Soumita Das
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Title(s) | Associate Professor, Pathology |
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School | Health Sciences |
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Address | 9500 Gilman Drive BRFII Room 4A21 La Jolla CA 92093
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Phone | 858-246-2062 |
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vCard | Download vCard |
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Overview My lab is interested in understanding the three-way crosstalk and interactions between gastro-intestinal epithelial cells, immune cells and microbe (beneficial as well as pathogenic). The host gut barrier is disrupted after encountering microbes/toxin/ microbial products linked to inflammation and chronic diseases. Inflammation following infection also leads to DNA damage, which predisposes the epithelium to neoplastic transformation and cancer progression. Our recently developed gut organoid/Gut-on-a-chip model with epithelial cells, immune cells and microbes will be utilized to investigate mechanisms for gastro-intestinal inflammatory diseases, both oncogenic and non-oncogenic. The model will be useful for the identification of new diagnostic and therapeutic targets, identification of beneficial vs harmful microbes and nutritional components and to screen efficacy of novel barrier-protective drugs to combat inflammation-linked diseases. The core expertise of the lab are biochemistry, molecular biology, cell biology, microbial pathogenesis and mucosal immunology.
Research ORNG Applications Bibliographic
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SPT6 promotes epidermal differentiation and blockade of an intestinal-like phenotype through control of transcriptional elongation. Nat Commun. 2021 02 04; 12(1):784.
Li J, Xu X, Tiwari M, Chen Y, Fuller M, Bansal V, Tamayo P, Das S, Ghosh P, Sen GL. PMID: 33542242.
View in: PubMed Mentions: Fields:
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E-cigarettes compromise the gut barrier and trigger inflammation. iScience. 2021 Feb 19; 24(2):102035.
Sharma A, Lee J, Fonseca AG, Moshensky A, Kothari T, Sayed IM, Ibeawuchi SR, Pranadinata RF, Ear J, Sahoo D, Crotty-Alexander LE, Ghosh P, Das S. PMID: 33537654.
View in: PubMed Mentions:
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TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin. Proc Natl Acad Sci U S A. 2020 10 27; 117(43):26895-26906.
Swanson L, Katkar GD, Tam J, Pranadinata RF, Chareddy Y, Coates J, Anandachar MS, Castillo V, Olson J, Nizet V, Kufareva I, Das S, Ghosh P. PMID: 33055214.
View in: PubMed Mentions: Fields: Translation: HumansAnimalsCells
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The DNA Glycosylase NEIL2 Suppresses Fusobacterium-Infection-Induced Inflammation and DNA Damage in Colonic Epithelial Cells. Cells. 2020 08 28; 9(9).
Sayed IM, Chakraborty A, Abd El-Hafeez AA, Sharma A, Sahan AZ, Huang WJM, Sahoo D, Ghosh P, Hazra TK, Das S. PMID: 32872214.
View in: PubMed Mentions: Fields:
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DDX5 promotes oncogene C3 and FABP1 expressions and drives intestinal inflammation and tumorigenesis. Life Sci Alliance. 2020 10; 3(10).
Abbasi N, Long T, Li Y, Yee BA, Cho BS, Hernandez JE, Ma E, Patel PR, Sahoo D, Sayed IM, Varki N, Das S, Ghosh P, Yeo GW, Huang WJM. PMID: 32817263.
View in: PubMed Mentions: Fields:
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Potentiation of calcium-activated chloride secretion and barrier dysfunction may underlie EGF receptor tyrosine kinase inhibitor-induced diarrhea. Physiol Rep. 2020 07; 8(13):e14490.
Kim Y, Quach A, Das S, Barrett KE. PMID: 32652816.
View in: PubMed Mentions: Fields:
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Helicobacter pylori infection downregulates the DNA glycosylase NEIL2, resulting in increased genome damage and inflammation in gastric epithelial cells. J Biol Chem. 2020 08 07; 295(32):11082-11098.
Sayed IM, Sahan AZ, Venkova T, Chakraborty A, Mukhopadhyay D, Bimczok D, Beswick EJ, Reyes VE, Pinchuk I, Sahoo D, Ghosh P, Hazra TK, Das S. PMID: 32518160.
View in: PubMed Mentions: 2 Fields:
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Congenital Tufting Enteropathy-Associated Mutant of Epithelial Cell Adhesion Molecule Activates the Unfolded Protein Response in a Murine Model of the Disease. Cells. 2020 04 11; 9(4).
Das B, Okamoto K, Rabalais J, Marchelletta RR, Barrett KE, Das S, Niwa M, Sivagnanam M. PMID: 32290509.
View in: PubMed Mentions: 1 Fields:
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Computational Approach to Identifying Universal Macrophage Biomarkers. Front Physiol. 2020; 11:275.
Dang D, Taheri S, Das S, Ghosh P, Prince LS, Sahoo D. PMID: 32322218.
View in: PubMed Mentions:
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Host engulfment pathway controls inflammation in inflammatory bowel disease. FEBS J. 2020 Sep; 287(18):3967-3988.
Sayed IM, Suarez K, Lim E, Singh S, Pereira M, Ibeawuchi SR, Katkar G, Dunkel Y, Mittal Y, Chattopadhyay R, Guma M, Boland BS, Dulai PS, Sandborn WJ, Ghosh P, Das S. PMID: 32003126.
View in: PubMed Mentions: 2 Fields:
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The stress polarity signaling (SPS) pathway serves as a marker and a target in the leaky gut barrier: implications in aging and cancer. Life Sci Alliance. 2020 03; 3(3).
Ghosh P, Swanson L, Sayed IM, Mittal Y, Lim BB, Ibeawuchi SR, Foretz M, Viollet B, Sahoo D, Das S. PMID: 32041849.
View in: PubMed Mentions: 1 Fields:
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Enteroids expressing a disease-associated mutant of EpCAM are a model for congenital tufting enteropathy. Am J Physiol Gastrointest Liver Physiol. 2019 11 01; 317(5):G580-G591.
Das B, Okamoto K, Rabalais J, Kozan PA, Marchelletta RR, McGeough MD, Durali N, Go M, Barrett KE, Das S, Sivagnanam M. PMID: 31433211.
View in: PubMed Mentions: 2 Fields: Translation: AnimalsCells
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Dysregulation of Intestinal Epithelial Cell RIPK Pathways Promotes Chronic Inflammation in the IBD Gut. Front Immunol. 2019; 10:1094.
Garcia-Carbonell R, Yao SJ, Das S, Guma M. PMID: 31164887.
View in: PubMed Mentions: 3 Fields: Translation: HumansAnimalsCells
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Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death. Proc Natl Acad Sci U S A. 2018 09 25; 115(39):E9192-E9200.
Garcia-Carbonell R, Wong J, Kim JY, Close LA, Boland BS, Wong TL, Harris PA, Ho SB, Das S, Ernst PB, Sasik R, Sandborn WJ, Bertin J, Gough PJ, Chang JT, Kelliher M, Boone D, Guma M, Karin M. PMID: 30209212.
View in: PubMed Mentions: 13 Fields: Translation: HumansAnimalsCells
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The Pivotal Role of DNA Repair in Infection Mediated-Inflammation and Cancer. Front Microbiol. 2018; 9:663.
Sahan AZ, Hazra TK, Das S. PMID: 29696001.
View in: PubMed Mentions:
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The Role of Ion Transporters in the Pathophysiology of Infectious Diarrhea. Cell Mol Gastroenterol Hepatol. 2018; 6(1):33-45.
Das S, Jayaratne R, Barrett KE. PMID: 29928670.
View in: PubMed Mentions: 13 Fields:
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Neutralization of cholera toxin with nanoparticle decoys for treatment of cholera. PLoS Negl Trop Dis. 2018 02; 12(2):e0006266.
Das S, Angsantikul P, Le C, Bao D, Miyamoto Y, Gao W, Zhang L, Eckmann L. PMID: 29470490.
View in: PubMed Mentions: 6 Fields: Translation: AnimalsCells
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ELMO1 Regulates Autophagy Induction and Bacterial Clearance During Enteric Infection. J Infect Dis. 2017 12 19; 216(12):1655-1666.
Sarkar A, Tindle C, Pranadinata RF, Reed S, Eckmann L, Stappenbeck TS, Ernst PB, Das S. PMID: 29029244.
View in: PubMed Mentions: 8 Fields: Translation: AnimalsCells
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Regulation of Rac1 and Reactive Oxygen Species Production in Response to Infection of Gastrointestinal Epithelia. PLoS Pathog. 2016 Jan; 12(1):e1005382.
den Hartog G, Chattopadhyay R, Ablack A, Hall EH, Butcher LD, Bhattacharyya A, Eckmann L, Harris PR, Das S, Ernst PB, Crowe SE. PMID: 26761793.
View in: PubMed Mentions: 16 Fields: Translation: HumansCells
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The role of C1q in recognition of apoptotic epithelial cells and inflammatory cytokine production by phagocytes during Helicobacter pylori infection. J Inflamm (Lond). 2015; 12:51.
Fox S, Ryan KA, Berger AH, Petro K, Das S, Crowe SE, Ernst PB. PMID: 26357509.
View in: PubMed Mentions:
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ELMO1 has an essential role in the internalization of Salmonella Typhimurium into enteric macrophages that impacts disease outcome. Cell Mol Gastroenterol Hepatol. 2015 Apr 01; 1(3):311-324.
Das S, Sarkar A, Choudhury SS, Owen KA, Castillo V, Fox S, Eckmann L, Elliott MR, Casanova JE, Ernst PB. PMID: 26878033.
View in: PubMed Mentions: 6 Fields:
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Brain angiogenesis inhibitor 1 is expressed by gastric phagocytes during infection with Helicobacter pylori and mediates the recognition and engulfment of human apoptotic gastric epithelial cells. FASEB J. 2014 May; 28(5):2214-24.
PMID: 24509909.
View in: PubMed Mentions: 12 Fields: Translation: HumansCells
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Year | Publications |
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2014 | 1 | 2015 | 2 | 2016 | 1 | 2017 | 1 | 2018 | 4 | 2019 | 2 | 2020 | 9 | 2021 | 2 |
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This graph shows the number and percent of publications by field.
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Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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