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Shannon Reilly

Title(s)Assistant Adjunct Professor, Medicine
SchoolHealth Sciences
Address9500 Gilman Drive #0757
La Jolla CA 92093
Phone858-534-0354
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    Collapse Research 
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    An Il-6/Stat3 autocrine axis in adipose tissue
    ADA 1-19-JDF-012Jan 1, 2019 - Dec 31, 2020
    Role: Principal Investigator
    An Il-6/Stat3 autocrine axis in adipose tissue
    NIH/NIDDK R03DK118195Jul 1, 2018 - Jun 30, 2020
    Role: Principal Investigator
    Il-6 and metabolic crosstalk between tissues
    NIH/NIDDK K01DK105075Sep 16, 2015 - Jul 31, 2018
    Role: Principal Investigator
    The role of non-canonical IKKs in metabolic disease
    NIH/NIDDK F32DK096851Sep 1, 2012 - Aug 31, 2015
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. Proc Natl Acad Sci U S A. 2019 07 23; 116(30):15184-15193. Wang L, Mazagova M, Pan C, Yang S, Brandl K, Liu J, Reilly SM, Wang Y, Miao Z, Loomba R, Lu N, Guo Q, Liu J, Yu RT, Downes M, Evans RM, Brenner DA, Saltiel AR, Beutler B, Schnabl B. PMID: 31289229.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKKe for the treatment of obesity. Bioorg Med Chem. 2018 11 01; 26(20):5443-5461. Beyett TS, Gan X, Reilly SM, Gomez AV, Chang L, Tesmer JJG, Saltiel AR, Showalter HD. PMID: 30270002.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKe and Reveal Mechanisms for Selective Inhibition. Mol Pharmacol. 2018 10; 94(4):1210-1219. Beyett TS, Gan X, Reilly SM, Chang L, Gomez AV, Saltiel AR, Showalter HD, Tesmer JJG. PMID: 30082428.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. RalA controls glucose homeostasis by regulating glucose uptake in brown fat. Proc Natl Acad Sci U S A. 2018 07 24; 115(30):7819-7824. Skorobogatko Y, Dragan M, Cordon C, Reilly SM, Hung CW, Xia W, Zhao P, Wallace M, Lackey DE, Chen XW, Osborn O, Bogner-Strauss JG, Theodorescu D, Metallo CM, Olefsky JM, Saltiel AR. PMID: 29915037.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    5. Lipotoxicity induces hepatic protein inclusions through TANK binding kinase 1-mediated p62/sequestosome 1 phosphorylation. Hepatology. 2018 10; 68(4):1331-1346. Cho CS, Park HW, Ho A, Semple IA, Kim B, Jang I, Park H, Reilly S, Saltiel AR, Lee JH. PMID: 29251796.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    6. ERR? Preserves Brown Fat Innate Thermogenic Activity. Cell Rep. 2018 03 13; 22(11):2849-2859. Ahmadian M, Liu S, Reilly SM, Hah N, Fan W, Yoshihara E, Jha P, De Magalhaes Filho CD, Jacinto S, Gomez AV, Dai Y, Yu RT, Liddle C, Atkins AR, Auwerx J, Saltiel AR, Downes M, Evans RM. PMID: 29539415.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    7. TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue. Cell. 2018 02 08; 172(4):731-743.e12. Zhao P, Wong KI, Sun X, Reilly SM, Uhm M, Liao Z, Skorobogatko Y, Saltiel AR. PMID: 29425491.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    8. Adapting to obesity with adipose tissue inflammation. Nat Rev Endocrinol. 2017 Nov; 13(11):633-643. Reilly SM, Saltiel AR. PMID: 28799554.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    9. Inhibition of IKK? and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes. Cell Metab. 2017 Jul 05; 26(1):157-170.e7. Oral EA, Reilly SM, Gomez AV, Meral R, Butz L, Ajluni N, Chenevert TL, Korytnaya E, Neidert AH, Hench R, Rus D, Horowitz JF, Poirier B, Zhao P, Lehmann K, Jain M, Yu R, Liddle C, Ahmadian M, Downes M, Evans RM, Saltiel AR. PMID: 28683283.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    10. A futile approach to fighting obesity? Cell. 2015 Oct 22; 163(3):539-40. Reilly SM, Saltiel AR. PMID: 26496598.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    11. A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis. Nat Commun. 2015 Jan 12; 6:6047. Reilly SM, Ahmadian M, Zamarron BF, Chang L, Uhm M, Poirier B, Peng X, Krause DM, Korytnaya E, Neidert A, Liddle C, Yu RT, Lumeng CN, Oral EA, Downes M, Evans RM, Saltiel AR. PMID: 25581158.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    12. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med. 2015 Feb; 21(2):159-65. Fang S, Suh JM, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky JM, Saltiel AR, Downes M, Evans RM. PMID: 25559344.
      View in: PubMed   Mentions: 119     Fields:    Translation:Animals
    13. Countering inflammatory signals in obesity. Nat Immunol. 2014 May; 15(5):410-1. Reilly SM, Saltiel AR. PMID: 24747704.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    14. Obesity: A complex role for adipose tissue macrophages. Nat Rev Endocrinol. 2014 Apr; 10(4):193-4. Reilly SM, Saltiel AR. PMID: 24492182.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    15. Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKe and TBK1. Elife. 2013 Dec 24; 2:e01119. Mowers J, Uhm M, Reilly SM, Simon J, Leto D, Chiang SH, Chang L, Saltiel AR. PMID: 24368730.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    16. An inhibitor of the protein kinases TBK1 and IKK-? improves obesity-related metabolic dysfunctions in mice. Nat Med. 2013 Mar; 19(3):313-21. Reilly SM, Chiang SH, Decker SJ, Chang L, Uhm M, Larsen MJ, Rubin JR, Mowers J, White NM, Hochberg I, Downes M, Yu RT, Liddle C, Evans RM, Oh D, Li P, Olefsky JM, Saltiel AR. PMID: 23396211.
      View in: PubMed   Mentions: 119     Fields:    Translation:AnimalsCells
    17. Transcriptional repression of mitochondrial function in aging: a novel role for the silencing mediator of retinoid and thyroid hormone receptors co-repressor. Antioxid Redox Signal. 2013 Jul 20; 19(3):299-309. Liu S, Reilly SM, Lee CH. PMID: 22703297.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    18. Nuclear receptor corepressor SMRT regulates mitochondrial oxidative metabolism and mediates aging-related metabolic deterioration. Cell Metab. 2010 Dec 01; 12(6):643-53. Reilly SM, Bhargava P, Liu S, Gangl MR, Gorgun C, Nofsinger RR, Evans RM, Qi L, Hu FB, Lee CH. PMID: 21109196.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    19. Role of peroxisome proliferator-activated receptor {delta}/{beta} in hepatic metabolic regulation. J Biol Chem. 2011 Jan 14; 286(2):1237-47. Liu S, Hatano B, Zhao M, Yen CC, Kang K, Reilly SM, Gangl MR, Gorgun C, Balschi JA, Ntambi JM, Lee CH. PMID: 21059653.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    20. Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. Cell Metab. 2008 Jun; 7(6):485-95. Kang K, Reilly SM, Karabacak V, Gangl MR, Fitzgerald K, Hatano B, Lee CH. PMID: 18522830.
      View in: PubMed   Mentions: 247     Fields:    Translation:AnimalsCells
    21. PPAR delta as a therapeutic target in metabolic disease. FEBS Lett. 2008 Jan 09; 582(1):26-31. Reilly SM, Lee CH. PMID: 18036566.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
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