Shannon Reilly

Title(s)Assistant Adjunct Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of fatty acid metabolism in adipocytes
    NIH R01DK126944Dec 3, 2020 - Nov 30, 2025
    Role: Principal Investigator
    An Il-6/Stat3 autocrine axis in adipose tissue
    ADA 1-19-JDF-012Jan 1, 2019 - Dec 31, 2020
    Role: Principal Investigator
    An Il-6/Stat3 Autocrine Axis in Adipose Tissue
    NIH R03DK118195Jul 1, 2018 - Jun 30, 2020
    Role: Principal Investigator
    Il-6 and metabolic crosstalk between tissues
    NIH K01DK105075Sep 16, 2015 - Jul 31, 2018
    Role: Principal Investigator
    The role of non-canonical IKKs in metabolic disease
    NIH F32DK096851Sep 1, 2012 - Aug 31, 2015
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chop/Ddit3 depletion in β cells alleviates ER stress and corrects hepatic steatosis in mice. Sci Transl Med. 2021 07 28; 13(604). Yong J, Parekh VS, Reilly SM, Nayak J, Chen Z, Lebeaupin C, Jang I, Zhang J, Prakash TP, Sun H, Murray S, Guo S, Ayala JE, Satin LS, Saltiel AR, Kaufman RJ. PMID: 34321322.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    2. FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes. Cell Rep. 2021 Jun 29; 35(13):109331. Abu-Odeh M, Zhang Y, Reilly SM, Ebadat N, Keinan O, Valentine JM, Hafezi-Bakhtiari M, Ashayer H, Mamoun L, Zhou X, Zhang J, Yu RT, Dai Y, Liddle C, Downes M, Evans RM, Kliewer SA, Mangelsdorf DJ, Saltiel AR. PMID: 34192547.
      View in: PubMed   Mentions:    Fields:    
    3. FGF21 is required for the metabolic benefits of IKKε/TBK1 inhibition. J Clin Invest. 2021 05 17; 131(10). Reilly SM, Abu-Odeh M, Ameka M, DeLuca JH, Naber MC, Dadpey B, Ebadat N, Gomez AV, Peng X, Poirier B, Walk E, Potthoff MJ, Saltiel AR. PMID: 33822771.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation. Cell Metab. 2020 12 01; 32(6):1012-1027.e7. Huh JY, Reilly SM, Abu-Odeh M, Murphy AN, Mahata SK, Zhang J, Cho Y, Seo JB, Hung CW, Green CR, Metallo CM, Saltiel AR. PMID: 33152322.
      View in: PubMed   Mentions: 1     Fields:    
    5. Catecholamines suppress fatty acid re-esterification and increase oxidation in white adipocytes via STAT3. Nat Metab. 2020 07; 2(7):620-634. Reilly SM, Hung CW, Ahmadian M, Zhao P, Keinan O, Gomez AV, DeLuca JH, Dadpey B, Lu D, Zaid J, Poirier B, Peng X, Yu RT, Downes M, Liddle C, Evans RM, Murphy AN, Saltiel AR. PMID: 32694788.
      View in: PubMed   Mentions:
    6. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. Proc Natl Acad Sci U S A. 2019 07 23; 116(30):15184-15193. Wang L, Mazagova M, Pan C, Yang S, Brandl K, Liu J, Reilly SM, Wang Y, Miao Z, Loomba R, Lu N, Guo Q, Liu J, Yu RT, Downes M, Evans RM, Brenner DA, Saltiel AR, Beutler B, Schnabl B. PMID: 31289229.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    7. Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKKε for the treatment of obesity. Bioorg Med Chem. 2018 11 01; 26(20):5443-5461. Beyett TS, Gan X, Reilly SM, Gomez AV, Chang L, Tesmer JJG, Saltiel AR, Showalter HD. PMID: 30270002.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    8. Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKε and Reveal Mechanisms for Selective Inhibition. Mol Pharmacol. 2018 10; 94(4):1210-1219. Beyett TS, Gan X, Reilly SM, Chang L, Gomez AV, Saltiel AR, Showalter HD, Tesmer JJG. PMID: 30082428.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    9. RalA controls glucose homeostasis by regulating glucose uptake in brown fat. Proc Natl Acad Sci U S A. 2018 07 24; 115(30):7819-7824. Skorobogatko Y, Dragan M, Cordon C, Reilly SM, Hung CW, Xia W, Zhao P, Wallace M, Lackey DE, Chen XW, Osborn O, Bogner-Strauss JG, Theodorescu D, Metallo CM, Olefsky JM, Saltiel AR. PMID: 29915037.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    10. Lipotoxicity induces hepatic protein inclusions through TANK binding kinase 1-mediated p62/sequestosome 1 phosphorylation. Hepatology. 2018 10; 68(4):1331-1346. Cho CS, Park HW, Ho A, Semple IA, Kim B, Jang I, Park H, Reilly S, Saltiel AR, Lee JH. PMID: 29251796.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    11. ERRγ Preserves Brown Fat Innate Thermogenic Activity. Cell Rep. 2018 03 13; 22(11):2849-2859. Ahmadian M, Liu S, Reilly SM, Hah N, Fan W, Yoshihara E, Jha P, De Magalhaes Filho CD, Jacinto S, Gomez AV, Dai Y, Yu RT, Liddle C, Atkins AR, Auwerx J, Saltiel AR, Downes M, Evans RM. PMID: 29539415.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    12. TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue. Cell. 2018 02 08; 172(4):731-743.e12. Zhao P, Wong KI, Sun X, Reilly SM, Uhm M, Liao Z, Skorobogatko Y, Saltiel AR. PMID: 29425491.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    13. Adapting to obesity with adipose tissue inflammation. Nat Rev Endocrinol. 2017 Nov; 13(11):633-643. Reilly SM, Saltiel AR. PMID: 28799554.
      View in: PubMed   Mentions: 243     Fields:    Translation:HumansCells
    14. Inhibition of IKKɛ and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes. Cell Metab. 2017 Jul 05; 26(1):157-170.e7. Oral EA, Reilly SM, Gomez AV, Meral R, Butz L, Ajluni N, Chenevert TL, Korytnaya E, Neidert AH, Hench R, Rus D, Horowitz JF, Poirier B, Zhao P, Lehmann K, Jain M, Yu R, Liddle C, Ahmadian M, Downes M, Evans RM, Saltiel AR. PMID: 28683283.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    15. A futile approach to fighting obesity? Cell. 2015 Oct 22; 163(3):539-40. Reilly SM, Saltiel AR. PMID: 26496598.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    16. A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis. Nat Commun. 2015 Jan 12; 6:6047. Reilly SM, Ahmadian M, Zamarron BF, Chang L, Uhm M, Poirier B, Peng X, Krause DM, Korytnaya E, Neidert A, Liddle C, Yu RT, Lumeng CN, Oral EA, Downes M, Evans RM, Saltiel AR. PMID: 25581158.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    17. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med. 2015 Feb; 21(2):159-65. Fang S, Suh JM, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky JM, Saltiel AR, Downes M, Evans RM. PMID: 25559344.
      View in: PubMed   Mentions: 190     Fields:    Translation:Animals
    18. Countering inflammatory signals in obesity. Nat Immunol. 2014 May; 15(5):410-1. Reilly SM, Saltiel AR. PMID: 24747704.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    19. Obesity: A complex role for adipose tissue macrophages. Nat Rev Endocrinol. 2014 Apr; 10(4):193-4. Reilly SM, Saltiel AR. PMID: 24492182.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    20. Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1. Elife. 2013 Dec 24; 2:e01119. Mowers J, Uhm M, Reilly SM, Simon J, Leto D, Chiang SH, Chang L, Saltiel AR. PMID: 24368730.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    21. An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice. Nat Med. 2013 Mar; 19(3):313-21. Reilly SM, Chiang SH, Decker SJ, Chang L, Uhm M, Larsen MJ, Rubin JR, Mowers J, White NM, Hochberg I, Downes M, Yu RT, Liddle C, Evans RM, Oh D, Li P, Olefsky JM, Saltiel AR. PMID: 23396211.
      View in: PubMed   Mentions: 164     Fields:    Translation:AnimalsCells
    22. Transcriptional repression of mitochondrial function in aging: a novel role for the silencing mediator of retinoid and thyroid hormone receptors co-repressor. Antioxid Redox Signal. 2013 Jul 20; 19(3):299-309. Liu S, Reilly SM, Lee CH. PMID: 22703297.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    23. Nuclear receptor corepressor SMRT regulates mitochondrial oxidative metabolism and mediates aging-related metabolic deterioration. Cell Metab. 2010 Dec 01; 12(6):643-53. Reilly SM, Bhargava P, Liu S, Gangl MR, Gorgun C, Nofsinger RR, Evans RM, Qi L, Hu FB, Lee CH. PMID: 21109196.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    24. Role of peroxisome proliferator-activated receptor {delta}/{beta} in hepatic metabolic regulation. J Biol Chem. 2011 Jan 14; 286(2):1237-47. Liu S, Hatano B, Zhao M, Yen CC, Kang K, Reilly SM, Gangl MR, Gorgun C, Balschi JA, Ntambi JM, Lee CH. PMID: 21059653.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    25. Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. Cell Metab. 2008 Jun; 7(6):485-95. Kang K, Reilly SM, Karabacak V, Gangl MR, Fitzgerald K, Hatano B, Lee CH. PMID: 18522830.
      View in: PubMed   Mentions: 308     Fields:    Translation:AnimalsCells
    26. PPAR delta as a therapeutic target in metabolic disease. FEBS Lett. 2008 Jan 09; 582(1):26-31. Reilly SM, Lee CH. PMID: 18036566.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
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