Shaun Mckinnie

TitlePostdoctoral Scholar
InstitutionUniversity of California San Diego
DepartmentCenter for Marine Biotechnology and Biomedecine
Address9500 Gilman Drive #0204
La Jolla CA 92093
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    1. Zheng J, McKinnie SMK, El Gamal A, Feng W, Dong Y, Agarwal V, Fenical W, Kumar A, Cao Z, Moore BS, Pessah IN. Organohalogens Naturally Biosynthesized in Marine Environments and Produced as Disinfection Byproducts Alter Sarco/Endoplasmic Reticulum Ca2+ Dynamics. Environ Sci Technol. 2018 May 01; 52(9):5469-5478. PMID: 29617551.
      View in: PubMed
    2. McKinnie SMK, Wang W, Fischer C, McDonald T, Kalin KR, Iturrioz X, Llorens-Cortes C, Oudit GY, Vederas JC. Synthetic Modification within the "RPRL" Region of Apelin Peptides: Impact on Cardiovascular Activity and Stability to Neprilysin and Plasma Degradation. J Med Chem. 2017 Jul 27; 60(14):6408-6427. PMID: 28685579.
      View in: PubMed
    3. Zhong JC, Zhang ZZ, Wang W, McKinnie SMK, Vederas JC, Oudit GY. Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases. Biochim Biophys Acta. 2017 Aug; 1863(8):1942-1950. PMID: 27825851.
      View in: PubMed
    4. McKinnie SM, Fischer C, Tran KM, Wang W, Mosquera F, Oudit GY, Vederas JC. The Metalloprotease Neprilysin Degrades and Inactivates Apelin Peptides. Chembiochem. 2016 08 17; 17(16):1495-8. PMID: 27377680.
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    5. Wang W, McKinnie SM, Farhan M, Paul M, McDonald T, McLean B, Llorens-Cortes C, Hazra S, Murray AG, Vederas JC, Oudit GY. Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17: Physiological Effects in the Cardiovascular System. Hypertension. 2016 08; 68(2):365-77. PMID: 27217402.
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    6. McKinnie SM, Rodriguez-Lopez EM, Vederas JC, Crowther JM, Suzuki H, Dobson RC, Leustek T, Triassi AJ, Wheatley MS, Hudson AO. Differential response of orthologous L,L-diaminopimelate aminotransferases (DapL) to enzyme inhibitory antibiotic lead compounds. Bioorg Med Chem. 2014 Jan 01; 22(1):523-30. PMID: 24268540.
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    7. Wang W, McKinnie SM, Patel VB, Haddad G, Wang Z, Zhabyeyev P, Das SK, Basu R, McLean B, Kandalam V, Penninger JM, Kassiri Z, Vederas JC, Murray AG, Oudit GY. Loss of Apelin exacerbates myocardial infarction adverse remodeling and ischemia-reperfusion injury: therapeutic potential of synthetic Apelin analogues. J Am Heart Assoc. 2013 Jul 01; 2(4):e000249. PMID: 23817469; PMCID: PMC3828798.
    8. Ross AC, McKinnie SM, Vederas JC. The synthesis of active and stable diaminopimelate analogues of the lantibiotic peptide lactocin S. J Am Chem Soc. 2012 Feb 01; 134(4):2008-11. PMID: 22280450.
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    9. Pattabiraman VR, McKinnie SM, Vederas JC. Solid-supported synthesis and biological evaluation of the lantibiotic peptide bis(desmethyl) lacticin 3147 A2. Angew Chem Int Ed Engl. 2008; 47(49):9472-5. PMID: 18937239.
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