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Shannon Reilly

TitleAssistant Adjunct Professor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0757
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    An Il-6/Stat3 autocrine axis in adipose tissue
    NIH/NIDDK R03DK118195Jul 1, 2018 - Jun 30, 2020
    Role: Principal Investigator
    Il-6 and metabolic crosstalk between tissues
    NIH/NIDDK K01DK105075Sep 16, 2015 - Jul 31, 2018
    Role: Principal Investigator
    The role of non-canonical IKKs in metabolic disease
    NIH/NIDDK F32DK096851Sep 1, 2012 - Aug 31, 2015
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Beyett TS, Gan X, Reilly SM, Gomez AV, Chang L, Tesmer JJG, Saltiel AR, Showalter HD. Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKKe for the treatment of obesity. Bioorg Med Chem. 2018 Sep 20. PMID: 30270002.
      View in: PubMed
    2. Beyett TS, Gan X, Reilly SM, Chang L, Gomez AV, Saltiel AR, Showalter HD, Tesmer JJ. Carboxylic acid derivatives of amlexanox display enhanced potency towards TBK1 and IKK? and reveal mechanisms for selective inhibition. Mol Pharmacol. 2018 Aug 06. PMID: 30082428.
      View in: PubMed
    3. Skorobogatko Y, Dragan M, Cordon C, Reilly SM, Hung CW, Xia W, Zhao P, Wallace M, Lackey DE, Chen XW, Osborn O, Bogner-Strauss JG, Theodorescu D, Metallo CM, Olefsky JM, Saltiel AR. RalA controls glucose homeostasis by regulating glucose uptake in brown fat. Proc Natl Acad Sci U S A. 2018 Jun 18. PMID: 29915037.
      View in: PubMed
    4. Ahmadian M, Liu S, Reilly SM, Hah N, Fan W, Yoshihara E, Jha P, De Magalhaes Filho CD, Jacinto S, Gomez AV, Dai Y, Yu RT, Liddle C, Atkins AR, Auwerx J, Saltiel AR, Downes M, Evans RM. ERR? Preserves Brown Fat Innate Thermogenic Activity. Cell Rep. 2018 Mar 13; 22(11):2849-2859. PMID: 29539415.
      View in: PubMed
    5. Zhao P, Wong KI, Sun X, Reilly SM, Uhm M, Liao Z, Skorobogatko Y, Saltiel AR. TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue. Cell. 2018 Feb 08; 172(4):731-743.e12. PMID: 29425491.
      View in: PubMed
    6. Cho CS, Park HW, Ho A, Semple IA, Kim B, Jang I, Park H, Reilly S, Saltiel AR, Lee JH. Lipotoxicity induces hepatic protein inclusions through TBK1-mediated p62/SQSTM1 phosphorylation. Hepatology. 2017 Dec 18. PMID: 29251796.
      View in: PubMed
    7. Reilly SM, Saltiel AR. Adapting to obesity with adipose tissue inflammation. Nat Rev Endocrinol. 2017 Nov; 13(11):633-643. PMID: 28799554.
      View in: PubMed
    8. Oral EA, Reilly SM, Gomez AV, Meral R, Butz L, Ajluni N, Chenevert TL, Korytnaya E, Neidert AH, Hench R, Rus D, Horowitz JF, Poirier B, Zhao P, Lehmann K, Jain M, Yu R, Liddle C, Ahmadian M, Downes M, Evans RM, Saltiel AR. Inhibition of IKK? and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes. Cell Metab. 2017 Jul 05; 26(1):157-170.e7. PMID: 28683283.
      View in: PubMed
    9. Reilly SM, Saltiel AR. A futile approach to fighting obesity? Cell. 2015 Oct 22; 163(3):539-40. PMID: 26496598.
      View in: PubMed
    10. Reilly SM, Ahmadian M, Zamarron BF, Chang L, Uhm M, Poirier B, Peng X, Krause DM, Korytnaya E, Neidert A, Liddle C, Yu RT, Lumeng CN, Oral EA, Downes M, Evans RM, Saltiel AR. A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis. Nat Commun. 2015 Jan 12; 6:6047. PMID: 25581158; PMCID: PMC4324568.
    11. Fang S, Suh JM, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky JM, Saltiel AR, Downes M, Evans RM. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med. 2015 Feb; 21(2):159-65. PMID: 25559344; PMCID: PMC4320010.
    12. Reilly SM, Saltiel AR. Countering inflammatory signals in obesity. Nat Immunol. 2014 May; 15(5):410-1. PMID: 24747704.
      View in: PubMed
    13. Reilly SM, Saltiel AR. Obesity: A complex role for adipose tissue macrophages. Nat Rev Endocrinol. 2014 Apr; 10(4):193-4. PMID: 24492182.
      View in: PubMed
    14. Mowers J, Uhm M, Reilly SM, Simon J, Leto D, Chiang SH, Chang L, Saltiel AR. Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKe and TBK1. Elife. 2013 Dec 24; 2:e01119. PMID: 24368730; PMCID: PMC3869376.
    15. Reilly SM, Chiang SH, Decker SJ, Chang L, Uhm M, Larsen MJ, Rubin JR, Mowers J, White NM, Hochberg I, Downes M, Yu RT, Liddle C, Evans RM, Oh D, Li P, Olefsky JM, Saltiel AR. An inhibitor of the protein kinases TBK1 and IKK-? improves obesity-related metabolic dysfunctions in mice. Nat Med. 2013 Mar; 19(3):313-21. PMID: 23396211; PMCID: PMC3594079.
    16. Liu S, Reilly SM, Lee CH. Transcriptional repression of mitochondrial function in aging: a novel role for the silencing mediator of retinoid and thyroid hormone receptors co-repressor. Antioxid Redox Signal. 2013 Jul 20; 19(3):299-309. PMID: 22703297; PMCID: PMC3691917.
    17. Reilly SM, Bhargava P, Liu S, Gangl MR, Gorgun C, Nofsinger RR, Evans RM, Qi L, Hu FB, Lee CH. Nuclear receptor corepressor SMRT regulates mitochondrial oxidative metabolism and mediates aging-related metabolic deterioration. Cell Metab. 2010 Dec 01; 12(6):643-53. PMID: 21109196; PMCID: PMC3033658.
    18. Liu S, Hatano B, Zhao M, Yen CC, Kang K, Reilly SM, Gangl MR, Gorgun C, Balschi JA, Ntambi JM, Lee CH. Role of peroxisome proliferator-activated receptor {delta}/{beta} in hepatic metabolic regulation. J Biol Chem. 2011 Jan 14; 286(2):1237-47. PMID: 21059653; PMCID: PMC3020731.
    19. Kang K, Reilly SM, Karabacak V, Gangl MR, Fitzgerald K, Hatano B, Lee CH. Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. Cell Metab. 2008 Jun; 7(6):485-95. PMID: 18522830; PMCID: PMC2586840.
    20. Reilly SM, Lee CH. PPAR delta as a therapeutic target in metabolic disease. FEBS Lett. 2008 Jan 09; 582(1):26-31. PMID: 18036566; PMCID: PMC2275052.
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