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    Shannon Reilly

    TitleAssistant Adjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0757
    CA La Jolla 92093
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Il-6 and metabolic crosstalk between tissues
      NIH/NIDDK K01DK105075Sep 16, 2015 - Jul 31, 2018
      Role: Principal Investigator
      The role of non-canonical IKKs in metabolic disease
      NIH/NIDDK F32DK096851Sep 1, 2012 - Aug 31, 2015
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Reilly S, Saltiel AR. Adapting to obesity with adipose tissue inflammation. Nat Rev Endocrinol. 2017 Aug 11. PMID: 28799554.
        View in: PubMed
      2. Oral EA, Reilly S, Gomez AV, Meral R, Butz L, Ajluni N, Chenevert TL, Korytnaya E, Neidert AH, Hench R, Rus D, Horowitz JF, Poirier B, Zhao P, Lehmann K, Jain M, Yu R, Liddle C, Ahmadian M, Downes M, Evans RM, Saltiel AR. Inhibition of IKK? and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes. Cell Metab. 2017 Jul 05; 26(1):157-170.e7. PMID: 28683283.
        View in: PubMed
      3. Reilly S, Saltiel AR. A futile approach to fighting obesity? Cell. 2015 Oct 22; 163(3):539-40. PMID: 26496598.
        View in: PubMed
      4. Reilly S, Ahmadian M, Zamarron BF, Chang L, Uhm M, Poirier B, Peng X, Krause DM, Korytnaya E, Neidert A, Liddle C, Yu RT, Lumeng CN, Oral EA, Downes M, Evans RM, Saltiel AR. A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis. Nat Commun. 2015 Jan 12; 6:6047. PMID: 25581158; PMCID: PMC4324568.
      5. Fang S, Suh JM, Reilly S, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky JM, Saltiel AR, Downes M, Evans RM. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med. 2015 Feb; 21(2):159-65. PMID: 25559344; PMCID: PMC4320010.
      6. Reilly S, Saltiel AR. Countering inflammatory signals in obesity. Nat Immunol. 2014 May; 15(5):410-1. PMID: 24747704.
        View in: PubMed
      7. Reilly S, Saltiel AR. Obesity: A complex role for adipose tissue macrophages. Nat Rev Endocrinol. 2014 Apr; 10(4):193-4. PMID: 24492182.
        View in: PubMed
      8. Mowers J, Uhm M, Reilly S, Simon J, Leto D, Chiang SH, Chang L, Saltiel AR. Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKe and TBK1. Elife. 2013 Dec 24; 2:e01119. PMID: 24368730; PMCID: PMC3869376.
      9. Reilly S, Chiang SH, Decker SJ, Chang L, Uhm M, Larsen MJ, Rubin JR, Mowers J, White NM, Hochberg I, Downes M, Yu RT, Liddle C, Evans RM, Oh D, Li P, Olefsky JM, Saltiel AR. An inhibitor of the protein kinases TBK1 and IKK-? improves obesity-related metabolic dysfunctions in mice. Nat Med. 2013 Mar; 19(3):313-21. PMID: 23396211; PMCID: PMC3594079.
      10. Liu S, Reilly S, Lee CH. Transcriptional repression of mitochondrial function in aging: a novel role for the silencing mediator of retinoid and thyroid hormone receptors co-repressor. Antioxid Redox Signal. 2013 Jul 20; 19(3):299-309. PMID: 22703297; PMCID: PMC3691917.
      11. Reilly S, Bhargava P, Liu S, Gangl MR, Gorgun C, Nofsinger RR, Evans RM, Qi L, Hu FB, Lee CH. Nuclear receptor corepressor SMRT regulates mitochondrial oxidative metabolism and mediates aging-related metabolic deterioration. Cell Metab. 2010 Dec 01; 12(6):643-53. PMID: 21109196; PMCID: PMC3033658.
      12. Liu S, Hatano B, Zhao M, Yen CC, Kang K, Reilly S, Gangl MR, Gorgun C, Balschi JA, Ntambi JM, Lee CH. Role of peroxisome proliferator-activated receptor {delta}/{beta} in hepatic metabolic regulation. J Biol Chem. 2011 Jan 14; 286(2):1237-47. PMID: 21059653; PMCID: PMC3020731.
      13. Kang K, Reilly S, Karabacak V, Gangl MR, Fitzgerald K, Hatano B, Lee CH. Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. Cell Metab. 2008 Jun; 7(6):485-95. PMID: 18522830; PMCID: PMC2586840.
      14. Reilly S, Lee CH. PPAR delta as a therapeutic target in metabolic disease. FEBS Lett. 2008 Jan 09; 582(1):26-31. PMID: 18036566; PMCID: PMC2275052.
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