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    Shyni Varghese

    TitleAssociate Researcher
    SchoolUniversity of California, San Diego
    DepartmentBioengineering
    Address9500 Gilman Drive #0412
    CA La Jolla 92093
    Phone858-822-7920
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Adenosine A2B receptor in bone health and osteoporosis
      NIH/NIAMS R01AR071552May 1, 2017 - Jan 31, 2022
      Role: Principal Investigator
      Bioinspired Synthetic Grafts for Bone Regeneration
      NIH/NIAMS R01AR063184Aug 1, 2013 - May 31, 2018
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Agrawal G, Aung A, Varghese S. Skeletal muscle-on-a-chip: an in vitro model to evaluate tissue formation and injury. Lab Chip. 2017 Sep 05. PMID: 28871305.
        View in: PubMed
      2. Shih YR, Kang H, Rao V, Chiu YJ, Kwon SK, Varghese S. In vivo engineering of bone tissues with hematopoietic functions and mixed chimerism. Proc Natl Acad Sci U S A. 2017 May 23; 114(21):5419-5424. PMID: 28484009.
        View in: PubMed
      3. Mo AH, Landon PB, Gomez KS, Kang H, Lee J, Zhang C, Janetanakit W, Sant V, Lu T, Colburn DA, Akkiraju S, Dossou S, Cao Y, Lee KF, Varghese S, Glinsky G, Lal R. Magnetically-responsive silica-gold nanobowls for targeted delivery and SERS-based sensing. Nanoscale. 2016 Jun 09; 8(23):11840-50. PMID: 27228391.
        View in: PubMed
      4. Aung A, Theprungsirikul J, Lim HL, Varghese S. Chemotaxis-driven assembly of endothelial barrier in a tumor-on-a-chip platform. Lab Chip. 2016 May 21; 16(10):1886-98. PMID: 27097908; PMCID: PMC4862883 [Available on 05/21/17].
      5. Wen C, Kang H, Shih YR, Hwang Y, Varghese S. In vivo comparison of biomineralized scaffold-directed osteogenic differentiation of human embryonic and mesenchymal stem cells. Drug Deliv Transl Res. 2016 Apr; 6(2):121-31. PMID: 26105532.
        View in: PubMed
      6. Seale NM, Varghese S. Biomaterials for pluripotent stem cell engineering: From fate determination to vascularization. J Mater Chem B Mater Biol Med. 2016 May 28; 4(20):3454-3463. PMID: 27446588.
        View in: PubMed
      7. Aung A, Bhullar IS, Theprungsirikul J, Davey SK, Lim HL, Chiu YJ, Ma X, Dewan S, Lo YH, McCulloch A, Varghese S. 3D cardiac µtissues within a microfluidic device with real-time contractile stress readout. Lab Chip. 2016 Jan 07; 16(1):153-62. PMID: 26588203.
        View in: PubMed
      8. Kar M, Vernon Shih YR, Velez DO, Cabrales P, Varghese S. Poly(ethylene glycol) hydrogels with cell cleavable groups for autonomous cell delivery. Biomaterials. 2016 Jan; 77:186-97. PMID: 26606444; PMCID: PMC4684457 [Available on 01/01/17].
      9. Rao V, Shih YR, Kang H, Kabra H, Varghese S. Adenosine Signaling Mediates Osteogenic Differentiation of Human Embryonic Stem Cells on Mineralized Matrices. Front Bioeng Biotechnol. 2015; 3:185. PMID: 26618155; PMCID: PMC4639610.
      10. Nakasaki M, Hwang Y, Xie Y, Kataria S, Gund R, Hajam EY, Samuel R, George R, Danda D, M J P, Nakamura T, Shen Z, Briggs S, Varghese S, Jamora C. The matrix protein Fibulin-5 is at the interface of tissue stiffness and inflammation in fibrosis. Nat Commun. 2015 Oct 15; 6:8574. PMID: 26469761; PMCID: PMC4634219.
      11. Davey SK, Aung A, Agrawal G, Lim HL, Kar M, Varghese S. Embedded 3D Photopatterning of Hydrogels with Diverse and Complex Architectures for Tissue Engineering and Disease Models. Tissue Eng Part C Methods. 2015 Nov; 21(11):1188-96. PMID: 26154197; PMCID: PMC4638205 [Available on 11/01/16].
      12. Shih YR, Phadke A, Yamaguchi T, Kang H, Inoue N, Masuda K, Varghese S. Synthetic bone mimetic matrix-mediated in situ bone tissue formation through host cell recruitment. Acta Biomater. 2015 Jun; 19:1-9. PMID: 25805106.
        View in: PubMed
      13. Kang H, Shih YR, Varghese S. Biomineralized matrices dominate soluble cues to direct osteogenic differentiation of human mesenchymal stem cells through adenosine signaling. Biomacromolecules. 2015 Mar 09; 16(3):1050-61. PMID: 25686297.
        View in: PubMed
      14. Kabra H, Hwang Y, Lim HL, Kar M, Arya G, Varghese S. Biomimetic Material-Assisted Delivery of Human Embryonic Stem Cell Derivatives for Enhanced In Vivo Survival and Engraftment. ACS Biomater Sci Eng. 2015 Jan 12; 1(1):7-12. PMID: 26280019.
        View in: PubMed
      15. Aung A, Seo YN, Lu S, Wang Y, Jamora C, del Álamo JC, Varghese S. 3D traction stresses activate protease-dependent invasion of cancer cells. Biophys J. 2014 Dec 02; 107(11):2528-37. PMID: 25468332; PMCID: PMC4255420.
      16. Kim HD, Heo J, Hwang Y, Kwak SY, Park OK, Kim H, Varghese S, Hwang NS. Extracellular-matrix-based and Arg-Gly-Asp-modified photopolymerizing hydrogels for cartilage tissue engineering. Tissue Eng Part A. 2015 Feb; 21(3-4):757-66. PMID: 25266634; PMCID: PMC4333611.
      17. Kang H, Wen C, Hwang Y, Shih YR, Kar M, Seo SW, Varghese S. Biomineralized matrix-assisted osteogenic differentiation of human embryonic stem cells. J Mater Chem B Mater Biol Med. 2014 Sep 01; 2(34):5676-5688. PMID: 25114796.
        View in: PubMed
      18. Kang H, Shih YV, Hwang Y, Wen C, Rao V, Seo T, Varghese S. Mineralized gelatin methacrylate-based matrices induce osteogenic differentiation of human induced pluripotent stem cells. Acta Biomater. 2014 Dec; 10(12):4961-4970. PMID: 25153779; PMCID: PMC4252258.
      19. Hwang Y, Suk S, Shih YR, Seo T, Du B, Xie Y, Li Z, Varghese S. WNT3A promotes myogenesis of human embryonic stem cells and enhances in vivo engraftment. Sci Rep. 2014 Aug 01; 4:5916. PMID: 25084050.
        View in: PubMed
      20. Caro-Diaz EJ, Aung A, Xu J, Varghese S, Theodorakis EA. Fusarisetins: Structure-function studies on a novel class of cell migration inhibitors. Org Chem Front. 2014 Apr 01; 1(2):135-139. PMID: 24910777.
        View in: PubMed
      21. Shih YR, Hwang Y, Phadke A, Kang H, Hwang NS, Caro EJ, Nguyen S, Siu M, Theodorakis EA, Gianneschi NC, Vecchio KS, Chien S, Lee OK, Varghese S. Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):990-5. PMID: 24395775; PMCID: PMC3903237.
      22. Hwang Y, Suk S, Lin S, Tierney M, Du B, Seo T, Mitchell A, Sacco A, Varghese S. Correction: Directed In Vitro Myogenesis of Human Embryonic Stem Cells and Their In Vivo Engraftment. PLoS One. 2013; 8(9). PMID: 24116259.
        View in: PubMed
      23. Hwang Y, Suk S, Lin S, Tierney M, Du B, Seo T, Mitchell A, Sacco A, Varghese S. Directed in vitro myogenesis of human embryonic stem cells and their in vivo engraftment. PLoS One. 2013; 8(8):e72023. PMID: 23977197; PMCID: PMC3747108.
      24. Hwang NS, Varghese S, Lee HJ, Zhang Z, Elisseeff J. Biomaterials directed in vivo osteogenic differentiation of mesenchymal cells derived from human embryonic stem cells. Tissue Eng Part A. 2013 Aug; 19(15-16):1723-32. PMID: 23510052; PMCID: PMC3699956.
      25. Chang CW, Hwang Y, Brafman D, Hagan T, Phung C, Varghese S. Engineering cell-material interfaces for long-term expansion of human pluripotent stem cells. Biomaterials. 2013 Jan; 34(4):912-21. PMID: 23131532; PMCID: PMC4160325.
      26. Phadke A, Shih YR, Varghese S. Mineralized synthetic matrices as an instructive microenvironment for osteogenic differentiation of human mesenchymal stem cells. Macromol Biosci. 2012 Aug; 12(8):1022-32. PMID: 22760917.
        View in: PubMed
      27. Nguyen QT, Hwang Y, Chen AC, Varghese S, Sah RL. Cartilage-like mechanical properties of poly (ethylene glycol)-diacrylate hydrogels. Biomaterials. 2012 Oct; 33(28):6682-90. PMID: 22749448; PMCID: PMC3572364.
      28. Soman P, Fozdar DY, Lee JW, Phadke A, Varghese S, Chen S. A Three-dimensional Polymer Scaffolding Material Exhibiting a Zero Poisson's Ratio. Soft Matter. 2012 May 14; 8(18):4946-4951. PMID: 24014252.
        View in: PubMed
      29. Soman P, Lee JW, Phadke A, Varghese S, Chen S. Spatial tuning of negative and positive Poisson's ratio in a multi-layer scaffold. Acta Biomater. 2012 Jul; 8(7):2587-94. PMID: 22465577; PMCID: PMC3409644.
      30. Phadke A, Zhang C, Arman B, Hsu CC, Mashelkar RA, Lele AK, Tauber MJ, Arya G, Varghese S. Rapid self-healing hydrogels. Proc Natl Acad Sci U S A. 2012 Mar 20; 109(12):4383-8. PMID: 22392977; PMCID: PMC3311386.
      31. Hwang Y, Phadke A, Varghese S. Engineered microenvironments for self-renewal and musculoskeletal differentiation of stem cells. Regen Med. 2011 Jul; 6(4):505-24. PMID: 21749208.
        View in: PubMed
      32. Zhang C, Sangaj N, Hwang Y, Phadke A, Chang CW, Varghese S. Oligo(trimethylene carbonate)-poly(ethylene glycol)-oligo(trimethylene carbonate) triblock-based hydrogels for cartilage tissue engineering. Acta Biomater. 2011 Sep; 7(9):3362-9. PMID: 21664305.
        View in: PubMed
      33. Ayala R, Zhang C, Yang D, Hwang Y, Aung A, Shroff SS, Arce FT, Lal R, Arya G, Varghese S. Engineering the cell-material interface for controlling stem cell adhesion, migration, and differentiation. Biomaterials. 2011 May; 32(15):3700-11. PMID: 21396708.
        View in: PubMed
      34. Hwang NS, Varghese S, Li H, Elisseeff J. Regulation of osteogenic and chondrogenic differentiation of mesenchymal stem cells in PEG-ECM hydrogels. Cell Tissue Res. 2011 Jun; 344(3):499-509. PMID: 21503601.
        View in: PubMed
      35. Lin S, Sangaj N, Razafiarison T, Zhang C, Varghese S. Influence of physical properties of biomaterials on cellular behavior. Pharm Res. 2011 Jun; 28(6):1422-30. PMID: 21331474; PMCID: PMC3099000.
      36. Lim HL, Chuang JC, Tran T, Aung A, Arya G, Varghese S. Dynamic Electromechanical Hydrogel Matrices for Stem Cell Culture. Adv Funct Mater. 2011 Jan 07; 21(1). PMID: 24273479.
        View in: PubMed
      37. Gillies AR, Smith LR, Lieber RL, Varghese S. Method for decellularizing skeletal muscle without detergents or proteolytic enzymes. Tissue Eng Part C Methods. 2011 Apr; 17(4):383-9. PMID: 20973753; PMCID: PMC3065727.
      38. Sangaj N, Kyriakakis P, Yang D, Chang CW, Arya G, Varghese S. Heparin mimicking polymer promotes myogenic differentiation of muscle progenitor cells. Biomacromolecules. 2010 Dec 13; 11(12):3294-300. PMID: 21058638; PMCID: PMC4136807.
      39. Hwang Y, Sangaj N, Varghese S. Interconnected macroporous poly(ethylene glycol) cryogels as a cell scaffold for cartilage tissue engineering. Tissue Eng Part A. 2010 Oct; 16(10):3033-41. PMID: 20486791.
        View in: PubMed
      40. Brafman DA, Chang CW, Fernandez A, Willert K, Varghese S, Chien S. Long-term human pluripotent stem cell self-renewal on synthetic polymer surfaces. Biomaterials. 2010 Dec; 31(34):9135-44. PMID: 20817292; PMCID: PMC2949524.
      41. Phadke A, Zhang C, Hwang Y, Vecchio K, Varghese S. Templated mineralization of synthetic hydrogels for bone-like composite materials: role of matrix hydrophobicity. Biomacromolecules. 2010 Aug 09; 11(8):2060-8. PMID: 20690714.
        View in: PubMed
      42. Varghese S, Hwang NS, Ferran A, Hillel A, Theprungsirikul P, Canver AC, Zhang Z, Gearhart J, Elisseeff J. Engineering musculoskeletal tissues with human embryonic germ cell derivatives. Stem Cells. 2010 Apr; 28(4):765-74. PMID: 20178108.
        View in: PubMed
      43. Hwang NS, Zhang C, Hwang YS, Varghese S. Mesenchymal stem cell differentiation and roles in regenerative medicine. Wiley Interdiscip Rev Syst Biol Med. 2009 Jul-Aug; 1(1):97-106. PMID: 20835984.
        View in: PubMed
      44. Hillel AT, Varghese S, Petsche J, Shamblott MJ, Elisseeff JH. Embryonic germ cells are capable of adipogenic differentiation in vitro and in vivo. Tissue Eng Part A. 2009 Mar; 15(3):479-86. PMID: 18673089.
        View in: PubMed
      45. Hwang NS, Varghese S, Lee HJ, Zhang Z, Ye Z, Bae J, Cheng L, Elisseeff J. In vivo commitment and functional tissue regeneration using human embryonic stem cell-derived mesenchymal cells. Proc Natl Acad Sci U S A. 2008 Dec 30; 105(52):20641-6. PMID: 19095799; PMCID: PMC2634917.
      46. Lee HJ, Yu C, Chansakul T, Hwang NS, Varghese S, Yu SM, Elisseeff JH. Enhanced chondrogenesis of mesenchymal stem cells in collagen mimetic peptide-mediated microenvironment. Tissue Eng Part A. 2008 Nov; 14(11):1843-51. PMID: 18826339.
        View in: PubMed
      47. Hwang NS, Varghese S, Elisseeff J. Derivation of chondrogenically-committed cells from human embryonic cells for cartilage tissue regeneration. PLoS One. 2008 Jun 25; 3(6):e2498. PMID: 18575581; PMCID: PMC2423617.
      48. Lee HJ, Yu C, Chansakul T, Varghese S, Hwang NS, Elisseeff JH. Enhanced chondrogenic differentiation of embryonic stem cells by coculture with hepatic cells. Stem Cells Dev. 2008 Jun; 17(3):555-63. PMID: 18513166; PMCID: PMC3189711.
      49. Hwang NS, Varghese S, Elisseeff J. Controlled differentiation of stem cells. Adv Drug Deliv Rev. 2008 Jan 14; 60(2):199-214. PMID: 18006108; PMCID: PMC2712932.
      50. Hwang NS, Varghese S, Puleo C, Zhang Z, Elisseeff J. Morphogenetic signals from chondrocytes promote chondrogenic and osteogenic differentiation of mesenchymal stem cells. J Cell Physiol. 2007 Aug; 212(2):281-4. PMID: 17520697.
        View in: PubMed
      51. Hwang NS, Varghese S, Lee HJ, Theprungsirikul P, Canver A, Sharma B, Elisseeff J. Response of zonal chondrocytes to extracellular matrix-hydrogels. FEBS Lett. 2007 Sep 04; 581(22):4172-8. PMID: 17692846; PMCID: PMC2692751.
      52. Varghese S, Hwang NS, Canver AC, Theprungsirikul P, Lin DW, Elisseeff J. Chondroitin sulfate based niches for chondrogenic differentiation of mesenchymal stem cells. Matrix Biol. 2008 Jan; 27(1):12-21. PMID: 17689060.
        View in: PubMed
      53. Wang DA, Varghese S, Sharma B, Strehin I, Fermanian S, Gorham J, Fairbrother DH, Cascio B, Elisseeff JH. Multifunctional chondroitin sulphate for cartilage tissue-biomaterial integration. Nat Mater. 2007 May; 6(5):385-92. PMID: 17435762.
        View in: PubMed
      54. Hwang NS, Varghese S, Elisseeff J. Cartilage tissue engineering: Directed differentiation of embryonic stem cells in three-dimensional hydrogel culture. Methods Mol Biol. 2007; 407:351-73. PMID: 18453267.
        View in: PubMed
      55. Hwang NS, Varghese S, Zhang Z, Elisseeff J. Chondrogenic differentiation of human embryonic stem cell-derived cells in arginine-glycine-aspartate-modified hydrogels. Tissue Eng. 2006 Sep; 12(9):2695-706. PMID: 16995803.
        View in: PubMed
      56. Hwang NS, Varghese S, Theprungsirikul P, Canver A, Elisseeff J. Enhanced chondrogenic differentiation of murine embryonic stem cells in hydrogels with glucosamine. Biomaterials. 2006 Dec; 27(36):6015-23. PMID: 16872674.
        View in: PubMed
      57. Varghese S, Theprungsirikul P, Ferran A, Hwang N, Canver A, Elisseeff J. Chondrogenic differentiation of human embryonic germ cell derived cells in hydrogels. Conf Proc IEEE Eng Med Biol Soc. 2006; 1:2643-6. PMID: 17946525.
        View in: PubMed
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