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Seth Field

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0707
La Jolla CA 92093
Phone858-822-1731
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    Collapse Research 
    Collapse Research Activities and Funding
    GOLPH3 Pathway Regulation of Golgi Structure and Function
    NIH/NIGMS R01GM120055Sep 1, 2016 - Aug 31, 2020
    Role: Principal Investigator
    High Throughput Screen to Identify Inhibitors of the Golgi GOLPH3 Pathway
    NIH/NCI R01CA201303Jun 1, 2016 - May 31, 2019
    Role: Principal Investigator
    Targeting a Novel Phosphoinositide Signaling Pathway for Cancer Therapy
    NIH/NCI R01CA138676Jun 4, 2009 - May 31, 2011
    Role: Principal Investigator
    Phosphoinositides Provide Unique Insights into Cell Biology and Pathophysiology
    NIH DP2OD004265Sep 30, 2008 - Aug 31, 2013
    Role: Principal Investigator
    PI-3-Kinase Signaling over Physiologic Time-Scales/Response to Insulin or IGF-1
    NIH/NIDDK R03DK075358Jul 1, 2006 - Jun 30, 2008
    Role: Principal Investigator
    PI-3-kinase mediated signaling by insulin and IGF-1
    NIH/NIDDK K08DK065108Sep 30, 2003 - Aug 31, 2008
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Buschman MD, Field SJ. MYO18A: An unusual myosin. Adv Biol Regul. 2018 Jan; 67:84-92. PMID: 28942352.
      View in: PubMed
    2. Field SJ. Spelunking for lipids in caveolae. J Biol Chem. 2017 08 25; 292(34):14308-14309. PMID: 28842476.
      View in: PubMed
    3. Makowski SL, Tran TT, Field SJ. Emerging themes of regulation at the Golgi. Curr Opin Cell Biol. 2017 04; 45:17-23. PMID: 28213314.
      View in: PubMed
    4. Xing M, Peterman MC, Davis RL, Oegema K, Shiau AK, Field SJ. GOLPH3 drives cell migration by promoting Golgi reorientation and directional trafficking to the leading edge. Mol Biol Cell. 2016 Dec 01; 27(24):3828-3840. PMID: 27708138.
      View in: PubMed
    5. Buschman MD, Xing M, Field SJ. The GOLPH3 pathway regulates Golgi shape and function and is activated by DNA damage. Front Neurosci. 2015; 9:362. PMID: 26500484; PMCID: PMC4595774.
    6. Akizu N, Cantagrel V, Zaki MS, Al-Gazali L, Wang X, Rosti RO, Dikoglu E, Gelot AB, Rosti B, Vaux KK, Scott EM, Silhavy JL, Schroth J, Copeland B, Schaffer AE, Gordts PL, Esko JD, Buschman MD, Field SJ, Napolitano G, Abdel-Salam GM, Ozgul RK, Sagiroglu MS, Azam M, Ismail S, Aglan M, Selim L, Mahmoud IG, Abdel-Hadi S, Badawy AE, Sadek AA, Mojahedi F, Kayserili H, Masri A, Bastaki L, Temtamy S, Müller U, Desguerre I, Casanova JL, Dursun A, Gunel M, Gabriel SB, de Lonlay P, Gleeson JG. Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction. Nat Genet. 2015 May; 47(5):528-34. PMID: 25848753; PMCID: PMC4414867.
    7. Buschman MD, Rahajeng J, Field SJ. GOLPH3 links the Golgi, DNA damage, and cancer. Cancer Res. 2015 Feb 15; 75(4):624-7. PMID: 25634214; PMCID: PMC4333064.
    8. Farber-Katz SE, Dippold HC, Buschman MD, Peterman MC, Xing M, Noakes CJ, Tat J, Ng MM, Rahajeng J, Cowan DM, Fuchs GJ, Zhou H, Field SJ. DNA damage triggers Golgi dispersal via DNA-PK and GOLPH3. Cell. 2014 Jan 30; 156(3):413-27. PMID: 24485452; PMCID: PMC4018323.
    9. Ng MM, Dippold HC, Buschman MD, Noakes CJ, Field SJ. GOLPH3L antagonizes GOLPH3 to determine Golgi morphology. Mol Biol Cell. 2013 Mar; 24(6):796-808. PMID: 23345592; PMCID: PMC3596250.
    10. Murray MJ, Ng MM, Fraval H, Tan J, Liu W, Smallhorn M, Brill JA, Field SJ, Saint R. Regulation of Drosophila mesoderm migration by phosphoinositides and the PH domain of the Rho GTP exchange factor Pebble. Dev Biol. 2012 Dec 01; 372(1):17-27. PMID: 23000359.
      View in: PubMed
    11. Bishé B, Syed GH, Field SJ, Siddiqui A. Role of phosphatidylinositol 4-phosphate (PI4P) and its binding protein GOLPH3 in hepatitis C virus secretion. J Biol Chem. 2012 Aug 10; 287(33):27637-47. PMID: 22745132; PMCID: PMC3431621.
    12. Schmid MC, Avraamides CJ, Dippold HC, Franco I, Foubert P, Ellies LG, Acevedo LM, Manglicmot JR, Song X, Wrasidlo W, Blair SL, Ginsberg MH, Cheresh DA, Hirsch E, Field SJ, Varner JA. Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3k?, a single convergent point promoting tumor inflammation and progression. Cancer Cell. 2011 Jun 14; 19(6):715-27. PMID: 21665146; PMCID: PMC3144144.
    13. Nhek S, Ngo M, Yang X, Ng MM, Field SJ, Asara JM, Ridgway ND, Toker A. Regulation of oxysterol-binding protein Golgi localization through protein kinase D-mediated phosphorylation. Mol Biol Cell. 2010 Jul 01; 21(13):2327-37. PMID: 20444975; PMCID: PMC2893995.
    14. Dippold HC, Ng MM, Farber-Katz SE, Lee SK, Kerr ML, Peterman MC, Sim R, Wiharto PA, Galbraith KA, Madhavarapu S, Fuchs GJ, Meerloo T, Farquhar MG, Zhou H, Field SJ. GOLPH3 bridges phosphatidylinositol-4- phosphate and actomyosin to stretch and shape the Golgi to promote budding. Cell. 2009 Oct 16; 139(2):337-51. PMID: 19837035; PMCID: PMC2779841.
    15. Bielas SL, Silhavy JL, Brancati F, Kisseleva MV, Al-Gazali L, Sztriha L, Bayoumi RA, Zaki MS, Abdel-Aleem A, Rosti RO, Kayserili H, Swistun D, Scott LC, Bertini E, Boltshauser E, Fazzi E, Travaglini L, Field SJ, Gayral S, Jacoby M, Schurmans S, Dallapiccola B, Majerus PW, Valente EM, Gleeson JG. Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies. Nat Genet. 2009 Sep; 41(9):1032-6. PMID: 19668216; PMCID: PMC2746682.
    16. Infante A, Laresgoiti U, Fernández-Rueda J, Fullaondo A, Galán J, Díaz-Uriarte R, Malumbres M, Field SJ, Zubiaga AM. E2F2 represses cell cycle regulators to maintain quiescence. Cell Cycle. 2008 Dec 15; 7(24):3915-27. PMID: 19066456.
      View in: PubMed
    17. Yang X, Ongusaha PP, Miles PD, Havstad JC, Zhang F, So WV, Kudlow JE, Michell RH, Olefsky JM, Field SJ, Evans RM. Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance. Nature. 2008 Feb 21; 451(7181):964-9. PMID: 18288188.
      View in: PubMed
    18. Chang JD, Sukhova GK, Libby P, Schvartz E, Lichtenstein AH, Field SJ, Kennedy C, Madhavarapu S, Luo J, Wu D, Cantley LC. Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis. Proc Natl Acad Sci U S A. 2007 May 08; 104(19):8077-82. PMID: 17483449; PMCID: PMC1864909.
    19. Gozani O, Field SJ, Ferguson CG, Ewalt M, Mahlke C, Cantley LC, Prestwich GD, Yuan J. Modification of protein sub-nuclear localization by synthetic phosphoinositides: evidence for nuclear phosphoinositide signaling mechanisms. Adv Enzyme Regul. 2005; 45:171-85. PMID: 16199078.
      View in: PubMed
    20. Field SJ, Madson N, Kerr ML, Galbraith KA, Kennedy CE, Tahiliani M, Wilkins A, Cantley LC. PtdIns(4,5)P2 functions at the cleavage furrow during cytokinesis. Curr Biol. 2005 Aug 09; 15(15):1407-12. PMID: 16085494.
      View in: PubMed
    21. Luo J, Field SJ, Lee JY, Engelman JA, Cantley LC. The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex. J Cell Biol. 2005 Aug 01; 170(3):455-64. PMID: 16043515; PMCID: PMC2171479.
    22. Yuan H, Luo J, Field S, Weissleder R, Cantley L, Josephson L. Synthesis and activity of C11-modified wortmannin probes for PI3 kinase. Bioconjug Chem. 2005 May-Jun; 16(3):669-75. PMID: 15898736.
      View in: PubMed
    23. Mitra P, Zhang Y, Rameh LE, Ivshina MP, McCollum D, Nunnari JJ, Hendricks GM, Kerr ML, Field SJ, Cantley LC, Ross AH. A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast. J Cell Biol. 2004 Jul 19; 166(2):205-11. PMID: 15249580; PMCID: PMC2172303.
    24. Iglesias A, Murga M, Laresgoiti U, Skoudy A, Bernales I, Fullaondo A, Moreno B, Lloreta J, Field SJ, Real FX, Zubiaga AM. Diabetes and exocrine pancreatic insufficiency in E2F1/E2F2 double-mutant mice. J Clin Invest. 2004 May; 113(10):1398-407. PMID: 15146237; PMCID: PMC406522.
    25. Chang JD, Field SJ, Rameh LE, Carpenter CL, Cantley LC. Identification and characterization of a phosphoinositide phosphate kinase homolog. J Biol Chem. 2004 Mar 19; 279(12):11672-9. PMID: 14701839.
      View in: PubMed
    26. Gozani O, Karuman P, Jones DR, Ivanov D, Cha J, Lugovskoy AA, Baird CL, Zhu H, Field SJ, Lessnick SL, Villasenor J, Mehrotra B, Chen J, Rao VR, Brugge JS, Ferguson CG, Payrastre B, Myszka DG, Cantley LC, Wagner G, Divecha N, Prestwich GD, Yuan J. The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell. 2003 Jul 11; 114(1):99-111. PMID: 12859901.
      View in: PubMed
    27. Field SJ, Lamia KA, Rameh LE, Cantley LC. Lipid research picks up speed on the slopes of Taos. Dev Cell. 2002 Apr; 2(4):407-10. PMID: 11970891.
      View in: PubMed