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Sheila Crowe

TitleProfessor In Residence
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0063
La Jolla CA 92093
Phone858-534-2757
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    Collapse Biography 
    Collapse Education and Training
    Fellowship1988 McMaster University
    Residency1986McMaster University
    Internship1983McMaster University
    MD1982McMaster University
    BSc1979University of Toronto (Trinity College)

    Collapse Research 
    Collapse Research Activities and Funding
    1/2 SDSU/UCSD Cancer Center Comprehensive Partnership
    NIH/NCI U54CA132379Dec 1, 2007 - Aug 31, 2020
    Role: Principal Investigator
    2/2 SDSU/UCSD Cancer Center Comprehensive Partnership
    NIH/NCI U54CA132384Dec 1, 2007 - Aug 31, 2020
    Role: Principal Investigator
    GI Response to Injury: Canada 2004
    NIH/NIDDK R13DK070501Sep 25, 2004 - Aug 31, 2005
    Role: Principal Investigator
    GASTROINTESTINAL RESPONSE TO INJURY: CANADA 2001
    NIH/NIDDK R13DK061930Sep 30, 2001 - Sep 29, 2002
    Role: Principal Investigator
    OXIDATIVE INJURY TO GASTRIC EPITHELIAL CELLS BY H. PYLORI
    NIH/NIDDK R01DK061769Sep 21, 2001 - Jul 31, 2016
    Role: Principal Investigator
    Research Training in Digestive Diseases
    NIH/NIDDK T32DK007769Jul 1, 1999 - Jun 30, 2015
    Role: Principal Investigator
    GASTROENTEROLOGY TRAINING GRANT
    NIH/NIDDK T32DK007202Jul 1, 1976 - Jun 30, 2017
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Robert ME, Crowe S, Burgart L, Yantiss RK, Lebwohl B, Greenson JK, Guandalini S, Murray JA. Statement on Best Practices in the Use of Pathology as a Diagnostic Tool for Celiac Disease: A Guide for Clinicians and Pathologists. Am J Surg Pathol. 2018 Jun 19. PMID: 29923907.
      View in: PubMed
    2. El-Serag HB, Kao JY, Kanwal F, Gilger M, LoVecchio F, Moss SF, Crowe S, Elfant A, Haas T, Hapke R, Graham DY. Houston Consensus Conference on Testing for Helicobacter pylori Infection in the United States. Clin Gastroenterol Hepatol. 2018 Mar 17. PMID: 29559361.
      View in: PubMed
    3. Boland BS, Riedl MA, Valasek MA, Crowe S, Sandborn WJ. Vedolizumab in Patients With Common Variable Immune Deficiency and Gut Inflammation. Am J Gastroenterol. 2017 Oct; 112(10):1621. PMID: 28978958.
      View in: PubMed
    4. Lok A, Burke CA, Crowe S, Woods KL. Society Leadership and Diversity: Hail to the Women! Am J Gastroenterol. 2017 Sep; 112(9):1353-1355. PMID: 28809385.
      View in: PubMed
    5. Lok A, Burke CA, Crowe S, Woods KL. Society Leadership and Diversity: Hail to the Women! Hepatology. 2017 09; 66(3):686-690. PMID: 28810060.
      View in: PubMed
    6. Lok A, Burke CA, Crowe S, Woods KL. Society Leadership and Diversity: Hail to the Women! Gastroenterology. 2017 Sep; 153(3):618-620. PMID: 28821326.
      View in: PubMed
    7. Lok A, Burke CA, Crowe S, Woods KL. Society Leadership and Diversity: Hail to the Women! Gastrointest Endosc. 2017 Aug 02. PMID: 28821325.
      View in: PubMed
    8. Butcher LD, den Hartog G, Ernst PB, Crowe S. Oxidative Stress Resulting From Helicobacter pylori Infection Contributes to Gastric Carcinogenesis. Cell Mol Gastroenterol Hepatol. 2017 May; 3(3):316-322. PMID: 28462373.
      View in: PubMed
    9. Rath S, Das L, Kokate SB, Ghosh N, Dixit P, Rout N, Singh SP, Chattopadhyay S, Ashktorab H, Smoot DT, Swamy MM, Kundu TK, Crowe S, Bhattacharyya A. Inhibition of histone/lysine acetyltransferase activity kills CoCl2-treated and hypoxia-exposed gastric cancer cells and reduces their invasiveness. Int J Biochem Cell Biol. 2017 01; 82:28-40. PMID: 27890795.
      View in: PubMed
    10. Pace LA, Crowe S. Duodenal Bulb Biopsies Remain Relevant in the Diagnosis of Adult Celiac Disease. Clin Gastroenterol Hepatol. 2016 Nov; 14(11):1589-1592. PMID: 27565522.
      View in: PubMed
    11. Leffler D, Kupfer SS, Lebwohl B, Bugin K, Griebel D, Lathrop JT, Lee JJ, Mulberg AE, Papadopoulos E, Tomaino J, Crowe S. Development of Celiac Disease Therapeutics: Report of the Third Gastroenterology Regulatory Endpoints and Advancement of Therapeutics Workshop. Gastroenterology. 2016 09; 151(3):407-11. PMID: 27456385.
      View in: PubMed
    12. Pace LA, Crowe S. Complex Relationships Between Food, Diet, and the Microbiome. Gastroenterol Clin North Am. 2016 06; 45(2):253-65. PMID: 27261897.
      View in: PubMed
    13. Ludvigsson JF, Agreus L, Ciacci C, Crowe S, Geller MG, Green PH, Hill I, Hungin AP, Koletzko S, Koltai T, Lundin KE, Mearin ML, Murray JA, Reilly N, Walker MM, Sanders DS, Shamir R, Troncone R, Husby S. Transition from childhood to adulthood in coeliac disease: the Prague consensus report. Gut. 2016 08; 65(8):1242-51. PMID: 27196596.
      View in: PubMed
    14. Das L, Kokate SB, Rath S, Rout N, Singh SP, Crowe S, Mukhopadhyay AK, Bhattacharyya A. ETS2 and Twist1 promote invasiveness of Helicobacter pylori-infected gastric cancer cells by inducing Siah2. Biochem J. 2016 06 01; 473(11):1629-40. PMID: 27048589; PMCID: PMC4888467.
    15. den Hartog G, Chattopadhyay R, Ablack A, Hall EH, Butcher LD, Bhattacharyya A, Eckmann L, Harris PR, Das S, Ernst PB, Crowe S. Regulation of Rac1 and Reactive Oxygen Species Production in Response to Infection of Gastrointestinal Epithelia. PLoS Pathog. 2016 Jan; 12(1):e1005382. PMID: 26761793; PMCID: PMC4711900.
    16. Fox S, Ryan KA, Berger AH, Petro K, Das S, Crowe S, Ernst PB. The role of C1q in recognition of apoptotic epithelial cells and inflammatory cytokine production by phagocytes during Helicobacter pylori infection. J Inflamm (Lond). 2015; 12:51. PMID: 26357509; PMCID: PMC4563842.
    17. Lebwohl B, Murray JA, Verdú EF, Crowe S, Dennis M, Fasano A, Green PH, Guandalini S, Khosla C. Gluten Introduction, Breastfeeding, and Celiac Disease: Back to the Drawing Board. Am J Gastroenterol. 2016 Jan; 111(1):12-4. PMID: 26259710; PMCID: PMC4720595.
    18. Boland BS, Widjaja CE, Banno A, Zhang B, Kim SH, Stoven S, Peterson MR, Jones MC, Su HI, Crowe S, Bui JD, Ho SB, Okugawa Y, Goel A, Marietta EV, Khosroheidari M, Jepsen K, Aramburu J, López-Rodríguez C, Sandborn WJ, Murray JA, Harismendy O, Chang JT. Immunodeficiency and autoimmune enterocolopathy linked to NFAT5 haploinsufficiency. J Immunol. 2015 Mar 15; 194(6):2551-60. PMID: 25667416; PMCID: PMC4355235.
    19. Leung J, Crowe S. Food allergy and food intolerance. World Rev Nutr Diet. 2015; 111:76-81. PMID: 25418393.
      View in: PubMed
    20. Rath S, Das L, Kokate SB, Pratheek BM, Chattopadhyay S, Goswami C, Chattopadhyay R, Crowe S, Bhattacharyya A. Regulation of Noxa-mediated apoptosis in Helicobacter pylori-infected gastric epithelial cells. FASEB J. 2015 Mar; 29(3):796-806. PMID: 25404713; PMCID: PMC4422360.
    21. Crowe S. Management of celiac disease: beyond the gluten-free diet. Gastroenterology. 2014 Jun; 146(7):1594-6. PMID: 24786557.
      View in: PubMed
    22. Bhattacharyya A, Chattopadhyay R, Mitra S, Crowe S. Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. Physiol Rev. 2014 Apr; 94(2):329-54. PMID: 24692350; PMCID: PMC4044300.
    23. Das S, Sarkar A, Ryan KA, Fox S, Berger AH, Juncadella IJ, Bimczok D, Smythies LE, Harris PR, Ravichandran KS, Crowe S, Smith PD, Ernst PB. Brain angiogenesis inhibitor 1 is expressed by gastric phagocytes during infection with Helicobacter pylori and mediates the recognition and engulfment of human apoptotic gastric epithelial cells. FASEB J. 2014 May; 28(5):2214-24. PMID: 24509909; PMCID: PMC3986834.
    24. Nagoya H, Futagami S, Shimpuku M, Tatsuguchi A, Wakabayashi T, Yamawaki H, Kodaka Y, Kawagoe T, Watarai Y, Makino H, Miyashita M, Tsuchiya S, Crowe S, Sakamoto C. Apurinic/apyrimidinic endonuclease-1 is associated with angiogenesis and VEGF production via upregulation of COX-2 expression in esophageal cancer tissues. Am J Physiol Gastrointest Liver Physiol. 2014 Feb; 306(3):G183-90. PMID: 24284961.
      View in: PubMed
    25. Boettcher E, Crowe S. Dietary proteins and functional gastrointestinal disorders. Am J Gastroenterol. 2013 May; 108(5):728-36. PMID: 23567359.
      View in: PubMed
    26. Crowe S. Personal perspectives on mentoring. Gastroenterology. 2013 Mar; 144(3):488-91. PMID: 23347674.
      View in: PubMed
    27. Bhandari A, Crowe S. Helicobacter pylori in gastric malignancies. Curr Gastroenterol Rep. 2012 Dec; 14(6):489-96. PMID: 23054813.
      View in: PubMed
    28. Gohil VB, Patrie JT, Shami VM, Sauer BG, Argo CK, Crowe S, Wang AY. Colonic diverticulosis is associated with an increased adenoma detection rate in patients undergoing first-time screening colonoscopy. J Interv Gastroenterol. 2012 Apr; 2(2):70-75. PMID: 23687589.
      View in: PubMed
    29. Hall EH, Crowe S. Environmental and lifestyle influences on disorders of the large and small intestine: implications for treatment. Dig Dis. 2011; 29(2):249-54. PMID: 21734392.
      View in: PubMed
    30. Hammerle CW, Crowe S. When to reconsider the diagnosis of irritable bowel syndrome. Gastroenterol Clin North Am. 2011 Jun; 40(2):291-307, vii. PMID: 21601781.
      View in: PubMed
    31. Crowe S. In the clinic. Celiac disease. Ann Intern Med. 2011 May 03; 154(9):ITC5-1-ITC5-15; quiz ITC5-16. PMID: 21536935.
      View in: PubMed
    32. Soutto M, Belkhiri A, Piazuelo MB, Schneider BG, Peng D, Jiang A, Washington MK, Kokoye Y, Crowe S, Zaika A, Correa P, Peek RM, El-Rifai W. Loss of TFF1 is associated with activation of NF-?B-mediated inflammation and gastric neoplasia in mice and humans. J Clin Invest. 2011 May; 121(5):1753-67. PMID: 21490402; PMCID: PMC3083788.
    33. Bhattacharyya A, Chattopadhyay R, Hall EH, Mebrahtu ST, Ernst PB, Crowe S. Mechanism of hypoxia-inducible factor 1 alpha-mediated Mcl1 regulation in Helicobacter pylori-infected human gastric epithelium. Am J Physiol Gastrointest Liver Physiol. 2010 Nov; 299(5):G1177-86. PMID: 20829524; PMCID: PMC2993173.
    34. Degaetani MA, Crowe S. A 41-year-old woman with abdominal complaints: is it food allergy or food intolerance? How to tell the difference. Clin Gastroenterol Hepatol. 2010 Sep; 8(9):755-9; quiz; e97. PMID: 20363367.
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    35. Ding SZ, Fischer W, Kaparakis-Liaskos M, Liechti G, Merrell DS, Grant PA, Ferrero RL, Crowe S, Haas R, Hatakeyama M, Goldberg JB. Helicobacter pylori-induced histone modification, associated gene expression in gastric epithelial cells, and its implication in pathogenesis. PLoS One. 2010 Apr 01; 5(4):e9875. PMID: 20368982; PMCID: PMC2848570.
    36. Chattopadhyay R, Bhattacharyya A, Crowe S. Dual regulation by apurinic/apyrimidinic endonuclease-1 inhibits gastric epithelial cell apoptosis during Helicobacter pylori infection. Cancer Res. 2010 Apr 01; 70(7):2799-808. PMID: 20332233; PMCID: PMC2848894.
    37. Pinkerton JV, Dalkin AC, Crowe S, Wilson BB, Stelow EB. Treatment of postmenopausal osteoporosis in a patient with celiac disease. Nat Rev Endocrinol. 2010 Mar; 6(3):167-71. PMID: 20173778.
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    38. Bhattacharyya A, Chattopadhyay R, Burnette BR, Cross JV, Mitra S, Ernst PB, Bhakat KK, Crowe S. Acetylation of apurinic/apyrimidinic endonuclease-1 regulates Helicobacter pylori-mediated gastric epithelial cell apoptosis. Gastroenterology. 2009 Jun; 136(7):2258-69. PMID: 19505426; PMCID: PMC2694750.
    39. O'Hara AM, Bhattacharyya A, Bai J, Mifflin RC, Ernst PB, Mitra S, Crowe S. Tumor necrosis factor (TNF)-alpha-induced IL-8 expression in gastric epithelial cells: role of reactive oxygen species and AP endonuclease-1/redox factor (Ref)-1. Cytokine. 2009 Jun; 46(3):359-69. PMID: 19376732; PMCID: PMC2846768.
    40. Alam MS, Kurtz CC, Rowlett RM, Reuter BK, Wiznerowicz E, Das S, Linden J, Crowe S, Ernst PB. CD73 is expressed by human regulatory T helper cells and suppresses proinflammatory cytokine production and Helicobacter felis-induced gastritis in mice. J Infect Dis. 2009 Feb 15; 199(4):494-504. PMID: 19281303.
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    41. Futagami S, Kawagoe T, Horie A, Shindo T, Hamamoto T, Suzuki K, Kusunoki M, Miyake K, Gudis K, Tsukui T, Crowe S, Sakamoto C. Celecoxib inhibits apurinic/apyrimidinic endonuclease-1 expression and prevents gastric cancer in Helicobacter pylori-infected mongolian gerbils. Digestion. 2008; 78(2-3):93-102. PMID: 18987470.
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    42. Futagami S, Hiratsuka T, Shindo T, Horie A, Hamamoto T, Suzuki K, Kusunoki M, Miyake K, Gudis K, Crowe S, Tsukui T, Sakamoto C. Expression of apurinic/apyrimidinic endonuclease-1 (APE-1) in H. pylori-associated gastritis, gastric adenoma, and gastric cancer. Helicobacter. 2008 Jun; 13(3):209-18. PMID: 18466396.
      View in: PubMed
    43. Mikesh LM, Crowe S, Bullock GC, Taylor NE, Bruns DE. Celiac disease refractory to a gluten-free diet? Clin Chem. 2008 Feb; 54(2):441-4; discussion 444-5. PMID: 18223137.
      View in: PubMed
    44. Minohara Y, Boyd DK, Hawkins HK, Ernst PB, Patel J, Crowe S. The effect of the cag pathogenicity island on binding of Helicobacter pylori to gastric epithelial cells and the subsequent induction of apoptosis. Helicobacter. 2007 Dec; 12(6):583-90. PMID: 18001397; PMCID: PMC3036973.
    45. Makola D, Peura DA, Crowe S. Helicobacter pylori infection and related gastrointestinal diseases. J Clin Gastroenterol. 2007 Jul; 41(6):548-58. PMID: 17577110.
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    46. Ding SZ, Minohara Y, Fan XJ, Wang J, Reyes VE, Patel J, Dirden-Kramer B, Boldogh I, Ernst PB, Crowe S. Helicobacter pylori infection induces oxidative stress and programmed cell death in human gastric epithelial cells. Infect Immun. 2007 Aug; 75(8):4030-9. PMID: 17562777; PMCID: PMC1952011.
    47. Catassi C, Kryszak D, Louis-Jacques O, Duerksen DR, Hill I, Crowe S, Brown AR, Procaccini NJ, Wonderly BA, Hartley P, Moreci J, Bennett N, Horvath K, Burk M, Fasano A. Detection of Celiac disease in primary care: a multicenter case-finding study in North America. Am J Gastroenterol. 2007 Jul; 102(7):1454-60. PMID: 17355413.
      View in: PubMed
    48. Dimberg EL, Crowe S, Trugman JM, Swerdlow RH, Lopes MB, Bourne TD, Burns TM. Fatal encephalitis in a patient with refractory celiac disease presenting with myorhythmia and carpal spasm. Mov Disord. 2007 Feb 15; 22(3):407-11. PMID: 17230474.
      View in: PubMed
    49. O'Hara AM, Bhattacharyya A, Mifflin RC, Smith MF, Ryan KA, Scott KG, Naganuma M, Casola A, Izumi T, Mitra S, Ernst PB, Crowe S. Interleukin-8 induction by Helicobacter pylori in gastric epithelial cells is dependent on apurinic/apyrimidinic endonuclease-1/redox factor-1. J Immunol. 2006 Dec 01; 177(11):7990-9. PMID: 17114472.
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    50. Ernst PB, Peura DA, Crowe S. The translation of Helicobacter pylori basic research to patient care. Gastroenterology. 2006 Jan; 130(1):188-206; quiz 212-3. PMID: 16401482.
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    51. Johnson AH, Frierson HF, Zaika A, Powell SM, Roche J, Crowe S, Moskaluk CA, El-Rifai W. Expression of tight-junction protein claudin-7 is an early event in gastric tumorigenesis. Am J Pathol. 2005 Aug; 167(2):577-84. PMID: 16049341; PMCID: PMC1603560.
    52. Barrera CA, Beswick EJ, Sierra JC, Bland D, Espejo R, Mifflin R, Adegboyega P, Crowe S, Ernst PB, Reyes VE. Polarized expression of CD74 by gastric epithelial cells. J Histochem Cytochem. 2005 Dec; 53(12):1481-9. PMID: 15923369; PMCID: PMC3957538.
    53. Bischoff S, Crowe S. Gastrointestinal food allergy: new insights into pathophysiology and clinical perspectives. Gastroenterology. 2005 Apr; 128(4):1089-113. PMID: 15825090.
      View in: PubMed
    54. Crowe S. Helicobacter infection, chronic inflammation, and the development of malignancy. Curr Opin Gastroenterol. 2005 Jan; 21(1):32-8. PMID: 15687882.
      View in: PubMed
    55. Ding SZ, O'Hara AM, Denning TL, Dirden-Kramer B, Mifflin RC, Reyes VE, Ryan KA, Elliott SN, Izumi T, Boldogh I, Mitra S, Ernst PB, Crowe S. Helicobacter pylori and H2O2 increase AP endonuclease-1/redox factor-1 expression in human gastric epithelial cells. Gastroenterology. 2004 Sep; 127(3):845-58. PMID: 15362040.
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    56. Bischoff S, Crowe S. Food allergy and the gastrointestinal tract. Curr Opin Gastroenterol. 2004 Mar; 20(2):156-61. PMID: 15703638.
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    57. Smith MF, Mitchell A, Li G, Ding S, Fitzmaurice AM, Ryan K, Crowe S, Goldberg JB. Toll-like receptor (TLR) 2 and TLR5, but not TLR4, are required for Helicobacter pylori-induced NF-kappa B activation and chemokine expression by epithelial cells. J Biol Chem. 2003 Aug 29; 278(35):32552-60. PMID: 12807870.
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    58. Denning TL, Takaishi H, Crowe S, Boldogh I, Jevnikar A, Ernst PB. Oxidative stress induces the expression of Fas and Fas ligand and apoptosis in murine intestinal epithelial cells. Free Radic Biol Med. 2002 Dec 15; 33(12):1641-50. PMID: 12488132.
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    59. Casola A, Garofalo RP, Crawford SE, Estes MK, Mercurio F, Crowe S, Brasier AR. Interleukin-8 gene regulation in intestinal epithelial cells infected with rotavirus: role of viral-induced IkappaB kinase activation. Virology. 2002 Jun 20; 298(1):8-19. PMID: 12093168.
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