial cells is modulated by Vibrio cholerae pathogenesis. FEBS Lett. 2005 Jun 20; 579(16):3449-60. Sarkar M, Das S, Bandyopadhaya A, Ray K, Chaudhuri K. PMID: 15946665.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    32. In vivo induced clpB1 gene of Vibrio cholerae is involved in different stress responses and affects in vivo cholera toxin production. Biochem Biophys Res Commun. 2005 Jun 17; 331(4):1365-73. Nag S, Das S, Chaudhuri K. PMID: 15883026.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    33. Differential protein expression profiles of gastric epithelial cells following Helicobacter pylori infection using ProteinChips. J Proteome Res. 2005 May-Jun; 4(3):920-30. Das S, Sierra JC, Soman KV, Suarez G, Mohammad AA, Dang TA, Luxon BA, Reyes VE. PMID: 15952739.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    34. Involvement of in vivo induced cheY-4 gene of Vibrio cholerae in motility, early adherence to intestinal epithelial cells and regulation of virulence factors. FEBS Lett. 2002 Dec 04; 532(1-2):221-6. Banerjee R, Das S, Mukhopadhyay K, Nag S, Chakrabortty A, Chaudhuri K. PMID: 12459494.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    35. Involvement of in vivo induced icmF gene of Vibrio cholerae in motility, adherence to epithelial cells, and conjugation frequency. Biochem Biophys Res Commun. 2002 Jul 26; 295(4):922-8. Das S, Chakrabortty A, Banerjee R, Chaudhuri K. PMID: 12127983.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
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